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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
Arjuna Subject : -
Articles 12 Documents
 1   2 
Search results for , issue "Vol 11, No 2 (2019)" : 12 Documents clear
EFEK PENAMBAHAN EKSTRAK ETANOL HERBA CIPLUKAN (PHYSALIS ANGULATA L) SEBAGAI SUPLEMEN TERAPI PADA RHEUMATOID ARTRITIS Vikasari, Suci Nar; Sujiatmo, Afifah Bambang; Sukandar, Elin Yulinah; Wahyuningsih, Sri; Solihah, Puspa Sari Dewi; Suryani, Suryani; Aisyah, Salmanda; Kuatrina, Kuatrina; Astuti, Niken Juni; Siftiani, Nindy Dwi
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.667

Abstract

Rheumatoid arthritis is an autoimmune disease characterized with chronic joint inflammation. Chronic inflammation leads to liver function abnormality. Previous study showed that Physalis angulata L. had antiinflammatory, hepatoprotector, and immunosupressan effect. This research aims was to evaluate the effect of ethanol extract of P.angulata as adjuvant on liver function of RA animals model. Animals was induced with 0.1 mL complete freund adjuvant (CFA) intraplantar. The dose of P.angulata extract was 50 mg/kg bw po. The extract was given for 10 days as adjuvant of 0.1125 mg/kg bw methotrexate. Evaluation of liver function consisted of measurement of aminotransferase (AST and ALT), alanine phosphatase (ALP), organ index, and histology. The result showed that CFA could increase the level of AST and ALP and decrease the level of ALT and organ index of control group. The extract of P.angulata as adjuvant of methotrexate could decrease the level of AST and ALP and increase the level of ALT and organ index compare to control group, but could not reach its normal value. Histology showed that the extract also could improve liver regeneration. The extract of P.angulata at dose of 50 mg/kg bw used as adjuvant could improve liver function of RA animals model. 
IDENTIFIKASI MOLEKULER BAKTERI SIMBION SPONS LAUT HALICLONA (REINERA) SP. SEBAGAI ANTIBAKTERI Pahriyani, Ani; Haq, Fitriana Mifthahul; Wahyudi, Priyo
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.674

Abstract

Bacterial symbiont known to be able to produce secondary metabolites, that it?s utilization as the source of bioactive compounds is increase. Study of Mulyaningsih (2016) has reported that the bacterial symbiont of sponge Spheciospongia inconstans from Harapan Island, Kepulauan Seribu has a potentcy to produce antibacterial compounds. The aim of this study was to identify species of symbiont bacterial isolates of sponge of Spheciospongia inconstans which can produce antibacterial substance based on  16S  rRNA  gene.  Total  DNA of the five bacterial isolates from previous study were isolated using Wizard Genomic DNA Purification Kit, then amplified the 16S rRNA gene using primers 27f and 1492r. The amplification results were sequenced and aligned using BLAST program. The results of this study only succeeded in identifying isolate 6FS3 of bacterial symbiont that had an 100% similarity with bacteria Bacillus thermophilus strain Sgz-10.

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