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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Search results for , issue "vol 9 no 2 (2026)" : 13 Documents clear
Resveratrol dalam Pengobatan Integratif: Menjembatani Pengetahuan Tradisional dan Terapi Modern Raghda Al-Sayed; Atheel Alwash; Khalid Zainulabdeen; Reem Waleed; Muna Bufaroosha; Shams Ismeal; Nany Hairunisa; Husnun Amalia; Hazim F Abbas; Emad Yousif
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.240-253

Abstract

Resveratrol is a polyphenolic stilbenoid found in plants such as grapes, berries, and peanuts, widely recognized for its antioxidant, anti-inflammatory, anticancer, antidiabetic, cardioprotective, neuroprotective, and anti-aging properties. Despite extensive preclinical evidence, its clinical translation remains limited by poor bioavailability and inconsistent trial outcomes. This review aims to synthesize current evidence on resveratrol’s mechanisms of action, therapeutic effects across disease models, synergistic drug interactions, and translational challenges, with a focus on its integration into modern integrative medicine. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science using the terms “resveratrol,” “polyphenol,” “integrative medicine,” and disease-specific keywords. The resuls was Resveratrol demonstrated anticancer effects via apoptosis induction and cell cycle arrest, cardioprotective effects through AMPK/SIRT1/eNOS activation, neuroprotection via Akt/PI3K signaling, and antidiabetic effects through improved insulin sensitivity. Synergistic interactions were identified with metformin (diabetes), statins/aspirin (cardiovascular disease), and chemotherapeutic agents (cancer). Bioavailability and formulation remain major challenges. Conclusion of this study Resveratrol holds significant therapeutic promise in integrative medicine, though robust clinical trials are needed to confirm efficacy and establish safe dosing protocols for clinical application.
Hubungan Pterigium dengan Kejadian Dry Eye pada Masyarakat di Kabupaten Tojo Una-Una, Sulawesi Anggraeni Adiwardhani; Husnun Amalia; Noviani Prasetyaningsih; Riani Witjaksana; Rizky Eka Adeliani
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.121-128

Abstract

Background Indonesia is a tropical country exposed to ultraviolet (UV) rays year-round, particularly in Central Sulawesi Province, which lies on the equator. Tojo Una Una Regency is located in this province, and the majority of its residents work as fishermen, who are frequently exposed to UV radiation, a risk factor for pterygium and dry eye. This profession has the highest incidence of pterygium, reaching 15.8%. This study will analyze the relationship between pterygium and dry eye. Methods The study design was cross-sectional with consecutive non-random sampling. A questionnaire was used to assess characteristics. Pterygium was diagnosed through an anterior segment examination by a general practitioner, followed by a double-blind ophthalmologist to assess the degree, location, and whether the pterygium was single or double-headed. The degree and diagnosis of dry eye were confirmed using the OSDI questionnaire. Results The study involved 400 respondents, and the prevalence of pterygium reached 85.25%, with cases predominantly bilateral (66.5%), single-headed (70.25%), female (72.75%), 26-45 age group (49.25%), and those working outdoors (77%). DES cases were found in 54.25%, with the majority being severe DES. A chi-square test showed a relationship between dry eye and pterygium (p<0.001). Conclusions There was a significant relationship between DES severity and pterygium incidence (p<0.001).
Terapi target terhadap Sel Punca Kanker Kolorektal dengan Fitofarmaka – sebuah review sistematik Martahadinan Martahadinan; Ika Silviadewi Inzaghi; Erik Prabowo; Ahmad Fathi Fuadi; Dimas Erlangga
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.194-206

Abstract

Colorectal cancer (CRC) is the third most common malignancy but ranks second after lung cancer in terms of mortality, posing a significant public health burden due to its high incidence and death rates. Cancer stem cells play an important role in chemoresistance, tumor progression, and recurrence in CRC. 5-Fluorouracil (5-FU) is a primary chemotherapeutic agent used to kill cancer cells and reduce the risk of recurrence. Resistance to 5-FU remains a major obstacle in CRC treatment, highlighting the need for novel therapeutic strategies targeting cancer stem cells. This review draws on data collected from various electronic databases, covering studies published between January 1, 2015, and December 31, 2024. The search focused on colorectal cancer stem cells (CCSCs) and compared outcomes between monotherapy chemotherapy and chemotherapy combined with phytopharmaceuticals. Preclinical experimental studies published in English and available in full text were included, while case reports, case series, clinical studies, systematic reviews, meta-analyses, clinical guidelines, studies using human tumor tissue samples, and non-English or unavailable full-text articles were excluded. The results were that eight preclinical studies were included, comprising seven controlled experimental studies and one uncontrolled in vitro study. Four studies used 5-FU as a control in combination with different phytopharmaceuticals, including pseudolaric acid B (PAB), morin and MST-312, and diethylaminobenzaldehyde (DEAB), and baicalin. The remaining four studies evaluated phytopharmaceuticals in combination with alternative chemotherapeutic agents, including oxaliplatin with resveratrol, cisplatin with atractylenolide I (ATL-1), and rapamycin with curcumin, or investigated ginsenoside Rg3R as monotherapy. Cellular apoptosis was the primary outcome, while apoptosis-related signaling pathways were evaluated as secondary outcomes. Phytopharmaceuticals as a promising area of research in overcoming chemotherapeutic resistance. The findings reflect a shift in current therapeutic strategies, increasingly favoring phytopharmaceutical-based treatments to reduce drug resistance and enhance the efficacy of chemotherapy with minimal side effects.
IgA Nephritis Vasculitis (Henoch-Schönlein Purpura) Associated with Previous Streptococcal Infection and Acute Rheumatic Fever Putu Evindya Vipascitadewi Nandanaya Bharata; I Made Setiadji; Putu Ayu Dewita Ganeswari; Luh Putu Venny Cempaka Sari
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.162-172

Abstract

Henoch–Schönlein purpura (HSP), now known as IgA vasculitis (IgAV), is an immune-mediated small-vessel vasculitis that primarily affects children. Although its precise etiology remains unclear, group A streptococcal infection is a well-recognized potential immune trigger. The co-occurrence of IgAV, acute rheumatic fever (ARF), rheumatic heart disease (RHD), and Sydenham chorea is an extremely rare clinical phenotype with high educational value. We report an adolescent male presenting with the classic systemic tetrad of IgAV: generalized palpable purpura, migratory arthralgia, abdominal pain, and nephritis (hematuria and proteinuria). Laboratory testing revealed elevated anti-streptolysin O (ASLO) titers (400 IU/mL) after recent pharyngitis. Concurrently, the patient met the Jones criteria for ARF, with Sydenham chorea and echocardiographic evidence of carditis consistent with RHD. Skin biopsy confirmed leukocytoclastic vasculitis, though direct immunofluorescence (DIF) for tissue IgA deposition was unavailable. Treatment with systemic corticosteroids led to significant short-term clinical improvement. However, due to geographical constraints, the patient transferred care to his regional hospital, precluding long-term longitudinal assessment of proteinuria and glomerular filtration rate (GFR) at our tertiary center. This case highlights a challenging clinical intersection of post-streptococcal syndromes and IgAV. Although the lack of DIF and definitive bacterial cultures is a diagnostic limitation, the classical clinical presentation and histopathology strongly support the working diagnosis.
Operasi Katarak pada Miopia Aksial Ekstrem Menggunakan Lensa Intraokular Berkekuatan Sangat Rendah dengan Cincin Penegang Kapsul: Laporan Kasus Kadek Rina Agustinawati; Cokorda Agung Dalem Pemayun
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.173-178

Abstract

Cataract surgery in patients with extreme axial myopia presents unique surgical challenges because of excessive axial elongation, difficulties in intraocular lens (IOL) power calculation, and potential zonular weakness. Implantation of an ultra-low power IOL is uncommon and may increase the risk of refractive prediction errors and capsular instability. Prophylactic use of a capsular tension ring (CTR) may improve capsular stability and postoperative IOL centration in selected high-risk eyes. A 49-year-old man with bilateral cataracts and extreme axial myopia presented with progressive visual impairment in both eyes. Preoperative best-corrected visual acuity was 1/300 in each eye, and optical biometry showed axial lengths exceeding 30 mm bilaterally. Sequential phacoemulsification was performed, with prophylactic implantation of a standard CTR followed by implantation of a +1.5-diopter posterior chamber IOL in each eye. The surgeries were completed without intraoperative complications. At one month postoperatively, best-corrected visual acuity improved to 20/50 in the right eye and 20/40 in the left eye. Both IOLs remained well centered, and no significant postoperative complications were observed. Conclusion was  Sequential phacoemulsification using an ultra-low-power IOL, combined with prophylactic CTR implantation, resulted in satisfactory early visual outcomes in this patient with extreme axial myopia. Careful preoperative planning, accurate IOL power calculation, and appropriate capsular stabilization are essential to optimize surgical outcomes in eyes with excessive axial length.
Hubungan perubahan kadar viral load dengan perubahan indeks massa tubuh selama terapi antiretroviral HIV/AIDS Nurul Rahmania Aryanti; Diana Samara
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.129-140

Abstract

Background Nutritional status in HIV patients is often associated with disease progression and the success of antiretroviral therapy (ART). Viral load is considered a key indicator of ART success, but its direct relationship with body mass index (BMI) is still inconsistent. Methods This study conducted at Fatmawati Central General Hospital, Jakarta, uses a cross-sectional design with combined analysis using the Wilcoxon signed-rank test to assess differences before and after ART, and Spearman's rho correlation test to assess the relationship between changes (Δ) in viral load levels (log10 copies/mL) and BMI (kg/m2) during ART in HIV/AIDS patients with a significance level of p < 0.05. Data were obtained from the medical records of HIV patients receiving ART, with analysis performed at two paired measurement periods categorized as pre-ART (during the initial 6 months of treatment) and post-ART (at the most recent follow-up). Results The number of subjects in this study is 113 HIV/AIDS patients with a median age of 33 years and the majority being male (75.2%). The median viral load significantly decreased from 3.95 before ART to 3.37 log10 copies/mL after antiretroviral therapy (p < 0.001), while the median body mass index increased from 21.51 to 22.22 kg/m² (p = 0.004). The Spearman correlation test showed no significant relationship between viral load levels and BMI before therapy (p = 0.146), after therapy (p = 0.942), or based on the change in values (Δ) during therapy (p = 0.402). Conclusions Antiretroviral therapy significantly reduces viral load levels and increases body mass index in HIV/AIDS patients. However, there is no significant relation between changes in viral load levels and changes in body mass index during antiretroviral therapy.
Sebuah Tinjauan Pustaka mengenai Restriksi Kalori dan Penuaan Kulit Gabriela Michele Rukma Juslim; Rossy Sintya Marthasari; Melisa Ayu
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.254-267

Abstract

Skin aging is a complex biological process influenced by the interaction of intrinsic factors, such as genetic, hormonal, and metabolic changes, and extrinsic factors, including ultraviolet (UV) radiation, pollution, smoking, and dietary habits. The combined effects of these factors lead to various structural and functional alterations in the skin, including reduced collagen synthesis, extracellular matrix degradation, increased oxidative stress, chronic inflammation, and impaired cellular regeneration. Clinically, these changes manifest as wrinkles, loss of skin elasticity, dryness, and hyperpigmentation. In recent years, nutritional interventions have emerged as a promising approach to delay the skin aging process. Among these strategies, calorie restriction has gained considerable attention due to its potential anti-aging effects. Calorie restriction is defined as a reduction in energy intake without causing malnutrition while maintaining an adequate supply of essential nutrients to preserve metabolic homeostasis. It has been shown to reduce the production of reactive oxygen species, attenuate oxidative stress, suppress chronic systemic inflammation, and modulate several molecular pathways involved in aging, including the insulin/insulin-like growth factor-1 (IGF-1), mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and sirtuin signaling pathways. Through these mechanisms, calorie restriction may help preserve skin structural integrity, improve cellular function, and delay the onset of visible signs of skin aging. This literature review aims to provide a comprehensive understanding of the mechanisms underlying skin aging, elucidate the relationship between nutrition and skin health, and summarize the current scientific evidence regarding the efficacy and underlying mechanisms of calorie restriction in slowing the skin aging process. The findings of this review are expected to serve as a foundation for the development of nutrition-based preventive and therapeutic strategies to promote skin health and improve the quality of life in the aging population.
Serial Kasus: Pola EEG dan Hubungannya dengan Luaran Pasien Pasca-Kembalinya Sirkulasi Spontan (ROSC) Rima Anindita Primandari; Winda Arista Haeriyoko; Fitri Octaviana; Astri Budikayanti
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.179-193

Abstract

Return of spontaneous circulation after cardiopulmonary resuscitation is often followed by hypoxic-ischemic brain injury, which may affect neurological recovery. Electroencephalography (EEG) is commonly used to evaluate brain function and prognosis in these patients. EEG patterns can be classified into benign, malignant, and highly malignant categories, which reflect the severity of brain injury. Objective of this study was to evaluate the relationship between EEG patterns and clinical outcomes in patients after return of spontaneous circulation. This case series included six patients who underwent EEG examination more than 24 hours after cardiac arrest. EEG findings were classified according to the Westhall classification and compared with clinical outcomes using the Cerebral Performance Category (CPC) scaler The Results were Four patients showed highly malignant EEG patterns, including electrocerebral inactivity or continuous suppression, and all had poor outcomes (CPC 4–5). Two patients with benign EEG patterns had relatively better outcomes (CPC 3–4). No patient achieved good neurological recovery (CPC 1–2). Low EEG reactivity was observed in all cases, and amplitudes below 10 µV were mostly found in patients with CPC 5. Highly malignant EEG patterns were strongly associated with poor neurological outcomes after return of spontaneous circulation. EEG may be useful as part of a multimodal approach for prognostic evaluation in post-cardiac arrest patients.
Crosstalk Apoptosis-Autofagi pada Kanker Serviks: Peran BAX, BCL-2, dan Cleaved Caspase-3 Diah Komala Sari; Mgs Irsan Saleh; Subandrate Subandrate; Shaum Shiyan
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.207-218

Abstract

Cervical cancer remains a major cause of cancer-related morbidity and mortality among women worldwide. In addition to persistent human papillomavirus (HPV) infection, dysregulation of cell survival and cell death mechanisms contributes to cervical cancer development and progression. Apoptosis and autophagy are two important biological processes involved in regulating cancer cell survival and death; however, the interaction between these processes remains complex and context-dependent. This review aimed to examine the crosstalk between apoptosis and autophagy in cervical cancer, with a particular focus on the roles of BAX, BCL-2, and cleaved Caspase-3. A narrative literature review was conducted using PubMed to identify publications related to apoptosis–autophagy crosstalk in cervical cancer, with particular attention to studies discussing BAX, BCL-2, cleaved Caspase-3, and selected autophagy-related regulators published between 2020 and 2025. Articles were selected based on relevance to the review topic and were synthesized descriptively to provide an overview of current evidence. The reviewed studies indicated that increased apoptotic activity was frequently associated with BAX upregulation, BCL-2 downregulation, and activation of cleaved Caspase-3. In contrast, autophagy exhibited a context-dependent role and functioned either as a mechanism of cancer cell death or as a protective process that promotes cancer cell survival. The interaction between BCL-2 and Beclin1, together with the PI3K/Akt/mTOR signaling pathway, emerged as important components of apoptosis–autophagy crosstalk. The conclusions was the balance between apoptosis and autophagy appears to influence cervical cancer cell responses to therapeutic interventions. BAX, BCL-2, and cleaved Caspase-3 may provide useful molecular information for future investigations of cervical cancer biology and therapeutic responses
Perubahan Antropometri dan Hemoglobin setelah Edukasi Gizi dan PMT pada Balita Malnutrisi Nugrahayu Widyawardani; Nurfitri Bustamam; Taufiq Fredrik Pasiak; Tuty Rizkianti; Citra Ayu Aprilia; Panji Octo Prasetio; Nevanya Rosaria Angelita; Fasya Fadhilah Agustin Mulyadi
Jurnal Biomedika dan Kesehatan Vol 9 No 2 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.141-150

Abstract

Background Malnutrition among children under five remains a major public health concern, including in semi-urban areas such as Klapanunggal, Bogor. Inadequate dietary intake may contribute to underweight, wasting, low hemoglobin concentration, and anemia. This study evaluated changes in maternal nutrition knowledge, child anthropometric indicators, and hemoglobin concentration following nutrition education and local food-based supplementary feeding. Methods A one-group pre–post intervention study involved 37 children aged 6–59 months with underweight or wasting. Mothers received nutrition education, while children received local food-based supplementary feeding for 28 days in the underweight group and 56 days in the wasting group. Data were collected using structured questionnaires, two non-consecutive 24-hour dietary recalls, anthropometric measurements, and capillary hemoglobin testing. Normality of paired differences was assessed using the Shapiro–Wilk test. Paired-samples t-tests were used for normally distributed data, while Wilcoxon signed-rank tests were used for non-normally distributed data. Results Maternal nutrition knowledge, weight-for-height z-scores, weight-for-age z-scores, and hemoglobin concentration increased significantly after the intervention. However, information on concurrent iron supplementation, infection treatment, and other clinical interventions was not systematically recorded. Conclusions Nutrition education and local food-based supplementary feeding were associated with improved maternal nutrition knowledge and child anthropometric indicators. The increase in hemoglobin concentration should be interpreted cautiously because potential concurrent supplementation and clinical treatment were not documented or controlled.

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