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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 1,063 Documents
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The suitability of sputum and blood culture in children with pneumonia at Sanglah General Hospital, Bali, Indonesia Ayu Setyorini Mestika Mayangsari; Ida Bagus Subanada; Putu Siadi Purniti; Wayan Agustini Selumbung
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.298 KB) | DOI: 10.15562/ism.v10i3.606

Abstract

Background: Pneumonia is one of the diseases in children with high morbidity, especially in children under 5 years old. In developing countries, the most common cause of pneumonia is bacteria. There is a newer method that gives a better reflection of the aetiology, which is the sputum examination. This study aims to determine the suitability of sputum and blood culture in children with pneumonia at Sanglah General Hospital, Bali.Methods: A cross-sectional study was conducted at Respirology Subdivision in Department of Child Health Sanglah Hospital from November 2016 until February 2017. A categorical comparative matching was carried out between 2 formula groups. The sputum culture and blood culture were obtained through Microbiology Laboratory at Sanglah General Hospital. Data were analysed using SPSS version 16 for Windows.Results: There were 50 children with pneumonia enrolled in this study. The children aged less than 1 years old were predominant (62%). There were a statistically systematic difference and only a fair agreement between blood and sputum culture (ĸ=0.257; p= 0.004). In a subject with positive sputum culture, 90.9% had a better outcome than the positive blood culture even though no statistically significant (RR=0.23; 95%CI: 0.15-22.53)Conclusion: There is suitability between the culture of sputum and blood cultures in children with pneumonia. Sputum culture has a higher probability to reveal the microorganism compared to blood cultures.
The correlation of upper airway abnormalities with obstructive sleep apnea syndrome in young adult Kanti Yunika; Febby Mardalita; Sefri Noventi; Dwi Marliyawati; Muhamad Thohar Arifin
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.987 KB) | DOI: 10.15562/ism.v11i2.608

Abstract

Background: Obstructive Sleep Apnea Syndrome (OSAS) is one of sleep disorder characterised by repeated episodes of total obstruction in the upper airway system during sleep. The incidence of OSAS is estimated to be 1-10% of general population. OSAS can be affected by several risk factors. One of risk factor of OSAS is upper airway abnormalities. The study aims to find out the association between individual risk factor including septum deviation, nasal turbinate hypertrophy, tonsillar hypertrophy and mallampati score with the incidence of OSAS in young adults.Methods: Analytic observational research with case-control design was carried out on young adults aged 18-23 years in the city of Semarang during May - September 2018 grouped into OSAS and non-OSAS based on Polysomnography (PSG), then history and physical examination were performed. Statistical tests were using chi-square, Fisher's exact test, and logistic regression.Result: Total of 22 people were included in OSAS group and 22 were included in the control group. Bivariate analysis showed septum deviation (p= 0.005), tonsillar hypertrophy (p=0.015) and mallampati score (p<0.001) significantly related to the incidence of OSAS, whereas nasal turbinate hypertrophy was not associated with OSAS incident. The results of multivariate analysis found that BMI had an OR value of 133 (95% CI 12.726 – 1390.002, p<0.001) independently associated with the occurrence of OSAS in young adults.Conclusion: Septal deviation, tonsillar hypertrophy, mallampati score are the risk factors for OSAS in young adults.
Hubungan kontrol glikemik dengan petanda gangguan ginjal dini pada pasien diabetes melitus tipe 2 Hadian Widyatmojo; Indranila Kustarini Samsuria; Ria Triwardhani
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.996 KB) | DOI: 10.15562/ism.v11i2.609

Abstract

Background: Glycemic control in type 2 diabetes mellitus (DM) which can be assessed by examination of fasting blood sugar (FBG) and glycosylated hemoglobin (HbA1c) is thought to be associated with renal complications. Several markers can be used to assess the rate of damage to early kidney function, such as serum creatinine, urine creatinine albumin ratio (uACR), and serum cystatin C. The relationship of glycemic control with early kidney disorder markers in type 2 DM patients still shows controversial results.. The aim of the study to investigate the relationship between glycemic control (FBG and HbA1c) with early kidney disorder markers (serum creatinine, uACR, and cystatin C) in patients with type 2 diabetes mellitus.Methods: Analytic observational study with cross sectional approach conducted in April - June 2019 involved 34 type 2 DM patients in Karang Ayu Health Center who met the inclusion and exclusion criteria. Examination of GDP levels using the hexokinase method, HbA1c levels using the HPLC method, serum creatinine using the Jaffe method, uACR is calculated based on the ratio between urine albumin and creatinine, and cystatin C levels using the ELISA method. Statistical tests using Spearman's non-parametric correlation with p <0.05 were considered significant.Results: The mean ± SD FBG and HbA1c levels were 130.41 ± 39.37 mg/ \dL and 8.21 ± 1.65%. Median (minimum-maximum) serum creatinine levels, uACR and serum cystatin C were 0.63 (0.35-2.79) mg/dL, 16.55 (4.1-29.8) mg/g and 0.72 (0.46 - 1.22) mg/L. The correlation of FBG levels with serum creatinine, uACR, and serum cystatin C were (r = 0.016; p = 0.927), (r = 0.293; p = 0.092), and (r = 0.334; p = 0.053). The relationship of HbA1c with serum creatinine, uACR, and cystatin C was (r = 0.120; p = 0.495), (r = 0.326; p = 0.059); and (r = 0.505; p = 0.002).Conclusions: There is no relationship between FBG with serum creatinine, uACR, and cystatin C. The HbA1c value is positively related to cystatin C but not related to serum creatinine and uACR in patients with type 2 diabetes mellitus. Latar belakang: Kontrol glikemik pada diabetes melitus tipe 2 (DM) yang dapat dinilai dengan pemeriksaan gula darah puasa (GDP) dan hemoglobin terglikosilasi (HbA1c) diduga berhubungan dengan komplikasi nefropati. Beberapa petanda dapat digunakan untuk menilai menilai kerusakan fungsi ginjal dini, misalnya kreatinin serum, rasio albumin kreatinin urin (uACR), dan cystatin C serum. Hubungan kontrol glikemik dengan petanda gangguan ginjal dini pada pasien DM tipe 2 masih menunjukkan hasil yang kontroversial. Mengetahui hubungan antara kontrol glikemik (GDP dan HbA1c) dengan petanda gangguan ginjal dini (Kreatinin serum, uACR, dan cystatin C) pada pasien diabetes melitus tipe 2.Metode: Penelitian observasional analitik dengan pendekatan belah lintang dilakukan pada bulan April - Juni 2019 melibatkan 34 pasien DM tipe 2 di Puskesmas Karang Ayu yang memenuhi kriteria inklusi dan ekslusi. Pemeriksaan kadar GDP menggunakan metode heksokinase, kadar HbA1c menggunakan metode HPLC, kreatinin serum menggunakan metode Jaffe, uACR dihitung berdasarkan rasio antara albumin dan kreatinin urin, dan kadar Cystatin C menggunakan metode ELISA. Uji statistik menggunakan korelasi non parametrik Spearman dengan p < 0,05 dianggap signifikan. Hasil: Rerata±SD kadar GDP dan HbA1c adalah 130,41±39,37 mg/dL dan 8,21±1,65%. Median (minimum-maksimum) kadar kreatinin serum, uACR dan cystatin C serum berturut-turut adalah 0,63(0,35-2,79) mg/dL, 16,55(4,1-29,8) mg/g, dan 0,72(0,46 – 1,22) mg/L. Korelasi kadar GDP dengan kreatinin serum, uACR, dan cystatin C serum adalah (r=0,016; p=0,927), (r=0,293; p=0,092), dan (r=0,334; p=0,053). Hubungan HbA1c dengan kreatinin serum, uACR, dan cystatin C adalah (r=0,120; p=0,495), (r=0,326; p= 0,059); dan (r = 0,505; p = 0,002).Simpulan: Tidak terdapat hubungan antara GDP dengan kreatinin serum, uACR, dan cystatin C. Nilai HbA1c berhubungan positif sedang dengan cystatin C namun tidak berhubungan dengan kreatinin serum dan uACR pada pasien diabetes melitus tipe 2.
Pola sidik jari (Dermatoglifi) sebagai metode skrining diagnostik Sindrom Down pada anak I Made Adi Narendranatha Komara; I Putu Oka Kresna Jayadi; I Gusti Ayu Gayatri Sidemen; Putu Triyasa; I Ketut Tangking Widiarsa; Sagung Putri Permana Lestari Murdhana Putere
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.264 KB) | DOI: 10.15562/ism.v11i2.610

Abstract

Background: Fluorescence in Situ Hybridization (FISH) or complete chromosomal examination (karyotyping) is an examination of the gold standard in the diagnosis of Down syndrome, but it is quite expensive, so not all people in the society can use it. The purpose of this study was to determine the differences between the mean frequency of dermatoglyphics occurrence patterns and to determine the level of sensitivity and specificity of dermatoglyphics diagnostic tests on people with Down Syndrome.Methods: The method used in this study was observational analytic with a cross sectional study on 28 children who have Down syndrome derived from SLB C Negeri Tuna Grahita and 28 normal children of primary school 14 Dauh Puri. Data analysis using Independent T-test, a diagnostic test with sensitivity and specificity parameters was conducted by Receiver Operating Characteristic (ROC) curve. Data were analyzed using SPSS version 17 for Windows.Results: The results showed that on average, the highest percentage fingerprint patterns in people with Down syndrome are ulnar loops with a mean 6.39, whereas in normal children is a whorl with a mean 2.25. The diagnostic test, ulnar loop pattern, has the highest degree of accuracy with a cut-off=4 followed by sensitivity value 1 (0.87 to 1) and a specificity 1 (0.87 to 1).Conclusion: There are differences in the frequency of occurrence of fingerprint patterns in children with Down syndrome and normal children, as well as the patterns of the ulnar loop has the highest accuracy rate of sensitivity and specificity of the diagnostic test. Latar Belakang: Fluorescence in Situ Hybridization (FISH) atau pemeriksaan kromosom lengkap (kariotyping) merupakan pemeriksaan baku emas dalam penegakan diagnosis sindrom Down, namun tergolong mahal sehingga tidak semua lapisan masyarakat mampu menggunakannya. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata frekuensi kemunculan pola dermatoglifi serta untuk mengetahui tingkat sensitivitas dan spesifisitas uji diagnostik dermatoglifi terhadap penderita sindrom Down.Metode: Metode yang digunakan pada penelitian ini adalah observasi analitik dengan studi potong lintang terhadap 28 anak yang mengalami sindrom Down didapat dari SLB C Negeri Tuna Grahita dan 28 anak normal dari SD Negeri 14 Dauh Puri. Analisis data menggunakan uji analisis T tidak berpasangan dan uji diagnostik dengan parameter sensitivitas dan spesifisitas menggunakan Reciever Operating Characteristic (ROC). Data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Hasil penelitian menunjukkan bahwa rata-rata persentase tertinggi pola sidik jari pada penderita sindrom Down adalah loop ulnar dengan nilai mean 6,39, sedangkan pada anak normal adalah whorl dengan nilai mean 2,25. Dalam uji diagnostik, pola loop ulnar memiliki tingkat akurasi tertinggi dengan cut off=4 diikuti nilai sensitivitas 1 (0,87-1) dan spesifisitas 1 (0,87-1).Kesimpulan: Terdapat perbedaan frekuensi kemunculan pola sidik jari pada anak dengan sindrom Down dan anak normal, serta pola loop ulnar memiliki tingkat akurasi sensitivitas dan spesifisitas tertinggi dalam uji diagnostik.
Hubungan antara osteopontin dengan rasio Ca : Mg dan nilai Ca X P: Studi pada penderita penyakit ginjal tahap akhir Muh Agus Barliyan; Indranila Kustarini Samsuria; Muji Rahayu
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (961.132 KB) | DOI: 10.15562/ism.v11i3.611

Abstract

Background: End-stage renal disease (ESRD) can impair mineral metabolisms in the human body, such as calcium (Ca), magnesium (Mg), and phosphate (P). Osteopontin is released by the kidneys and inhibits vascular calcification. Examination of the Ca:Mg ratio and Ca x P product in ESRD to see vascular calcification complications and is considered better than a single examination.Objective: To analyze the correlation of osteopontin levels with the ratio of Ca: Mg and product Ca x P in ESRD patients.Methods: Analytic observational study with cross sectional approach was conducted in February-June 2019 involving 30 ESRD patients while hemodialysis at Permata Medika Hospital in Semarang with consecutive sampling. They were screened according to the inclusion and exclusion criteria. Calcium, magnesium and phosphate levels were measured using K lite cornley with the Ion-Selective Electrode (ISE) method. The Ca:Mg ratio and Ca x P product were calculated manually. Osteopontin levels were measured using the ELISA method. Correlation using Spearman test with p<0.05 was considered significant. Results: The median Ca:Mg ratio was 4.63 (3.27 - 5.58) and the Ca x P product was 58.26 mg2/dl2 (19.53 - 111.24). Correlation of osteopontin with Ca:Mg ratio and Ca x P product are respectively with r=0.370 (p=0.044) and with r=0.406 (p=0.026).Conclusion: Osteopontin is correlated to the level of Ca:Mg ratio and Ca x P product in ESRD patients.  Latar belakang: Penyakit ginjal tahap akhir (PGTA) dapat mempengaruhi metabolisme mineral, seperti kalsium (Ca), magnesium (Mg), dan fosfat (P). Osteopontin yang dikeluarkan oleh ginjal berfungsi menghambat kalsifikasi vaskuler. Pemeriksaan rasio Ca:Mg dan nilai Ca x P pada PGTA untuk melihat komplikasi kearah kalsifikasi pembuluh darah dan dianggap lebih baik daripada pemeriksaan tunggal.Tujuan: Menganalisis korelasi kadar osteopontin dengan rasio Ca:Mg dan nilai Ca x P pada pasien PGTA.Metode: Penelitian observasional analitik dengan pendekatan potong lintang dilakukan pada bulan Februari-Juni 2019 melibatkan 30 pasien PGTA saat melakukan hemodialisis di RS Permata Medika Semarang yang memenuhi kriteria inklusi dan ekslusi dengan teknik consecutive sampling. Kadar kalsium, magnesium dan fosfat diukur menggunakan alat K lite cornley dengan metode Ion Selective Electrode (ISE) dan rasio Ca:Mg dan Ca x P dihitung manual. Pemeriksaan kadar osteopontin menggunakan metode ELISA. Analisis statistika menggunakan uji Spearman dengan p<0,05 dianggap bermakna.Hasil: Hasil median rasio Ca:Mg adalah 4,63 (3,27 – 5,58) dan nilai Ca x P adalah  58,26 mg2/dl2 (19,53 – 111,24). Korelasi osteopontin dengan rasio Ca:Mg dan nilai Ca x P berturut-turut adalah r= 0,370 (p=0,044) dan r=0,406 (p=0,026).Simpulan: Kadar osteopontin berkorelasi dengan rasio Ca:Mg dan nilai Ca x P pada pasien PGTA.
Testicular tunica vaginalis grafting for the treatment of Peyronie’s disease: a case report Rahmat Husein; Antono Pratanu
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1057.066 KB) | DOI: 10.15562/ism.v11i1.612

Abstract

Introduction: Peyronie’s disease (PD) is a progressive fibrotic tissue disorder of the penile tunica albuginea. PD can cause the formation of fibrous plaques, penile deformity, pain during erection, penile curvature, and erectile dysfunction (ED). Surgical treatment is the gold standard in PD because it is a fast and reliable therapy. There are many surgical options for PD such as plication procedures, incision and grafting procedures, and implantation of penile prosthesis. There are three types of graft material have been reported: autologous graft, xenograft and synthetic graft. Considering the higher rate of infections, inflammatory reactions and allergies, synthetic grafts are rarely used. Autologous graft is currently widely used because of the incidence of inflammatory reactions and low allergic reactions. Tunica vaginalis grafts are rarely used widely. Testicular tunica vaginalis was first reported as an autologous graft in 1980.Case Report: A 53-year-old man comes to the urology clinic at Sidowaras Hospital complaining of pain during erection and erection cannot be straight. This complaint has been felt since a few months ago but the patient ignored it. An assessment of ED with International Index of Erectile Function (IIEF)-5 score obtained a score of 12 (mild-moderate dysfunction). Physical examination found a curvature of the penis around 700 and in palpation there was a hard lump on the dorsal penis. After the diagnosis was made, testicular tunica vaginalis grafting procedure was performed on this patient. At a 6-month re-evaluation after surgery, patient-reported reduced penile pain on erection with improved erectile function score (IIEF)-5 score 21 (mild dysfunction).Conclusion: Testicular tunica vaginalis grafting was chosen because it is feasible and safe for patient with PD. Testicular tunica vaginalis Grafting used due to their easy incorporation into host tissue and few incidences of local inflammatory reaction.
Hubungan proteinuria dan batu saluran kemih: studi analitik Zulfikar Ali; Eko Arianto
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.298 KB) | DOI: 10.15562/ism.v%vi%i.613

Abstract

Latar Belakang: Batu saluran kemih (BSK) masih merupakan salah satu masalah tersering yang dihadapi urolog. Proteinuria dapat ditemukan pada kondisi gagal ginjal kronis (GGK), infeksi saluran kemih (ISK), keganasan, ataupun BSK. Protein urin diketahui berperan dalam proses supersaturasi dan agregasi BSK. Studi terkini menemukan hubungan protein marker urin dengan BSK pada level molekular setelah proses elektroforesis. Penelitian ini bertujuan untuk mengetahui hubungan proteinuria pada urinalisa dengan BSK.Metode: Penelitian ini adalah penelitian studi potong lintang dengan subjek pasien poli urologi di RSUD Kardinah, Tegal. Total sampel 200 pasien yang dikelompokkan menjadi 100 pasien BSK dan 100 pasien kontrol. Seluruh pasien dilakukan pemeriksaan ultrasound (USG) sebagai pemeriksaan diagnosis awal, kemudian dilakukan pemeriksaan urinalisa. Proteinuria dianggap positif untuk nilai protein urin +1 sampai +4 dan negatif pada nilai protein urin trace dan negatif. Variabel lain yang dianalisa adalah ISK, ph urin, usia, dan jenis kelamin.Hasil: Pasien laki-laki memiliki kecenderungan BSK yang lebih tinggi dibandingkan perempuan dengan rasio 1,8:1. Rentang usia kelompok BSK 23-78 tahun dan pada kelompok kontrol 17-85 tahun. Tidak didapatkan hubungan yang bermakna antara proteinuria dengan BSK (p = 0,203). Terdapat hubungan antara ISK dengan BSK (p = 0,002) dan ph urin dengan BSK (p = 0,024). Terdapat hubungan antara ISK dengan proteinuria pada uji univariat dan multivariat (p = 0,000).Kesimpulan: Tidak didapatkan hubungan antara proteinuria dengan BSK. Terdapat hubungan antara proteinuria dengan ISK. Proteinuria muncul karena proses inflamasi pada kasus infeksi akibat batu. Penelitian lanjutan diperlukan untuk menentukan jenis protein urin yang menjadi inhibitor pada pasien non stone former dan jenis protein urin yang ditemukan pada stone former.
Chronic pulmonary aspergillosis – chronic cavitary pulmonary aspergillosis: a case report Francis Celeste; Ency Eveline
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1680.286 KB) | DOI: 10.15562/ism.v11i2.614

Abstract

Background: Chronic pulmonary aspergillosis (CPA) includes several disease manifestations. Almost all cases of CPA are caused by A. fumigatus. There are several underlying diseases that predispose patients to CPA. Treatment is often individualised depending on underlying disease process and the patient’s pulmonary status.Case presentation: A 57-year-old male with a history of renal transplant in the year 2006, routine on immunosuppressants, pulmonary tuberculosis relapse on anti-tuberculosis medications, aspergillosis on long term voriconazole, and DM type 2 presented with dyspnea, massive hemoptysis and productive cough 3 months before admission. Patient was diagnosed with aspergillosis in October 2012 through bronchoscopy. Microbiology result showed Aspergillus flavus. Enhanced thoracal CT result showed a cavitating nodule with soft tissue lesion in upper right lung, with fibrotic changes in the right lung and mild tubular bronchiectasis, with bilateral pleural thickening. Patient was then planned for lung resection due to the persistent pulmonary cavity. However, his clinical condition worsened and the patient passed away a few days before surgery.Conclusion: Diagnosing chronic pulmonary aspergillosis can often be challenging. The diagnosis of CPA can be inferred from a single chest radiograph. Despite this, detailed and sequentially acquired radiographic data may be required to observe both the typical radiographic features and the very slow progression of this disease. Treatment is often individualised. Azoles are the antifungal drug of choice when required.
Perbedaan atherogenic index of plasma, ox-LDL dan troponin I pada pasien penyakit jantung koroner stabil dan sindrom koroner akut Eti Dwi Purwati; Purwanto Adhipireno; Muji Rahayu
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.746 KB) | DOI: 10.15562/ism.v11i3.615

Abstract

Background: Coronary heart disease (CHD) is caused by atherosclerosis in the coronary arteries. Lipid lipoprotein abnormalities as the pathogenesis basic of atherosclerosis can be assessed using atherogenic index of plasma (AIP) and oxidized low density lipoprotein level (ox-LDL). Troponin I has a role in heart muscle damage due to ischemia in CHD. This study aimed to determine the differences of AIP, ox-LDL and troponin I levels in patients with stabel CHD and acute coronary syndrome (ACS).Methods: This is an observational analytic study with cross-sectional including 34 stable CHD patients and 34 ACS patients from January to March 2019 at Kariadi hospital Semarang. Measurement of triglycerides (TG) and HDL using automatic chemistry, AIP is calculated from log TG/HDL, ox-LDL levels using the ELISA method, troponin I using the ELFA method. AIP statistical analysis used independent t-test while ox-LDL and troponin I levels statistical analysis was using Mann whitney U test. Significant difference was determiner when p < 0.05.Results: Mean ± SD of AIP in stable CHD was 0.52 ±  0.25 and ACS was 0.55 ± 0.23 with  p = 0.622. Median (min-max) of ox-LDL in stable CHD was 324.74 pg/ml (67.44 – 891.98) and ACS was 717.18 pg/ml (87.35 – 1959.4) with p £ 0.001 and median (min – max) troponin I in stable CHD was 0.026 ug/L (0.018 – 0.035) and ACS was 1.5 ug/L (0.003 – 40) with p £ 0.001.Conclusion: There were significant differences in ox-LDL and troponin I levels between stable CHD and ACS. There was no significant differences ofAIP show in stable CHD patients and ACS. Pendahuluan: Penyakit jantung koroner (PJK) disebabkan aterosklerosis pada arteri koroner. Kelainan lipid lipoprotein yang menjadi dasar patogenesis aterosklerosis dapat dinilai dengan atherogenic index of plasma (AIP), oxidized low density lipoprotein (ox-LDL). Troponin I berperan pada kerusakan otot jantung akibat iskemia pada PJK. Tujuan dari penelitian ini adalah untuk membuktikan perbedaan nilai AIP, kadar ox-LDL dan troponin I pada pasien PJK stabil dan sindrom koroner akut (SKA).Metode: Penelitian observasional analitik dengan pendekatan potong lintang dilakukan pada 34 pasien PJK stabil dan 34 pasien SKA di RSUP Dr. Kariadi Semarang. Penetapan trigliserida (TG) dan HDL menggunakan kimia otomatik, AIP dihitung dari log TG/HDL, kadar ox-LDL menggunakan metode ELISA, troponin I mengunakan metode ELFA. Analisis statistik AIP menggunakan independent t-test sedangkan kadar ox-LDL dan troponin I menggunakan Mann whitney U test. Perbedaan bermakna apabila p < 0.05.Hasil: Rerata ± SD nilai AIP PJK stabil adalah 0.52 ± 0.25 dan SKA 0.55 ± 0.23 dengan p = 0.622. Median (min – maks) ox-LDL PJK stabil 324.74 (67.44 – 891.98) pg/ml dan SKA 717.18 (87.35 – 1959.4) pg/ml dengan nilai p £ 0.001, dan median (min – maks) troponin I PJK stabil 0.026 (0.018 – 0.035) ug/L dan SKA 1.5 (0.003 – 40) ug/L dengan nilai p £ 0.001.Simpulan: Terdapat perbedaan bermakna kadar ox-LDL dan troponin I dan perbedaan tidak bermakna nilai AIP pada pasien PJK stabil dan SKA.
Prevalensi gambaran faktor risiko penyakit jantung koroner pada pasien diabetes melitus tipe-2 di RSUP Sanglah Denpasar periode 2015 Ni Putu Widya Nandasari; Desak Gde Diah Dharma Santhi; I Wayan Putu Sutirta Yasa
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.181 KB) | DOI: 10.15562/ism.v11i2.616

Abstract

Introduction: The main causes of mortality and morbidity in patients with Type-2 Diabetes Melitus (T2DM) is coronary heart disease. This study aims to describe various risk factors for coronary heart disease, modified and unmodified included among patients with T2DM in Sanglah General Hospital, within 2015.Method: The research uses descriptive cross-sectional design with total sampling technique has been used as sampling method. Data was taken from patients’s medical record within the period of January to December 2015. It was processed using SPSS 21 and presented in a frequency distribution table and crosstabulation based on risk factors. Around 48 samples which met the criteria were included in this study.Result: It was obtained that the prevalence of the unmodified risk factors of CHD in T2DM were male gender (87.5%) and aged ≥45 years old (95.8%). The modified factors are fasting blood glucose ≥126 mg/dL (83.3%), body mass index ≥25 kg/m2 (64.6%), random blood glucose ≥200 mg/dL (58.3%), HDL ≤45 mg/dL (41.7%), triglycerides ≥150 mg/dL (22.9%), blood pressure ≥140/90 mmHg (22.9%), total cholesterol ≥200 mg/dL (22.9%), and LDL ≥160 mm/dL (8.3%).Conclusion: It can be concluded that men with age ≥45 years, fasting blood glucose, body mass index, and uncontrolled random blood glucose are risk factor for CHD in T2DM in Sanglah Hospital. Therefore, monitoring of blood sugar levels and body mass index in patients with T2DM are necessary to prevent CHD. Latar Belakang: Penyebab mortalitas dan morbiditas utama pada pasien Diabetes Melitus Tipe-2 (DMT2) adalah penyakit jantung coroner (PJK). Penelitian ini bertujuan untuk mengetahui gambaran berbagai faktor risiko penyakit jantung koroner yang tidak dapat diubah dan dapat diubah pada penderita DMT2 di Rumah Sakit Umum Pusat Sanglah periode 2015. Metode: Penelitian menggunakan desain deskriptif cross-sectional, dan pengambilan sampel dilakukan dengan teknik total sampling. Data diambil berdasarkan rekam medis pasien periode Januari – Desember 2015. Kemudian data diolah menggunakan SPSS 21, dan disajikan dalam bentuk tabel distribusi frekuensi dan crosstabulation berdasarkan faktor risiko.Hasil: Didapatkan sebanyak 48 sampel penelitian yang memenuhi kriteria dan dapat digunakan dalam studi ini, diperoleh prevalensi gambaran faktor risiko PJK pada DMT2 yang tidak dapat diubah adalah jenis kelamin laki-laki (87,5%) dan usia ≥45 tahun (95,8%). Faktor yang dapat diubah seperti gula darah puasa ≥126 mg/dL (83,3%), indeks masa tubuh ≥25 kg/m2 (64,6%), gula darah sewaktu ≥200 mg/dL (58,3%), HDL ≤45 mg/dL (41,7%), trigliserida ≥150 mg/dL (22,9%), tekanan darah ≥140/90 mmHg (22,9%), kolesterol total ≥200 mg/dL (22,9%), dan LDL ≥160 mm/dL (8,3%).Conclusion: Laki-laki dengan usia ≥45 tahun, gula darah puasa, indeks masa tubuh, dan gula darah sewaktu yang tidak terkontrol merupakan faktor risiko untuk terjadinya PJK pada DMT2 di RSUP Sanglah. Sehingga diperlukan pengawasan kadar gula darah dan indeks masa tubuh pada pasien DMT2 agar tidak terjadi PJK.

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