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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Human Papillomavirus High-risk Type Infection on Perianal Giant Condyloma Acuminatum Rio Maruli Tampubolon; M. Izazi Hari Purwoko; Mutia Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.519

Background: Giant condyloma acuminatum (GCA) is a large form of condyloma acuminatum that become locally invasive, destructive, but non-metastasizing, caused by human papillomavirus (HPV). Giant condyloma is a rare disease, with only 0.1% incidence in the general population. Most commonly caused by HPV type 6 and 11 infections, in this case, reported HPV high-risk type. Case presentation: A 20-years-old man, the main complaint is enlarging, easy bleeding perianal tumor with pruritus and constipation for 2 months. Physical examination found skin-colored, verrucous surface. Some have smooth surface, cauliflower-like tumor on perianal region, size 7x4x2cm. Syphilis and HIV Serology laboratory tests are non-reactive. Koilocytes appear on histopathologic examination. High-risk HPV type detected on HPV genotyping. This patient was diagnosed as GCA. Topical agent 25% podophyllin tincture applied to the lesions once a week. Improvement appears after eighth-time therapy. Discussion: High-risk type HPV infection, detected in the patient, have an important role in GCA development. Decreased immune system and other risk factors also have a role in GCA.

Left Ventricular Thrombus in Old Myocardial Infarction Abdul Alim Rahimi; Akmal Mufriadi Hanif; Taufik Rizkian Asir
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.520

Background. Left ventricular thrombus is a major risk factor for systemic thromboembolism, a complication of acute and chronic myocardial infarction. The high incidence of left ventricular thrombus in untreated acute myocardial infarction patients can be described in the pre-thrombolytic era. Left ventricular thrombus occurred in 7-46% of cases, especially in anterior or apical myocardial infarction. Case presentation. A 57-year-old man is reported with complaints of shortness of breath and a history of chest pain typical of angina, hypertension, diabetes mellitus, and smoking. On electrocardiographic examination, infrequent premature ventricular contraction and anterior extensive old myocardial infarction were found. Transthoracic echocardiography examination revealed protuberant thrombi at the apex of the left ventricle with a size of 14 x 15 mm, left ventricular ejection fraction of 20%, and akinetic at extensive anterior, anterior, anterolateral, broad apical, inferoseptal, and inferior segments. Conclusion. Untreated acute myocardial infarction has a high risk of developing left ventricular thrombus. Intravenous unfractional heparin and VKA in left ventricular thrombus patients with an increased risk of embolism respond well.

Pseudophakic Retinal Detachment: A Narrative Review Karniela Ayuni Putri; Weni Helvinda; Khalilul Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.522

Cataract surgery causes changes in intraocular conditions that are a risk factor for retinal detachment. One of the conditions that can occur during cataract surgery is posterior capsule rupture which can increase the risk of pseudophakic retinal detachment (PRD). PRD examination is often obstructed by opacification of the posterior capsule, a reflection of the intraocular lens (IOL), or poor mydriasis. Scleral buckle, pneumatic retinopexy, and primary pars plana vitrectomy, with or without a combination of the scleral buckle, are surgical techniques used in the management of PRD patients. Anatomical and functional postoperative success rates in PRD patients were found to be higher after primary pars plana vitrectomy (PPV) with or without a scleral buckle. This literature review aims to discuss the epidemiology, risk factors, pathogenesis, and management of PRD.

Clinical Profile of Proptosis in Dr. M. Djamil General Hospital Padang Feby Helwina; Ardizal Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.523

Background. Proptosis is a condition that describes a protrusion or forward shift of the eyeball and is commonly used to describe the condition of protrusion of the eyeball. Proptosis generally occurs due to a mismatch between the orbital capacity and the volume of the tissue structure in the orbital cavity. It is a common manifestation of a wide variety of diseases of the structures in and around the orbit and in some systemic diseases. This study aimed to describe the clinical profile of proptosis patients in Dr. M. Djamil General Hospital Padang. Methods. We reviewed the medical record of the oncology subdivision of ophthalmology patients associated with proptosis retrospectively, such as inflammatory, infectious, tumors, and vascular, admitted to the M.Djamil General Hospital in Padang from January 2019 to August 2020. The ocular and systemic history and examination details were recorded. Results. We found 48 proptosis patients from January 2019 to August 2020, consisting of 30(62.5%) males and 18(37,5%) females. The majority of subjects were in the Adult age group (79,17%). Unilateral and bilateral proptosis were found in 37(77%) and 11(23%), with mostly axial proptosis (83,33%). Inflammatory tumors were found in 17(35,41) and 29(60%) patients. Conclusion. Proptosis is a common clinical feature of various local and systemic diseases. Even though proptosis have diverse etiology and pathogenesis, they usually present with similar clinical manifestation. Proptosis may be one of the most important keys to disease guidance from a close structure that requires a multidisciplinary approach.

Evisceration Versus Enucleation in Ocular Globe Injury Nasyayya Akbari Nazar; Hendriati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.524

Evisceration and enucleation have been acceptable therapeutic modalities to treat not only severe ocular trauma but also various ocular conditions, such as intraocular tumors, endophthalmitis, and blind-painful-cosmetically disfiguring eyes, over the last two centuries. Clinical indications and choices of procedure, whether enucleation or evisceration, vary among institutions, surgeon experience, and severity of structure loss. In the past, enucleation has been preferred by most surgeons for various reasons, including the fear of sympathetic ophthalmia (SO) after evisceration. Despite the possibility of causing SO, anophthalmic socket also has complications, including superior sulcus defect, conjunctival surface changes, implant exposure, fornix/socket contraction, and eyelid malposition. This literature review will discuss indication, technique, and decision with regard to enucleation or evisceration after ocular trauma.

Heart Failure Due to Mitral Stenosis Complicated Atrial Fibrillation in Pregnancy Deddy Khairul
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.525

Background. This case report aims to discuss the management of heart failure due to mitral stenosis with complications of atrial fibrillation in pregnancy. Case presentations. A 35-year-old pregnant woman came to the ER M. Djamil Hospital with complaints of shortness of breath 3 days before being admitted to the hospital. Complaints of shortness of breath accompanied by palpitations felt fast and irregular, appeared suddenly when the patient was resting, and lasted continuously. Physical examination showed a pulse rate of 120-130x/minute, increased jugular venous pressure, and palpable cardiac ictus 1 finger lateral to the left midclavicular at the V intercostal space. ECG examination revealed atrial fibrillation- rapid ventricular response (AF RVR). The patient was diagnosed with atrial fibrillation- rapid ventricular response et causa suspect mitral stenosis NYHA Fc III, et causa rheumatic heart disease. Conclusion. The management of atrial fibrillation rapid ventricular response in this patient was done by giving digoxin 0.25 mg orally. Patients are given anticoagulants to prevent thromboembolic complications. This patient was advised to undergo valve replacement surgery considering the degree of stenosis, complications, and a thorough assessment.

Intraventricular Hemorrhage in Children with COVID-19 Confirmed Utari Gustiany G; Rahmi Lestari; Finny Fitry Yani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.526

Background. The most common symptom of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is respiratory symptoms. However, neurological symptoms in adult patients are increasingly being reported. In children, neurological symptoms of COVID-19 are still underreported. This case report was aimed to describe intraventricular hemorrhage in a child with Covid-19 infection. Case presentation. We report a case of a 15-year-old girl with intraventricular bleeding, which is one of the COVID-19 infection symptoms or a possible symptom of a multisystem inflammatory syndrome in children (MIS-C). Laboratory tests on the first day of treatment showed an increase in leukocytes and decreased lymphocytes. On the 6th day of treatment, the patient had worsening symptoms of consciousness and high fever. The results of laboratory examination showed a decrease in kidney function and an increase in D-dimer. Conclusion. Severe clinical manifestations of COVID-19 can be in the form of neurological manifestations, one of which is intraventricular hemorrhage.

Short Chain Fatty Acid (SCFA) Gut Biota and Interleukin 6 (IL-6) Related to the Severity of Systemic Lupus Erithematosus (SLE) at Dr. Mohammad Hoesin General Hospital Palembang Edwin Nugraha Fitriawan; Eddy Mart Salim; Erial Bahar; Nova Kurniati; Yuniza; Syamsu Indra; Norman Djamaludin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.527

Background. SLE is an autoimmune disease characterized by the presence of autoantibodies in the nucleus, deposition of immune complexes, and can attack various body tissues. Gut biota in this case short-chain fatty acids (SCFA) play a role in the inflammatory process in the SLE, while the levels of IL- 6 can also be associated with a response to inflammation which will be seen in the degree of SLE activity. This study aims to determine the correlation of SCFA Gut biota and IL - 6 with SLE degree activity. Methods. This study is a cross-sectional study with a correlation test design, conducted from November 2021-January 2022 at RSMH Palembang with the research subjects being all SLE patients seeking treatment at the Allergy-Immunology Division of RSMH Palembang with categories of mild and moderate-severe SLE activity degree. Examination of SCFA Gut biota using stool samples and serum IL-6 levels were associated with SLE activity degree. Statistical analysis of the correlation test with Spearman for numerical data not normally distributed, and continued with linear regression test to assess the multivariate analysis in this study. Results. The sample consisted of 32 patients, every 16 patients with mild and moderate-severe SLE activity degrees. The correlation between SCFA Gut biota with SLE activity degree was found to have a correlation coefficient of r=-0.777 with p=0.000. Correlation between IL-6 with SLE activity degree obtained a correlation coefficient of r=0.910 with p=0.000, while the correlation test between IL-6 and SCFA Gut biota obtained r=-0.633 with a value of p=0.000. Multivariate analysis found that 70.5% of SCFA Gut biota and IL-6 affected SLE activity degree. Conclusion. SCFA Gut biota and IL-6 had a significant correlation in statistical tests with the SLE activity degree.

Early Clinical Outcome of Limb Salvage Surgery of Osteosarcoma in the Lower Extremity Using Liquid Nitrogen Primadika Rubiansyah; Muhammad Randi Akbar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.528

Background. Osteosarcoma in the lower extremity has become a challenge for orthopedic surgeons to manage because surgeons need to preserve the affected joint's functions and retain stability as physiologic as possible. Thus, limb salvage surgery may be the treatment of choice. One of the techniques using liquid nitrogen provides better functionality and efficacy in preventing recurrence. Methods. From October 2020 to October 2021, 7 patients with primary musculoskeletal sarcoma underwent limb salvage surgery (LSS) by wide resection of the tumor and reconstruction using recycled Autograft treated with liquid nitrogen. The resected bone was dipped in liquid nitrogen for 15 min and thawed at room temperature for 15 min. The recycled bone was re-implanted into its original site and stabilized with internal fixation, and some of them followed with arthroplasty. Results. Average age was 14.14 years old. The most common site was the distal femur which was found in 3 cases (42,8%). During the 6-months-follow-up period, all patients had a good function (mean functional MSTS score of 90%) with one case of local recurrence in the re-implanted bone and one case of infection. No metastasis was reported in any patient. Conclusion. Satisfying functional results were recorded in all subjects treated with cryosurgery in Dr. Mohammad Hoesin General Hospital Palembang with equal results with studies around the world.

Metabolic Control Status Related to Quality of Life in Children with Type 1 Diabetes Mellitus at Dr. M. Djamil General Hospital Padang Ivanny Khosasih; Asrawati Nurdin; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.529

Background. Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease requiring lifelong treatment. Good metabolic control could maintain an optimal quality of life. HbA1C is a reliable parameter of metabolic control. Poor metabolic control results in decreased quality of life for T1DM. This study aims to evaluate the relationship between metabolic control status and quality of life in children with T1DM at Dr. M. Djamil General Hospital Padang. Methods. This cross-sectional study on 52 T1DM children aged 8–16 years using consecutive sampling methods at the pediatric endocrinology outpatient clinic, Dr. M. Djamil General Hospital Padang, from April-September 2021. HbA1C was calculated using the High-Performance Liquid Chromatography (HPLC) method and classified into good and poor control. Quality of life was assessed using PedsQl 4.0 and classified as impaired and unimpaired. The Chi-square test was used for data analysis. The P-value of <0.05 was considered statistically significant. Results. The majority of respondents were girls (57.7%), and most of them had good nutritional status (73.1%). The mean age at diagnosis was 11.21±2.57 years, and they had suffered from T1DM for 2.21±1.28 years. A family history of diabetes was found in 57.7% of respondents. Complications found were hypoglycemia (19.2%) and diabetic ketoacidosis (50%). Poor metabolic control was found in 78.8% of respondents. Quality of life was impaired in 40.4% of respondents, especially in school functions. This study found that respondents with impaired quality of life had poor metabolic status (p<0.034). Conclusion. T1DM patients with poor metabolic control status have impaired quality of life.

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Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA