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INDONESIA
Indonesian Journal of Applied Sciences
Published by Universitas Padjadjaran
ISSN : 20899203     EISSN : 25811991     DOI : -
Core Subject : Social,
Environmental Science
Indonesian Journal of Applied Sciences (IJAS) is a scientific journal published three times a year (April, August, December). Indonesian Journal of Applied Sciences publish original research results related to research in the field of natural science, covering a wide range of topics written in the field of knowledge: medicine, agriculture, animal husbandry, fisheries, pharmaceuticals, and other exact sciences
Arjuna Subject : -
Articles 3 Documents
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Search results for , issue "Vol 8, No 1 (2018)" : 3 Documents clear
AKTIVITAS ANTIANGIOGENESIS EKSTRAK BERAS HITAM (Oryza sativa L. indica) PADA CHORIOALANTOIC MEMBRANE (CAM) SEBAGAI KANDIDAT ANTIKANKER ANTIANGIOGENESIS ACTIVITY OF BLACK RICE (Oryza sativa L. indica) ON CHORIOALANTOIC MEMBRANE (CAM) AS ANTICANCER CANDIDATE Fitria Diniah Janah Sayekti; Muhammad Taufiq Qurrohman
Indonesian Journal of Applied Sciences Vol 8, No 1 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.663 KB) | DOI: 10.24198/ijas.v8i1.18654

Abstract

AbstrakAngiogenesis memberikan kontribusi pada karsinogenesis atau pertumbuhan sel kanker yang tidak terkendali. Pertumbuhan tumor atau kanker dapat dikontrol melalui penghambatan angiogenesis. Salah satu bahan alam yang berpotensi sebagai bahan pangan fungsional prevensi kanker adalah beras hitam. Penelitian ini bertujuan untuk mempelajari dan mengetahui aktivitas antiangiogenesis ekstrak beras hitam (Oryza sativa L. indica) pada  Chorioallantoic Membrane (CAM) sebagai kandidat antikanker. Parameter yang diamati dalam penelitian adalah banyaknya pembuluh darah baru atau respon angiogenesis pada CAM setelah pemberian ekstrak beras hitam dengan konsentrasi masing-masing 20, 25, 50, 60 dan 75 µg/mL. Ekstrak beras hitam menghambat pembentukan pembuluh darah pada CAM. Rata-rata jumlah pembuluh darah pada konsentrasi ekstrak beras hitam 20, 25, 50, 60 dan 75  µg/mL berturut-turut adalah 27,6; 21,0; 3,67; 3,0; 2,0. Pada kontrol dengan larutan NaCl 0,9 %, jumlah rata-rata pembuluh darah adalah adalah 35,33. Kata Kunci : Beras hitam (Oryza sativa L. indica), angiogenesis, antikanker  AbstractAngiogenesis contributes to uncontrolled carcinogenesis or cancer cell growth. Tumor or cancer growth can be controlled through inhibition of angiogenesis. One of the natural ingredients that have the potential as a cancer prevention functional food ingredient is black rice. This study aims to study and determine the antiangiogenesis activity of black rice extract (Oryza sativa L. indica) on the Chorioallantoic Membrane (CAM) as an anticancer candidate. The parameters observed in the study were the number of new blood vessels or the response of angiogenesis to CAM after the administration of black rice extract with a concentration of 20, 25, 50, 60 and 75 µg / mL, respectively. The higher the concentration of black rice extract showed a decrease in the number of blood vessels formed. The average number of blood vessels at concentrations of black rice extract 20, 25, 50, 60 and 75 µg / mL were 27.6; 21.0; 3.67; 3.0; 2.0. In the control with 0.9% NaCl solution, the average number of blood vessels was 35.33. Keywords: Black rice ( Oryza sativa L. indica), angiogenesis, anticancer
A Review: Is Ginger (Zingiber officinale var. Roscoe) Potential for Future Phytomedicine? Dina Mulyana Syafitri; Jutti Levita; Mutakin Mutakin; Ajeng Diantini
Indonesian Journal of Applied Sciences Vol 8, No 1 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.755 KB) | DOI: 10.24198/ijas.v8i1.16466

Abstract

AbstractZingiber officinale Roscoe (red:ginger), is one of the most widely consumed medicinal herbs in the world has been widely used to treat various disorders in Indonesia. There are three known types of ginger: giant ginger or white ginger (Zingiber officinale var. Roscoe), small white ginger or ginger emprit (Zingiber officinale var. Amarum), and red ginger (Zingiber officinale var. Rubrum). The main components of ginger rhizome are carbohydrates, lipids, essential oils, terpenes, and phenol compounds such as gingerol (23-25%) and shogaol (18-25%). Many studies had confirmed benefical effects of ginger against inflammation, free radicals, diabetes melitus, bacterial infection, cancer, nausea, etc. Z. officinale var. rubrum is considered a safe herbal remedy with only slight and not significant adverse effects. This plant is potential fur future phytomedicine, however it needs further explorations on its clinical studies in humans is expected, especially the efficacy and safety of the risk of side effects.
Review: Hepatoprotector Compounds in Plant Extracts DICHY NURYADIN ZAIN; Riezki Amalia; Jutti Levita
Indonesian Journal of Applied Sciences Vol 8, No 1 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.095 KB) | DOI: 10.24198/ijas.v8i1.16967

Abstract

Many plants have been reported to possess hepatoprotective activity. The mechanism has not yet been revealed, but it was predicted due to the antioxidants that could prevent the formation of free radicals produced by hepatotoxins. Of the 30 plants studied, Crocus sativus gave the largest hepatoprotector activity at a dose of 20 mg / kg, followed by Uncaria gambier Roxb. with a dose of 30 mg / kg and Melastoma malabathricum Leaf at a dose of 50 mg / kg. Keywords: Liver, CYP450, antioxidant, free radicals

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