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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Disseminated Tuberculosis in Breastfeeding Mother: A Case Report Dewi Oktavia Djasmi; Roza Kurniati; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.734

Background: Disseminated tuberculosis is defined as the involvement of two or more extrapulmonary organs due to Mycobacterium tuberculosis infection, which spreads hematogenously. Disseminated tuberculosis is a life-threatening condition, especially if diagnosis and treatment are delayed. This study aimed to describe disseminated tuberculosis in a breastfeeding mother. Case presentation: A 21-year-old woman was admitted to Dr. M. Djamil General Hospital with chief complaints of shortness of breath. The symptoms were accompanied by chronic cough, fever, night sweats, and weight loss. From the physical examination, there was a decrease in left lung breath sounds as high as right intercostal V. On the gene expert results, the PCR was positive for Mycobacterium tuberculosis. Chest X-ray shows a miliary pattern and left pleural effusion. Pleural fluid analysis reveals the presence of exudate. Patients were treated with anti-tuberculosis drugs, namely Isoniazid, rifampicin, pyrazinamide, and ethambutol, with pyridoxine. Anti-tuberculosis drug therapy in the intensive phase is given for 2 months and is continued for 6-9 months for the continuation phase, depending on the patient's clinical condition. Breastfeeding was still continued in this case. The patient's baby is advised to be evaluated for active tuberculosis. Conclusion: There are no contraindications for giving anti-TB drugs to breastfeeding mothers unless the mother has mammary TB or drug-resistant TB. In children under 5 years who have close contact with active tuberculosis patients and, after being evaluated, do not have active tuberculosis, the child is treated as suspected latent TB infection with Isoniazid for at least 6 months and accompanied by pyridoxine administration.

The Effect of Apium graveolens (Linn) Extract on Reepithelialization of Incision Wounds: In Vivo Study Muhammad Avicenna Abdul Syukur; Endang Mahati; Vega Karlowee; Hermawan Istiadi; Indah Saraswati; Najatullah; Muflihatul Muniroh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.735

Background: A wound is a disorder of the continuity of the epithelial layer of the skin or mucosa and can result from physical or thermal damage. Proliferation and remodeling processes are important phases in incision wound healing. Celery is believed to have the potential to regulate the inflammatory phase and accelerate the process of proliferation and remodeling of wound tissue. This study aims to evaluate the potency of celery extract (Apium graveolens (Linn)) on incision wound healing in vivo. Methods: This study was an in vivo experimental study. A total of 24 rats were used in this study and divided into 4 treatment groups (2 control and 2 treatment groups). Analysis of epithelial thickness ratio and epithelial length was performed using SPSS using univariate and bivariate. Results: The control group had the lowest epithelial thickness ratio, followed by 50% extract, 75% extract, and finally, the gentamicin group. The length of newly formed epithelium in wounds treated with Apium graveolens (Linn) extract group 70% (mean 1.461 mm) was similar to that treated with gentamicin 0.1% (mean 1.457 mm) and much better than those treated without extract (0.869 mm). Conclusion: Celery extract (Apium graveolens (Linn)) has the potential to accelerate the process of reepithelialization of incision wounds in vivo studies.

Relationship between Febrile Seizures and the Incidence of Microcytic Hypochromic Anemia in Children at Sanjiwani General Hospital, Gianyar, Indonesia I Dewa Ayu Agung Diah Sutarini; Romy Windiyanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.736

Background: Febrile seizures are the most common seizures in children. As many as 2% to 5% of children aged less than 5 years have had seizures accompanied by fever, and most occurrences are at the age of 17-23 months. Microcytic hypochromic anemia causes hypoxic conditions and neuronal instability due to iron depletion. This study aimed to explore the relationship between febrile seizures and the incidence of microcytic hypochromic anemia in children at Sanjiwani General Hospital, Gianyar, Indonesia. Methods: This study was an analytic observational study with a cross-sectional approach. A total of 59 subjects participated in this study. Data analysis was carried out with the help of SPSS software in univariate and bivariate to determine the relationship between febrile seizures and microcytic hypochromic anemia. Results: There is a relationship between the incidence of febrile seizures and the incidence of microcytic hypochromic anemia, with p<0.05. This study also showed that the risk of febrile seizures increased 1.7 times higher in individuals with microcytic hypochromic anemia. Conclusion: There is a relationship between the incidence of febrile seizures and the incidence of microcytic hypochromic anemia in pediatric patients at Sanjiwani General Hospital, Gianyar, Indonesia.

Correlation between Facial Skin Damage Due to UV Exposure and Facial Skin Porphyrin Level: Study on Students of SMA Kalam Kudus II Jakarta, Indonesia Fendy Wellen; Sukmawati Tansil Tan; Yohanes Firmansyah; Hendsun Hendsun
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.737

Background: UV exposure causes physical and chemical damage. UV causes damage to the skin barrier physically due to the heating process. Meanwhile, chemically, UV causes the formation of oxidants which are responsible for the process of oxidative stress. Damage to skin cells causes loss of the body's natural barrier against various threats from microorganisms. Propionibacterium acnes is one of the commensal bacteria on the skin, which will produce products in the form of porphyrins. This study aimed to determine the correlation between UV-induced skin damage and porphyrin levels in SMA Kalam Kudus II Jakarta, Indonesia. Methods: This study was an analytic observational study with a cross-sectional approach. A total of 92 research subjects who were students of SMA Kalam Kudus II Jakarta, Indonesia, participated in this study. Facial skin porphyrin levels and levels of facial skin damage due to sun exposure (UV damage proportion) as measured by a skin analyzer. UV damage and porphyrin assessments according to the T Zone and V Zone regions and obtained the average results from the 3 regions. Correlation analysis was performed with the help of SPSS software. Results: The higher the percentage of skin damage due to UV correlated positively with the higher the percentage of porphyrin levels, with a value of r = 0.529. Conclusion: There is a positive correlation between UV-induced skin damage and porphyrin levels in students of SMA Kalam Kudus II Jakarta, Indonesia.

Alcohol-Induced Hyperosmolar Hyperglycemic State in Type 1 Diabetes Mellitus: A Case Report I Dewa Ayu Agung Diah Sutarini; Romy Windiyanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.738

Background: Adolescents with diabetes mellitus who consume alcohol increase the risk of developing diabetic ketoacidosis (DKA) and HHS. In addition, alcohol consumption has long-term adverse effects on the glycemic control of type 1 diabetes mellitus. This study aimed to describe cases of alcohol-induced hyperosmolar hyperglycemic state in adolescents with type 1 diabetes mellitus. Case presentation: A teenage boy, aged 15 years, came with his family to the ER with complaints of weakness. The patient also complained of persistent tingling in the legs for the last two weeks. Three days before entering the hospital, the patient also felt blurred vision that disturbed him while studying at school. The results of the physical examination stated that the general condition was weak, compos mentis, pulse 80x/minute, blood pressure 110/70 mmHg, respiratory rate 20x/minute, axillary temperature 36ºC, weight 65 kg, and height 165 cm. Examination of the extremities showed a slow return of skin turgor. Laboratory evaluation showed an increased leukocyte count (10.45x103/μL), and blood gas analysis showed mild acidosis (HCO3 24.3 mmol/L, PCO2 38.6 mmHg, PO2 82 mmHg, tCO2 26 mmol/L, pH 7.4, and SaO2 96%), HbA1c 14.2%, glucose at 621 mg/dL (hyperglycemia), C-peptide 0.87 ηg/dL. The patient was diagnosed with hyperglycemia, hyperosmolar state, type 1 diabetes mellitus, and mild dehydration. Conclusion: The main management of alcohol-induced hyperosmolar hyperglycemic state in type 1 diabetes mellitus is fluid resuscitation to achieve hemodynamic stability, correction of electrolyte abnormalities, gradual reduction of blood sugar levels, and hyperosmolality. Insulin administration to lower blood sugar levels is done after stable hemodynamics.

Relationship between Albumin Levels and the Incidence of Ascites in Patients with Liver Cirrhosis Vesri Yoga; Arnelis; Nasrul Zubir; Saptino Miro; Andry Kurniawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.739

Background: Patients with cirrhosis often develop hypoalbuminemia. In conditions of hepatic dysfunction, albumin synthesis is decreased due to hepatic dysfunction and abnormal distribution of portal blood flow. Ascites is a major complication and an important sign in the course of cirrhosis and is associated with 50% mortality after two years. 75% of patients' ascites etiology is liver cirrhosis, 10% malignancy, 3% heart failure, 2% tuberculosis, 1% pancreatitis, and others. Methods: This cross-sectional study was conducted from the medical records of patients with liver cirrhosis who were treated at the internal medicine section of Dr. M Djamil General Hospital, Padang, in 2015-2020. Patients with heart defects, malignancy, tuberculosis, pancreatitis, kidney failure, and incomplete medical record data were excluded from the study. Patients were grouped according to the presence or absence of ascites and albumin levels. Analysis using the chi-square test in 2020. Results: From 225 cases, 103 cases were analyzed. 77 were men (74.8%), and 26 were women (25.2%). The age of the patient was in the range of 40-60 years. No ascites were found in 30 people (29.1%), and 73 people (70.9%) had ascites. From normal albumin levels, five were without ascites, and four were with ascites. On mild hypoalbumin, 13 had no ascites, and 38 people had ascites. On severe hypoalbumin, 12 people were without ascites and 31 with ascites. A chi-square test was analyzed, and it was found that there was no relationship between the incidence of ascites and albumin levels (p 0.182). Conclusion: The incidence of ascites is not related to blood albumin levels.

Comparison of Antibacterial Effectiveness of Arabica Coffee Bean Extract (Coffea arabica L.) Roasted and Non-Roasted Against Bacteria Enterococcus faecalis Shirley Adriana; Phimatra Jaya Putra; Verawati Sinaga
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.740

Background: Dental caries that are not handled properly cause cavities and open the dental pulp so that it becomes a pathway for microorganisms to enter the root canals. The most common microorganisms found in root canal infections are Enterococcus faecalis. Arabica coffee beans have bioactive compounds such as alkaloids, saponins, and tannins, which inhibit the growth of bacteria. This study aimed to compare the antibacterial effectiveness of roasted and non-roasted Arabica coffee bean extracts against bacteria Enterococcus faecalis. Methods: This study was an in vitro experimental study. This research uses culture Enterococcus faecalis, which were divided into 10 groups (2 control groups, 4 treatment groups of roasted coffee beans, and 4 groups of non-roasted coffee beans). Inhibition zone diameter analysis was carried out with the help of SPSS using univariate and bivariate. Results: Non-roasted Arabica coffee bean extract showed better effectiveness in inhibiting bacterial growth Enterococcus faecalis, along with increasing the concentration of the extract. Conclusion: Non-roasted Arabica coffee bean extract is more effective as an antibacterial against the bacteria Enterococcus faecalis compared to roasted Arabica coffee bean extract.

Comparison of Dimensional Stability of Alginate Impressions by Spraying 0.5% Sodium Hypochlorite Against Kepok Banana Peel Extract (Musa paradisiaca Linn.) Cindy Denhara Wijaya; Mangatas Halomoan Parluhutan Hutagalung; Laurencia Kasih Putri Hulu
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.741

Background: The process of impressions of hard and soft tissues in the oral cavity is a fairly routine activity in dentistry. Alginate is an irreversible elastic impression material that is often used. Alginate can be disinfected using soaking or spraying techniques. This disinfection solution itself has side effects that are quite serious for patient health. This study aimed to find out Comparison of the dimensional stability of alginate impressions by spraying 0.5% sodium hypochlorite against kepok banana peel extract (Musa paradisiaca Linn.). Methods: This study was experimental research. The research object used was dimension of alginate impressions which were grouped into control and treatment groups. Assessment of the projection value of the antero-posterior (AP) and cross arch (CA) lines was carried out with digital calipers. Data analysis was carried out with the help of SPSS version 25 in univariate and bivariate. Results: The results of this study showed that the mean value of the AP and CA lines in the kepok banana peel extract treatment group did not show a significant difference with the control treatment (sodium hypochlorite 0.5%), p-value> 0.05. Conclusion: Spraying kepok banana peel extract with various concentrations did not cause changes in the dimensions of the alginate impressions.

Overview of Knowledge, Attitudes, and Behaviors Related to Halitosis in Online Motorcycle Taxi Drivers in Sei Putih Tengah Sub District, Petisah District, Medan, Indonesia Suci Erawati; Idamawati Nababan; Anisa Ulfah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.743

Background: Halitosis is a sign of dental and oral health problems. Halitosis is characterized by the presence of an unpleasant odor in the oral cavity. Halitosis is caused by many things, one of which is a result of impaired saliva production, which is caused by smoking. Online motorcycle taxi drivers are in a community that is very close to smoking. This study aimed to provide an overview of aspects of knowledge, attitudes, and behavior related to halitosis in online motorcycle taxi drivers in Sei Putih Tengah Sub District, Petisah District, Medan, Indonesia. Methods: Descriptive observational study. A total of 36 research subjects, namely online motorcycle taxi drivers, participated in this study. Observation of knowledge, attitudes, and behavior refers to a questionnaire developed by the halitosis clinic at the University of Basel, Switzerland. Univariate analysis was carried out with the help of SPSS software. Results: The majority of research subjects are independently aware of bad breath and experience similar complaints <1 year. The majority of research subjects felt bad breath after waking up in the morning. The majority of research subjects also stated that dentists were the choice for consultation regarding bad breath disorders. The majority of research subjects know the origin of bad breath, the source of bad breath, and know that smoking is the cause of bad breath. Most research subjects did not feel ashamed of other people even though they felt they had bad breath. Conclusion: Knowledge and behavior related to halitosis are good, although attitudes related to halitosis are not good among online motorcycle taxi drivers in Sei Putih Tengah Sub District, Petisah District, Medan, Indonesia.

Comparison of Antibacterial Effectiveness of Rambutan Leaf Extract (Nephelium lappaceum L.) and Tin Leaf Extract (Ficus carica L.) to Streptococcus mutans Member Reni Purba; Dian Soraya Tanjung; Rona Angelin Purba
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.744

Background: Caries is an infectious disease accompanied by damage to the surface tissue of enamel, dentin and extends toward the pulp. Microorganisms that have a role in the formation of caries, namely Streptococcus mutans. Rambutan leaves and tin leaves are plants that have an antibacterial effect. This study aimed to compare the antibacterial effects of rambutan and tin leaves on the bacteria Streptococcus mutans. Methods: In vitro experimental studies. A total of 30 petri dishes that have been added 1-2 ose of bacterial culture Streptococcus mutans and MHA (mueller hinton agar) were used in this study, with 10 test groups, namely 2 control groups, 4 rambutan leaves extract test groups, and 4 tin leaves extract test groups. Data analysis was carried out with the help of SPSS using univariate and bivariate. Results: Extracts of rambutan leaves and tin leaves show the ability to inhibit the bacterial growth of Streptococcus mutans, along with increasing the dose of the extract. However, the inhibition ability of tin leaf extract was not as great as that of rambutan leaf extract at the same concentration. Conclusion: Rambutan leaf extract (Nephelium lappaceum L.) has effectiveness as an antibacterial Streptococcus mutans more optimal than tin leaf extract (Ficus carica L.).

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Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA