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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Chronic Fatigue Syndrome Ridho Berlianto; Arina Widya Murni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.542

Background: Chronic fatigue syndrome is a collection of symptoms characterized by complaints of fatigue that lasts for at least six months or more. It can be accompanied by symptoms of low-grade fever, myalgia, arthralgia, cephalgia, and a sore throat that is sometimes accompanied by enlarged glands. The main psychological symptoms of chronic fatigue syndrome are depression and sleep disturbances. Case Presentation: A 26-year old male patient was treated with a main complaint of feeling tired since 6 months before he was admitted to the hospital. The patient claimed that he was unable to do activities independently because he experienced extreme tiredness. He also complained of a headache that was felt when under stress and was not relieved by rest along with a stabbing-like pain that moved around throughout his body, which also does not decrease with changes in position or rest. He also has heartburn felt since 4 months ago when eating spicy foods, eating late, and especially when experiencing mental stress, which often was accompanied by nausea and vomiting. The results of his physical, laboratory and supporting examinations were all within normal limits. The patient was then diagnosed with chronic fatigue syndrome and functional dyspepsia. Conclusion: Approaches to medical treatment of chronic fatigue syndrome can be done based on general treatment of physical and psychological symptoms experienced. In these circumstances, antidepressant drug therapy and psychotherapy such as cognitive behavioral therapy is needed. In addition, rehabilitation therapy may also be necessary because several studies show that gradual physical exercise yield significant improvement in chronic fatigue syndrome patients.

The Role of Calcium in the Skin Barrier Nopriyati; Ahmad Ligar Suherman; Yulia Farida Yahya; Mutia Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.543

Calcium is a macro mineral that is an important part of the body. Bones and teeth contain more than 99% of the human body calcium. Calcium also found in other tissues such as skin. The concentration of calcium in the body tends to decrease with age because released from the body through sweat, skin cells, and faeces. Calcium intake varies worldwide with an average of 175-1233 mg/day. Many countries in Asia have an average calcium intake of less than 500 mg/day. The skin barrier function is in the epidermis, the formation of the epidermal barrier and the maintenance of homeostasis are important to protect the individual from the external environment and organisms. Epidermal calcium gradient, endoplasmic reticulum (ER) calcium homeostasis, and calcium influx through calcium channels play important roles in keratinocyte differentiation, barrier formation, and barrier homeostasis. Understanding the mechanism of regulation and function of calcium related to skin barrier homeostasis is aimed to improve understanding of calcium in the skin barrier

Association of Early Drain Removal with Formation of Seroma in Breast Cancer Patients After Modified Radical Mastectomy Ramadanus; Daan Khambri; Wirsma Arif Harahap
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.544

Background: The installation of drainage after MRM surgery has been aimed at reducing seroma formation. However, when the drain should be removed has not been studied well. This study aims to determine the association of early drain removal with seroma formation. Methods: A nested cohort study was conducted on 40 breast cancer patients undergoing MRM surgery. Patients were divided into 2 groups; off-drain day I and day III post-surgery. Seroma formation was assessed 7 days after the patient was discharged. Results: Seroma formation seven days after discharge occurs in 25 of the total 40 patients (62.5%). There was no difference in seroma incidence between groups of patients on the off-drain day I and day III seven days after discharge (65% vs. 60%) (p 1,000) or the number of seromas (157.31 +120.00 ml vs. 149.58 + 110.00 ml) (p 0.437). Conclusion: Removing the drain faster does not reduce the incidence and number of seromas seven days after discharge.

Factors Affecting Chronic Heart Failure in Patients with End-Stage Renal Disease at Bhayangkara Hospital Denpasar Ni Gusti Ayu Putu Lestari Santika Dewi; A. A. Ayu Dwi Adelia Yasmin; Ni Made Citra Riesti Wulan; I Gede Catur Wira Natanagara
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.545

Background: Patients with end-stage renal disease (ESRD) have a twofold risk of developing heart failure. A number of factors in ESRD patients are related to chronic heart failure (CHF). The intervention of cardiovascular risk factors in the early stages of chronic kidney disease (CKD) can reduce mortality from heart disease and slow the severity of kidney deterioration. This study aims to examine the factors that affect CHF in patients with ESRD. Methods: This study was a cross-sectional analytic observational study of 49 patients with ESRD based on consecutive sampling. The data collected were primary and secondary data on ESRD patients at the Cardiac Polyclinic, Internal Medicine Polyclinic, and the Medical Records Unit Bhayangkara Hospital Denpasar. Results: In this study, it was found that most patients were in the age group ≥40 years (92%) and male gender (63%). From the chi-square test analysis, it was found that the factors affecting CHF in patients with ESRD are hypertension (HT) (p-value < 0.001) with prevalence ratio (PR) 11.19 (1.69-73.92), type 2 diabetes mellitus (T2DM) (p-value = 0.008) with PR 1.72 (1.18-2.51), obesity (p-value < 0.001) with PR 6.67 (2.34-18.92), and smoking (p-value = 0.027) with PR 1.6 (1.02-2.49). Conclusion: It can be concluded that the factors affecting CHF in patients with ESRD are HT, T2DM, obesity, and smoking. The results of this study are expected to be used as an illustration so that in the future, prevention can be made for factors affecting CHF in ESRD patients.

HIV Drug Resistance Mutations Rizka Nadia; Dwitya Elvira; Raveinal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.547

ART resistance, according to WHO, is the presence of one or more mutations in HIV that reduces the ability of certain drugs or drug groups to inhibit viral replication. According to the 2019 HIV Drug Resistance Report issued by the WHO, the prevalence of Antiretroviral Therapy (ART) drug resistance is 3%-29%. The prevalence of HIV drug resistance varies by country. In developed countries, the prevalence ranges from 6.6% to 11%. There are two types of resistance to ART: primary and secondary resistance. Primary resistance reflects the acquisition of drug-resistant strains in individuals who have recently been infected and have not received therapy. Secondary resistance occurs after treatment with ART. Resistance to antiretroviral therapy, mainly NRTIs, NNRTIs, and protease inhibitors, is caused by continuous inhibition of the HIV reverse transcriptase enzyme. World Health Organization (WHO) has recommended two NRTIs plus Lopinavir or Atazanavir as a second-line regimen for individuals who have failed treatment with efavirenz or dolutegravir; two NRTIs plus Darunavir and Lopinavir plus Raltegravir are recommended as an alternative due to cost constraints and the fact that Darunavir is unstable in moderately hot conditions.

Talipes Equinovarus (TEV) and VACTERL Associated Anomalies: Narrative Literature Review Huda Fajar Arianto; Faesal A Maodah; Yunus Abdul Bari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.548

Clubfoot or known as Talipes Equinovarus (TEV), is a common anomaly in world population of newborn. This condition was reported in many studies as isolated anomaly but may come with other associated congenital anomalies. This review aims to further discuss the classification of TEV, its etiopathogenesis and how to diagnosis with all kind of VACTERL associated anomaly together with TEV. Many studies show a range of incidence between 1.1-4.5 per 1000 live birth per year and there is a chance of its condition followed by multiple congenital anomalies. Even though, this anomaly was an idiopathic condition, but still there is multifactorial etiology for its in which revealed through many studies also. Nevertheless, the orthopedic management of TEV with or without other congenital conditions still continue to develop to make a better improvement for the patients.

Growth Profile in Pediatric Patients with Diabetes Mellitus at Dr. M. Djamil General Hospital, Padang Michael Mettafortuna Sephberlian; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.549

Background: Diabetes mellitus (DM) is a glucose metabolism disorder characterized by chronic hyperglycemia that often occurs and is a major health problem. During puberty, increased Growth Hormone (GH) secretion results in increased insulin resistance. This study aimed to describe the growth profile of pediatric patients with diabetes mellitus at Dr. M. Djamil General Hospital. Methods: A descriptive retrospective study with conducted by collecting data on body height, HbA1C level, and status of puberty from medical records at the pediatric ward of Dr. M. Djamil General Hospital from January 2019 - December 2020. Results: The sample was 67 (63 T1DM, 2 T2DM, and 2 double DM). Ten of them with short stature (8 with poor metabolic control). Conclusion: Children with DM may experience growth disturbance.

Successful Long-Term Monitoring of Children with Scrofuloderma, Malnutrition, and HIV Destri Linjani; Finny Fitry Yani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.550

Background: Scrofuloderma is a skin TB that occurs percontinuitatum from tissues underneath, such as lymph nodes, muscles, and bones. It often affects children and young adults. The incidence of TB disease is estimated to increase 20-fold in children with HIV infection. Poor nutrition can affect the mortality rate of children with HIV infection. This case report presents long-term monitoring of boys aged 1 year 5 months with scrofuloderma, malnutrition, and HIV infection. The case report aims to assist children and caregivers in undergoing treatment to prevent drug withdrawal and nutritional procedures and monitor the growth and development of children. Case presentation: A 1-year and 5-month-old boy with a complaint of ulcers on his right neck since 12 months ago. He also complained of diarrhea 12 months ago, accompanied by recurrent stomatitis and progressive weight loss since 3 months ago. He looked pale 1 month ago. Blood laboratory examination with hemoglobin 5.1 gr/dl, leukocytes 5280 / mm3, platelets 323,000 / mm3, hematocrit 20%, reactive anti-HIV test, CD4 examination with a value of 178 cells / L, negative tuberculin test, a chest x-ray showed infiltrate in both lung fields, and bajah examination of the nodules in the Colli dextra region, with the impression of granulomatous inflammation that can be caused by mycobacterial infection. Conclusion: Tuberculosis is the most common opportunistic infection found in children with HIV infection and increases the mortality rate. There is a relationship between nutritional status and the incidence of mortality in HIV/AIDS children, so it is necessary to monitor children for adherence to treatment, improve nutritional status and reduce morbidity and mortality rates.

Pathogenesis Coronavirus Disease 2019 (COVID-19): Narrative Literature Review Sofía Lucila Rodríguez Rivera; José Antonio Infante Cantú; Héctor R. Martínez; Enrique Caro Osorio
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.551

The pathogenesis of COVID-19 occurs in 3 phases according to the pathophysiology and clinical degree. The three phases are grouped into the initial phase of infection, the pulmonary phase, and the hyperinflammatory phase. The initial phase of infection begins with the inoculation of the virus into host cells. This virus infects cells in the airways that line the alveoli. SARS CoV-2 will bind to receptors found on the epithelium of the respiratory tract, gastrointestinal tract, and endothelium of blood vessels and make its way into cells. The second phase is the pulmonary phase. In this phase, there is viral multiplication and inflammation in the lungs. The binding of SARS-CoV-2 to the ACE2 receptor causes ACE2 deficiency and an imbalance of the renin-angiotensin system (RAS). In the third phase, namely hyper inflammation, excessive cytokine production after SARS-CoV-2 infection will increase the permeability of the capillary wall membrane around the infected alveoli, causing edema, pulmonary dyspnea, and hypoxemia. The presence of plasma fluid in the alveoli and loss of elasticity due to decreased surfactant function due to type 2 pneumocyte infection caused by SARS-CoV-2 infection causes acute respiratory distress syndrome in COVID-19 patients.

Effectiveness Diagnosis of Pulmonary Tuberculosis (TB) in Children Based on Clinical Symptoms Seshy Tinartayu; Syarrah Tiara Harrini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.541

Background: Diagnosis of pulmonary tuberculosis (TB) in children is still a challenge because the gold standard by examining sputum AFB is difficult. This study aimed to see the effectiveness of diagnosing TB in children based on clinical symptoms. Methods: This study is a retrospective study with a case-control design, and consecutive sampling from the medical records of pediatric TB patients at Panembahan Senopati Hospital, Bantul for the period January 2014 - December 2016. The total population is 90, and the sample is 73. Children diagnosed with a score (score 6) are in the control group (n=30), while children with a diagnosis score of <6 were diagnosed with pulmonary TB based on clinical symptoms, we categorized them into the case group (n=43). Results: There was no difference in gender, age, and group domicile. However, there was no significant difference in nutritional status (malnutrition), long cough, and chest X-ray. The difference between the two groups was found in symptoms of fever and enlarged lymph nodes. Also, it was found in TB contacts and the Mantoux test but this could be a recall bias because in the diagnosis group this is rarely done. The sequential scoring parameters from the most common were chest X-ray, malnutrition, cough, enlargement of lymph nodes, fever, contact TB, and the Mantoux test. Improvement of symptoms (cough, fever, lymph nodes, and chest X-ray) after 6 months of therapy occurred 100% in both groups. Conclusion: The diagnosis of TB in children based on clinical symptoms can be used as an effective alternative.

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Location Kab. ogan ilir, Sumatera selatan INDONESIA

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Contact Name
Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

Phone
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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
-

Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA