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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Vol 4, No 4 (2019)" : 13 Documents clear
THE EFFECTS OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTIONATION OF SECHIUM EDULE JACQ. SWARTZ ON TRIGLYCERIDE LEVELS IN MALE RATS WITH TYPE 2 DIABETES MELLITUS Siahaan, Jekson Martiar; Julianto, Endy; Silitonga, Hendrika Andriana
Indonesian Journal of Medicine Vol 4, No 4 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The prevalence of diabetes mellitus (DM) from year to year is increasing. Hyper­glycemia that occurs in DM is caused by oxidative stress that damages pancreatic ? cells. This situation can be controlled with synthetic hypoglycemic drugs, but it requires high medical costs. Therefore, alternative therapies that are easily available, relatively inexpensive, have potential anti-hypoglycemia and anti-cholesterolemia which is found in conjoined flasks (Sechium edule (Jacq.) Swartz) which contains flavonoids are needed. The purpose of this study was to analyze the effectiveness of ethanol extract and fractionation of ethyl acetate extracts of Sami (pumpkin) (Sechium edule (Jacq.) Swartz) as anti-hipoglycemia and anti-hypertriglycerides in white male wistar rats (Rattus novergius sp.) induced by STZ-NA-HFDD.Subjects and Method: A randomized controlled trial was conducted to assess the effectiveness of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract. The sample included white male wistar rats (Rattus novergius sp.) Hyperglycemia induced by STZ-NA-HFD. The dependent variable was triglyceride levels. The independent variables were administration of ethanol extract and fractionation of pumpkin fruit ethyl acetate extract.Results: Ethyl acetate fraction 45 mg/kgBW better reduce triglyceride levels but statistically does not have significant differences between groups.Conclusion: The group that received Metformin and the group that was given ethanol extract 45 mg/kgBW had lower triglyceride levels compared to the other therapy and control groups.Keywords: Hipertrigliseridemia, diabetes mellitus, STZ-NA-HFDCorrespondence: Jekson Martiar Siahaan. Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: Jekson.siahaansked­@­gmail.comIndonesian Journal of Medicine (2019), 4(4): 371-375https://doi.org/10.26911/theijmed.2019.04.04.10 
THE EFFECT OF HOLISTIC PROGRAMS ON CORTISOL SERUM LEVELS IN POLYCISTIC OVARIUM SYNDROME Hadisaputro, Suharyo; Suwandono, Agus; Kurniawati, Erna Yovi
Indonesian Journal of Medicine Vol 4, No 4 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The increasing prevalence of polycystic ovary syndrome (PCOS) in Indonesia reaches 8-10%. Patients with polycystic ovary syndrome are at risk of experiencing complex psychological disorders and decreased well-being. Psychological disorders in polycystic ovary syndrome are at risk of developing physical symptoms and increasing insulin resistance. The Holistic Program consists of a combination of diet yoga and remembrance therapy as an integrated holistic therapy. There is no non-pharmacological therapy that is holistically integrated to reduce serum cortisol levels in polycystic ovary syndrome. This study aimed to examine the effect of holistic programs on cortisol serum levels in polycistic ovarium syndrome.Subjects and Method: This was a randomized controlled trials conducted in Yogyakarta. A sample of 30 women patients with PCOS aged 19-40 years old was selected for this study. The sample was divided into 2 groups. The intervention group received holistic program for 14 days. The dependent variable was cortisol serum. The independent variable was holistic program. Cortisol serum and insulin levels were measure by ELISA method at the Integrated Research and Testing Laboratory, Universitas Gadjah Mada, Yogyakarta. Insulin resistance was calculated using the HOMA IR method. The data were analyzed by independent t-test and different test Paired t-testResults: Serum cortisol levels in the intervention group were lower than the control group. Serum cortisol levels decrease after the implementation of a holistic program.Conclusion: The holistic program that was carried out for 14 days in polycystic ovary syndrome is effective to reduce serum cortisol levels.Keywords: holistic program, cortisol serum, polycystic ovary syndromeCorrespondence: Erna Yovi Kurniawati. Masters Program in Applied Midwifery, School of Health Polytechnics, Ministry of Health Semarang. Jl. Tirto Agung, Pedalangan, Banyumanik, Semarang 50239, Central Java. Mobile: +6287739122352. Email: yovi.raharjanto@gmail.comIndonesian Journal of Medicine (2019), 4(4): 376-382https://doi.org/10.26911/theijmed.2019.04.04.11
THE EFFECTS OF TAMOXIFEN AND CHEMOTHERAPY AFTER SURGERY ON THE RECURRENCE AND SURVIVAL OF BREAST CANCER PATIENTS WITH POSITIVE HORMONE RECEPTOR: A META-ANALYSIS Delimasari, Trisakti Halimah; Tamtomo, Didik; Murti, Bhisma
Indonesian Journal of Medicine Vol 4, No 4 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Breast cancer is the most common type of cancer suffered by women in the world. The combination of tamoxifen and chemotherapy significantly reduces the risk of recur­rence and mortality in breast cancer patients. This study aimed to analyze how effective the com­bination of tamoxifen and chemotherapy after surgery to reduce the risk of recurrence and mortality in breast cancer patients with positive hormone receptor.Subjects and Method: This study used systematic review and meta-analysis. The researcher collected articles from the Pubmed journal database. The subjects of the study were women with breast cancer after surgery. The dependent variable was recurrence and survival (mortality). The independent variables were tamoxifen and chemotherapy. Data were analyzed based on the fixed and random effects model using RevMan 5 software.Results: There were 3 articles with 3,761 women who were involved in the analysis process. The combination of tamoxifen and chemotherapy could reduce the risk of recurrence in women with positive hormone receptor (ER+) breast cancer (HR=0.68; 95%CI=0.58 to 0.80; p=0.001). The combination of tamoxifen and chemotherapy showed weak and non-significant decreasing trend in reducing the risk of mortality in women with ER+breast cancer (HR=0.87; 95%CI=0.73 to 1.03; p= 0.11).Conclusion: The combination of tamoxifen and chemotherapy in women with ER+ breast cancer is effective in reducing the risk of recurrence. However, it does not increase survival.Keywords: tamoxifen, chemotherapy, breast cancer.Correspondence:Trisakti Halimah Delimasari. Program Studi Ilmu Kesehatan Kesehatan, Universitas Sebe­las Maret. Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: tri­sak­ti­hd­1994­@g­mail.­com. Mobile: +6285 293 994 629.Indonesian Journal of Medicine (2019), 4(4): 346-353https://doi.org/10.26911/theijmed.2019.04.04.07

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