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All Journal JFIOnline Jurnal Buana Farma
Solihah, Puspa Sari Dewi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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EFEK PENAMBAHAN EKSTRAK ETANOL HERBA CIPLUKAN (PHYSALIS ANGULATA L) SEBAGAI SUPLEMEN TERAPI PADA RHEUMATOID ARTRITIS Vikasari, Suci Nar; Sujiatmo, Afifah Bambang; Sukandar, Elin Yulinah; Wahyuningsih, Sri; Solihah, Puspa Sari Dewi; Suryani, Suryani; Aisyah, Salmanda; Kuatrina, Kuatrina; Astuti, Niken Juni; Siftiani, Nindy Dwi
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.667

Abstract

Rheumatoid arthritis is an autoimmune disease characterized with chronic joint inflammation. Chronic inflammation leads to liver function abnormality. Previous study showed that Physalis angulata L. had antiinflammatory, hepatoprotector, and immunosupressan effect. This research aims was to evaluate the effect of ethanol extract of P.angulata as adjuvant on liver function of RA animals model. Animals was induced with 0.1 mL complete freund adjuvant (CFA) intraplantar. The dose of P.angulata extract was 50 mg/kg bw po. The extract was given for 10 days as adjuvant of 0.1125 mg/kg bw methotrexate. Evaluation of liver function consisted of measurement of aminotransferase (AST and ALT), alanine phosphatase (ALP), organ index, and histology. The result showed that CFA could increase the level of AST and ALP and decrease the level of ALT and organ index of control group. The extract of P.angulata as adjuvant of methotrexate could decrease the level of AST and ALP and increase the level of ALT and organ index compare to control group, but could not reach its normal value. Histology showed that the extract also could improve liver regeneration. The extract of P.angulata at dose of 50 mg/kg bw used as adjuvant could improve liver function of RA animals model. 
TINJAUAN LITERATUR: AKTIVITAS FARMAKOLOGI DAN KANDUNGAN SENYAWA DARI KACANG KEDELAI (Glycine max L.) Sadino, Asman; Apriani, Riza; Solihah, Puspa Sari Dewi; Rachmawati, Siti
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1569

Abstract

Soybean (Glycine max L.) is a functional food from the legume group that is rich in bioactive compounds and has the potential to prevent degenerative diseases. This review aims to assess the content of the main active compounds and pharmacological activities of soybeans based on current scientific evidence. The method used is narrative review through literature searches on Google Scholar and PubMed databases of full-text articles published in the period 2010-2025. Articles included were in vitro and in vivo experimental studies that addressed the compound content and pharmacological activity of soybeans, while review articles, proceedings, and irrelevant publications were excluded. From the selection process, 12 articles were obtained that met the criteria for analysis. The results showed that isoflavones are the dominant compounds in soybeans that play a role in various pharmacological activities that can be grouped into several main categories, namely antioxidant and anti-inflammatory activities, metabolic activities (antidiabetes, antiobesity, and antihyperuricemia), and cardiovascular activities (antihypertension and anticholesterol). In addition, soy also shows potential as a supportive agent in the prevention of cancer and osteoporosis. Based on these findings, soy has great potential to be developed as a functional food and therapeutic support material in the prevention of degenerative diseases.
Co-Authors Aisyah, Salmanda Apriani, Riza ASMAN SADINO, ASMAN Astuti, Niken Juni Elin Yulinah Kuatrina, Kuatrina RR. Ella Evrita Hestiandari Siftiani, Nindy Dwi SITI RACHMAWATI Suci Nar Vikasari, Suci Nar Sujiatmo, Afifah Bambang Suryani Suryani