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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Comparison of Outcomes in Critically Ill Patients Installed with Mechanical Ventilation Performed Early and Late Tracheostomy at Dr. M. Djamil General Hospital Padang Rahmat Hidayat; Muhammad Riendra; Rahmat Taufik
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.701

Background: Tracheostomy is an alternative that is widely used as airway access after the use of a ventilator in the care of critically ill patients. Several factors are known to influence the outcome in patients undergoing tracheostomy. This study aimed to compare the outcomes of critically ill patients installed with mechanical ventilation performed early and late tracheostomy in Dr. M Djamil General Hospital, Padang, Indonesia. Methods: This study was an analytical observational study with a cross-sectional approach. A total of 97 research subjects participated in this study. Data analysis was carried out with the help of SPSS software in a univariate and bivariate manner between tracheostomy time (early and late) with patient outcomes in the form of death and length of stay. Results: There was a statistical difference in the mortality rate in critically ill patients with mechanical ventilation performed early and late tracheostomy, p = 0.014. There is a statistical difference in the length of stay in the intensive care unit in critically ill patients with mechanical ventilation performed early and late tracheostomy with p = 0.000. Conclusion: There are differences in outcomes in the form of mortality and length of stay in critically ill patients who have tracheostomy installed at Dr. M. Djamil General Hospital Padang, Indonesia.

Comparison of Maternal and Perinatal Outcomes of Pregnancy with Systemic Lupus Erythematosus in Planned Referrals Compared to Emergency Referrals Based on the Maternal Fetal Triage Index at Dr. Kariadi General Hospital, Semarang, Indonesia Gayuh Tunggal Rachmadhini; Rakhma Yanti Hellmi; Yuli Trisetiyono; Arufiadi Anityo Mochtar; Endy Cahyono; Ratnasari Dwi Cahyanti; Putri Sekar Wiyati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.702

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks the skin and the musculoskeletal, kidney, neuropsychiatric, hematological, cardiovascular, pulmonary, and reproductive systems. In pregnancies with SLE, early referral to the hospital with the involvement of obstetricians and rheumatologists, and other specialists as needed, as well as individual management plans, regular reviews, and early recognition of flares and complications, are important. This study aimed to determine the differences in maternal and perinatal outcomes referred by planned referrals compared to emergency referrals, especially in pregnant patients with SLE. Methods: This study was an analytic observational study with a retrospective cohort approach. A total of 40 subjects participated in this study. Data analysis using SPSS software was carried out univariate and bivariate to examine the relationship between types of referrals and maternal and perinatal outcomes. Results: There were significant differences between the types of emergency referrals and planned referrals in the variable incidence of preeclampsia and SLE exacerbations. There were no significant differences between the types of emergency referrals and planned referrals on the variable incidence of lupus nephritis, maternal death, premature delivery, fetal growth restriction, fetal death, and the incidence of neonatal lupus syndrome. Conclusion: The incidence of severe preeclampsia and SLE exacerbation was lower in planned referrals compared to emergency referrals in pregnant patients with SLE at Dr. Kariadi General Hospital, Semarang, Indonesia.

Diagnosis and Management of Mirizzi Syndrome Related to Gallstones: A Narrative Literature Review Diego Lesgenia; Arnelis; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.703

Mirizzi syndrome (MS) is a rare condition caused by compression of the common hepatic duct due to gallstones located in the cystic duct or neck of the gallbladder. Biliary pain, jaundice, and fever are the most common clinical manifestations of MS. Patients usually report a history of biliary pain with jaundice. There are no pathognomonic features in the history and physical examination. Patients may also come with acute cholecystitis, acute cholangitis, or pancreatitis. In cases where MS is suspected, the diagnosis can be made by ultrasonography (US), computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP), and endoscopic retrograde cholangiopancreatography (ERCP). Surgery is the main treatment for cases of MS and is a challenge because preoperative diagnosis is difficult, thus impacting management during surgery. This literature review aimed to describe the features of MS related to gallstones and management options.

Profile of Side Effects of Chemotherapy in Non-Small Cell Lung Cancer Patients (NSCLC) Undergoing Chemotherapy at Dr. M. Djamil General Hospital, Padang, Indonesia Isnaniyah Usman; Sabrina Ermayanti; Afriani Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.704

Background: Chemotherapy is one of the treatment options for lung cancer at any stage. Side effects due to chemotherapy are still a problem in the treatment of lung cancer patients. Chemotherapy drugs have different side effects according to their pharmacokinetics and pharmacodynamics. This study aimed to determine the side effects of both hematological and non-hematological chemotherapy in non-small cell lung cancer patients treated at the lung ward of Dr. M. Djamil General Hospital, Padang, Indonesia, from 2017 to 2019. Methods: This was a descriptive observational study, a total of 42 study subjects. The study subjects were non-small cell lung cancer patients undergoing first-line chemotherapy. Sociodemographic, clinical, and laboratory data analysis was carried out with the help of SPSS software in a univariate manner. Results: The study subjects were mostly male (85.36%), the age range of 40-60 years (66.67%), at risk of exposure from work (45.23%), smokers (59.52%), had a history of pulmonary TB (11.9%), history of COPD (2.38%), history of malignancy of other organs (2.38%) with the most cell type being adenocarcinoma (54.76%). The most common hematological side effects were first-degree anemia (21.43%) and first-degree leukopenia (21.43%). The most non-hematological side effects were first-degree alopecia (90.48%), followed by first-degree nausea and vomiting (78.57%). Conclusion: Chemotherapy side effects were found in all regimens given with mild degrees. The side effects obtained were in the form of hematological and non-hematological side effects.

Pulmonary Embolism: A Narrative Literature Review Bobby Hasibuan; Oea Khairsyaf; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.705

Pulmonary embolism (PE) is a pulmonary emergency that is quite common with various clinical manifestations, from asymptomatic to life-threatening. The incidence of pulmonary embolism is reported to be 1 per 1000 population, with 50,000 deaths per year. Making the diagnosis is difficult because the symptoms vary widely in each patient. Management of acute pulmonary embolism is carried out with a systematic approach involving early intervention, patient risk stratification, selection of therapy, and determination of the length of treatment.

Cost of Treating Coronavirus Disease 2019 (COVID-19) Patients in Hospitals and Influencing Factors: A Systematic Literature Review Henri Azis; Atik Nurwahyuni; Firdinand
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.706

Background: Increasing beds for COVID-19 patients is not a simple matter for hospitals because hospitals cannot directly increase the number of existing beds due to limited facilities, infrastructure, equipment, and resources. Careful calculations are needed in terms of preparing the room and treating COVID patients, especially the estimated costs needed to treat COVID patients in the hospital. This expenditure is important so that it can be an illustration of the hospital how much expenditure is needed. This study aimed to determine the number of costs incurred for treating COVID-19 patients in hospitals and the factors that influence these costs. Methods: This study was conducted by systematic literature review using the PRISMA statement conducted May-June 2021. An article search was conducted on Pubmed, Scopus, Proquest, and Google Scholar with the inclusion criteria, namely research related to the cost of treating COVID-19 patients in hospitals and the factors that influence the amount of these costs. Results: A systematic search obtained six articles. Studies vary greatly in study design and perspective included in the cost category. Estimated costs for COVID-19 care range from $63/day to $2,990/day. Factors that affect the cost of care include age, previous medical history, degree of infection or severity of COVID-19, length of stay, place of care, and need for a ventilator. Conclusion: There is a considerable economic burden associated with the incident of COVID-19. Several factors affect the cost of COVID-19, namely the length of the treatment period and the need for intensive rooms and ventilators.

The Role of Galectin-3 in Acute Myocardial Infarction: A Narrative Literature Review Haviz Reddy; Akmal M. Hanif; Taufik Rizkian; Wahyudi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.709

Galectin-3 (Gal-3) is a protein, namely a lectin, that binds to beta galactosides. Gal-3 has been shown to be related to the process of fibrosis, classification of atherosclerosis, and cardiac remodeling. Gal-3 regulation is known to be involved in the process of atherogenesis. Low-density lipoprotein (LDL) Oxidation increases Gal-3 expression in vascular smooth muscle cells. Gal-3 also induces fibroblasts and vascular smooth muscle cells to proliferate and produce fibrosis-related proteins in the extracellular matrix. Inhibition of Gal-3 can reduce the atherosclerotic process and reduce the progression of plaque formation. Gal-3 also induces fibroblasts and vascular smooth muscle cells to proliferate and produce fibrosis-related proteins in the extracellular matrix. Inhibition of Gal-3 can reduce the atherosclerotic process and reduce the progression of plaque formation. Several clinical trials have focused on the role of Gal-3 in acute myocardial infarction patients showing that Gal-3 is upregulated. In these patients. This literature review aims to describe the role of Gal-3 in acute myocardial infarction.

Comparison of SARS-CoV2 IgG Antibody Levels in Health Workers with and without a History of COVID-19 Infection after Heterologous Vaccination at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Ferda Puspalina; Nova Kurniati; Eddy Mart Salim; Yuniza; Zen Ahmad
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.713

Background: The COVID-19 pandemic, which has spread very quickly, has created crises in all aspects of life around the world. The administration of the COVID-19 heterologous vaccine in Indonesia is prioritized for high-risk groups, one of which is health workers. This study aimed to determine the comparison of quantitative IgG antibody levels for SARS CoV2 between health workers with and without a history of being infected with COVID-19 after heterology vaccination at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study was a cross-sectional analytic observational study. A total of 64 subjects participated in this study. Data analysis was carried out with the help of SPSS software in univariate and bivariate. Results: SARS-CoV2 IgG antibody levels with and without a history of being infected with COVID-19 after heterologous vaccination did not find a significant difference in IgG levels between the two groups. However, the quantitative IgG levels of SARS-CoV2 in the infected history group were greater, namely 4834.25 AU/mL, compared to no history of COVID-19 infection of 3833.35 AU/mL Conclusion: There is a difference in the average SARS-CoV 2 IgG between subjects with a history of being infected with COVID-19 and without a history of COVID-19 at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, although statistically, it is not significantly different.

The Relationship between Menstrual Patterns and Pain Scale in Endometriosis Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Fatimah Usman; Megan Reginia Rusli; Eka Handayani Oktharina; Kemas Yusuf Effendi; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.714

Background: Endometriosis is a disease characterized by the presence of tissue resembling the endometrium (uterine lining) outside the uterus. This causes a chronic inflammatory reaction that can result in the formation of scar tissue in the pelvis and other parts of the body. Pain is the most common clinical complaint in cases of endometriosis. Pain during menstruation is often confused with pain due to endometriosis, so treatment delays often occur. This study aimed to determine the relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This was cross-sectional analytic observational study. A total of 55 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 25 software in univariate and bivariate. Results: Menstrual cycle, duration, color, and volume of menstrual blood are not related to pain intensity in endometriosis patients. Conclusion: There is no relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Profile of Ocular Fibrous Histiocytoma Tumors at Dr. M. Djamil General Hospital, Padang, Indonesia Eka Alpasra; Ardizal Rahman; Mardijas Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.716

Background: Ocular fibrous histiocytoma tumors originate from histiocytic cells or primitive mesenchymal cells. A fibrous histiocytoma is basically composed of a mixture of fibroblastic cells, histiocytes, blood vessels, and collagen in various proportions. This study aimed to determine the profile of ocular fibrous histiocytoma tumors at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study was a descriptive observational study. A total of 8 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 24 software, and univariate analysis was carried out. Results: The majority of subjects were female, with an age range of 41-60 years. The clinical symptoms felt by patients are the presence of a mass. The majority of study subjects had disease onset < 6 months, and tumor sizes were 1-5 cm. The majority of tumor locations are on the eyelid, and the histopathologic overview shows xanthelasma and dermatofibromas. Excision therapy is the therapy for the majority of research subjects. Conclusion: Most types of fibrous histiocytoma tumors at Dr. M. Djamil General Hospital, Padang, Indonesia, are benign type and locally aggressive.

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Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

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Kab. ogan ilir,

Sumatera selatan

INDONESIA