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Jurnal Sinaps
Published by Universitas Sam Ratulangi
ISSN : 26152002     EISSN : 26152002     DOI : -
Core Subject : Health, Science, Education,
Education Neuroscience Public Health
Sinaps: Jurnal Neurologi Manado (Nomor ISSN online 2615-2002)adalah Jurnal terbitan dari Perhimpunan Dokter Spesialis Saraf Cabang Manado dan Bagian/KSM Neurologi FK Unsrat/RSUP Prof. Dr. R.D Kandou Manado
Arjuna Subject : Ilmu Syaraf - Neorologi
Articles 85 Documents
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Gambaran Fungsi Kognitif Pra Lanjut Usia di Pos Binaan Terpadu Puskesmas Kopelma Darussalam Kota Banda Aceh Nova Dian Lestari; Rayya Az-Zahra; Dessy Rakhmawati Emril; Nirwana Lazuardi Sary; Suherman
Jurnal Sinaps Vol. 6 No. 1 (2023): Volume 6 Nomor 1, Februari 2023
Publisher : Neurologi Manado

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Abstract

Populasi lansia yang terus meningkat memberikan manfaat jika lansia tersebut sehat, tangguh dan kuat. Deteksi dini terkait penurunan fungsi kognitif pada masa pra lansia sangat diperlukan sehingga upaya menghambat progresivitas gangguan segera dilakukan untuk menjaga kapasitas fungsional pada masa lansia. Tujuan penelitian adalah untuk mengetahui gambaran fungsi kognitif dan domain kognitif pada kelompok pra lanjut usia. Jenis penelitian adalah deskriptif. Sampel dipilih dengan metode non-probability sampling dengan teknik total sampling dan didapatkan 60 subjek. Penelitian dilakukan di Pos Binaan Terpadu (Posbindu) Puskesmas Kopelma Darussalam yang mencakup 5 desa. Instrumen yang digunakan dalam penelitian ini adalah MoCA-Ina dan pengambilan data dilakukan secara wawancara. Hasil penelitian menunjukkan 55% kelompok pra lanjut usia memiliki fungsi kognitif yang tidak normal dan 45% normal. Domain yang menurun pada subjek tidak normal adalah memori tertunda (97%), fungsi eksekutif (93,9%), atensi (78,8%), bahasa (75,8%), dan visuospasial (48,5%). Sedangkan domain yang menurun pada subjek normal adalah memori tertunda (88,9%), bahasa (44,4%), fungsi eksekutif (40,7%), atensi (22,2%), dan visuospasial (14,8%). Kesimpulan penelitian ini adalah terjadi penurunan fungsi kognitif pada kelompok pra lansia di Posbindu Puskesmas Kopelma Darussalam yang didominasi dengan penurunan pada domain memori.
PERAN PLATELET RICH PLASMA PADA REGENERASI SARAF
Jurnal Sinaps Vol. 6 No. 1 (2023): Volume 6 Nomor 1, Februari 2023
Publisher : Neurologi Manado

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Abstract

Nerve cell regeneration is the regrowth or recovery of nerve tissue, cells, or products from cells after injury. Peripheral nerves that are injured will undergo a series of complex and coordinated processes to remove damaged tissue and start the repair process which will eventually undergo a regeneration process. Platelet rich plasma (PRP) is an autologous blood sample that has a platelet concentration above the normal level contained in blood plasma. Platelet rich plasma is rich in growth factors such as platelet derived growth factor (PDGF), transforming growth factor–β (TGF-β), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), Insulin-like Growth Factor 1,2 (IGF-1, IGF-2) and Fibroblast Growth Factor (FGF). Platelet rich plasma can increase Schwann cell proliferation, migration of Schwann cells and synthesis of extracellular matrix such as collagen which has benefits in nerve regeneration. Platelet rich plasma has a positive effect on nerve regeneration. The neuroregenerative and neuroprotective potential of PRP depends on the amount of growth factor released upon activated platelets. Platelet rich plasma with high growth factor can act as a catalyst to speed up the healing process and nerve regeneration.
RADIKULOPATI LUMBAL Muhammad Hafiz Moulvi; Jan Izaac Ferdinandus
Jurnal Sinaps Vol. 6 No. 3 (2023): Volume 6 Nomor 3, September 2023
Publisher : Neurologi Manado

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Abstract

Low back pain is one of the neuromusculoskeletal complaint that is commonly found in practice. Low back pain usually happens in men above 40 yo, and women around 50-60 yo. The cause of low back pain varies, such as nerve root compression, trauma, bone degeneration, disc herniation, infection, inflammation, vascular disturbance, or can be neoplasm. Management of low back pain can be carried-out non-operatively or operatively, depending on the severity, the syumptoms that arise, and the response to non-operative treatment.
TINJAUAN BIOMOLEKULAR PATOFISIOLOGI DAN PENEGAKAN DIAGNOSIS Juwita; Hidayaturrahmi; Adista, Ansari; Khairunnisa
Jurnal Sinaps Vol. 6 No. 3 (2023): Volume 6 Nomor 3, September 2023
Publisher : Neurologi Manado

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Abstract

Cancer is characterized by the uncontrolled growth and spreading of abnormal cells. Cancer-induced bone pain (CIBP) is a significant problem affecting the majority of cancer patients, especially those suffering from metastatic disease due to cancer. The pathogenesis of CIBP involves tumor cells, bone cells, inflammatory microenvironment, and neural tissue. RNA noncoding miR-708-5p/CXCL13 has an important role in enhancement development of bone cancer pain through the initiation of neuroinflammation and hyperalgesia. Early recognition of bone pain in cancer and establishing a diagnosis are essential for timely intervention to relieve pain, prevent complications such as bone fractures, and improve the patient's quality of life. Management of bone pain in cancer patients is very complex and requires a multidisciplinary approach.
METODE SKRINING STROKE LARGE VESSEL OCCLUSION (LVO) MENGGUNAKAN ASESMEN VISION, APHASIA, NEGLECT (VAN) Andriyani; Habibi, Irbi Eki
Jurnal Sinaps Vol. 6 No. 3 (2023): Volume 6 Nomor 3, September 2023
Publisher : Neurologi Manado

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Abstract

Acute stroke is a sudden episode of stroke that can cause long-term motor disturbances and impair cognitive abilities in patients. Stroke is the leading cause of the highest disability and the second leading cause of death worldwide. Approximately 62% of stroke patients are ischemic stroke, and 24-46% of all ischemic stroke cases involve large vessel occlusion (LVO). LVO stroke is a condition that occurs due to blockage in the large blood vessels in the brain and has a poor prognosis. The management of LVO stroke depends greatly on time to achieve satisfactory results in patients. The screening method considered effective in LVO stroke cases is using the Vision, Aphasia, Neglect (VAN) assessment based on the clinical symptoms of the patient. This VAN assessment tests the cortical function of patients while still making motor function as the main symptom. Patients in the Positive VAN category have a sensitivity of 100%, specificity of 90%, a positive predictive value of 74%, and a negative predictive value of 100% to detect LVO stroke.

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