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All Journal Farmaka Indonesian Journal of Applied Sciences Jurnal Farmasi Klinik Indonesia Indonesian Journal of Science and Technology
Riezki Amalia
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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REVIEW: MOLECULARLY IMPRINTED-SOLID PHASE EXTRACTION (MI-SPE) DALAM ANALISIS KONTAMINAN PANGAN SAQILA ALIFA RAMADHAN; Riezki Amalia
Farmaka Vol 17, No 2 (2019): Farmaka (Agustus)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.437 KB) | DOI: 10.24198/jf.v17i2.22238

Abstract

ABSTRAKKontaminasi dalam bahan pangan dapat menyebabkan terjadinya peristiwa keracunan. Beberapa metode telah dikembangkan untuk preparasi dan analisis kandungan suatu kontaminan dalam bahan pangan. Metode yang umum digunakan dalam preparasi bahan pangan adalah Solid Phase Extraction (SPE). Untuk meningkatkan selektivitas SPE dalam pemurnian sampel, maka digunakan penerapan teknik Molecularly Imprinted Polymer (MIP) dalam sorben SPE. Review ini membahas beberapa aplikasi dari Molecularly Imprinted-Solid Phase Extraction (MI-SPE) dalam analisis kontaminan pangan. Berdasarkan hasil review, MI-SPE dapat digunakan untuk ekstraksi kontaminan pangan seperti akrilamid, bisfenol, melamin, organofosfat, fenarimol, triazin, okratoksin A, ampisilin, tetrasiklin, fluoroquinolon, dan kloramfenikol.Kata Kunci : Pangan, Solid Phase Extraction (SPE), Molecularly Imprinted Polymer (MIP), Molecularly Imprinted-Solid Phase Extraction (MI-SPE) ABSTRACTContamination in food can cause poisoning incident. Several methods have been developed for the preparation and analysis of contaminants in food. The method commonly used in food preparation is Solid Phase Extraction (SPE). To increase the SPE's selectivity in sample purification, the application of Molecularly Imprinted Polymer (MIP) technique in SPE's sorbent was used.  This review discussed several applications of Molecularly Imprinted-Solid Phase Extraction (MI-SPE) in food's contaminants analysis. Based on the review, MI-SPE can be used to purify contaminants in food like acrylamide, bisphenol, melamine, organophosphate, fenarimol, triazine, ochratoxin A, ampicillin, tetracycline, fluoroquinolone, and chloramphenicol.Keywords: Food's contaminants, Solid Phase Extraction (SPE), Molecularly Imprinted Polymer (MIP), Molecularly Imprinted-Solid Phase Extraction (MI-SPE)
Review: Hepatoprotector Compounds in Plant Extracts DICHY NURYADIN ZAIN; Riezki Amalia; Jutti Levita
Indonesian Journal of Applied Sciences Vol 8, No 1 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.095 KB) | DOI: 10.24198/ijas.v8i1.16967

Abstract

Many plants have been reported to possess hepatoprotective activity. The mechanism has not yet been revealed, but it was predicted due to the antioxidants that could prevent the formation of free radicals produced by hepatotoxins. Of the 30 plants studied, Crocus sativus gave the largest hepatoprotector activity at a dose of 20 mg / kg, followed by Uncaria gambier Roxb. with a dose of 30 mg / kg and Melastoma malabathricum Leaf at a dose of 50 mg / kg. Keywords: Liver, CYP450, antioxidant, free radicals
Artikel Review: Interaksi Silang Pensinyalan WNT dan TGF-β pada Kanker Paru dengan MikroRNA sebagai Mayoritas Regulator Nita Rahmasari; Melisa I. Barliana; Riezki Amalia
Indonesian Journal of Clinical Pharmacy Vol 10, No 1 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.1.62

Abstract

Posisi pertama untuk kejadian dan mortalitas kanker paru di dunia saat ini masih menjadi tantangan untuk menemukan dan mengembangkan terapi potensial bagi pasien kanker paru. Pemahaman pada tingkat molekular mengenai progres tumor pada kanker sangat diperlukan untuk menemukan rejimen terapi yang efektif; terdapat perubahan genetik pada berbagai jalur pensinyalan pengatur proses biologi yang terlibat selama karsinogenesis. Pensinyalan WNT dan TGF-β telah banyak diidentifikasi pada beberapa penelitian, khususnya mengenai interaksi keduanya dalam tumorigenesis paru, namun belum cukup diulas secara jelas. Oleh karena itu, dilakukan pengkajian terhadap 10 artikel riset yang diakses secara online melalui database MeSH PubMed dengan kata kunci “Receptors, Wnt/Wnt Signaling Pathway/Wnt Proteins” AND “Receptors, Transforming Growth Factor beta/Transforming Growth Factor beta” AND “Lung Neoplasms/Small Cell Lung Carcinoma/Carcinoma, Non-Small-Cell Lung”, untuk menyusun ulasan mengenai interaksi silang keduanya pada kanker paru secara lebih jelas. Secara menyeluruh, interaksi silang antara pensinyalan WNT dan TGF-β meregulasi pemrograman Cancer Stem Cell (CSC) dan Epithelial–Mesenchymal Transition (EMT) selama tumorigenesis dan prognosis kanker paru yang berdampak pada metastasis, peningkatan agresivitas, serta kemoresistensi tumor. Interaksi silang pensinyalan WNT dan TGF-β pada kanker paru dapat terjadi secara langsung pada tingkat kompleks transkripsi mereka ataupun dengan melibatkan suatu mediator penting, yang sebagian besarnya diperankan oleh mikroRNA. Terdapat berberapa mikroRNA yang telah teridentifikasi baik pada kanker paru dalam meregulasi interaksi silang antara pensinyalan WNT dan TGF-β, seperti miR-1827, miR-3127-5p, dan miR-128-3p. Pembahasan ini mengimplikasikan peluang yang tinggi pada penekanan kedua jalur WNT dan TGF-β secara simultan dan efektif dengan menargetkan suatu molekul yang berpotensi untuk kanker paru.Kata kunci: Interaksi silang pensinyalan, kanker paru, pensinyalan TGF-β, pensinyalan WNT  Review Article: Crosstalk between WNT and TGF-β signaling in Lung Cancer with MicroRNA as Majority of RegulatorsAbstractThe discovery and development of potential therapies to reduce the incidence and mortality of lung cancer is still a challenge. Consequently, identifying an effective therapeutic regimen is necessary for tumor progression in cancer at the molecular level due to genetic changes in various signaling pathways that regulate the biological processes involved during carcinogenesis. WNT and TGF-β signaling have been widely identified in several studies, with regards to the interaction of both in pulmonary tumorigenesis although they have not been adequately reviewed clearly. Hence, an assessment of 10 research articles was conducted online through the MeSH PubMed database with the keywords “Receptors, Wnt/Wnt Signaling Pathway/Wnt Proteins” AND “Receptors, Transforming Growth Factor beta/Transforming Growth Factor beta” AND “Lung Neoplasms/Small Cell Lung Carcinoma/Carcinoma, Non-Small-Cell Lung”, to compile an overview of the crosstalk. Furthermore, the crosstalk between WNT and TGF-β signaling regulates the programming of Cancer Stem Cell (CSC) and Epithelial–Mesenchymal Transition (EMT) during tumorigenesis and prognosis of lung cancer that leads to metastasis, increased aggressiveness, and tumor chemoresistance. The crosstalk of WNT and TGF-β signaling in lung cancer can occur directly at the level of their transcription complex or by involving an important mediator, most of which is played by microRNA. There are several microRNAs identified in regulating crosstalk between WNT signaling and TGF-β, such as miR-1827, miR-3127-5p, and miR-128-3p. The discussion implies a high opportunity for the simultaneous and effective suppression of both WNT and TGF-β pathways by targeting a molecule that has the potential for lung cancer.Keywords: Lung cancer, signaling crosstalk, TGF-β signaling, WNT signaling
In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition W. Wahyuni; Ajeng Diantini; Mohammad Ghozali; Anas Subarnas; Euis Julaeha; Riezki Amalia; Adryan Fristiohady; Andini Sundowo; Sofa Fajriah; Yuni Elsa Hadisaputri; Raden Maya Febrianti; Fauzia Azzahra; Agung W.M. Yodha; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 2 (2022): IJOST: VOLUME 7, ISSUE 2, September 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i2.50547

Abstract

Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate were 134.59; 170 ; 128.11; and 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited the lowest migration rate (3.32%). The free bond energies of sitostenon, 1,7-diphenyl-6-heptene-3-one, sinapyl alcohol acetate, and sinapyl alcohol diacetate were -11.81; -8.25; -6.64; and -6.28 kcal/mol, respectively. All compounds were more effective in stabilizing the Matrix metalloproteinase 1 complex. Isolation from EA rhizomes have the potential to be developed as anti-metastatic for Triple-Negative Breast Cancer.
Co-Authors Adryan Fristiohady Agung W.M. Yodha Anas Subarnas Andini Sundowo DIANTINI, AJENG - Euis Julaeha Fauzia Azzahra, Fauzia I. Sahidin Jutti Levita Melisa I. Barliana Mohammad Ghozali Nita Rahmasari Raden Maya Febrianti SAQILA ALIFA RAMADHAN Sofa Fajriah W. Wahyuni Yuni Elsa Hadisaputri Zain, Dichy Nuryadin