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All Journal JURNAL KIMIA SAINS DAN APLIKASI Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry JURNAL FARMASI GALENIKA Jurnal Farmagazine Current Research on Biosciences and Biotechnology Narra J Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kebidanan, Keperawatan dan Kesehatan (J-BIKES) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika
Rika Hartati
Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Senyawa Antioksidan dari Ekstrak n-Heksana Daun Asam Jawa (Tamarindus indica L.) dari Banyuresmi, Garut - Indonesia Fidrianny, Irda; Zahidah, Ellis Siti; Hartati, Rika
Acta Pharmaceutica Indonesia Vol 39, No 3 & 4 (2014)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.126 KB)

Abstract

Pada proses metabolisme tubuh radikal bebas terbentuk secara alami, dalam jumlah tertentu diperlukan tubuh karena merupakan bagian dari sistem pertahanan tubuh. Jika tubuh terpapar radikal bebas berlebihan dan terus menerus dapat menyebabkan kerusakan sel bahkan kematian sel. Antioksidan merupakan senyawa yang dapat menghambat reaksi oksidasi dengan mengikat radikal bebas dan molekul yang sangat reaktif. Berdasarkan beberapa penelitian, daun asam Jawa (Tamarindus indica L.) diketahui memilki efek antioksidan. Selain itu, daun asam Jawa telah banyak dimanfaatkan oleh masyarakat untuk mengobati berbagai macam penyakit. Penelitian ini bertujuan untuk menguji aktivitas antioksidan berbagai ekstrak daun asam Jawa dengan DPPH, menetapkan IC50 peredaman DPPH, menetapkan kadar fenol total, flavonoid total, karotenoid total dari masing-masing ekstrak, menganalisis korelasi fenol total, flavonoid total, dan karotenoid total terhadap aktivitas peredaman DPPH dan mengisolasi senyawa aktif antioksidan dari ekstrak daun asam Jawa. Simplisia daun asam Jawa diekstraksi dengan refluks menggunakan tiga pelarut dengan kepolaran meningkat yaitu n-heksana, etil asetat, dan etanol. Dilakukan pemantauan pada setiap ekstrak secara kromatografi lapis tipis (KLT). Uji aktivitas peredaman radikal bebas DPPH (2,2-difenil-1-pikrilhidrazil), IC50 peredaman DPPH, penentuan flavonoid total, fenol total, karotenoid total dilakukan dengan spektrofotometri ultraviolet-sinar tampak dan analisis korelasinya dengan aktivitas peredaman DPPH menggunakan metode Pearson. Ekstrak n-heksana difraksinasi secara kromatografi cair vakum (KCV). Fraksi ke-4-5 selanjutnya dilakukan subfraksinasi secara kromatografi kolom. Subfraksi 31 dimurnikan dengan KLT preparatif dan dilakukan uji kemurnian secara KLT. Simplisia daun asam Jawa (Tamarindus indica L.) mengandung flavonoid, fenol, terpenoid, steroid/triterpenoid. Ekstrak etanol daun asam Jawa (BJ ekstrak 1 % 0,81 g/mL) menunjukkan aktivitas peredaman DPPH tertinggi (66,74%) dengan IC50 peredaman DPPH 2,05 µg/mL, fenol total 6,17 g GAE/100 g, flavonoid total 3,22 g QE/100 g, karotenoid total 0,35% g BE/100 g. Satu senyawa antioksidan E diperoleh dari ekstrak n-heksana. Aktivitas peredaman DPPH ekstrak etanol daun asam Jawa berbeda bermakna terhadap ekstrak etil asetat dan ekstrak n-heksana (p<0.05). Golongan fenol merupakan kontributor utama pada aktivitas antioksidan ekstrak daun asam Jawa dengan metode DPPH. Senyawa antioksidan E merupakan senyawa aglikon flavonol yang mempunyai -OH bebas pada C-3 dan diduga mempunyai -OH bebas pada cincin A dan atau B.Kata kunci: antioksidan, DPPH, asam Jawa, daun, ekstrak n-heksana, isolat EAbstractIn metabolism process free radicals are formed naturally. The body needs a certain amount as a part of the bodys defense system. If body is exposed by free radicals excessively and continuously can cause cell damage and even cell death. Antioxidant are compounds that can inhibit the oxidation reaction by binding to free radicals and highly reactive molecules. Based on several studies, tamarind (Tamarindus indica L.) leaves were known to have the effect of antioxidants. In addition, tamarind leaves have been used by people for treating various diseases. This research aimed to test the antioxidant activity of various extracts of tamarind leaves by DPPH method, determine IC50 DPPH scavenging activity, total phenolic, total flavonoids, total carotenoid of each extract, analyze their correlation with DPPH scavenging activity and isolation antioxidant compound of tamarind leaves extract. Crude drug of tamarind leaves was extracted by reflux aparatus using three solvents with increasing polarity, n-hexane, ethyl acetate and ethanol. Each extract were monitored by TLC, IC50 DPPH scavenging activity, total phenolic, total flavonoids, total carotenoid of each extracts by ultraviolet-visible spectrophotometry and their correlation with DPPH scavenging activity by Pearson method. N-hexane extract was fractionated by vacuum liquid chromatography. Then fractions 4-5 were subfractionated by column chromatography. Subfraction 31 was purified using preparative thin layer chromatography (TLC) and purity test was performed by TLC. Crude drug of tamarind (Tamarindus indica L.) leaves contained flavonoids, phenolic compound, terpenoids, steroids / triterpenoids. Ethanol extract of tamarind leaves (MW 1 % extract was 0.81 g / mL) showed the highest DPPH scavenging activity (66.74 % ) with IC50 of DPPH scavenging activity 2.05 µg/mL. Total phenolic, flavonoid, carotenoid content were 6.17 g GAE/100 g, 3.22 g QE/100 g and 0.35 g BE/100 g, respectively. An antioxidant compound E was obtained from n-hexane extract. The antioxidant activity of ethanol extract significantly different with n-hexane extract and ethyl acetate extract (p<0.05). Phenolic compounds were the major contributor in tamarind leaves extract using DPPH assay. Antioxidant compound E was flavonol aglycone that had free -OH group in C-3 and expected had free -OH in ring A and or ring B.Keywords: antioxidant, DPPH, tamarind, leaves, n-hexane extract, isolate E
ISOLASI SENYAWA 5, 3’,4’ TRIHIDROKSI FLAVONOL DARI DAUN BUNGUR (Lagerstroemia speciosa PERS.) Roni, Asep; Suganda, Asep Gana; Hartati, Rika
JURNAL FARMASI GALENIKA Vol 5 No 2 (2018): Jurnal Farmasi Galenika Volume 5 No. 2, 2018
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.274 KB)

Abstract

Bungur (Lagerstroemia speciosa Pers.) adalah salah satu tumbuhan obat yang tumbuh di Indonesia. Dalam pengobatan tradisional daun bungur digunakan sebagai obat diabetes, biasanya digunakan dalam bentuk rebusan juga digunakan untuk mengobati kencing batu, kencing manis, dan tekanan darah tinggi. Biji tumbuhan ini dapat digunakan untuk mengobati tekanan darah tinggi dan kencing manis, sedangkan bagian kulit kayu digunakan untuk mengobati diare, disentri dan kencing darah. Daun bungur memiliki kandungan kimia, seperti saponin, flavonoid dan tanin, sedangkan pada kulit batang bungur mengandung flavonoid dan tanin. Namun penelitian kandungan kimia tumbuhan yang bermanfaat tersebut masih sedikit dilaporkan. Oleh karena itu, eksplorasi bahan alami yang mempunyai aktivitas biologis menjadi salah satu target para peneliti, berdasarkan beberapa penelitian yang telah dikembangkan, senyawa-senyawa yang mempunyai aktivitas farmakologi diantaranya adalah senyawa flavonoid, sehingga pada penelitian ini dilakukan isolasi, karakterisasi dan identifikasi flavonoid dari daun bungur. Ekstraksi dilakukan dengan alat Refluks menggunakan tiga pelarut dengan kepolaran meningkat (n-heksana, etil asetat, dan etanol). Ekstrak etil asetat daun bungur (Lagerstroemia speciosa Pers.) difraksinasi lanjut menggunakan kromatografi kolom dengan elusi landaian (n-heksana-etil asetat-metanol). Fraksi terpilih kemudian dimurnikan dengan kromatografi lapis tipis preparatif sehingga didapatkan fraksi yang mengandung senyawa X. Setelah dimurnikan, senyawa X dikarakterisasi menggunakan penampak bercak spesifik, spektrofotometri UV. Berdasarkan hasil spektrum UV-sinar tampak panjang gelombang maksimum senyawa X adalah 361 nm dan 272 nm. Setelah penambahan pereaksi geser menimbulkan perubahan panjang gelombang maksimum (batokromik) setelah penambahan NaOH, asam borat/HCl. Ekstrak etil asetat daun bungur diperoleh senyawa X adalah suatu flavonoid, struktur yang diusulkan adalah 5,3’,4’ trihidroksi flavonol.
Senyawa Antioksidan dari Ekstrak n-Heksana Daun Asam Jawa (Tamarindus indica L.) dari Banyuresmi, Garut - Indonesia Irda Fidrianny; Ellis Siti Zahidah; Rika Hartati
Acta Pharmaceutica Indonesia Vol. 39 No. 3 & 4 (2014)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pada proses metabolisme tubuh radikal bebas terbentuk secara alami, dalam jumlah tertentu diperlukan tubuh karena merupakan bagian dari sistem pertahanan tubuh. Jika tubuh terpapar radikal bebas berlebihan dan terus menerus dapat menyebabkan kerusakan sel bahkan kematian sel. Antioksidan merupakan senyawa yang dapat menghambat reaksi oksidasi dengan mengikat radikal bebas dan molekul yang sangat reaktif. Berdasarkan beberapa penelitian, daun asam Jawa (Tamarindus indica L.) diketahui memilki efek antioksidan. Selain itu, daun asam Jawa telah banyak dimanfaatkan oleh masyarakat untuk mengobati berbagai macam penyakit. Penelitian ini bertujuan untuk menguji aktivitas antioksidan berbagai ekstrak daun asam Jawa dengan DPPH, menetapkan IC50 peredaman DPPH, menetapkan kadar fenol total, flavonoid total, karotenoid total dari masing-masing ekstrak, menganalisis korelasi fenol total, flavonoid total, dan karotenoid total terhadap aktivitas peredaman DPPH dan mengisolasi senyawa aktif antioksidan dari ekstrak daun asam Jawa. Simplisia daun asam Jawa diekstraksi dengan refluks menggunakan tiga pelarut dengan kepolaran meningkat yaitu n-heksana, etil asetat, dan etanol. Dilakukan pemantauan pada setiap ekstrak secara kromatografi lapis tipis (KLT). Uji aktivitas peredaman radikal bebas DPPH (2,2-difenil-1-pikrilhidrazil), IC50 peredaman DPPH, penentuan flavonoid total, fenol total, karotenoid total dilakukan dengan spektrofotometri ultraviolet-sinar tampak dan analisis korelasinya dengan aktivitas peredaman DPPH menggunakan metode Pearson. Ekstrak n-heksana difraksinasi secara kromatografi cair vakum (KCV). Fraksi ke-4-5 selanjutnya dilakukan subfraksinasi secara kromatografi kolom. Subfraksi 31 dimurnikan dengan KLT preparatif dan dilakukan uji kemurnian secara KLT. Simplisia daun asam Jawa (Tamarindus indica L.) mengandung flavonoid, fenol, terpenoid, steroid/triterpenoid. Ekstrak etanol daun asam Jawa (BJ ekstrak 1 % 0,81 g/mL) menunjukkan aktivitas peredaman DPPH tertinggi (66,74%) dengan IC50 peredaman DPPH 2,05 µg/mL, fenol total 6,17 g GAE/100 g, flavonoid total 3,22 g QE/100 g, karotenoid total 0,35% g BE/100 g. Satu senyawa antioksidan E diperoleh dari ekstrak n-heksana. Aktivitas peredaman DPPH ekstrak etanol daun asam Jawa berbeda bermakna terhadap ekstrak etil asetat dan ekstrak n-heksana (p<0.05). Golongan fenol merupakan kontributor utama pada aktivitas antioksidan ekstrak daun asam Jawa dengan metode DPPH. Senyawa antioksidan E merupakan senyawa aglikon flavonol yang mempunyai -OH bebas pada C-3 dan diduga mempunyai -OH bebas pada cincin A dan atau B.Kata kunci: antioksidan, DPPH, asam Jawa, daun, ekstrak n-heksana, isolat EAbstractIn metabolism process free radicals are formed naturally. The body needs a certain amount as a part of the body's defense system. If body is exposed by free radicals excessively and continuously can cause cell damage and even cell death. Antioxidant are compounds that can inhibit the oxidation reaction by binding to free radicals and highly reactive molecules. Based on several studies, tamarind (Tamarindus indica L.) leaves were known to have the effect of antioxidants. In addition, tamarind leaves have been used by people for treating various diseases. This research aimed to test the antioxidant activity of various extracts of tamarind leaves by DPPH method, determine IC50 DPPH scavenging activity, total phenolic, total flavonoids, total carotenoid of each extract, analyze their correlation with DPPH scavenging activity and isolation antioxidant compound of tamarind leaves extract. Crude drug of tamarind leaves was extracted by reflux aparatus using three solvents with increasing polarity, n-hexane, ethyl acetate and ethanol. Each extract were monitored by TLC, IC50 DPPH scavenging activity, total phenolic, total flavonoids, total carotenoid of each extracts by ultraviolet-visible spectrophotometry and their correlation with DPPH scavenging activity by Pearson method. N-hexane extract was fractionated by vacuum liquid chromatography. Then fractions 4-5 were subfractionated by column chromatography. Subfraction 31 was purified using preparative thin layer chromatography (TLC) and purity test was performed by TLC. Crude drug of tamarind (Tamarindus indica L.) leaves contained flavonoids, phenolic compound, terpenoids, steroids / triterpenoids. Ethanol extract of tamarind leaves (MW 1 % extract was 0.81 g / mL) showed the highest DPPH scavenging activity (66.74 % ) with IC50 of DPPH scavenging activity 2.05 µg/mL. Total phenolic, flavonoid, carotenoid content were 6.17 g GAE/100 g, 3.22 g QE/100 g and 0.35 g BE/100 g, respectively. An antioxidant compound E was obtained from n-hexane extract. The antioxidant activity of ethanol extract significantly different with n-hexane extract and ethyl acetate extract (p<0.05). Phenolic compounds were the major contributor in tamarind leaves extract using DPPH assay. Antioxidant compound E was flavonol aglycone that had free -OH group in C-3 and expected had free -OH in ring A and or ring B.Keywords: antioxidant, DPPH, tamarind, leaves, n-hexane extract, isolate E
Isolation of bioactive compounds with tyrosinase inhibitory activity from the methanol extract of meniran herb (Phyllanthus niruri Linn.) Syefira Salsabila; Rika Hartati; Laode M.R. Al Muqarrabun; Nurinanda Prisky Qomaladewi; Ariranur Haniffadli; Andi Rifki Rosandy; Agus Chahyadi; Elfahmi
Current Research on Bioscences and Biotechnology Vol. 3 No. 2 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.3.2/GOO6ZULV

Abstract

Meniran (Phyllanthus niruri L.) is a wild plant in the Euphorbiaceae family which grows in tropical climates. The plant is known to possess antioxidant activity and is rich in phenolic compounds. Since plants with high phenolic content and high antioxidant activity are known to exhibit high tyrosinase inhibitory activity, the purpose of this study is to determine the inhibitory activity of the tyrosinase enzyme by the methanol extract of meniran (P. niruri L.) and to isolate secondary metabolites from the extract and fractions which exhibit inhibitory activity against tyrosinase. The in vitro tyrosinase inhibitory activity assay was conducted using the 96-well microplate method with kojic acid as the positive control, while the separation and purification of compounds were carried out using chromatography techniques. The methanol extract and n-hexane fraction showed tyrosinase inhibitory activity with IC50 of 11.05±0.16 and 2.57±0.08 mg/ml, respectively. Three bioactive compounds were succesfully isolated from the n-hexane fraction. Based on the UV and NMR spectra, compounds 1, 2, and 3 were identified as phyllanthin, phyltetralin, and hypophyllanthin, respectively. Furthermore, phyllanthin (1) was shown to demonstrate inhibitory activity against tyrosinase with IC50 of 0.6322 mM. In conclusion, both meniran extract and phyllanthin (1) were found to exhibit inhibitory acitivity against the tyrosinase enzyme. In the future they can be candidates for the treatment against hyperpigmentation and also as an active ingredient in skincare formulations.
UJI AKTIVITAS ANTIOKSIDAN DAUN BIOLA (Ficus Lyrata Warb.) Delta Baharyati; Komar Ruslan Wirasutisna; Rika Hartati
Jurnal Farmagazine Vol 9, No 1 (2022): Jurnal Farmagazine
Publisher : STF Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47653/farm.v9i1.553

Abstract

Radikal bebas merupakan salah satu faktor penyebab penyakit degeneratif dalam tubuh meningkat. Paparan radikal bebas yang berlebihan membuat tubuh membutuhkan antioksidan dari luar. Daun biola (Ficus lyrata Warb.) memiliki aktivitas antioksidan. Tujuan penelitian untuk menentukan aktivitas antioksidan ekstrak, fraksi dan subfraksi daun biola dengan metode peredaman 2,2-difenil-1-pikrilhidrazil (DPPH). Metode ektraksi dengan cara maserasi menggunakan pelarut etanol 96%. Fraksinasi dilakukan dengan cara ekstrasi cair-cair menggunakan tiga pelarut dengan tingkat kepolaran meningkat, yaitu n-heksana, etil asetat, dan air-etanol, serta di pantau dengan kromatografi lapis tipis (KLT) dan di uji aktivitas antioksidan. Fraksinasi terpilih disederhanakan dengan kromatografi kolom sistem elusi gradient dan diuji aktivitas antioksidan. Hasil aktivitas antioksidan yang paling kuat ditunjukkan oleh fraksi etil asetat dengan nilai IC50 sebesar 9,31±0,304 µg/ml.
In Silico Study on Interaction and Preliminary Toxicity Prediction of Eleutherine americana Components as an Antifungal and Antitoxoplasmosis Candidate Sophi Damayanti; Nadiyah Athifah Salim Martak; Benny Permana; Adi Suwandi; Rika Hartati; Indra Wibowo
Indonesian Journal of Chemistry Vol 20, No 4 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.96 KB) | DOI: 10.22146/ijc.48570

Abstract

Red bulbs of Eleutherine americana (Aubl.) Merr. ex K. Heyne has been known for its high content of naphthoquinones that have antifungal and antiparasitic activities. In this research, in silico interaction study was performed between 31 compounds reported to be found in E. americana with the selected target proteins for antifungal and antitoxoplasmosis activity using the molecular docking method. An ORPs (OSBP-related proteins), Osh4 (PDB ID: 1ZHX), and N-myristoyltransferase (Nmt, PDB ID: 1IYL) were used as the antifungal target proteins. Toxoplasma gondii purine nucleoside phosphorylase (TgPNP, PDB ID: 3MB8) and calcium-dependent protein kinase-1 (TgCDPK1, PDB ID: 4M84) were used as antitoxoplasmosis target proteins. Three-dimensional structures of the test compounds were made and optimized using GaussView 6.0 and Gaussian 09W. The target proteins were prepared using the Discovery Studio 2016 Program. Aquatic toxicity prediction as the preliminary assessment of the safety of the compounds was performed using ECOSAR v2.0. The results suggest that the compound having both the smallest free binding energy compared with positive control and other test compounds and low predicted toxicity is β-sitosterol with a free binding energy of ‒11.55 and ‒11.18 kcal/mol towards Osh4 and Nmt and ‒8.06 and ‒10.29 kcal/mol towards TgPNP and TgCDPK1, respectively.
Simple Method of 9,10-Anthraquinone Assay in Eleutherine americana (Aubl.) Merr. ex K. Heyne using High-Performance Liquid Chromatography Sophi Damayanti; Samuel Gunadi Tanusondjaja; Benny Permana; Rika Hartati; Dian Ayu Eka Pitaloka; Indra Wibowo
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64701

Abstract

Eleutherine americana (E. americana) is a medicinal plant commonly found on the island of Borneo, Indonesia. This plant is known to have several biological activities. However, anthraquinone residues are generally present as contaminants. This study was aimed to develop a method of determining the levels of 9,10-anthraquinone in plant extracts and fractions using High Performance Liquid Chromatography (HPLC). The research aims to optimize the mobile phase, the system suitability test, and the system validation. The optimal mobile phase was acetonitrile:distilled water 1:1 v/v with a flow rate of 1.25 mL/min. The validation result shows that the linearity was obtained with a correlation coefficient (r) of 0.9995 and an r2 coefficient of 0.9991. The estimated limits for detection and quantification values were 0.178 and 0.594 µg/mL, respectively. In the intraday and inter-day accuracy test, the coefficient of variance for reference was 0.627 and 0.774, while the results for the sample were 2.966 and 2.658. The percentage recovery rate for reference was between 98.976–101.452%, and for the sample, the result was 89.191–94.667%. The average 9,10-anthraquinone content in the acetate fraction of E. americana plant was 9.799 µg/g ± 5.243.
Method development of quercitrin enrichment from asthma-plant (Euphorbia hirta L.) using aromatic macroporous resin Sumail Sidik Ode Ishak; Amrianto; Diah Astari Salam; Rika Hartati
Current Research on Bioscences and Biotechnology Vol. 4 No. 1 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.4.1/2G0E50F6

Abstract

Asthma-plant contains high amount of quercitrin which make it a potential new source for flavonoids. This study aims to develop a method of quercitrin enrichment by utilizing macroporous resin, which is known to be safer, more eco-friendly, economics, and efficient. Evaluations were conducted over the performance and separation characteristics of the macroporous resin in quercitrin enrichment as well as the adsorption and desorption of quercitrin by the macroporous resin. The results showed that the adsorption process of the macroporous resin in relation to the amount of quercitrin in the extract were in accordance with the second order model, which means that the process of adsorption is affected by other compounds. Furthermore, the examination of the isotherm adsorption fit the Freundlich’s model (R2 = 0.9850) rather than the Langmuir’s one (R2 = 0.4334). In the optimal condition, the enrichment of quercitrin by using macroporous resin increased the abundance of quercitrin by nearly five times, from 3.60% of quercitrin content in the extract to 17.02% in the quercitrin-rich fraction, with recovery yield of 50.39%.
ANTIMICROBIAL ACTIVITY TEST OF 96% ETHANOL EXTRACT OF FLOWERS, LEAVES, AND STEM BARK OF TIGARUN (Crateva magna DC.) AGAINST Staphylococcus aureus and Malassezia furfur Najwi Hasani; Rika Hartati; Elin Julianti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.848

Abstract

Staphylococcus aureus and Malassezia furfur One of the microbes that can cause folliculitis is the inflammation of the skin in the hair follicles. The use of natural ingredients as antimicrobials must be developed as an alternative to overcome the resistance and side effects of chemical drugs. Tigarun (Crataeva magna DC.) is a typical plant in South Kalimantan that can be developed as a natural antimicrobial agent for the treatment of skin infections. Previous studies have reported that tigarun has antimicrobial activity, but no studies have reported its potential antimicrobial activity against folliculitis-causing microbes. Therefore, this study aimed to determine the antimicrobial activity of 96% ethanol extracts of the flowers, leaves, and stem bark of tigarun (Crataeva magna DC.) against microbes that cause folliculitis, including Staphylococcus aureus and Malassezia furfur. Extraction was performed by the maceration method using 96% ethanol. The antimicrobial activities of the extracts were tested using the agar diffusion method. Based on the results of the antimicrobial activity test using the agar diffusion method, the tigarun flower extract showed better antimicrobial activity than the leaf and tigarun bark extracts. Flower extract activity at 200 mg/mL concentrations against Staphylococcus aureus (10.65 ± 0.25) and the fungus Malassezia furfur (7.40 ± 0.40) with moderate inhibition zone ketogenic  Keywords: Folliculitis, tigarun, antimicrobial, agar diffusion
ANTIMICROBIAL ACTIVITY TEST OF 96% ETHANOL EXTRACT OF FLOWERS, LEAVES, AND STEM BARK OF TIGARUN (Crateva magna DC.) AGAINST Staphylococcus aureus and Malassezia furfur Najwi Hasani; Rika Hartati; Elin Julianti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.848

Abstract

Staphylococcus aureus and Malassezia furfur One of the microbes that can cause folliculitis is the inflammation of the skin in the hair follicles. The use of natural ingredients as antimicrobials must be developed as an alternative to overcome the resistance and side effects of chemical drugs. Tigarun (Crataeva magna DC.) is a typical plant in South Kalimantan that can be developed as a natural antimicrobial agent for the treatment of skin infections. Previous studies have reported that tigarun has antimicrobial activity, but no studies have reported its potential antimicrobial activity against folliculitis-causing microbes. Therefore, this study aimed to determine the antimicrobial activity of 96% ethanol extracts of the flowers, leaves, and stem bark of tigarun (Crataeva magna DC.) against microbes that cause folliculitis, including Staphylococcus aureus and Malassezia furfur. Extraction was performed by the maceration method using 96% ethanol. The antimicrobial activities of the extracts were tested using the agar diffusion method. Based on the results of the antimicrobial activity test using the agar diffusion method, the tigarun flower extract showed better antimicrobial activity than the leaf and tigarun bark extracts. Flower extract activity at 200 mg/mL concentrations against Staphylococcus aureus (10.65 ± 0.25) and the fungus Malassezia furfur (7.40 ± 0.40) with moderate inhibition zone ketogenic  Keywords: Folliculitis, tigarun, antimicrobial, agar diffusion
Co-Authors . Elfahmi Adi Suwandi Agus Chahyadi Amrianto Andi Rifki Rosandy Ariranur Haniffadli Asep Gana Suganda Asep Gana Suganda Atina Rizkiya Choirunnisa Cheong, Min Kyoung Daryono H. Tjahjono Defri Rizaldy Delta Baharyati Diah Astari Salam Dian Ayu Eka Pitaloka Elfahmi Elfahmi, Elfahmi Elin Julianti Ellis Siti Zahidah Fadhilah, Ismah Ibtihal Fadhilah, Syifa Fitriansyah, Sani Nurlaela Fransiska Kurniawan Hegar Pramastya HENI RACHMAWATI I Ketut Adnyana Indra Wibowo Indra Wibowo Irda Fidrianny Irda Fidrianny Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Laode M.R. Al Muqarrabun Marlina Indriastuti Muhamad Insanu Muhamad Insanu Muslihin, Nisrina Nadiyah Athifah Salim Martak Najwi Hasani Nurinanda Prisky Qomaladewi Permana, Benny Putri, Rian Destiyani Roni, Asep Salsabila, Syefira Samuel Gunadi Tanusondjaja Sophi Damayanti Sumail Sidik Ode Ishak Zahidah, Ellis Siti Zhafira Amalia Regiana