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An Urinary Excretion Profile of 500 mg Ascorbic Acid in Healthy Adults Mutakin, Mutakin
Indonesian Journal of Clinical Pharmacy Vol 1, No 2 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.069 KB)

High doses of ascorbic acid have been commercially available as adjuvant. However, the pharmacologicalimportance of this supplement is yet questionable. The aim of this study is to investigate the 24 hours excretion profile of ascorbic acid after oral administration of 500 mg single dose in healthy volunteer. The urine samples were collected at 2, 4, 6, 8, and 24 hours after administration. The samples were extracted with trichloroacetic acid, followed by colorimetric measurement. The excretion profile showed a curve with concentrations of 14.4, 15.2, 15.6, 14.9, and 14.2% at 2, 4, 6, 8, and 24 hours, respectively. This suggests that 74.3% of ascorbic acid to be excreted via urine as an excessive amount and a high adjuvant dosage should be reconsidered.Key words: Ascorbic acid, oral administration, single dose, excretion profileProfil Ekskresi 500 mg Asam Askorbat dalam Saluran Urin pada Orang Dewasa SehatAbstrakAsam askorbat dosis tinggi telah tersedia secara komersil sebagai suplemen. Akan tetapi, kegunaan secara farmakologi pada suplemen ini masih dipertanyakan. Tujuan dari penelitian ini adalah untuk mengetahui profil ekskresi asam askorbat selama 24 jam setelah pemberian oral 500 mg dosis tunggal pada sukarelawan sehat. Sampel urin dikumpulkan pada jam ke-2, 4, 6, 8, dan 24 setelah pemberian. Sampel diekstraksi dengan asam trikloroasetat lalu diukur dengan metode kolorimetri. Profil ekskresi menunjukkan bahwa terbentuk kurva pada konsentrasi secara berurutan 14,4; 15,2; 15,6; 14.9; dan 14,2% pada jam ke-2, 3, 6, 8 dan 24. Hal ini menunjukkan bahwa 74,3% asam askorbat diekskresikan melalui urin dalam jumlah besar dan pemakaian dosis tinggi suplemen seharusnya dipertimbangkan.Kata kunci: Asam askorbat, pemberian oral, dosis tunggal, profil ekskresi

EFEKTIVITAS PROGRAM NASIONAL PEMBERDAYAAN MASYARAKAT MANDIRI PEDESAAN (PNPM-MP) DALAM MENUNJANG PEMBANGUNAN PERTANIAN DI KECAMATAN NGAMBUR KABUPATEN LAMPUNG BARAT Mutakin, Mutakin; Gitosaputro, Sumaryo; Adawiyah, Rabiatul
Jurnal Ilmu-Ilmu Agribisnis Vol 1, No 2 (2013)
Publisher : Lampung University

This study aims to determine (1) the effectiveness of rural community empowerment national program (PNPM-MP) and (2) factors related to the level of the effectiveness of the program in supporting agricultural development. Research was conducted in Ngambur sub district of West Lampung Regency from February to April 2012. Respondents were 68 farmers taken proportionally from 21 farmer groups. Method used was a descriptive analysis. The correlation between variables was tested using Rank Spearman correlation analysis. Result showed that the PNPM-MP was quite effective in supporting agricultural development in Ngambur Subdistrict of West Lampung Regency. The factors related to the level of the effectiveness in supporting agricultural development were the level of knowledge of the group members, the role of facilitator and district management team activities, and the amount of the PNPM-MP fund. The factor not related to the effectiveness of the PNPM-MP in supporting agricultural development in sub Ngambur West Lampung Regency was the level of participation of group members. Keywords: agricultural, effectiveness, independent, program, empowerment

The Oral Health and Comorbid Diseases Knowledge Between Urban and Rural Community during Pandemic Wahyuni, Indah Suasani; Herawati, Irma Erika; Puspitasari, Irma Melyani; Mutakin, Mutakin; Milanda, Tiana; Levita, Jutti
KEMAS: Jurnal Kesehatan Masyarakat Vol 18, No 1 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v18i1.31454

The restriction of social mobility and activity during the COVID-19 pandemic has been implemented to stop the deadly transmission of the SARS-CoV2 virus. People are forced to stay at home and strictly perform the COVID-19 health protocol in their daily activities. Currently, a continuous self-maintenance of the health, including oral health, is considered the best strategy worldwide. This community service activity aimed to assess the knowledge of the urban and rural adult community about oral health, comorbidity, and the quality of life (QoL) during this pandemic situation by using a pre-and post-test quasi-experimental design with an intervention of health-knowledge sharing using leaflets and videos, and a WHOQOL 2012 questionnaire to study the QoL. Paired t-test was used as statistical analysis. Total respondents were 131 (n = 76 for urban and n = 55 for rural), selected using the purposive sampling method. There was a significant difference between the results of the pre-test and post-test in both urban and rural groups (t count ranged from 1.69 to 5.98; p 0.05). Based on the WHOQOL 2012 questionnaire, both urban (90.79%) and rural (87.27%) respondents indicated a good QoL, while the remaining was scored as medium. Physical conditions/pain was the main domain that directly affects the QoL in both communities. It could be concluded that the knowledge-sharing intervention to the community gave a good impact in enhancing the knowledge of the respondents, however, a continuous program should be further carried out for better results.

KANDUNGAN Na/K DALAM BUAH TROPIS DI TIGA NEGARA ASEAN: KAJIAN PUSTAKA Andini, Alfita Nur; Hasanah, Aliya Nur; Mutakin, Mutakin
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.2923

Hipertensi pada masyarakat mengalami peningkatan prevalensi disebabkan oleh faktor gaya hidup dan pola makan. Hipertensi dapat dicegah dengan manajemen konsumsi makanan seperti buah-buahan dalam mempertahankan asupan kalium. Buah merupakan salah satu sumber makanan yang mengandung tinggi kalium. Kalium dapat mempertahankan tekanan darah dalam rentang normal jika bekerja bersama natrium. Tingginya konsumsi kalium dalam buah dapat membantu proses natriuresis sehingga tekanan darah sistolik dan diastolik akan turun. Tujuan dari ulasan ini adalah mengetahui kadar natrium dan kalium dalam buah tropis di tiga negara ASEAN untuk mengontrol tekanan darah pada masyarakat. Studi ini melibatkan 12 jurnal dan artikel nasional maupun internasional sesuai dengan kata kunci yang digunakan yaitu “kadar, kalium, natrium, buah tropis”. Buah tropis mengandung lebih banyak kalium dengan rasio 0,5-100 kali kadar natrium yang dapat membantu dalam mengontrol tekanan darah. Hasil studi ini menunjukkan buah tropis dengan kandungan kalium tinggi terdapat pada durian chanee kadar mencapai 4358,6 mg/100g, sedangkan kandungan natrium tinggi terdapat pada buah merah dengan kadar mencapai 166,67 mg/100g.

Wanita Sebagai Pondasi Peradaban Perspektif Hadis Karmilah, Karmilah; Rikaeni, Ike; Yulianti, Ayu; Zainuddin, Ahmad; Mutakin, Mutakin; Muhajir, Muhajir; Ahmad, Lalu Turjiman
Mimbar Kampus: Jurnal Pendidikan dan Agama Islam Vol 23 No 1 (2024): Mimbar Kampus: Jurnal Pendidikan dan Agama Islam
Publisher : Fakultas Tarbiyah IAI Nasional Laa Roiba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/mk.v23i1.5657

Women have played a significant role in the history of human civilization, including Islamic civilization. Muslim women such as Khadijah, Aisha, and other female companions (shahabiyah) have made substantial contributions in various fields, including science, propagation of the faith, and activism. However, stigmas against highly educated women persist in certain societies. This research aims to investigate the Hadith perspective on women, education, and their role in Islamic civilization. This qualitative research employs a literature review to gather information. Relevant Hadiths pertaining to the concept of women's education are collected, analyzed deductively and inductively. Education is a fundamental right for all individuals, including women. Women's education is the key to empowering them in various aspects of life. The Hadith underscores the importance of seeking knowledge, especially religious knowledge. This research contributes to a deeper understanding of the crucial role women play in shaping Islamic civilization and addresses the stigma surrounding women's education.

The Health Profile of Students and Teachers in Madrasah Al Ihsan, Kecamatan Ciparay, Kabupaten Bandung Febrina, Ellin; Herawati, Irma E.; Wahyuni, Indah S.; Rusdianto, Aziiz M.; Hendriani, Rini; Puspitasari, Irma M.; Mutakin, Mutakin; Halimah, Eli; Sumiwi, Sri A.; Levita, Jutti
Pharmacology and Clinical Pharmacy Research Vol 9, No 2 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i2.51203

The prevalence of diabetes mellitus and hypertension in Indonesia is increasing both in low- and high-income communities. Therefore, health awareness should be started from a younger age for the prospective future generation. This study, included in a community engagement activity, aims to assess the health profile, in terms of blood pressure (BP) and total cholesterol, of the students (by cross-sectional method) and teachers (by cohort method) of a private madrasah in the rural area of Kecamatan Ciparay, Kabupaten Bandung, West Java. 54 students and 10 teachers participated in this study. Results revealed that the students' average systolic and diastolic BP were 120.23 mmHg and 78.67 mmHg, respectively. The average systolic BP of the teachers in August 2021, January 2022, and August 2022 was 136.8 mmHg, 128.1 mmHg, and 131.9 mmHg, respectively. The average diastolic BP of the teachers in August 2021, January 2022, and August 2022 were 91.6 mmHg, 87.3 mmHg, and 87.1 mmHg, respectively. Moreover, the average cholesterol levels of the students (148.38 mg/dL) and the teachers (190.81 mg/dL) were categorized as normal. Taken together, the health profile of the students and the teachers in Madrasah Al Ihsan is within the normal range. This activity gets positive support from the school and needs sustainability.

KANDUNGAN Na/K DALAM BUAH TROPIS DI TIGA NEGARA ASEAN: KAJIAN PUSTAKA Andini, Alfita Nur; Hasanah, Aliya Nur; Mutakin, Mutakin
Jurnal Ilmiah Farmako Bahari Vol 15 No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.2923

Hipertensi pada masyarakat mengalami peningkatan prevalensi disebabkan oleh faktor gaya hidup dan pola makan. Hipertensi dapat dicegah dengan manajemen konsumsi makanan seperti buah-buahan dalam mempertahankan asupan kalium. Buah merupakan salah satu sumber makanan yang mengandung tinggi kalium. Kalium dapat mempertahankan tekanan darah dalam rentang normal jika bekerja bersama natrium. Tingginya konsumsi kalium dalam buah dapat membantu proses natriuresis sehingga tekanan darah sistolik dan diastolik akan turun. Tujuan dari ulasan ini adalah mengetahui kadar natrium dan kalium dalam buah tropis di tiga negara ASEAN untuk mengontrol tekanan darah pada masyarakat. Studi ini melibatkan 12 jurnal dan artikel nasional maupun internasional sesuai dengan kata kunci yang digunakan yaitu “kadar, kalium, natrium, buah tropis”. Buah tropis mengandung lebih banyak kalium dengan rasio 0,5-100 kali kadar natrium yang dapat membantu dalam mengontrol tekanan darah. Hasil studi ini menunjukkan buah tropis dengan kandungan kalium tinggi terdapat pada durian chanee kadar mencapai 4358,6 mg/100g, sedangkan kandungan natrium tinggi terdapat pada buah merah dengan kadar mencapai 166,67 mg/100g.

IMPLEMENTASI AUGMENTED REALITY UNTUK ESTIMASI BOBOT DAN HARGA JUAL HEWAN TERNAK SAPI BERBASIS ANDROID Mutakin, Mutakin; Sundari, Shinta Siti; Sumaryana, Yusuf
Jurnal Informatika dan Teknik Elektro Terapan Vol. 12 No. 2 (2024)
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jitet.v12i2.4120

Penaksiran bobot dan penetapan harga dalam penjualan sapi merupakan aspek penting yang dapat memengaruhi keadilan dan efisiensi transaksi. Metode tradisional yang melibatkan penilaian visual manusia seringkali tidak akurat, menyebabkan kesenjangan harga yang signifikan. Ketersediaan alat ukur yang memadai juga menjadi hambatan, khususnya di daerah pedesaan. Penelitian ini mengusulkan pengembangan aplikasi Android berbasis Augmented Reality (AR) untuk mengestimasi bobot dan harga sapi secara akurat. Metode pengembangan yang digunakan adalah model ADDIE, yang melibatkan analisis, desain, development, implementasi, dan evaluasi. Hasil pengujian aplikasi menunjukkan nilai rata-rata error 6% dan 13% untuk pengukuran panjang badan dan lingkar dada, serta akurasi 98% untuk estimasi bobot badan menggunakan rumus Winter Indonesia. Selain itu, aplikasi juga dapat menghitung harga jual dan bobot karkas sapi berdasarkan estimasi bobot badan.

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