ISM (Intisari Sains Medis) : Jurnal Kedokteran
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Articles
1,063 Documents
<![CDATA[Assessment of quality of life among chronic kidney disease patients undergoing hemodialysis in Sanglah General Hospital, Denpasar from April-May 2017 using EQ-5D-5L questionnaire ]]>
<![CDATA[Ni Putu Rani Apsari Dewi]]>;
<![CDATA[Yenny Kandarini]]>;
<![CDATA[I Gde Ketut Sajinadiyasa]]>;
<![CDATA[Triharnoto Triharnoto]]>
<![CDATA[ Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/ism.v11i1.172
<![CDATA[Introduction: Hemodialysis or renal function replacement therapy is routine medical care for chronic kidney disease (CKD) patients. Many problems arise among patients with chronic kidney disease (CKD) undergoing hemodialysis, including physical, psychological, social and family relationships. Those will affect patient’s quality of life (QOL).Method: A cross-sectional study performed from April-May 2017 in Sanglah General Hospital Denpasar using EuroQol 5 (EQ-5D-5L) Questionnaire to assess the Health-Related Quality of Life (HRQOL). All of CKD patients undergoing hemodialysis in Sanglah General Hospital Denpasar that matched the inclusion and exclusion criteria were recruited to this study.Results: There were 46 patients participated in this study. Overall, 37 (86.05%) were male and divided into four age groups. The reported HRQOL as measured by means of EQ-5D-5L Index Value and EQ-VAS (Visual Analog Scale) Score was 0.71 ± 0.22 and 75.7 ± 0.635, respectively. The median of EQ-5D-5L Index Value and EQ-VAS Score was 0.71 [0.63-0.84] and 75 [70-80].Conclusion: This study provided associations between sociodemographic characteristics and their HRQOL. Healthcare providers should be aware of low HRQOL among patients with female gender, elderly patients and unemployed patients to improve their quality of life.]]>
<![CDATA[Pengaruh puasa berselang terhadap berat badan pada mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Udayana ]]>
<![CDATA[Putu Ayu Adi Supraba]]>;
<![CDATA[I Wayan Gede Sutadarma]]>;
<![CDATA[Ida Ayu Dewi Wiryanthini]]>
<![CDATA[ Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020) ]]>
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DOI: 10.15562/ism.v11i3.173
<![CDATA[Background: Body weight is used as a measure of body mass in kilogram (kg). The way which is effective for weight loss is a lifestyle changes like diet and exercise. Besides low calorie diet, we can do intermittent fasting to prevent overweight and obesity.Aim: This research aims to know the effect of intermittent fasting on body weight in young adult group.Methods: This research uses pretest-posttest control group design which was conducted during Ramadhan fasting in 2017 in the Department of Physiology, Faculty of Medicine, Udayana University. The subject is divided into two groups, namely fasting group and unfasting group as many as 40 people, respectively. The data include weight before and after fasting.Results: Normality test obtained both fasting groups with p=0.326 and unfasting one with p=0.317, so that both groups are homogenous. Paired-sample t test on the weight for the beginning and end of the fasting group obtained the value of p=0.000, whereas in unfasting group obtained 0.149.Conclusion: Intermittent fasting affects early weight loss and final body weight on fasting group consequently. As for the unfasting group, it was obtained no significant distinction between initial weight compare with latest weight. Latar belakang: Berat badan digunakan sebagai ukuran massa tubuh dalam kilogram (kg). Cara yang paling efektif untuk menurunkan berat badan adalah perubahan gaya hidup meliputi diet dan olahraga. Selain diet rendah kalori, cara untuk mencegah kelebihan berat badan dan obesitas adalah puasa berselang.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh puasa berselang terhadap berat badan pada kelompok dewasa muda.Metode: Penelitian ini menggunakan pretest-posttest groups control design yang dilakukan saat puasa Ramadhan 2017 di bagian Fisiologi Fakultas Kedokteran Universitas Udayana. Subjek penelitian dibagi menjadi dua kelompok yaitu kelompok puasa dan kelompok tidak puasa yang masing-masing berjumlah 40 orang. Data yang diambil meliputi berat badan sebelum dan sesudah puasa.Hasil: Hasil uji normalitas didapatkan untuk kelompok puasa dengan p=0.326 dan kelompok tidak puasa p=0.317 yang berarti kedua kelompok homogen. Pada uji t-test berpasangan untuk berat badan awal dan akhir pada kelompok puasa didapatkan nilai p=0.000, sedangkan pada kelompok tidak puasa didapatkan nilai p= 0.149.Simpulan: Puasa berselang berpengaruh terhadap penurunan berat badan awal dan berat badan akhir pada kelompok puasa. Sedangkan bagi kelompok tidak puasa, tidak didapatkan perbedaan yang bermakna antara berat badan awal dengan berat badan akhir.]]>
<![CDATA[Pemberian ekstrak etanol Cordyceps militaris dapat menurunkan kadar glukosa darah dan menghambat penurunan massa sel beta pankreas pada tikus diabetes mellitus yang diinduksi dengan Streptozotocin dan Nikotinamid ]]>
<![CDATA[Jopy Wikana]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018) ]]>
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DOI: 10.15562/ism.v9i2.174
<![CDATA[Background: The antioxidant and anti-inflammatory effects of Cordyceps militaris extracts can neutralize the increased production of Reactive Oxygen Species (ROS) due to hyperglycemia conditions, as well as neutralize NO produced through inducible Nitric Oxide Synthase (iNOS). Thus, the antioxidant effects of C. militaris extract are expected to decrease DNA damage and ER stress leading to intrinsic apoptosis of pancreatic beta cells. Another positive effect of C. militaris which is expected to suppress glucotoxicity is its hypoglycemic effect.Methods: The design of this study was Randomized Post-test Only Control Group Design. The study was conducted on mice divided into three groups: negative control group (DM + placebo), treatment 1 group and treatment 2 group.Results: Based on study on 15 rats, each 5 rats per group, it was found that the mean blood glucose level in control group was 399,20 ± 28,07 mg/dl, mean of blood glucose level of treatment 1group (extraction 50% ethanol Cordyceps militaris) was 198.60 ± 30.42 mg/dl, and, the mean blood glucose levels of the treatment 1 group (extract ethanol Cordyceps militaris 100%) was 141.00 ± 17.03 mg/dl. With One Way ANOVA test found that p-value = 0,001. Immunohistochemical examination result shows that beta cell mass is more prominent in either treatment group 1 and treatment group 2 compare to the control group.Conclusions: There were significant differences in blood glucose levels after extracted ethanol Cordyceps militaris. It is further known that ethanol extract of Cordyceps militaris can decrease blood glucose level by 50,25% at 50% concentration and 64,68% at 100% concentration. Immunohistochemical examination result shows that ethanol extract of C. militaris seem could inhibit the decrease of beta cell mass especially at 100% concentration.]]>
<![CDATA[Lower back pain on computer use on Information and Computer Technics (IT Management) students from STMIK STIKOM University Bali ]]>
<![CDATA[Krisna Priya Ponusamy]]>;
<![CDATA[Luh Made Indah Sri Handari Adiputra]]>;
<![CDATA[I Made Krisna Dinata]]>;
<![CDATA[I Made Muliarta]]>
<![CDATA[ Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020) ]]>
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DOI: 10.15562/ism.v11i3.175
<![CDATA[Background: Lower back pain is a pain syndrome that occurs in the lower back region as various causes. This disorder is most commonly found among students, especially in those who sit with the wrong body posture.Aims: The purpose of this study was to determine how does using the computer for an extended period causes lower back pain for students and to identify the prevention method of lower back pain because of using that equipment.Methods: This study used cross-sectional design using primary data through questionnaire and interview. The sample population of this research is Information and Computer Technics (IT Management) students in STMIK STIKOM University Bali. Using the entire sampling method yielded 32 samples. Results: There is a significant result of using the computer for a long time and sitting postures toward lower back pain complaints on students in STMIK STIKOM University Bali.Conclusion: Based on the results of the study is still very necessary to give attention and changes on the amount of time using a computer and sitting postures for students to support the health of students.]]>
<![CDATA[Metilasi DNA dalam Perkembangan Kanker Kolorektal ]]>
<![CDATA[Ni Nyoman Ayu Dewi]]>;
<![CDATA[Ni Made Pramita Widya Suksmarini]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018) ]]>
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DOI: 10.15562/ism.v9i2.176
<![CDATA[Kanker kolorektal adalah kanker yang terjadi pada kolon (usus besar) dan rektum. Kanker kolorektal menempati urutan kedua sebagai penyebab kanker di negara-negara berkembang dengan angka kematian yang tinggi. Selama ini perubahan genetik dipandang sebagai faktor paling penting dalam inisiasi dan progresivitas kanker. Namun beberapa tahun terakhir diketahui bahwa perubahan epigenetik juga memiliki peran yang sama pentingnya dengan perubahan genetik dalam perkembangan kanker. Perubahan epigenetik meliputi metilasi DNA, modifikasi histon, dan non-coding RNA. Diantara ketiga mekanisme ini, metilasi DNA adalah yang paling banyak dipelajari. Dalam artikel ini dibahas mengenai proses metilasi DNA pada sel normal dan sel kanker, khususnya kanker kolorektal. Pengetahuan dan pemahaman mengenai mekanisme epigenetik sangat diperlukan untuk kepentingan pencegahan maupun pengobatan kanker.]]>
<![CDATA[Cognitive impairment in cerebral toxoplasmosis with pre-HAART HIV infection: a case report ]]>
<![CDATA[Dico Gunawijaya]]>;
<![CDATA[Dian Kusumastuti]]>;
<![CDATA[Widya Putra]]>;
<![CDATA[Nurlina Ekasari]]>
<![CDATA[ Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019) ]]>
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DOI: 10.15562/ism.v10i2.177
<![CDATA[Background: Dementia can be caused by infection in the central nervous system, primarily by HIV infection. The majority of the symptoms are short-term memory impairment accompanied by concentration and motoric deceleration. Opportunistic infections of Toxoplasma gondii often accompanies and aggravates the cognitive impairment that occurs.Case: Male, 55-year-old, complained by the family to be forgetful and hard to concentrate since last two weeks and got worse over time. The daily activities of the patient were often disturbed. The awareness, cranial nerve, motor function, sensory, and autonomic were within normal limits. Laboratory tests showed reactive IgG anti-toxoplasma (4520.00 IU / mL) and CD4 128 cells/µL. A non-contrast head CT-Scan showed multiple ill-bordered hypodense lesions with broad peripheral edema in left cerebral hemispheres. Test of cognitive function with MoCA-Ina scored 13 and MMSE scored 19.Discussion: Dementia in HIV manifests as a collection of symptoms of cognitive and motor impairment that interfere with daily activities. The pathogenesis is thought to be caused by interactions with viral proteins and secondary inflammation. Chronic toxoplasmosis is associated with the incidence of dementia in HIV, which usually occurs when CD4 <200 cells/µL. The underlying pathology of inflammation responsible for neurotransmitter modulation and oxidative stress. HAART administration related to a risk reduction of dementia in HIV. High penetrating antiretroviral lowers viral load better, so it can reliably reduce inflammation while slowing the progression of cognitive impairment.Conclusion: HIV infection often leads to dementia, either with or without opportunistic infections. Currently, HAART is the only therapy, accompanied by education and follow-up of the patient's cognitive function.]]>
<![CDATA[Hubungan status gizi terhadap angka kejadian community-acquired pneumonia (CAP) pada balita di RSUP Sanglah Denpasar ]]>
<![CDATA[Putu Nandika Wintari]]>;
<![CDATA[Putu Siadi Purniti]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018) ]]>
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DOI: 10.15562/ism.v9i3.178
<![CDATA[Latar Belakang: Pneumonia hingga saat ini masih tercatat sebagai penyebab utama kematian pada anak-anak. Di rumah sakit, penyakit pneumonia termasuk dalam daftar 10 penyakit penyebab kematian pada penderita rawat inap yakni sebesar 2,92% dari seluruh kematian Pneumonia memiliki beberapa faktor resiko yang dapat memperberat penyakit tersebut antara lain adalah status gizi yang dimiliki penderita. Penelitian ini bertujuan untuk melihat hubungan antara status gizi dengan angka kejadian pneumonia.Metode: Disain penelitian adalah cross-sectional study dengan sampel 168 orang. Sebagai variabel bebas adalah status gizi sedangkan pneumonia sebagai variabel tergantung. Data yang digunakan diambil dari buku catatan pasien SMF Ilmu Kesehatan Anak RSUP Sanglah.Hasil: Dari sampel yang berjumlah 168 orang, ternyata 119 orang dengan gizi baik, dan 49 orang dengan gizi buruk. Pasien yang mengalami pneumonia adalah 84 orang dan yang bukan mengalami pneumonia adalah 84 orang. Hasil uji bivariat menunjukkan adanya hubungan yang bermakna antara status gizi dengan angka kejadian pneumonia p = 0,011 (p < 0,05), dengan nilai OR sebesar 2,425 (95% CI 0,216 - 4,839).Simpulan: Dari hasil penelitian ini dapat disimpulkan bahwa ada hubungan yang bermakna antara status gizi dan angka kejadian pneumonia pada pasien anak yang dirawat di SMF Ilmu Kesehatan Anak RSUP Sanglah.]]>
<![CDATA[Correlation between body mass index and waist circumference among diabetes mellitus patients in Denpasar, Bali ]]>
<![CDATA[Kausalya Neelamagam]]>;
<![CDATA[Desak Made Wihandani]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018) ]]>
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DOI: 10.15562/ism.v9i3.179
<![CDATA[Background: Obesity is one of the most important modifiable risk factors for type 2 diabetes. There are two types of obesity the general obesity which measured using the body mass index (BMI) and central obesity measured by using waist circumference (WC) or waist/hip ratio. This research aims to investigate the correlation between body mass index and waist circumference among diabetic patients in Indonesian population.Methods: The study was carried out using the cross-sectional plan, by analyzing the secondary data that was collected from previous research on diabetic patients that was conducted in Medical Faculty of Universitas Udayana, Bali. The research was done in 4 months from October 2015 - January 2016, and the data was categorized based on BMI, WC, gender, age, family history of diabetes and duration of diabetes mellitus.Results: On a total of 96 sample there were 5 (5.2%) were having general obesity BMI >30 kg/m2, while 61(63.5%) were having central obesity, where the WC measurement for a male was >102 cm and for a female was >88 cm. From the study, it proves that there was a strong correlation in between BMI and WC (r = 0.752, 𑃠< 0.01). It indicates the correlation was positive and significant.Conclusions: It is concluded that people who have a higher BMI tend to have a higher waist circumference value and with that, both the BMI and WC strongly correlate. As a suggestion, it is recommended to conduct the study using primary data for future research]]>
<![CDATA[Correlation between clean and healthy lifestyle behavior of mother with the incident of diarrhea in toddlers at working area of Puskesmas I Negara, Jembrana - Bali ]]>
<![CDATA[Sharrmila Rajan Inderan]]>;
<![CDATA[Wayan Weta]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018) ]]>
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DOI: 10.15562/ism.v9i3.180
<![CDATA[Background: Diarrhea defines as the increase of defecation frequency more than usual, which is more than three times per day, accompanied by the change of feces’ consistency become way waterier with or without blood and mucus. Risk factors that can cause diarrhea included the transmission of bacteria, immune deficiency from the host increases the vulnerable towards diarrhea and environment factor along behavior. The combination of unhealthy environmental factors because of tainted diarrhea bacteria and bad human behavior was the main cause of diarrhea. This research aims to know the correlation between clean and healthy lifestyle behavior of mother with the incidents of diarrhea in toddlers.Methods: This research is an analytic study with cross-sectional approach. The data of this study were collected through questionnaire. The data were analyzed by univariate and bivariate.Results: 50 samples were included in this study with 58% aged 20-30 years old. Bivariate analysis showed that clean and healthy lifestyle behavior category of mother, washing hand, and toilet usage were correlated with the incidence of diarrhea in toddlers with PR (p-value) consecutively 1,9 (p=0.028); 3.9 (p=0.004); and 6.25 (p=0.002).Conclusions: Majority of respondents have bad clean and healthy lifestyle behavior (CHLB) category, and the incidence of diarrhea in toddler tends to be more in mothers with bad clean and healthy lifestyle behavior (CHLB) category.]]>
<![CDATA[Deteksi dini skoliosis di tingkat Sekolah Dasar Katolik Santo Yoseph 2 ]]>
<![CDATA[Cok Gde Prema Kurnia Baswara]]>;
<![CDATA[I Wayan Weta]]>;
<![CDATA[Luh Seri Ani]]>
<![CDATA[ Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019) ]]>
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DOI: 10.15562/ism.v10i2.185
<![CDATA[Introduction: The number of cases of scoliosis found in the world is high reach 4.5% of the total world general population, while for Indonesia and Bali there has been no incidence rate for the scoliosis. The most common case of scoliosis found is idiopathic as much as 80% of the total cases found so far. Early detection of this scoliosis plays a role to know early on whether there are abnormalities in the spine or not and if there is can to be prevented from getting worse.Method: This study is an observational descriptive study by directly measuring the spine of elementary school students by using a scoliometer.Result: Total of 96 primary school students who met the inclusion and exclusion criteria, the most sexes were women with 51 students (53.1%), who were suspected of having scoliosis were 62 (64.4%), on adolecent suspected of scoliosis with 39 students (81,3%) and scoliosis criteria was mostly found in intermediate criteria of 55 students (88,7%)Conclusion: The prevalence of scoliosis in primary school students is 88%, most scoliosis criteria are found at the intermediate level, and female sex is more likely to have scoliosis than men]]>
