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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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Steven-Johnson Syndrome associated with anti-tuberculosis drugs: a case reports I Gusti Ayu Risma Pramita; Tjokorda Dalem Pemayun
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Introduction: Steven-Johnson syndrome (SJS) is an acute reaction to the skin and mucous membranes that is characterised by damage and flaking of the skin, accompanied by pain and can cause death. Treatment with anti-TB drugs sometimes results in side effects including SJS Â as one of the skin rash reaction and liver dysfunction. Steven-Johnson syndrome incidence and mortality due to anti-TB is quite rate and here we present a case with SJS and some other drugs side effect symptoms who passed away on the ninth day of treatment.Â Case description: A 53-year-old woman admitted to our emergency department with dyspnea, fatigue, erosion on oral mucosa, and erythema appears in the whole body accompanied by itch since two weeks ago, she also has yellowish sclera. She is in ongoing therapy of anti-tuberculosis drugs. History of hepatitis B, on admission there was marked elevation of leukocyte and liver function test (AST and ALT). Systemic corticosteroid was given as characterised therapy with topical steroid and antibiotics regimen for maculopapular rash.Conclusion: SJS is an emergency requiring high attention and intensive care evaluation with administration of intravenous systemic steroids as primary immunosuppressive therapy.

The association between Body Surface Area (BSA) and vitamin D level among obese adolescent patients in Denpasar, Bali, Indonesia Luh Gede Yuliadewi NS; I Gusti Lanang Sidiartha
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background:Â Prevalence of obesity in adolescent in Indonesia is still high. An obese adolescent is likely to stay obese into adulthood and tends to develop into cardiovascular and metabolic diseases. Obese subjects have larger body surface area and should be able to produce more vitamin D from cutaneous synthesis. This study aims to determine the prevalence of obesity in adolescent in Denpasar, determine vitamin D status among obese adolescents and obtained an association between body surface area and vitamin D levels.Methods:Â A descriptive observational study using a cross-sectional approach has been conducted among 51 obese adolescents in Denpasar during May to December 2018. Several variables assessed in this study were age, sex, weight, height, Body Mass Index (BMI), Body Surface Area (BSA), and vitamin D levels. Factors associated with vitamin D levels in obese adolescence were analyzed with appropriate statistical analysis. Data were analyzed using SPSS version 17 for Windows.Â Results:Â From 51 subjects, 32 (62.74%) male and 19 (37.26%) female subjects were enrolled in this study. The mean weight and height of respondents were 89.4Â±9.8 kg and 158.6Â±7.3 cm. In addition, the average Body Mass Index (BMI) and Body Surface Area (BSA) were 33.6Â±3.4 kg/m2 and 2.1Â±0.2 m2. The mean Vitamin D levels was 18.9Â±4.9 ng/mL with 40 subjects (78,4%) were known in a vitamin D deficiency state. There was a significant weak positive association between BSA and vitamin D levels (r=0.32; p=0,002).Conclusion:Â Most obese adolescents were in vitamin D deficiency with a significant weak positive association between BSA and vitamin D levels.Â

Pengaruh kadar haemoglobin dan hematokrit dengan insiden kegagalan arteriovenous fistula pada pasien gagal ginjal kronik stadium V Satrio Ryandi; Ketut Putu Yasa; I Gede Raka Widiana
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Chronic Kidney Disease (CKD) is a disease that requires important attention. Chronic kidney failure is mentioned as kidney damage that occurs more or equal to 3 months in the form of abnormal structural or functional damage from the kidney with or without a decrease in GFR. Management of chronic renal failure is hemodialysis. Hemodialysis performed on patients with chronic renal failure requires appropriate vascular access.Method: This study involved 76 respondents with a cross-sectional observation design in patients with stage V chronic kidney disease in Sanglah Hospital Denpasar from January 2018 to December 2018 conducted by arteriovenous fistula, with an age range of 17 years to 65 years, who have undergone regular hemodialysis for more than 3 month and with complete medical records.Result: From this study it was found, characteristics based on age ? 55 years were 40 respondents (52.6%) and age <55 were 36 respondents (47.4%). Characteristics based on gender obtained male data as many as 43 respondents (56.6%) and women as many as 33 respondents (43.4%). Characteristics based on BMI obtained a median value of 26. Characteristics based on BMI ? 26 Kg / m2 were 39 respondents (51.3%) and BMI <26 Kg / m2 were 37 respondents (48.7%). Characteristics based on INR ? 1.2 were 10 respondents (13.2%) and INR 0.9-1.1 were 66 respondents (86.8%). Characteristics based on DM disease obtained with DM disease data as many as 17 respondents (22.4%) and without DM disease as many as 59 respondents (77.6%). Patients with hemoglobin hemoglobin levels <9.9 gr / dl with non-patent AVF 47 (73.4%) and ? 9.9 gr / dl with non-patent AVF 17 (26.6%) while hemoglobin levels <9, 9 gr / dl with patent AVF of 3 (25%) and ? 9.9 gr / dl with patent AVF of 9 (75%) [PR=1,4; IK1,07-1,91; p=0,001].Conclusion: Hemoglobin <9.9 associated with failure of AVF. Low hemoglobin is the most important risk factor for the occurrence of AVF failure in CRF patients. Hematocrit <29.18 related to AVF failure. Gagal Ginjal Kronik (GGK) merupakan penyakit yang memerlukan perhatian penting. Gagal ginjal kronik disebutkan sebagai kerusakan ginjal yang terjadi lebih atau sama dengan 3 bulan baik berupa kerusakan struktur atau fungsi yang abnormal dari ginjal dengan atau tanpa penurunan GFR yang dilakukan kepada pasien GGK memerlukan akses vaskular yang tepat.Metode: Penelitian ini melibatkan 76 responden dengan rancangan observasi crossectional pada pasien gagal ginjal kronis stadium V di RSUP Sanglah Denpasar dari mulai bulan Januari 2018 sampai Desember 2018 yang dilakukan arteriovenous fistula, dengan rentang umur 17 tahun sampai 65 tahun, yang sudah menjalani hemodialisis regular lebih dari 3 bulan dan dengan catatan medis yang lengkap. Hasil: Karakteristik berdasarkan umur ? 55 tahun sebanyak 40 responden (52,6%) dan umur < 55 sebanyak 36 responden (47,4%). Karakteristik berdasarkan jenis kelamin didapatkan data laki-laki sebanyak 43 responden (56,6%) dan perempuan sebanyak 33 responden (43,4%). Karakteristik berdasarkan BMI didapatkan nilai median 26. Karakteristik berdasarkan BMI ? 26 Kg/m2 sebanyak 39 responden (51,3%) dan BMI < 26 Kg/m2 sebanyak 37 responden (48,7%). Karakteristik berdasarkan INR ? 1,2 sebanyak 10 responden (13,2%) dan INR 0,9-1,1 sebanyak 66 responden (86,8%). Karakteristik berdasarkan penyakit DM didapatkan data dengan penyakit DM sebanyak 17 responden (22,4%) dan tanpa penyakit DM sebanyak 59 responden (77,6%). Pasien dengan kadar haemoglobin Haemoglobin < 9,9 gr/dl dengan AVF tidak paten sebanyak 47(73,4%) dan ? 9,9 gr/dl dengan AVF tidak paten sebanyak 17(26,6%) sedangkan kadar haemoglobin < 9,9 gr/dl dengan AVF paten sebanyak 3 (25%) dan ? 9,9 gr/dl dengan AVF paten sebanyak 9 (75%) [PR=1,4; IK1,07-1,91; p=0,001].Simpulan: Hemoglobin < 9,9 berhubungan dengan kegagalan AVF. Haemoglobin yang rendah menjadi faktor risiko yang paling berperan terhadap terjadinya kegagalan AVF pada pasien GGK..Hematokrit < 29,18 berhubungan dengan kegagalan AVF.

Keberhasilan Terapi Rituximab pada Seorang Pasien dengan Lupus Nephritis Berat: Laporan Kasus Ni Putu Dewi Indriyani; Pande Ketut Kurniari; Gede Kambayana
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Lupus nephritis is one of complication of systemic lupus erythematosus (SLE) which manifests to the kidneys. Lupus nephritis occur in 50-60% of cases in the first ten years of the onset of SLE. Standard therapy for lupus nephritis are immunosuppressive drugs such as corticosteroids and cytostatics. In a refracter case, biologic agent has giving new hope.Case description: We report a case of seventeen years old female with chief complaints of edema in both feet, skin rash caused by sun exposure, joint pain, mouth ulcer with positive ANA test, proteinuria and high blood sugar level. Patient was then diagnosed with SLE, lupus nephritis and other types of DM. Patient was treated with combination theraphy of cycloposphamide and Rituximab. Patient then discharged in good condition.Conclusion: we suggest that combination of cycloposphamide and Rituximab is effective in controlling SLE and reducing the dose of steroid theraphy.Keyword: biological agents, systemic lupus erythematosus, lupus nephritis Latar belakang: Lupus nephritis merupakan salah satu komplikasi penyakit Systemic Lupus Erythematosus (SLE) yang bermanifestasi ke ginjal. Komplikasi lupus nephritis terjadi pada 50-60% kasus dalam sepuluh tahun pertama onset penyakit SLE. Terapi lupus nephritis meliputi obat-obatan imunosupresif seperti kortikosteroid dan sitostatika. Pada kasus-kasus yang refrakter, terapi dengan agen biologis memberikan harapan baru. Harapan hidup jangka panjang dan renal survival pasien SLE dengan lupus nephritis secara progresif telah mengalami peningkatan sejak ditemukannya agen biologis, rujukan yang lebih dini, dan kriteria diagnostik yang lebih baik.Deskripsi kasus:Kami melaporkan kasus seorang perempuan, berusia 17 tahun, suku Timor, datang dengan keluhan utama bengkak pada kedua punggung kaki, kemerahan pada kulit bila terkena sinar matahari, nyeri sendi, ulserasi pada mulut, dengan hasil laboratorium ANA test positif, proteinuria, disertai kadar gula darah yang tinggi. Pasien didiagnosis dengan SLE, lupus nephritis, dan DM Tipe lain. Setelah diberikan terapi cycloposphamide dan Rituximab, kondisi pasien membaik. Kesimpulan: regimen terapi ini efektif untuk mengontrol penyakit SLE dan memungkinkan untuk penurunan dosis terapi steroid.

Peningkatan kadar Mean Platelet Volume-Lymphocyte Ratio (MPVLR) terhadap resiko diabetik nefropati pada pasien dengan diabetes melitus tipe II (DM-2) di RSUP Sanglah, Bali, Indonesia Budi Ratna Aryani; I Made Yoga Prabawa; Made Ratna Saraswati
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Diabetic Nephropathy (DN) is Diabetes Mellitusâ€™s microvascular complication with albuminuria and decrease glomerular filtration rate. DN pathogenesis is related with inflammatory process induced by chronic hyperglycaemia. Mean platelet volume (MPV)Â and platelet-lymphocyte ratio (PLR) are potential for reviewing systemic inflammation. The combination of MPV and PLR index into MPVLR shows significant results in prognostic patients with diabetes mellitus and acute myocardial infarction and predicted DN. This study aims to determine the MPVLR index of DN risk in type II diabetes mellitus patients at Sanglah Hospital, Denpasar.Method: Cross-sectional study of 50 DM-2 patients at Sanglah Hospital in 2016. The data is secondary data from the medical records of DM-2 patients according the inclusion and exclusion criteria with purposive sampling technique. Diabetic nephropathy is diagnose based on diagnostic criteria. Complete blood count (CBC) using the CELL-DYN Ruby System. MPVLR is an absolute comparison of the calculation of MPV and total lymphocytes. T-test and Mann-Whitney Test to assess differences mean of data. The MPVLR index for diabetic nephropathy was assessed by Receiver Operating Curve (ROC) and Area Under the Curve (AUC). p <0.05 is statistically significant.Results: 50 data were grouped into nephropathy and without nephropathy groups. Men is dominant in both groups (p>0.05). The MPVLR ratio was statistically significantly higher in the nephropathy group (5.11 Â± 2.20; P = 0.004). The MPVLR index cut point value was 3.835 with a sensitivity value of 73.7% and specificity of 71%.Conclusion: MPVLR can use as independent predictor of diabetic nephropathy in diabetic patients.Â Latar Belakang: Diabetik Nefropati (DN) merupakan komplikasi mikrovaskular Diabetes Melitus dengan albuminuria dan penurunan estimasi laju filtrasi glomerulus. Patogenesis DN berkaitan dengan proses inflamasi terinduksi hiperglikemia kronis. Indeks rerata volume trombosit (MPV) dan rasio trombosit-limfosit (PLR) potensial untuk meninjau inflamasi sistemik. Gabungan indeks MPV dan PLR menjadi MPVLR menunjukan hasil yang signifikan dalam diagnostik prognostik pada pasien diabetes melitus dan infarksi miokardial akut serta menjadi prediktor DN. Penelitian ini bertujuan untuk mengetahui indeks MPVLR terhadap risiko DN pada pasien diabetes melitus tipe II di RSUP Sanglah, Denpasar.Metode: Studi potong lintang (cross-sectional) terhadap 50 pasien DM-2 di RSUP Sanglah tahun 2016. Data penelitian adalah data sekunder dari rekam medis pasien DM-2 yang memenuhi kriteria Inklusi dan Eksklusi dengan teknik purposive sampling. Diabetik nefropati ditegakkan berdasarkan kriteria diagnosis. Pemeriksaan darah lengkap (DL) menggunakan CELL-DYN Ruby System. Rasio MPV terhadap limfosit (MPVLR) adalah perbandingan absolut dari perhitungan MPV dan limfosit total. Uji-t dan Uji Mann-Whitney untuk menilai perbedaan antara rata-rata data dua kelompok. Indeks MPVLR terhadap diabetic nefropati dinilai dengan Receiver Operating Curve (ROC) dan Area Under the Curve (AUC). Nilai p<0,05 bermakna secara statistik.Hasil: 50 data dikelompokkan menjadi kelompok dengan nefropati dan tanpa nefropati. Jenis kelami laki-laki dominan di kedua keompok tersebut (p>0,05). Rasio MPVLR secara statistik bermakna lebih tinggi pada kelompok dengan nefropati (5,11Â±2,20; P=0,004). Nilai titik potong indeks MPVLR sebesar 3,835 dengan nilai sensitifitas sebesar 73,7% dan spesifisitas 71%.Simpulan: MPVLR dapat sebagai prediktor kuat dan independen diabetik nefropati pada pasien diabetes.

Efficacy of topical steroid therapy for phimosis treatment: a systematic review Andika Rendy; Arry Rodjani; Irfan Wahyudi
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Circumcision is the gold standard in the management of phimosis cases. Nowadays, there is some basic science research that showed topical steroid might be used to decrease the morbidity of phimosis cases. This research aims to determine which management is more effective in treating phimosis by using a systematic evidence-based medicine approach.Methods: Literature searching was done to find journals that are deemed appropriate for these cases. We included 3 RCT studies in this review. Critical appraisal was conducted to determine the efficacy of topical steroid. We compared those two methods in managing cases of phimosis among children.Results: Topical steroids effectively cause the preputium skin be soft and comfortable to retract. In several cases, some patients had difficulty to get retracted. For these cases, circumcision is needed.Conclusion: Topical steroid is effective in reducing the phimosis signs and symptoms, especially in patients who are younger and less than 3 years old. Further study and meta-analysis should be conducted in Indonesia to determine the effectiveness of this therapy in Indonesia.

Depression among first-year medical students in Universitas Udayana in 2016 Shireen Anusha Gnanadoss Jebakum; Anak Ayu Sri Wahyuni
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Depression is categorized as a mood disorder which causes changes in a person’s activity as well as life perception and could even cause suicides. Medical students are more distressed than the general population.Aim: This research was conducted to determine the degree of depression among 1st year medical students of Universitas Udayana.Method: This is research is using based on descriptive cross sectional study in order to obtain data about the amount of knowledge students about depression in Udayana University from November 2015 – January 2016. 100 sample sizes are needed for this study. The Beck’s Depression Inventory (BDI) questionnaire is also used in this study.Results: Most of the students in the Medical Faculty of Udayana University have a relatively normal feeling of good and bad that happens in life. A smaller number of students have shown to have mild mood disturbances and but does not indicate the presence depression. The majority of students who suffered from depression are 17 years old based on the BDI scoring, which consisted of 4 students.Conclusion: There female students, they who were living alone, and they who were unable to sleep normally, had the higher prevalence of suffering depression.

Gambaran profil lipid dan dislipidemia pada remaja dengan obesitas di kota Denpasar, Bali, Indonesia Luh Gede Yuliadewi NS; I Made Arimbawa
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: Obesity results in an increase fat accumulation in the body, related to blood lipid levels, and causes dyslipidemia. Dyslipidemia is one of the main risk factors for cardiovascular events. This study aims to determine the overview of lipid profiles and dyslipidemia in adolescents with obesity in the city of Denpasar, Bali, Indonesia.Method: A descriptive observational analytic study with a cross-sectional design was conducted on 51 obese adolescents in Denpasar using a two-stage random sampling technique. The variables assessed included examining lipid profiles such as total cholesterol, High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), and triglycerides. Data were analyzed with SPSS version 23 for Windows.Results: The results showed that there were 25 male subjects (49.01%) and 26 female subjects (50.99%) with an average age of 15.00Â±3.41 years. The mean body weight was 89.39Â±9.81 kg, the mean height was 158.62Â±7.31 cm, and the Body Mass Index (BMI) was 33.56Â±3.36 kg/m2. The mean total cholesterol 170.57 Â± 25.92 mg/dl, HDL 47.59 Â± 10.24 mg/dl, LDL 113.61 Â± 26.64 mg/dl, and triglycerides 126.14 (75.00) mg/dl. Dyslipidemia status based on criteria for total cholesterol levels was found in 27 subjects (52.9%), followed by HDL (23.59%), LDL (52.90%), and based on triglyceride levels of 15.70% subjects. Dyslipidemia based on the overall lipid profile was found in 36 subjects (70.60%).Conclusions: Most subjects had total cholesterol levels above normal, HDL levels below normal, LDL levels above normal, and most subjects experienced dyslipidemia.Â Latar belakang: Obesitas mengakibatkan peningkatan akumulasi lemak berlebihan dalam tubuh, berkaitan dengan kadar lipid darah dan menyebabkan terjadinya dislipidemia. Dislipidemia merupakan salah satu faktor resiko utama untuk terjadinya kardiovaskular. Penelitian ini bertujuan untuk mengetahui gambaran gambaran profil lipid dan dislipidemia pada remaja dengan obesitas di kota Denpasar, Bali, Indonesia.Metode: Penelitian observasioanal deskriptif dengan desain potong lintang dilakukan terhadap 51 remaja dengan obesitas di kota Denpasar menggunakan teknik two-stages random sampling. Variabel yang dinilai meliputi pemeriksan profil lipid seperti kolesterol total, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), dan trigliserida. Data dianalisis dengan SPSS versi 23 untuk Windows.Hasil: Hasil penelitian menunjukkan bahwa terdapat 25 subyek berjenis kelamin laki-laki (49,01%) dan 26 subyek perempuan (50,99%) dengan rerata usia 15,00Â±3,41 tahun. Rerata berat badan 89,39Â±9,81 kg, rerata tinggi badan 158,62Â±7,31 cm dan Indeks Massa Tubuh (IMT) 33,56Â±3,36 kg/m2. Rerata kolesterol total 170,57Â±25,92 mg/dl, HDL 47,59Â±10,24 mg/dl, LDL 113,61Â±26,64 mg/dl, dan trigliserida 126,14 (75,00) mg/dl. Status dislipidemia berdasarkan kriteria kadar kolesterol total didapatkan pada 27 subyek (52,9%), diikuti dengan HDL (23,59%), LDL (52,9%), dan berdasarkan kadar trigliserida sebesar 15,70% subyek. Dislipidemia berdasarkan keseluruhan profil lipid didapatkan pada 36 subyek (70,6%).Simpulan: Sebagian besar subyek memiliki kadar kolesterol total diatas normal, kadar HDL di bawah normal, kadar LDL di atas normal, dan sebagian besar subyek mengalami dislipidemia.

A jejunal atresia type I in newborn: a case report Anak Agung Adi Suryaningrat; Kadek Deddy Ariyanta
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: Intestinal atresia is a common cause of neonatal intestinal obstruction. Jejunal atresia occurs more frequently than duodenal or colonic atresias, while single atresias are most commonly encountered. This case report aims to evaluate the recent management of jejunal atresia type I in newborn.Case Description: We report one case of jejunal atresia types I. A 8-days old newborn was born with signs of upper gastrointestinal obstruction. Bile-stained vomiting was reported on the third day of life. Postnatal abdominal X-ray showed the triple bubble sign. Laparotomy was performed at 9th days of life when it revealed the type of jejunal atresia type 1. The resection procedure on the atresia, such as tapering and end to end anastomosis, was performed. Laparotomy revealed the type I Jejuno-ileal atresia 20 cm from Treitz ligament then resection on the atresias, tapering, and end to end anastomosis was performed. Post-operative, the baby was admitted to NICU with total parenteral nutrition and continued antibiotics due to sepsis.Conclusion: The case was referred to the neonatal intensive care unit post-surgery with a carefully monitored fluid balance, temperature, and sign of sepsis. A definitive antibiotic was given due to sepsis, as well as total parenteral nutrition.Â

Gambaran karakteristik kanker anak di RSUP Sanglah, Bali, Indonesia periode 2008-2017 Yohannes Adinatha; Ketut Ariawati
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: Childhood cancer is estimated to increase every year. Child cancer divided into leukemia and solid tumors. In RSCM Jakarta, the most common cancers are Acute Leukemia, Brain Tumor (10-15%), Retinoblastoma (10-12%), and other malignancies. This study aims to determine the characteristics of childhood cancer at Sanglah General Hospital Denpasar in the period 2008-2017.Method: A cross-sectional retrospective descriptive study was conducted by taking patient's medical records of leukemia and solid tumors data in children admitted to Sanglah General Hospital during 2008-2017. The parameters assessed in this study were the type of cancer in children, age, sex, or residence domicile. Data were analyzed with SPSS software version 17 for Windows.Results: The results obtained 410 pediatric cancer patients during the 2008-2017 time period, which consisted of 240 cases of leukemia (58.5%) and 170 cases of solid tumors (41.5%). Most cases were 0-5 years old (61.5%), males (50.7%), and domiciled in Bali (72.4%). Acute lymphoblastic leukemia (LLA) is the most common hematologic malignancy in children, which occupies 41.0% of total cancers proportion, followed by retinoblastoma (14.0%), malignant lymphoma (9.0%), and neuroblastoma (5.0%).Conclusion: Most cancers in children occur at the age of 0-5 years, male sex, and domicile in Bali. Besides, acute lymphoblastic leukemia (LLA) is the most common hematologic malignancy in children.Â Latar Belakang: Penyakit kanker anak diperkirakan meningkat setiap tahunnya. Kanker anak secara garis besar dibagi dua, yaitu keganasan darah (leukemia) dan tumor padat. DI RSCM Jakarta, kanker tersering yaitu Leukemia Akut, Tumor Otak (10-15%), Retinoblastoma (10-12%), dan keganasan lainnya.Penelitian ini bertujuan untuk mengetahui karakteristik kanker anak di RSUP Sanglah Denpasar dalam perioder 2008-2017.Metode: Penelitian deskriptif retrospektif potong lintang dilakukan dengan pengambilan data rekam medis pasien leukemia dan tumor padat anak yang menjalani perawatan di RSUP Sanglah Denpasar periode tahun 2008-2017. Parameter yang dinilai pada penelitian ini adalah jenis kanker pada anak, usia, jenis kelamin, maupun domisili tempat tinggal. Data dianalisis dengan piranti lunak SPSS versi 17 untuk Windows. Hasil: Hasil penelitian mendapatkan 410 pasien kanker anak selama rentang waktu 2008-2017 dimana terdiri atas 240 kasus leukemia (58,5%) dan 170 kasus tumor padat (41.5%). Sebagian besar kasus berusia 0-5 tahun (61,5%), berjenis kelamin laki-laki (50,7%), dan berdomisili di Bali (72,4%). Leukemia Limfoblastik Akut (LLA) merupakan keganasan hematologi tersering pada anak dimana menempati proposi 41,0% dari total kanker, diikuti Retinoblastoma (14,0%), Limfoma maligna (9,0%), dan Neuroblastoma (5,0%).Kesimpulan: Sebagian besar kanker pada anak terjadi pada usia 0-5 tahun, berjenis kelamin laki-laki, dan domisili di Bali. Di samping itu, Leukemia Limfoblastik Akut (LLA) merupakan keganasan hematologi anak tersering pada anak.

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