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CERATA Jurnal Ilmu Farmasi
Published by STIKES Muhammadiyah Klaten
ISSN : 20891458     EISSN : 26851229     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology
CERATA Jurnal Ilmu Farmasi is a collection of publication journals, covering a lot of common problems or issues related to the Pharmaceutical sciences, including Pharmacetics, Biopharmacy, Drug Delivery Systems, Pharmaceutical Physics, Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Biotechnology and Microbiology, Pharmacology and Toxicology, Pharmacokinetics, Clinical and Community Pharmacy, Pharmaceutical Regulation and Marketing, Herbal Medicine
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Articles 7 Documents
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Search results for , issue "Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi" : 7 Documents clear
Pengaruh Suhu terhadap Stabilitas Larutan Vitamin C (Acidum ascorbicum) dengan Metode Titrasi Iodometri Putu Vellina Damayanti; I Gusti Ngurah Jemmy Anton Prasetia
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

The stability of pharmaceutical preparations is a very important criterion for a good production result where the stability of the drug can be influenced by external factors such as temperature. The sample used was a vitamin C solution with another name Acidum Ascorbicum (ascorbic acid) with a molecular formula of C6H8O6 and a molecular weight of 176.13 g / mol where the solution was tested for stability using the Iodometric titration method. Based on the calculation results, the vitamin C levels obtained in sample I (without heating) were 0.16644% w/v, in sample II (heating for 30 minutes) was 0.06376% w/v, in sample III (heating for 60 minutes) which is 0.15675% w/v, in sample IV (heating for 90 minutes) is 0.15288% w/v, and in sample V (heating for 120 minutes) is 0.16063% w/v. Thus, an increase in temperature can accelerate the occurrence of reactions that can disturb a substance's stability. Vitamin C The longer the heating time, the more vitamin C is oxidized, so that the remaining vitamin C levels will decrease due to the decomposition process.
Pengaruh Purifikasi Terhadap Kandungan Zat Aktif Dan Aktivitas Antioksidan Ekstrak Etanol 50% Daun Kelor (Moringa oleifera L.) Diyan Sakti Purwanto; Hari Susanti; Nining Sugihartini
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Purifikasi ekstrak etanol 50% daun kelor (Moringa oleifera L.) dilakukan untuk meningkatkan kandungan zat aktif flavanoid, β-karoten, saponin dan tanin yang memiliki aktivitas sebagai antioksidan. Tujuan penelitian ini adalah mengetahui jenis pelarut yang paling optimal antara etil asetat dan n-heksan dalam fraksinasi ekstrak etanol 50% daun kelor. Penelitian dimulai ekstraksi etanol 50% daun kelor dengan maserasi dan dilanjutkan evaporator kemudian waterbath sampai diperoleh ekstrak kental. Ekstrak kental yang diperoleh dari ekstraksi selanjutnya dilakukan purifikasi. Fraksinasi dengan melarutkan ekstrak kental etanol 50% daun kelor (E1) dan aquades pada suhu 70ºC kemudian ditambahkan etil asetat pada corong pisah hingga di peroleh fraksi etil asetat (E2), ekstrak kental etanol 50% daun kelor (E1) ditambahkan n-heksan pada corong pisah hingga terjadi pemisahan fase sehingga diperoleh fraksi n-heksana (E3). Ekstrak dan fraksi dievaluasi parameter meliputi kadar air ekstrak dengan gravimetri, kadar β-karoten dengan HPLC dan aktivitas antioksidan dengan DPPH. Data dianalisis statistik dengan taraf kepercayaam 95%. Hasil Penelitian menunjukkan bahwa kadar air ekstrak etanol 50% daun kelor adalah 4,16 dengan CV 4,62%. Kadar β-karoten paling optimal pada fraksi n-heksana (E3) kemudian etil asetat (E2) dan etanol 50% (E1) yaitu 1.48 ± 0.01%, 1.19 ± 005% dan 0.73 ± 0.01%. Sedangkan aktivitas antioksidan (IC50) paling optimal pada fraksi n-heksana (E3) kemudian etanol 50% (E1) dan etil asetat (E2) yaitu 40.83 ± 0.04 ug/ml, 47.75 ± 0.09 ug/ml dan 58.79 ± 0.10ug/ml. Nilai aktivitas antioksian menunjukkan pada fraksi n-heksana dan ekstrak etanol 50% termasuk dalam kategori sangat kuat sedangkan fraksi etil asetat termasuk dalam kategori kuat sehingga berpotensi sebagai antioksidan.
Pemeriksaan Kualitas Air Minum Secara Mikrobiologis di Daerah Bukit Jimbaran Arie Pradina Putri I Putu Mas
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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The main problem faced in drinking water consumtion is contamination both chemically and biologically. The increasing population in the Bukit Jimbaran area makes demand for drinking water increased. This study was aims to examine the quality of drinking water microbiologically in Bukit Jimbaran area. Research had been carried out in the Laboratory of Microbiology and Virology, Faculty of Mathematics and Natural Science, Udayana University by taking samples from 3 drilled wells and 3 refill drinking water depots randomly. This research was experimental used Most Probable Number (MPN) test for the microbiological of the water that consist of presumptive test using Lactose Broth (LB), confirmative test using Brilliant Green Lactose Broth (BGLB), and complete test using endo jelly media. The result of presumptive test showed two samples of drilled well drinking water and three samples of refill drinking water were positive for Coliform. The result of confirmative test and complete test showed that three refill drinking water samples were positive for Coliform faecal bacteria and E. coli, which showed that the samples were not suitable for consumption
Formulasi Sediaan Sabun Mandi Padat Dengan Zat Aktif Ekstrak Kulit Buah Alpukat (Persea Americana MILL) Zaenal Fanani; Vivin Rosvita; Nur Aisah; Novam Danu Pamungkas; Ilun Fadillah
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Avocado peel contains alkaloids, flavonoids and saponins, where these compounds have potential as antibacterial. This study aims to utilize avocado peel extract in the form of bath soap which has the potential to remove dirt, dead skin cells, dull skin amd prevent skin irritation. By paying attention to formula for the solid soap, in terms of addition 3 types of oil and variations in the concentration of coconut oil. This study used sample of avocado peel extract, Persea Americana Mill. The extraction method uses maceration, with 96% ethanol as solvent. Quality testing based on organoleptic, including (color, shape, and smell). Based on the pH value of soap, using universal indicator pH instrument. Quality testing also includes foam height and stability, moisture content, and free alkali which is carried out by the alkalimetric titration method. The pH value test results obtained an average of 10.6, so that it meets SNI 2016 which is 99-11. Testing the foam height with an average of 2.23 cm, so that it meets SNI 2016 which is 1.3-22 cm. Foam stability obtained an average of 25.62%, so that it meets SNI 2016 which is 60-70%. The moisture content obtained an average of 14.3%, so that it meets SNI 2016 which is maximum of 15%. And the alkali value obtained an average of 0.53%, does not meet SNI 2016 because the maximum alkali value is 0.1%.
Penetapan Kadar Tanin Dari Bunga Telang (Clitoria ternatea L.) Secara Permanganometri Choiril Hana Mustofa; Anita Agustina Styawan; Nofia Putri Lestari
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Telang flowers can be found thriving in watery areas in Indonesia, their purple flowers bloom throughout the year. Telang flowers have been studied to contain phenolic chemicals, flavonoids, anthocyanins, flavonol glycosides, kaempferol glycosides, quercetin glycosides, myristetin glycosides, terpenoids, flavonoids, tannins and steroids. Tannins are plant polyphenols that function to bind and precipitate proteins. In the world of tannin medicine serves to treat diarrhea, stop bleeding, and treat hemorrhoids. There are two main types of tannins namely condensed tannins and hydrolyzed tannins. The purpose of this study was to determine the tannin content in the extract of telang (Clitoria ternatea L.) flowers using the permanganometric method. Determination of tannin levels by permanganometric method. Permanganometry is a titration method using potassium permanganate, which is a strong oxidizing agent as a titrant. This property of KMnO4 is known as an auto-indicator. The result of the determination of the tannin content of the telang flower (Clitoria ternatea L.) by permanganometry was 13.86% b/b.
Artikel Analisis Kadar Tanin Ekstrak Metanol Bunga Telang (Clitoria ternatea L.) dengan Metode Spektrofotometri UV-Vis Sana Nurul Khasanah; Sutaryono; Qory Addin
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : UNIVRSITAS MUHAMMADIYAH KLATEN

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Abstract

Telang flower (Clitoria ternatea L) has many benefits for humans in terms of medicine. Telang flower (Clitoria ternatea L) is efficacious for treating bronchitis, red eyes, throat, skin diseases, urinary disorders and anti-toxins. Telang flower has tannin compounds that function as antioxidants and antimicrobials. The purpose of this study was to determine the tannin content of the telang flower (Clitoria ternatea L) using the UV-Vis Spectrophotometry method. The research method used is observational. The population in this study was the telang flower (Clitoria ternatea L), the telang flower was extracted using the maceration method with 70% methanol as solvent. Quantitatively analyzed using UV-Vis Spectrophotometry method. The results showed that the quantitative test using UV-Vis Spectrophotometry at a wavelength of 753.5 nm with an absorbance of 1,352. The standard curve for gallic acid is y = 0.0085x – 0.0835, the value of r = 0.9912. The average tannin content obtained is 1.611% (w/w).
Tingkat Pengetahuan Mahasiswa DIII Farmasi Stikes Muhammadiyah Klaten Terhadap Covid – 19 Muchson Arrosyid; Rahmi Nurhaini; Rosi Nur Indahsari
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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The Covid-19 pandemic is the event of the 2019 coronavirus disease spreading around the world. The role of the level of knowledge is very important to be able to determine decisions in a person's behavior so that it can be a strong basis for suppressing the number of Covid-19 infections so that they do not increase. The purpose of this study was to determine the level of knowledge of DIII Pharmacy students of STIKES Muhammadiyah Klaten against Covid-19. This research uses descriptive research method, the sampling technique used is Proportionate Stratified Random Sampling where the sample used is DIII Pharmacy students of STIKES Muhammadiyah Klaten as many as 68 respondents. The data collection tool in this research is a questionnaire and the data analysis used is univariate. The results showed that the knowledge of DIII Pharmacy students of STIKES Muhammadiyah Klaten on Covid-19 for the high category was 75%, the medium category was 23.5%, and the less category was 1.5%. Based on the characteristics of respondents with high knowledge, namely at the age of 19 years (25%), female gender (63.2%), and level II (26.5%).

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