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INDONESIA
Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 46, No 10 (2024): Online May 2024" : 5 Documents clear
Gambaran Karakteristik Pasien Tuberkulosis Pasien di Puskesmas I Denpasar Selatan Putu Satyakumara Upadhana; Gede Agus Indra Pramana; Putu Restu Pertiwi; I Wayan Dediyana
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1697-1703.2024

Abstract

Tujuan: Tuberkulosis (TB) merupakan penyakit yang disebabkan oleh Mycobacterium tuberculosis. Penyakit ini masih memiliki morbiditas dan mortalitas yang sangat besar di seluruh dunia. Studi ini bertujuan untuk mengetahui gambaran karakteristik pasien tuberkulosis di Puskesmas I Denpasar Selatan. Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan potong lintang. Data yang digunakan adalah data sekunder dari data register pasien tuberkulosis di Puskesmas I Denpasar Selatan pada Januari 2022 – Maret 2023 dengan teknik total sampling.Hasil: Sebanyak 53 pasien dilibatkan dalam penelitian ini. Sebagian besar pasien adalah laki-laki (n=34;64,2%), dan berusia <60 tahun (n=46;86,8%). Sebanyak 9 pasien memiliki riwayat diabetes mellitus tipe 2 (17,0%). Sebagian besar pasien terkonfirmasi bakteriologis (n=44;83,0%), dengan hasil pemeriksaan tes cepat molekuler (TCM) yang paling banyak dijumpai adalah MTB detected medium (n=21;47,7%), diikuti dengan MTB detected high (n=9;20,5%), dan MTB detected low (n=8;18,2%). Mayoritas pasien tergolong ke dalam tuberkulosis paru (n=50;94,3%) dan hanya 3 pasien tergolong ke dalam tuberkulosis ekstra paru (n=3;5,7%). Terkait dengan profil pengobatan, mayoritas dari pasien mendapatkan pengobatan kategori I (n=47;88,7%), dan hanya 6 pasien mendapatkan pengobatan dengan dosis harian (n=6;11,3%). Kesimpulan: Sebagian besar pasien tuberkulosis pada studi ini adalah berjenis kelamin laki-laki, berusia <60 tahun, dan terkonfirmasi secara bakteriologis. Mayoritas pasien mendapatkan pengobatan kategori I.
Efek Pemberian Mesenchymal Stem Cell Wharton's Jelly (MSC-WJ) terhadap Gambaran Histologi Pankreas Hewan Model Diabetes Melitus Tipe 1 Endrinaldi Endrinaldi; Tofrizal Tofrizal; Elmatris Elmatris; Sisca Dwi Yarni
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1704-1711.2024

Abstract

Objective: This study was conducted to determine the effect of administering Mesenchymal Stem Cell Wharton Jelly (MSC-WJ) on the histological appearance of the pancreas of rat in a type 1 diabetes mellitus model. Methods: This research is an experimental research with a Posttest-Only Control Group Design. The sample consisted of 3 groups (Normal, T1DM, T1DM + MSC-WJ). The treatment group was treated with MSC-WJ for 4 weeks. Data analysis used One Way ANOVA and Post Hoc Bonferroni tests. Results: WJ-MSC can increase the mean diameter and area of the islets of Langerhans in the T1DM rat group from 98.08 mm – 126.85 mm and from 4911.95 mm2 – 8995.35 mm2, but this difference is not yet significant (p > 0.05). Conclusion This research shows that there is improvement in pancreatic damage by administering WJ-MSC to diabetic rat due to alloxan induction.
The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Ika Kurnia Febrianti; Andani Eka Putra; Raveinal Raveinal; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1712-1723.2024

Abstract

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects  (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death
Dapur Makanan Pendamping-Air Susu Ibu (MP-ASI) di Daerah Bencana Malampah, Pasaman Barat Hendra Amalfi; Nice Rachmawati Masnadi
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1734-1743.2024

Abstract

Indonesia legislation number 24 of 2007 at 55 concerning disaster management states that children (babies and toddlers) are a vulnerable group when a disaster occurs.1 Children are a vulnerable population and have special health problems that must be considered when a disaster occurs. One of them is the very limited availability of complementary foods (MP-ASI) and this condition will worsen the nutritional status of children in disaster areas.2,3,4 The provision of food menus for toddlers in natural disaster conditions is limited because public kitchen do not prepare special menu for toddlers so that children consume food that is also consumed by adults, including instant food. The availability of MP-ASI ingredient can be achieved from public kitchens with the help and cooperation of various parties including volunteers by setting up MP-ASI kitchen so that nutritional intake for toddlers is fulfilled in disaster conditions.5 This was a activities report on establishing MP-ASI in the disaster area, Malampah, Pasaman. It has been expected to be a reference for establishing MP-ASI kitchen in disaster area, as consideration in creating operational standards for establishing MP-ASI kitchen in disaster area, and assist in managing public MP-ASI kitchen in natural disaster area.
Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat Dede Rahman Agustian; Andani Eka Putra; Dessy Arisanty
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1724-1733.2024

Abstract

Objective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: RNA samples were taken from 98 confirmed COVID-19 cases across various area in West Sumatra. Genetic amplification and next-generation sequencing (NGS) were performed to identify the presence of the Asp614Gly mutation. The frequency of mutations was analyzed using bioinformatics software. Results: Out of the 98 samples analyzed, approximately 97% exhibited the Asp614Gly mutation. The geographic distribution of this mutation showed significant variation among the districts of West Sumatra, with the highest prevalence in urban areas. Conclusion: These findings indicate that the Asp614Gly mutation is highly prevalent in West Sumatra. Associated with increased virus transmissibility, this mutation dominates the circulating virus strains in the region, highlighting the need for ongoing genetic surveillance to guide public health interventions and vaccination strategies.

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