cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Adi Darmawan
Contact Email
adidarmawan@live.undip.ac.id
Phone
-
Journal Mail Official
jksa@live.undip.ac.id
Editorial Address
-
Location
Kota semarang,
Jawa tengah
INDONESIA
JURNAL KIMIA SAINS DAN APLIKASI
Published by Universitas Diponegoro
ISSN : 14108917     EISSN : 25979914     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering
urnal Kimia Sains dan Aplikasi (p-ISSN: 1410-8917) and e-ISSN: 2597-9914) is published by Department of Chemistry, Diponegoro University. This journal is published four times per year and publishes research, review and short communication in field of Chemistry.
Arjuna Subject : -
Articles 864 Documents
 83   84   85   86   87 
On-Off-On Fluorescent Potential Progesterone Detection Using N-Doped Carbon Dots from Oil Palm Empty Fruit Bunch Elvina Dhiaul Iftitah; Diah Mardiana; Amalia Indah Anindia Darmawan; Aura Putri Farisca
Jurnal Kimia Sains dan Aplikasi Vol 29, No 8 (2026): Volume 29 Issue 8 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.8.545-553

Abstract

Progesterone is an important steroid hormone involved in reproductive regulation and hormonal homeostasis, making its accurate determination essential for clinical and biomedical applications. In this study, nitrogen-doped carbon dots (N-CDs) were synthesized from oil palm empty fruit bunch (OPEFB) waste using o-phenylenediamine (o-PD) via a hydrothermal method and applied as a fluorescent biosensor for progesterone detection. Carbon dots (CDs) have attracted significant interest as fluorescent nanomaterials due to their excellent optical properties, stability, and biocompatibility. The synthesis condition of N- CDs was 180°C for 4 h, producing N-CDs with an average hydrodynamic size of 5.04 nm based on DLS analysis, while LR-TEM analysis showed individual N- CDs with an average size of 3.6 nm. The N-CDs exhibited good stability under pH 6–7. The sensing mechanism relied on a fluorescence on–off–on system involving N-CDs, H2O2, and progesterone, in which H2O2 quenched fluorescence via photoinduced electron transfer (PET), while progesterone restored the signal by inhibiting electron transfer. The developed sensor exhibited a linear response over the range of 20–100 nM, with an R2 of 0.9956 and an LOD of 5.827 nM. Furthermore, the sensor exhibited recovery in fetal bovine serum (132.41% and 73.98%) with RSD values below 1%, demonstrating its potential as a simple and sensitive platform for progesterone detection in complex biological samples.
Effect of Surfactant Mass on the Production of Few-Layer Graphene from Nipah Shell Charcoal (FLG-Nyp) Using the Liquid Phase Exfoliation Method Ilma Fadlilah; Ayu Pramita; Zhilal Shadiq
Jurnal Kimia Sains dan Aplikasi Vol 29, No 8 (2026): Volume 29 Issue 8 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.8.554-558

Abstract

This study aims to investigate the effect of surfactant mass on graphene production from Nipah shell charcoal (FLG-Nyp) via the Liquid Phase Exfoliation (LPE) method. The mass of Linear Alkylbenzene Sulfonate (LAS) surfactant was varied at 2 g, 2.5 g, and 3 g, with a fixed charcoal mass of 3 g and 250 mL of deionized water. The sonication process was carried out for three hours, after which the resulting suspension was dried at 105°C for two hours to obtain FLG powder. Characterization was performed using Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD), and UV–Vis spectrophotometry. SEM results showed that adding up to 3 g of surfactant produced thinner FLG sheets with more homogeneous dispersion. XRD analysis revealed that the diffraction peak of FLG-Nyp3 appeared at 2θ = 26.50°, consistent with literature values, indicating the formation of an amorphous structure with the highest degree of exfoliation among the three variants. UV–Vis analysis exhibited a characteristic absorption band at 232 nm for all three samples. The results indicate that the exfoliation of graphitic carbon sheets increased with increasing surfactant mass.
Green-Synthesised Silver Nanoparticle–Loaded Sodium Alginate Beads Using Asplenium nidus for Potential Antibacterial and Hg²⁺ Ion Sensing Applications Doni Notriawan; Eka Angasa; Reza Pertiwi; Zavira Nurjali; Meiliana Ngasti Wati
Jurnal Kimia Sains dan Aplikasi Vol 29, No 8 (2026): Volume 29 Issue 8 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.8.559-567

Abstract

Silver nanoparticles (AgNPs) have attracted considerable interest due to their antibacterial properties and potential for metal-ion sensing. This study aimed to develop sodium alginate/silver nanoparticle (SA/AgNPs) beads using Asplenium nidus leaf extract and evaluate their antibacterial activity and colourimetric response toward Hg2+ ions. AgNPs were biosynthesised using Asplenium nidus leaf extract and incorporated into a sodium alginate matrix to form SA/AgNPs nanocomposite beads. The formation of AgNPs was indicated by a colour change from clear yellow to brown and confirmed by UV–Vis absorption in the range of 420–450 nm. The resulting SA/AgNPs nanocomposite beads exhibited antibacterial activity against Escherichia coli, producing an inhibition zone of approximately 1 mm, whereas sodium alginate beads without AgNPs showed no inhibition zone. In addition, the SA/AgNPs nanocomposite beads exhibited a concentration-dependent visual response toward Hg2+ ions (10–80 ppm), with a distinct colour change from brown to white, while the beads exposed to demineralised water remained brown after 24 h. These findings demonstrate that Asplenium nidus leaf extract can facilitate the biosynthesis of AgNPs and that the resulting SA/AgNPs nanocomposite beads exhibit both antibacterial activity and a visible response toward Hg2+ ions. The combination of a plant-mediated synthesis approach and alginate-based bead fabrication provides a simple platform with potential for antibacterial applications and preliminary colourimetric detection of Hg2+ ions.
Identification of CCNA2 as a Therapeutic Target in Cholangiocarcinoma and Evaluation of Indonesian Jamu-Derived Phytochemicals through Network Pharmacology and Molecular Docking Reny Rosalina; Rian Ka Praja
Jurnal Kimia Sains dan Aplikasi Vol 29, No 8 (2026): Volume 29 Issue 8 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.8.523-537

Abstract

Cholangiocarcinoma (CCA) remains a highly aggressive malignancy with limited therapeutic options and poor prognosis, particularly in Southeast Asia, including Indonesia. The identification of novel molecular targets is essential to improve treatment strategies. This study aimed to identify key therapeutic targets in CCA and evaluate the potential of Indonesian jamu-derived phytochemicals as candidate inhibitors using an integrated computational approach. Differentially expressed genes (DEGs) associated with CCA were analyzed and intersected with disease-related datasets to construct a protein–protein interaction (PPI) network, from which hub genes were identified. Among these, CCNA2, a critical regulator of cell cycle progression, was selected as the primary target due to its central role in tumor proliferation and strong network connectivity. Subsequently, selected phytochemicals derived from Indonesian medicinal plants commonly used in jamu, including Curcuma longa, Curcuma xanthorrhiza, Zingiber officinale, and Kaempferia galanga, were screened for ethnobotanical relevance, their reported anticancer activities in modulating cell cycle progression, and drug-likeness using Lipinski’s rule of five. Molecular docking analysis was performed to evaluate the binding affinity of these compounds against CCNA2. Several phytochemicals demonstrated favorable binding energies comparable to or exceeding that of the native ligand (−8.8 kcal/mol), indicating strong interaction potential within the active site of the protein. The binding interactions were stabilized through hydrogen bonding, hydrophobic interactions, and π- related interactions, suggesting a plausible mechanism for inhibitory activity. This study highlights CCNA2 as a promising therapeutic target in CCA and demonstrates the potential of Indonesian jamu phytochemicals as candidate inhibitors. These findings provide a scientific basis for further experimental validation and support the integration of traditional herbal medicine into modern drug discovery pipelines for cholangiocarcinoma treatment.

Page 87 of 87 | Total Record : 864

 83   84   85   86   87 

Filter by Year

1998 2026


Reset
Filter By Issues
All Issue Vol 29, No 8 (2026): Volume 29 Issue 8 Year 2026 Vol 29, No 7 (2026): Volume 29 Issue 7 Year 2026 Vol 29, No 6 (2026): Volume 29 Issue 6 Year 2026 Vol 29, No 5 (2026): Volume 29 Issue 5 Year 2026 Vol 29, No 4 (2026): Volume 29 Issue 4 Year 2026 Vol 29, No 3 (2026): Volume 29 Issue 3 Year 2026 Vol 29, No 2 (2026): Volume 29 Issue 2 Year 2026 Vol 29, No 1 (2026): Volume 29 Issue 1 Year 2026 Vol 28, No 10 (2025): Volume 28 Issue 10 Year 2025 Vol 28, No 9 (2025): Volume 28 Issue 9 Year 2025 Vol 28, No 8 (2025): Volume 28 Issue 8 Year 2025 Vol 28, No 7 (2025): Volume 28 Issue 7 Year 2025 Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025 Vol 28, No 5 (2025): Volume 28 Issue 5 Year 2025 Vol 28, No 4 (2025): Volume 28 Issue 4 Year 2025 Vol 28, No 3 (2025): Volume 28 Issue 3 Year 2025 Vol 28, No 2 (2025): Volume 28 Issue 2 Year 2025 Vol 28, No 1 (2025): Volume 28 Issue 1 Year 2025 Vol 27, No 12 (2024): Volume 27 Issue 12 Year 2024 Vol 27, No 11 (2024): Volume 27 Issue 11 Year 2024 Vol 27, No 10 (2024): Volume 27 Issue 10 Year 2024 Vol 27, No 9 (2024): Volume 27 Issue 9 Year 2024 Vol 27, No 8 (2024): Volume 27 Issue 8 Year 2024 Vol 27, No 7 (2024): Volume 27 Issue 7 Year 2024 Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024 Vol 27, No 5 (2024): Volume 27 Issue 5 Year 2024 Vol 27, No 4 (2024): Volume 27 Issue 4 Year 2024 Vol 27, No 3 (2024): Volume 27 Issue 3 Year 2024 Vol 27, No 2 (2024): Volume 27 Issue 2 Year 2024 Vol 27, No 1 (2024): Volume 27 Issue 1 Year 2024 Vol 26, No 12 (2023): Volume 26 Issue 12 Year 2023 Vol 26, No 11 (2023): Volume 26 Issue 11 Year 2023 Vol 26, No 10 (2023): Volume 26 Issue 10 Year 2023 Vol 26, No 9 (2023): Volume 26 Issue 9 Year 2023 Vol 26, No 8 (2023): Volume 26 Issue 8 Year 2023 Vol 26, No 7 (2023): Volume 26 Issue 7 Year 2023 Vol 26, No 6 (2023): Volume 26 Issue 6 Year 2023 Vol 26, No 5 (2023): Volume 26 Issue 5 Year 2023 Vol 26, No 4 (2023): Volume 26 Issue 4 Year 2023 Vol 26, No 3 (2023): Volume 26 Issue 3 Year 2023 Vol 26, No 2 (2023): Volume 26 Issue 2 Year 2023 Vol 26, No 1 (2023): Volume 26 Issue 1 Year 2023 Vol 25, No 12 (2022): Volume 25 Issue 12 Year 2022 Vol 25, No 11 (2022): Volume 25 Issue 11 Year 2022 Vol 25, No 10 (2022): Volume 25 Issue 10 Year 2022 Vol 25, No 9 (2022): Volume 25 Issue 9 Year 2022 Vol 25, No 8 (2022): Volume 25 Issue 8 Year 2022 Vol 25, No 7 (2022): Volume 25 Issue 7 Year 2022 Vol 25, No 6 (2022): Volume 25 Issue 6 Year 2022 Vol 25, No 5 (2022): Volume 25 Issue 5 Year 2022 Vol 25, No 4 (2022): Volume 25 Issue 4 Year 2022 Vol 25, No 3 (2022): Volume 25 Issue 3 Year 2022 Vol 25, No 2 (2022): Volume 25 Issue 2 Year 2022 Vol 25, No 1 (2022): Volume 25 Issue 1 Year 2022 Vol 24, No 7 (2021): Volume 24 Issue 7 Year 2021 Vol 24, No 6 (2021): Volume 24 Issue 6 Year 2021 Vol 24, No 5 (2021): Volume 24 Issue 5 Year 2021 Vol 24, No 4 (2021): Volume 24 Issue 4 Year 2021 Vol 24, No 3 (2021): Volume 24 Issue 3 Year 2021 Vol 24, No 2 (2021): Volume 24 Issue 2 Year 2021 Vol 24, No 1 (2021): Volume 24 Issue 1 Year 2021 Vol 23, No 12 (2020): Volume 23 Issue 12 Year 2020 Vol 23, No 11 (2020): Volume 23 Issue 11 Year 2020 Vol 23, No 10 (2020): Volume 23 Issue 10 Year 2020 Vol 23, No 9 (2020): Volume 23 Issue 9 Year 2020 Vol 23, No 8 (2020): Volume 23 Issue 8 Year 2020 Vol 23, No 7 (2020): Volume 23 Issue 7 Year 2020 Vol 23, No 6 (2020): Volume 23 Issue 6 Year 2020 Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020 Vol 23, No 4 (2020): Volume 23 Issue 4 Year 2020 Vol 23, No 3 (2020): Volume 23 Issue 3 Year 2020 Vol 23, No 2 (2020): Volume 23 Issue 2 Year 2020 Vol 23, No 1 (2020): Volume 23 Issue 1 Year 2020 Vol 22, No 6 (2019): Volume 22 Issue 6 Year 2019 Vol 22, No 5 (2019): Volume 22 Issue 5 Year 2019 Vol 22, No 4 (2019): Volume 22 Issue 4 Year 2019 Vol 22, No 3 (2019): Volume 22 Issue 3 Year 2019 Vol 22, No 2 (2019): Volume 22 Issue 2 Year 2019 Vol 22, No 1 (2019): volume 22 Issue 1 Year 2019 Vol 21, No 4 (2018): volume 21 Issue 4 Year 2018 Vol 21, No 3 (2018): Volume 21 Issue 3 Year 2018 Vol 21, No 2 (2018): Volume 21 Issue 2 Year 2018 Vol 21, No 1 (2018): Volume 21 Issue 1 Year 2018 Vol 20, No 3 (2017): Volume 20 Issue 3 Year 2017 Vol 20, No 2 (2017): Volume 20 Issue 2 Year 2017 Vol 20, No 1 (2017): Volume 20 Issue 1 Year 2017 Vol 19, No 3 (2016): Volume 19 Issue 3 Year 2016 Vol 19, No 2 (2016): Volume 19 Issue 2 Year 2016 Vol 19, No 1 (2016): Volume 19 Issue 1 Year 2016 Vol 18, No 3 (2015): Volume 18 Issue 3 Year 2015 Vol 18, No 2 (2015): Volume 18 Issue 2 Year 2015 Vol 18, No 1 (2015): Volume 18 Issue 1 Year 2015 Vol 17, No 3 (2014): Volume 17 Issue 3 Year 2014 Vol 17, No 2 (2014): Volume 17 Issue 2 Year 2014 Vol 17, No 1 (2014): Volume 17 Issue 1 Year 2014 Vol 16, No 3 (2013): Volume 16 Issue 3 Year 2013 Vol 16, No 2 (2013): Volume 16 Issue 2 Year 2013 Vol 16, No 1 (2013): Volume 16 Issue 1 Year 2013 Vol 15, No 3 (2012): Volume 15 Issue 3 Year 2012 Vol 15, No 2 (2012): Volume 15 Issue 2 Year 2012 Vol 15, No 1 (2012): Volume 15 Issue 1 Year 2012 Vol 14, No 3 (2011): Volume 14 Issue 3 Year 2011 Vol 14, No 2 (2011): Volume 14 Issue 2 Year 2011 Vol 14, No 1 (2011): Volume 14 issue 1 Year 2011 Vol 13, No 3 (2010): Volume 13 Issue 3 Year 2010 Vol 13, No 2 (2010): Volume 13 Issue 2 Year 2010 Vol 13, No 1 (2010): Volume 13 Issue 1 Year 2010 Vol 12, No 3 (2009): Volume 12 Issue 3 Year 2009 Vol 12, No 2 (2009): Volume 12 Issue 2 Year 2009 Vol 12, No 1 (2009): Volume 12 Issue 1 Year 2009 Vol 11, No 3 (2008): Volume 11 Issue 3 Year 2008 Vol 11, No 2 (2008): Volume 11 Issue 2 Year 2008 Vol 11, No 1 (2008): Volume 11 Issue 1 Year 2008 Vol 10, No 3 (2007): Volume 10 Issue 3 Year 2007 Vol 10, No 2 (2007): Volume 10 Issue 2 Year 2007 Vol 10, No 1 (2007): Volume 10 Issue 1 Year 2007 Vol 9, No 3 (2006): Volume 9 Issue 3 Year 2006 Vol 9, No 2 (2006): Volume 9 Issue 2 Year 2006 Vol 9, No 1 (2006): Volume 9 Issue 1 Year 2006 Vol 8, No 3 (2005): Volume 8 Issue 3 Year 2005 Vol 8, No 2 (2005): Volume 8 Issue 2 Year 2005 Vol 8, No 1 (2005): Volume 8 Issue 1 Year 2005 Vol 7, No 3 (2004): Volume 7 Issue 3 Year 2004 Vol 7, No 2 (2004): Volume 7 Issue 2 Year 2004 Vol 7, No 1 (2004): Volume 7 Issue 1 Year 2004 Vol 6, No 3 (2003): Volume 6 Issue 3 Year 2003 Vol 6, No 2 (2003): Volume 6 Issue 2 Year 2003 Vol 6, No 1 (2003): Volume 6 Issue 1 Year 2003 Vol 5, No 3 (2002): Volume 5 Issue 3 Year 2002 Vol 5, No 2 (2002): Volume 5 Issue 2 Year 2002 Vol 5, No 1 (2002): Volume 5 Issue 1 Year 2002 Vol 3, No 3 (2000): Volume 3 Issue 3 Year 2000 Vol 3, No 2 (2000): Volume 3 Issue 2 Year 2000 Vol 3, No 1 (2000): Volume 3 Issue 1 Year 2000 Vol 2, No 4 (1999): Volume 2 Issue 4 Year 1999 Vol 2, No 3 (1999): Volume 2 Issue 3 Year 1999 Vol 2, No 2 (1999): Volume 2 Issue 2 Year 1999 Vol 2, No 1 (1999): Volume 2 Issue 1 Year 1999 Vol 1, No 1 (1998): Volume 1 Issue 1 Year 1998 More Issue