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Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 792 Documents
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ANALISA FAKTOR RISIKO YANG MEMPENGARUHI INFEKSI SCABIES DI PONDOK PESANTREN DARUNNA’IM YAPIA PARUNG BOGOR Isniani Ramadhani
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1744-1756.2024

Abstract

Prevalensi scabies di Indonesia masih tinggi di pesantren. Study ini bertujuan untuk mengetahui faktor yang mempengaruhi kejadian infeksi scabies, pengaruh hubungannya dan  faktor yang mana yang paling berpengaruh  terhadap kejadian infeksi scabies di pesantren. Dilakukan di Pesantren Darunna’im Yapia, Desa Warujaya, Parung, Bogor pada tahun 2023. Menggunakan desain cross-sectional dengan pendekatan observasional kuantitatif. Responden adalah  siswa-siswi berusia 12 – 18 tahun dengan jumlah 74. Analisis data menggunakan uji bivariat Chi-Square dan Regresi Logistik Binner. Hasil uji Bivariat Chi-Square menunjukkan adanya hubungan antara jenis kelamin (p = 0,004 OR = 4,4299), tingkat usia (p= 0,000 OR = 19,556), tingkat pendidikan (p =  0,007 OR = 4,000) dan personal hygiene ( p =  0,003 OR = 7,931) dengan kejadian infeksi scabies. Analisis Regresi Logistik Binner menunjukkan variabel tingkat usia merupakan variabel yang paling dominan mempengaruhi kejadian infeksi scabies (Sig. 0,036 ExpB 11,744). Simpulan penelitian adalah faktor risiko yang mempengaruhi kejadian scabies di Pensantren Darunna’im Yapia adalah jenis kelamin, tingkat usia, tingkat pendidikan dan personal hygiene. Keempat faktor tersebut secara bersama-sama berpengaruh secara signifikansi sebesar 41,4% terhadap kejadian infeksi scabies dan faktor tingkat usia merupakan variabel yang paling dominan mempengaruhi kejadian infeksi scabies (Sig. 0,036 ExpB 11,744).
Glycemic control and serum albumin in type 2 diabetes patients: What does observational study say? Nelvia Okta Yosa
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1790-1800.2024

Abstract

Glycemic control is important to prevent organ damage in Type 2 Diabetes Melitus (T2DM) Patients, especially liver and kidney. One of parameter used to see the decreasing function of both organs is serum albumin. Aim : The aim of this study was to identify the association between glycemic control and serum albumin level on T2DM patoents. Method :  This is an observational analytical study using cross sectional design. This study was conducted at RSUP Dr. M. Djamil Padang using T2DM patients medical records on 2019-2021. The level of HA1c <7% was cathegorised as good glycemic control and Hb1c >7% was cathegorised as poor glycemic control. Results : The results showed that there was an association between glycemic control and serum albumin level on T2DM patients at RSUP Dr. M. Djamil Padang. Conclusion : Glycemic control was inversely associated with serum albumin levels in patients with T2DM in RSUP Dr. M. Djamil Padang
Uji Organoleptik dan Zat Gizi Formula Bareh Randang dengan Penambahan Dadih Terhadap Penurunan Hiperkolesterolemia Lastrie Asrya; Fivi Melva Diana; Zulkarnain Agus
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1912-1927.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui uji organoleptik dan kandungan zat gizi formula bareh randang dengan penambahan dadih terhadap penurunan hiperkolesterolemia. Metode: Jenis penelitian ini eksperimen dengan melakukan percobaan langsung menggunakan Rancangan Acak Lengkap (RAL) dengan empat taraf penambahan dadih yaitu 0 gr, 15 gr, 25 gr dan 35 gr per satu formula adonan yang dilakukan dengan dua kali pengulangan. Uji organoleptik dilakukan oleh 25 orang panelis. Data dianalisis dengan uji kruskal wallis dan Uji lanjut mann whitney. Uji laboratorium dilakukan uji kandungan zat gizi proksimat dan uji BAL. Hasil : Berdasarkan uji organoleptik formula terbaik didapatkan dengan penambahan dadih 25 gr. Dari hasil uji kruskal wallis menunjukkan adanya perbedaan nyata p<0,05 terhadap warna, rasa dan teksture sedangkan pada aroma tidak terdapat perbedaan nyata P>0,05. Dari pengujian kandungan BAL ditemukan bahwa pada produk bareh randang mengandung BAL 108CFU/g yang bermanfaat sebagai makanan probiotik. Kesimpulan: Dalam pembuatan produk bareh randang sebaiknya menggunakan penambahan dadih 25 gram.Kata kunci: hiperkolesterolemia; dadih; bareh randang; organoleptik; zat gizi
GAMBARAN HISTOPATOLOGI LIMPA MENCIT (Mus musculus Balb/C) YANG DIINFEKSI DENGAN Plasmodium berghei Intania Dwiputri Hendriani
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1928-1938.2024

Abstract

Objective: to determine the histopathological picture of the spleen of mice (Mus musculus Balb/C) infected with Plasmodium berghei which has been immunized with An. sundaicus salivary gland extract. Method: This type of research is a descriptive study with a quantitative approach. This research was conducted at the Histology Laboratory of the Faculty of Medicine, Andalas University, from March 2023 to September 2024. Result: research on the histopathological picture of the spleen of mice Mus musculus Balb / C infected with Plasmodium berghei showed the number of spleen cell megakaryocytes in the control group with an average of 2.63 per field of view, in the pellet extract group 2.23 per field of view and in the supernatant extract group 2.13 per field of view. Conclusion: the average megakaryocyte cells in the spleen were the highest in mice injected with the control group and the average megakaryocyte cells in the spleen were the lowest in mice injected with the supernatant extract group.
Case Report of Esophageal Food Impaction in Partially Edentulous Patient Diflayzer Diflayzer
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1965-1975.2024

Abstract

Introduction: Esophageal food impactionis a medical ailment characterised by the obstruction of the oesophagus due to food becoming stuck. Loss of teeth can lead to food impaction, which lowers the ability to chew and create a bolus. This can cause bigger food particles that interfere with swallowing. Objective: Understanding diagnosis dan management of Esophageal Food Impaction in which partially Edentulous as risk factor.  Case Report: A 60-year-old man came with complaints of having difficulty in swallowing since 3 days before admission. There was history of feeling something stuck in his throat after swallowing a chunk of meat. Oral cavity examination revealed missing 21 of teeth. There was standing secretion in pyriform sinus. The patient was managed with diagnostic and therapeutic esophagoscopy with diagnosis of impaction of "meat" food in the esophagus. A chunk of meat was removed at the level of 18 cm away from upper incisor. After removal, difficulty of swallowing was improved. Conclusion: Food bolus impaction “meat” can be successfully removed using rigid esophagoscopy without any complications. There was significant improvement in symptoms after removal of food impaction. Loss of teeth is a risk factor for food impaction in this case. 
Pengaruh Pemberian Ekstrak Daun Kelor (Moringa Oleifera) Sebagai Antioksidan Terhadap Kadar Malondialdehyde Pada Tikus Model Hiperglikemia Asti Marian Sari; Eti - Yerizel; Hudila Rifa karmia
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1957-1964.2024

Abstract

Tujuan: Mengetahui pengaruh pemberiak ekstrak Moringa Oleifera terhadap kadar malondialdehyde pada tikus wistar model hiperglikemia. Metode: Penelitian ini melibatkan 20 ekor tikus strain wistar betina yang berumur 8-12 minggu dengan bobot 200-250 gram yang memenuhi kriteria inklusi maupun ekslusi. Tikus dibagi menjadi kelompok empat, yaitu Kelompok kontrol negatif (K-), Kontrol positif (K+), Perlakuan 1 (P1) dan Perlakuan 2 (P2). Kelompok P1 hanya diberikan makan dan minum standar saja, tanpa perlakuan. Kelompok K+ diinjeksi aloksan secara Intraperotoneal dengan dosis 100 mg/kgBB sehingga tikus menjadi hiperglikemia, P1 diberi injeksi aloksan menjadi hiperglikemia dan diberikan ekstrak moringa oleifera dengan dosis 250 mg/kgBB dan P2 injeksi aloksan menjadi hiperglikemia dan diberikan ekstrak moringa oleifera dengan dosis 500 mg/ kgBB selama 21 hari, Pada hari ke-22 semua kelompok diambil darah untuk dilakukan pemeriksaan kadar malondialdehyde. Hasil: Rerata kadar malondialdehid pada K-, K+, P1 dan P2 berturut-turut, yaitu 1,81±0,06 nmol/mL, 3,81±0,24 nmol/mL, 2,55±0,30 nmol/ mL, 2,09±0,21 nmol/mL, dengan nilai p=0,01. Kesimpulan : Pemberian ekstrak moringa oleifera sebagai antioksidan berpengaruh terhadap penurunan kadar malondialdehid
Exploring the Link Between Oxidative Stress Reduction and Liver Function Improvement in Jaundiced Rats with Lactococcus lactis D4 Avit Su Suchitra
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1948-1956.2024

Abstract

Objective: To explore the correlation between the reduction of oxidative stress and liver enzyme function in rats with obstructive jaundice, using malondialdehyde (MDA) levels as a biochemical marker, and its impact on serum glutamic oxaloacetic transaminase (SGOT) levels; Method: This experimental study used a post-test only randomized control group design in three groups of Rattus norvegicus strain Wistar rats with an obstructive jaundice model. The rats underwent biliary duct ligation and received Lactococcus lactis D4 starter fermented milk for 7 days. Oxidative stress was assessed by measuring MDA levels and Liver function was assessed by measuring levels of SGOT ; Result: The correlation analysis show an r-value of 0.886 revealed that there a very strong positive correlation between MDA and SGOT levels after LLD4 administration; Conclusion: Lactococcus lactis D4 starter fermented milk can improve liver function, indicated by decreased MDA levels and SGOT  levels in experimental animals.
Analisis Ekspresi Protein c-Fos pada Cell Line Kanker Payudara Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1900-1911.2024

Abstract

Tujuan: Untuk menganalisis ekspresi protein c-Fos pada cell line kanker payudara. Metode: Penelitian ini merupakan penelitian eksperimental murni menggunakan metode imunositofluoresens untuk melihat jumlah intensitas ekspresi protein c-Fos dengan sampel penelitian adalah cell line MCF-7 mewakili kanker payudara subtipe luminal A, cell line SKBR3 mewakili kanker payudara subtipe HER2+, dan cell line HaCat mewakili sel normal. Ekspresi protein c-Fos diinduksi dengan EGF 50 ng/mL, ATP 100µM dan gabungan ATP+EGF selama 45 menit. Perhitungan intensitas protein c-Fos menggunakan aplikasi imageJ. Hasil penelitian ekspresi c-Fos dianalisis menggunakan uji oneway anova  apabila p<0.05 dianggap berbeda secara signifikan. Hasil: Ekspresi protein c-Fos pada cell line yang diberi perlakuan ATP dan EGF meningkat dibandingkan kontrol. Peningkatan intensitas protein c-Fos terdapat pada ketiga jenis cell line. Tidak terdapat perbedaan bermakna pada ketiga jenis sel berdasarkan jenis induksi (p>0,05). Kesimpulan: Pemberian ATP, EGF dan kombinasi ATP+EGF meningkatkan intensitas protein c-Fos pada cell line kanker payudara tipe MCF-7 dan SKBR3.
Facial Nerve Paresis in Ramsay Hunt Syndrome iltania mince
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1976-1986.2024

Abstract

Introduction: Ramsay Hunt syndrome (SRH) is known as otic herpes zoster or geniculate ganglion herpes zoster, which is a late complication of Varicella-Zoster Virus (VZV) infection, which causes inflammation of the geniculate ganglion of cranial nerve VII. The SRH triad is ipsilateral facial paralysis, otalgia, and vesicular rash. Case Report:28 year old man with complaints of slanted face since 5 days ago. Right ear pain occurred 2 weeks ago, 1 day later a fluid-filled nodule appeared on the right earlobe and right cheek. On physical examination, yellowish crusts were found on the right side of the face, the auris dextra showed erythema and crusting in the turbinate and antihelix regions. In the Schirmer test the ratio of right and left tears is > 50%, the acoustic reflex is right (-) left (+). The patient was diagnosed with House-Brackmann grade III peripheral facial nerve paresis, good motor function 70% at the level of the geniculate ganglion et causaRamsay Hunt syndrome. Patients are given antiviral therapy, high doses of corticosteroids tapering offand physiotherapy. Conclusion: Management of patients with Ramsay Hunt syndrome by administering antivirals, high doses of corticosteroids, physiotherapy and rehabilitation.Keywords: ramsay hunt syndrome, varicella zoster virus, herpes zoster oticus
Kebutuhan Spiritual Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisa di RSUD dr. Zainoel Abidin Banda Aceh Safira Zahara; Irfanita Nurhidayah; Fikriyanti Fikriyanti
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1939-1947.2024

Abstract

Tujuan: Mengetahui kebutuhan spiritual pasien gagal ginjal kronik yang menjalani hemodialisa di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh. Metode: Penelitian ini bersifat deskriptif eksploratif, cara pengumpulan data dilakukan dengan membagikan kuesioner Spiritual Needs Questionnaire (SpNQ) yang terdiri dari 19 pertanyaan yang diberikan kepada  pasien. Populasi dalam penelitian ini adalah pasien gagal ginjal kronik yang menjalani hemodialisa di Instalasi Dialisis Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh dengan teknik pengambilan sampel consecutive sampling pada 165 pasien. Hasil: Didapatkan bahwa pasien membutuhkan kebutuhan spiritual dari yang tertinggi meliputi kebutuhan beragama (95,2%), kebutuhan memberi (92,7%), kebutuhan kedamaian (92,1%), dan kebutuhan makna keberadaan (87,9%). Kesimpulan: Penelitian ini menujukkan bahwa pasien gagal ginjal kronik yang menjalani hemodialisa sangat membutuhkan kebutuhan spiritual. Diharapkan penelitian ini mampu membantu tenaga kesehatan dalam memenuhi kebutuhan spiritual pasien. 

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