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Jurnal Sinaps
Published by Universitas Sam Ratulangi
ISSN : 26152002     EISSN : 26152002     DOI : -
Core Subject : Health, Science, Education,
Education Neuroscience Public Health
Sinaps: Jurnal Neurologi Manado (Nomor ISSN online 2615-2002)adalah Jurnal terbitan dari Perhimpunan Dokter Spesialis Saraf Cabang Manado dan Bagian/KSM Neurologi FK Unsrat/RSUP Prof. Dr. R.D Kandou Manado
Arjuna Subject : Ilmu Syaraf - Neorologi
Articles 85 Documents
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BELL’S PALSY ASSOCIATED WITH COVID-19: A CASE REPORT Anthonius Kurniadi; Leopold Pondaag
Jurnal Sinaps Vol. 4 No. 3 (2021): Volume 4 Nomor 3, September 2021
Publisher : Neurologi Manado

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Introduction. Peripheral neuropathy caused by SARS-CoV-2 infection has been reported. Case reports have described facial nerve palsy associated with Covid-19. Here we report a Bell’s palsy case in a post Covid-19 patient.Case Report. A 43-year-old male came to neurology outpatient clinic complaining of left face palsy since a day before. He has been tested positive for SARS-CoV-2 20 days ago, experienced a mild symptomatic phase, and has been declared negative after the second test 4 days ago. One day before the left facial palsy, he experienced pain on his left ear. Acyclovir, prednisolone, methylcobalamine, and physiotherapy have been given as the treatment of Bell’s palsy after Covid-19 for the patient and came out with good result. After two weeks of treatment, the patient has gained back the muscle strength of his left face to nearly normal condition. Discussion. The SARS-CoV-2 route of entry to the nervous system is still unclear. Peripheral neuropathy is thought to be caused by immunological reaction induced by the virus. The SARS-CoV-2 has caused systemic hyperinflammation with macrophage activation syndrome and cytokine storm. The immune mediated peripheral nerve manifestation occurs characteristically after the acute phase of infection has ended, just like the one experienced by the patient. The treatment was given empirically. Steroids and antiviral have been justly given according to common treatment of Bell’s palsy and showed good results. Analysis of cerebrospinal fluid, blink reflex study, magnetic resonance imaging, and high resolution ultrasonography are advisable ancillary examinations.
DESCRIPTION OF THE NERVE CONDUCTIVE STUDY RESULTS OF PATIENTS WITH DIABETIC POLYNEUROPATHY IN MANADO, INDONESIA Hugo Dwiputra Wiradarma; Stella; Herlyani Khosama; Seilly Y Jehosua
Jurnal Sinaps Vol. 3 No. 1 (2020): Volume 3 Nomor 1, Februari 2020
Publisher : Neurologi Manado

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Introduction: Diabetic Polyneuropathy (DP) is one of the most frequent complications of diabetes mellitus (DM) which causes high morbidity and mortality. Axonal degeneration is a pathognomonic sign of DP pathophysiology. Nerve conductive study is a common neurophysiologic tool to diagnose DP, however there were no any descriptive study for it in Manado. This study aims to describe the distribution and prevalence of the affected nerve, thus a mapping of the neuropathy in diabetic patients can be obtained. Methods: The data were taken retrospectively by including subjects aged >30 years old who suffer from DM and had complaints of burning sensation, numbness, tingling and prickling in the lower and upper extremities with a symmetrical distribution of gloves and stockings. Subjects with a history of alcohol consumption, thyroid disease, impaired kidney & liver function, heart and adrenal disease were excluded. Nerve conduction study was performed on motor and sensory nerves in both upper and lower extremities. Results: There were 59 subjects included in this study, with nearly identical ratio (men 50.85% & women 49.15%) with a mean age of 56.7 years old (ranging from 34 to 80 years old). All subjects had axonal polyneuropathy (100%) and 27.1% subjects had secondary demyelination. Entrapment abnormalities were most commonly found in the median nerve (57.6%). The most common motor abnormalities were peroneal nerve (81.4%) and sural nerve for sensory abnormalities (98.3%). Discussion: All subjects had axonal disorders and small proportion of patients had secondary demyelination which was caused by metabolic and microvascular complications of diabetes. Entrapments were most commonly found in the median nerve, possibly because of the highest mobility for repetitive movements in hands. All patients exhibited sensorimotor disorders with the greatest abnormalities found in the lower extremities in accordance to length-dependent neuropathy.
RATIONAL USE OF ANTIPLATELETS IN VASCULAR NEUROINTERVENTION PROCEDURES Gilbert Tangkudung; David Susanto; Ferrdy Pratama Wijaya
Jurnal Sinaps Vol. 4 No. 3 (2021): Volume 4 Nomor 3, September 2021
Publisher : Neurologi Manado

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Vascular neurointervention procedures have a risk of complications, both intraprocedural and post-procedure. The most common complication is thromboembolic. Administration of antiplatelet agents can prevent the risk of these occurrences. Several antiplatelet agents have been studied and tested in neurointerventional vascular procedures. Knowing the right time and doses of antiplatelet can reduce the side effects that can occur during its administration so it can provide a good outcome after the procedures
EPIDURAL CORTICOSTEROID INJECTION IN THE MANAGEMENT OF LUMBAR DISC HERNIATION Dessy R Emril; Novina Rahmati
Jurnal Sinaps Vol. 4 No. 1 (2021): Volume 4 Nomor 1, Februari 2021
Publisher : Neurologi Manado

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Low back pain (LBP) is commonly found in daily practice and a major cause of disability in the world. The most common cause of LBP is herniated disc. Various therapeutic modalities can be an option in the management of LBP caused by herniated disc including conservative therapy, epidural corticosteroid injection, and surgery. In patients who do not respond to conservative therapy and do not meet the criteria for surgery, the only therapy recommended for the patient is epidural corticosteroid injection. Epidural corticosteroid injection has significant effectiveness in reducing pain, restoring function, and reducing the risk for surgery.
LITERATURE REVIEW: MONOCLONAL ANTIBODY THERAPY FOR MIGRAINE Owen Johanes Maliangkay; Timothy L. Batasina; Ferrdy Pratama Wijaya; Theresia Runtuwene; Arthur H.P. Mawuntu
Jurnal Sinaps Vol. 4 No. 1 (2021): Volume 4 Nomor 1, Februari 2021
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Migraine headaches are one of the most frequent types of primary headaches, and they can be difficult to treat. Pharmacological and non-pharmacological therapy, as well as abortive and preventative therapy, are all options for treatment. Calcitonin Gene-Related Peptide (CGRP) plays a key role in migraine pathophysiology and is now being employed as an abortive and preventive treatment. CGRP antagonist therapy and monoclonal antibodies (MAB) are two types of therapy that block the CGRP pathway. So far, four MAB treatments for migraine have shown promise. Clinicians should be familiar with MAB therapy for migraine since it is likely to become a popular treatment option in the future.
Aspek Neuroanatomi dan Pencitraan pada Cerebral Venous Sinus Thrombosis (CVST) Hidayaturrahmi Hidayaturrahmi; Ika Waraztuti; Zefri Suhendar
Jurnal Sinaps Vol. 5 No. 1 (2022): Volume 5 Nomor 1, Februari 2022
Publisher : Neurologi Manado

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Cerebral Venous Sinus Thrombosis (CVST) merupakan gangguan neurologis yang relatif jarang tetapi berdampak serius, dan menjadi reversibel jika terdiagnosis secara tepat dan mendapat pengobatan yang tepat. Diagnosis yang tepat untuk mengenali CVST sangatlah diperlukan. Pemahanam Neuroanatomi dan pencitraan sangat berperan penting dalam diagnosis CVST karena faktor penyebab dan manifestasi klinis dari gangguan ini bervariasi. Pasien akan memperoleh penanganan segera secara efektif apabila CVST dapat didiagnosis sejak awal. Diagnosis yang terlambat akan menimbulkan morbiditas dan mortalitas yang tinggi.
Aspek Klinis dan Tatalaksana Duchenne Muscular Dystrophy Pada Anak Tita Menawati Liansyah; Hidayaturrahmi Hidayaturrahmi
Jurnal Sinaps Vol. 5 No. 2 (2022): Volume 5 Nomor 2, Juni 2022
Publisher : Neurologi Manado

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Duchenne muscular dystrophy (DMD) is an X-linked recessive disease, progressive muscular type, hereditary in nature, and is inherited through X-linked recessive so that it only affects boys, while girls are carriers. Usually patients die in the second decade due to complications of pulmonary infection or heart failure. Clinically DMD patients are unable to walk at the age of about 10 years. Surgery and rehabilitation, can help patients to prolong ambulation function and provide a sense of comfort.
HUBUNGAN INTENSITAS NYERI PUNGGUNG BAWAH UNILATERAL DENGAN DERAJAT OSTEOARTRITIS DAN INTENSITAS NYERI LUTUT KONTRALATERAL DI RUMAH SAKIT UMUM DAERAH DR. ZAINOEL ABIDIN BANDA ACEH Riska Santi Putri; Dessy Rakhmawati Emril; Syamsul Rizal; Nova Dian Lestari; Yopie Afriandi Habibie
Jurnal Sinaps Vol. 5 No. 2 (2022): Volume 5 Nomor 2, Juni 2022
Publisher : Neurologi Manado

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Introduction: Low back pain (LBP) is one of the most common forms of musculoskeletal pain and is often encountered in everyday life. LBP can interfere with a person's work performance so that it can reduce human productivity. The pain caused by LBP can radiate to the ipsilateral leg and cause the contralateral leg to withstaand more weight due to the inability of the ipsilateral leg. This condition can also cause osteoarthritis (OA) in the contralateral leg of patients with LBP. Aims: This study aims to analyze the relationship between unilateral lower back pain and the degree of contralteral knee osteoarthritis at Dr. Zainoel Abidin Banda Aceh. Methods: This study was an observational analytic study with a cross-sectional design. The sample in this study was taken using the total sampling method. Based on the inclusion and exclusion criteria, 17 people can be analyzed. Data collection was carried out by collecting medical records in neurological clinics and radiology installations.Results: The results of this study indicate that 50% of respondents showed a degree of pain on a scale of 5 (moderate category), 40% of respondents indicated the degree of knee OA grade 2 and grade 3. Based on the results of the analysis with the Spearman test, it was found that there was a relationship between unilateral low back pain intensity and the degree OA of the contralateral knee (p value = 0.026) and based on the results of the analysis with the Spearman test, it was also found that there was a relationship between the intensity of unilateral low back pain and the intensity of contralateral knee pain (p value = 0.047). Discussion: The conclusion of this study is that there is a relationship between unilateral low back pain with the degree of osteoarthritis and the intensity of contralteral knee pain in Dr. General Hospital. Zainoel Abidin Banda Aceh.
MIXED PAIN PADA LOW BACK PAIN: ELABORASI DAN IDENTIFIKASI Juwita; Dessy R. Emril; Rachmad Suhanda
Jurnal Sinaps Vol. 5 No. 3 (2022): Volume 5 Nomor 3, September 2022
Publisher : Neurologi Manado

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Low back pain is a health problem that is very common and has an impact on the financial well-being of both patients and their families. Based on pathophysiology, pain can be divided into nociceptive, neuropathic, and central sensitization pain. In about 85% low back pain cases, it is not known which type of pain plays a greater role so that patients suffer from pain for more than 1 year. Currently known as Mixed Pain, namely pain with a combination of pathophysiology that underlies the pain such as nociceptive with neuropathic pain. The term pain cannot yet be formally defined, so the term mixed pain has not been used widely enough to define pain. It is necessary to conduct a search on clinical indicators of mixed pain so that the process of identifying the type of pain is better, the selection of therapy becomes more rational, and the patient's quality of life improves.
Resusitasi Pada Cedera Otak Traumatik Ika Waraztuty; Dewi Prahaztuty; Tita Menawati Liansyah; Hidayaturahmi
Jurnal Sinaps Vol. 5 No. 3 (2022): Volume 5 Nomor 3, September 2022
Publisher : Neurologi Manado

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Cedera otak adalah perubahan fungsi otak atau terdapat bukti patologi pada otak yang disebabkan oleh kekuatan mekanik eksternal. Konsekuensi akibat cedera otak dipengaruhi beberapa faktor seperti usia, faktor komorbid, sepsis, dan tatalaksana yang didapatkan. Tujuan utama penanganan cedera otak traumatik adalah meminimalkan edema serebri, mencegah peningkatan tekanan inrakranial, dan mengoptimalkan cerebral perfusion pressure (CPP) sehingga akan menurunkan angka kejadian cedera otak sekunder. Semua pasien yang dicurigai mengalami cedera otak traumatik harus menjalani primary dan secondary survey yang meliputi pemeriksaan jalan napas, pernapasan, dan sirkulasi. Dilanjutkan dengan monitor tekanan Intra Kranial, suhu tubuh, profilaksis kejang, pemberian anestesi, analgetika, dan sedasi serta pencegahan Deep Venous Thrombosis dan koagulopati.

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