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Contagion: Scientific Periodical Journal of Public Health and Coastal Health
Published by Universitas Islam Negeri Sumatera Utara
ISSN : -     EISSN : 26850389     DOI : 10.30829/contagion
Core Subject : Health,
Health Professions Public Health
Contagion: Scientific Periodical Journal of Public Health and Coastal Health, A Scientific Periodic Journal of Public Health published by the Public health Study Program of The Faculty of Public Health UINSU Medan. This Journal prioritiez the collaboration of lecturers and students with scope of the discussion is about Public Health, Health and Islam, and Coastal Health. This Journal is published twice, published on June and December.
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Articles 518 Documents
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Effects of Online Prenatal Yoga on Anxiety Level and Quality of Life Among Third Trimester Pregnant Women in North Cikarang District Urbaningrum, Bambang Amelia Fajriati; Pramatirta, Akhmad Yogi; Sari, Puspa; Susiarno, Hadi; Tarawan, Vita Murniati; Iskandar, Shelly
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.26236

Abstract

The third trimester of pregnancy, is a vulnerable period for anxiety due to physical changes, sleep disturbances, hormonal shifts, and concerns about childbirth. According to statistics from the WHO, up to 10% of pregnant women and 13% of postpartum women suffer from mental health problems, among which the prevalence of prenatal anxiety is as high as 15%. These conditions may impair maternal and fetal health and reduce quality of life. Prenatal yoga, especially movements targeting the psoas muscle, has been proposed to alleviate stress and anxiety. This study aimed to examine the effects of prenatal yoga on anxiety levels and quality of life among women in the later stages of pregnancy in North Cikarang District. A total of 64 participants took part in this quasi-experimental study. They were allocated into two groups based on health centers: an intervention group (n=32), which received eight online prenatal yoga sessions, and a control group (n=32), which continued routine antenatal care. To assess the impact of the intervention, anxiety levels were evaluated both before and after the treatment using the “Perinatal Anxiety Screening Scale (PASS)”, and quality of life was measured using the “World Health Organization Quality of Life Scale-Brief (WHOQOL-BREF)”. Data analysis was performed using the Wilcoxon and Mann-Whitney statistical tests. The findings revealed a significant decrease in anxiety levels among participants in the intervention group compared to those in the control group (p < 0.001). Furthermore, participants who engaged in prenatal yoga experienced notable enhancements in their quality of life, encompassing physical, psychological, social, and environmental aspects (p < 0.001). Overall, the study concludes that prenatal yoga serves as an effective approach to alleviating anxiety and enhancing the overall quality of life for women in the later stages of pregnancy in North Cikarang District Keywords: Anxiety, Third-Trimester Pregnancy, Quality of Life, Pregnant Women, Online Prenatal Yoga
Reduction of VEGF Levels by Phaleria macrocarpa Flavonoids in an Endometriosis Mouse (Mus musculus) Model Diarsy, Amina; Amalia, Fany Hardiati; Sutrisno, Sutrisno; Nurseta, Tatit; Ratnaningrum, Safrina Dewi
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25355

Abstract

Endometriosis occurs when endometrial-like cells proliferate at ectopic sites outside the uterus. The advancement of endometriotic lesions is strongly influenced by VEGF, as it stimulates the formation of new blood vessels. In contrast, flavonoids derived from Phaleria macrocarpa extract possess inhibitory effects on both pro-inflammatory signaling molecules and pro-angiogenic pathways. This study investigated the effects of flavonoids from Phaleria macrocarpa extract on VEGF levels in the peritoneal fluid of endometriosis mouse models. This research employed a post-test-only control group experimental design. A total of thirty mice (Mus musculus) were assigned to six groups: a healthy control group, an untreated endometriosis group, and four endometriosis groups receiving isolated flavonoids from Phaleria macrocarpa extract at doses of 3.75, 7.5, 15, and 30 mg/mouse/day (n=5). Peritoneal fluid samples were collected from all groups to examine VEGF levels using ELISA. The results were expressed as mean ± SD and subsequently evaluated using a one-way ANOVA with LSD post-hoc test at a significance level of p-value < 0.05. Flavonoids at the dose of 30 mg/day significantly decreased the VEGF levels compared to the group of endometriosis mouse models (p-value=0.001). Flavonoids decreased VEGF levels as an angiogenic factor in peritoneal fluid, which may play a role in the proliferation of endometriosis tissue. Keywords: Flavonoid, Phaleria macrocarpa, VEGF, Endometriosis
Bladder Rhabdomyosarcoma in Adolescents at a Tertiary Centre in Indonesia: A Case Series with Focus on Age-Specific Treatment Response and Diagnostic Challenges Kharisma, Andhyka Brillian; Hendri, Ahmad Zulfan; Soeroharjo, Indrawarman
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25908

Abstract

Bladder rhabdomyosarcoma (RMS) is a rare type of soft tissue cancer in adolescents, and it often shows up with vague urinary symptoms that can be easy to miss. Compared to younger children, teenagers tend to respond less well to treatment and have lower survival rates, even when given equally intensive therapies. This difference seems to come from both biology and the challenges of diagnosis. We saw two adolescent male patients, aged 17 and 21, who came in with blood in the urine. Imaging with ultrasound and contrast CT scans revealed solid bladder masses with clear hyperenhancement (delta HU 37-38). Pathology and immunohistochemistry (desmin, myogenin, MyoD1) confirmed embryonal RMS, one conventional type and one botryoid variant. Both were staged as pT2bN0M0. Each patient underwent partial cystectomy after an initial TURBT. Neither received chemotherapy. Case 1 had a laparoscopic partial cystectomy in February 2023, while Case 2 had surgery three years earlier. Both were followed closely with cystoscopy every 3-6 months. At 30 and 36 months post-surgery, respectively, both remain disease-free, with normal bladder function and no need for catheters. These cases show that adolescents with localized bladder RMS can do well when the tumor is completely removed, even without chemotherapy. CT hyperenhancement helps raise suspicion, while immunohistochemistry confirms the diagnosis. Partial cystectomy not only achieves complete resection but also preserves bladder function. Ongoing surveillance is critical, and age-specific treatment strategies, focused on surgery plus careful follow-up, deserve further study for this group. Keywords: Rhabdomyosarcoma, Bladder Tumour, Adolescent, Age-Specific Treatment, Diagnostic Delay, Bladder Preservation, Partial Cystectom
Determinants of Relapse Among Schizophrenia Patients in West Kalimantan: A Cross-sectional Study Kirana, Wahyu; Safitri, Dewin; Anggreini, Yunita Dwi
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.26541

Abstract

Relapse can affect functional impairment, rehospitalization, readmission, and long-term disability among schizophrenia patients. Although several factors, such as medication adherence, internalized stigma, and family support, are recognized as determining factors, there is still limited evidence from the Indonesian context, especially in West Kalimantan. This study aimed to evaluate the factors associated with relapse among schizophrenia patients. A quantitative, cross-sectional design was conducted at a mental hospital in West Kalimantan. A total of 63 patients and their families participated in this study, selected using a consecutive sampling technique. The MMAS-8, ISMI-9, and family support questionnaires were used to collect the data; patients completed the MMAS-8 and ISMI-9 questionnaires directly, whereas their&#8194;families completed the family support questionnaire using a Google Form. The patients' medical reports were used to identify the relapse rate. Data were analyzed using Fisher's exact test and multivariate logistic regression.? Fisher's exact test showed that medication adherence was significantly associated with relapse (p = 0.02, p < 0.05), while internalized stigma and family support were not associated (p = 0.21; p = 0.12, p > 0.05). Medication adherence was the strongest factor associated with relapse, with an Adjusted Odds Ratio (AOR) of 2.091. This finding suggests that schizophrenia patients with a low level of medication adherence were over two times more likely to experience a lifetime relapse compared to those with a higher level of medication adherence?Keywords: ?Family Support, Internalized Stigma, Medication Adherence, Relapse, Schizophrenia
Immunohistochemical Profile of Er, Pr, Her2, and Ki-67 In Breast Cancer Patients Nurprilinda, Marliana; Manalu, Erida; Simanjuntak, Tiroy Sari B.; Andreas, Reinhard Christovel
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25681

Abstract

Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide, with hormonal factors playing a critical role in tumor development and progression. This study aims to describe the immunohistochemical profile of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 in breast cancer patients at MRCCC Siloam Semanggi Hospital in 2022. A retrospective descriptive study was conducted using a total sampling of anatomical pathology archives, comprising 316 breast cancer cases. The most common age group was 40-49 years. ER positivity was observed in 229 patients (72.5%), while PR positivity was found in 183 patients (57.9%). HER2 overexpression (3+) was identified in 75 patients (23.7%); cases with equivocal HER2 (2+) required confirmation by in situ hybridization. High proliferative activity, indicated by Ki-67 ≥20%, was present in 262 patients (82.9%). These findings indicate a predominance of hormone receptor-positive tumors with high proliferative indices, highlighting the importance of immunohistochemical profiling in guiding prognosis assessment, therapeutic decision-making, and selection of targeted and systemic treatments in breast cancer management. Keywords: Breast Cancer, Immunohistochemistry, Estrogen Receptor (ER), HER2, Ki-67
Environmental and Behavioral Factors of “3M Plus” Practices (Cover, Drain and Recycle) Associated with Dengue Fever Incidence in Cilongok District, Banyumas Regency Lailatul Mardhiyah; Suhartono Suhartono; Mursid Raharjo; Nur Endah Wahyuningsih; Sulistiyani Sulistiyani
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 8, No 1 (2026): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v8i1.27790

Abstract

Dengue hemorrhagic fever has been a public health concern in Cilongok District evident by a sharp increase in its cases in the last two years. This study aims to analyze the relationship between physical, biological, and social environmental factors, as well as the behavior of 3M Plus, with the incidence of dengue hemorrhagic fever in Cilongok District, Banyumas Regency. The research followed a quantitative approach of observational analytics with a case-control design. A total of 60 respondents were involved, consisting of 30 cases and 30 controls that were selected using neighborhood-matched controls based on a residential distance of less than 100 meters. Data analysis was carried out using chi square test and logistic regression. The results of the study show a cumulative increase in dengue cases from 26 cases in 2023 to 126 cases in 2024. Spatial analysis showed an uneven distribution of cases with high concentrations in densely populated areas, especially Langgongsari Village, Pageraji Village, and Panusupan Village. Indoor temperature was significantly associated with the incidence of dengue (p = 0.038; OR = 3.500), as well as air humidity (p = 0.039; OR = 3.455). Biological factors measured through the House Index (p = 0.398; OR = 1.902) and Container Index (p = 0.398; OR = 1.902) do not indicate a meaningful relationship. In social environmental factors, the habit of hanging clothes was significantly related to the incidence of dengue (p = 0.004; OR = 5.675), as well as the absence of gauze wire in house ventilation (p = 0.008; OR = 5,231). The other 3M Plus behavioral variables did not show a significant relationship. This study shows that the incidence of dengue fever in Cilongok District is influenced by microclimatic conditions in the house and specific behaviors that increase the chances of human-vector contact. Efforts to control dengue need to integrate ventilation and humidity management of the house with targeted behavior change interventions, especially reducing clothing storage in the room and increasing household physical protection Keyword: dengue hemorrhagic fever, environmental factors, 3M Plus behavior
Prognostic Value of the Neutrophil–Lymphocyte Ratio for 28-Day Mortality in Hospitalized Pulmonary Tuberculosis Ali Napiah Nasution; Perwita Sari Sinaga; Sri Wahyuni Nasution
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 8, No 1 (2026): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v8i1.26437

Abstract

Pulmonary tuberculosis (TB) remains a leading cause of infectious mortality. The neutrophil–lymphocyte ratio (NLR) is an accessible inflammatory index that may stratify short-term risk in hospitalized TB. To examine whether admission NLR predicts 28-day mortality in pulmonary TB. We conducted a retrospective cohort at Royal Prima General Hospital, Medan (1 January 2023–31 December 2024), among adults (18–65 years) admitted with active pulmonary TB. Demographics, TB category, day-1 neutrophil and lymphocyte counts (to derive NLR), and 28-day outcomes were abstracted from medical records. NLR was analyzed as a continuous variable and as a binary variable using a receiver operating characteristic (ROC)-derived cut-off. Group comparisons used t/Mann–Whitney tests as appropriate; prognostic performance was assessed by area under the ROC curve (AUC). The results of the analysis show that NLR has a significant ability to identify patients at risk of death during treatment. This finding has important implications for clinical management, where the use of NLR as a routine biological marker can assist medical personnel in triage and more timely therapeutic decision-making. Therefore, the application of this parameter is expected to help reduce mortality rates through closer monitoring of high-risk patient groups. Keywords: Pulmonary Tuberculosis, Neutrophil–Lymphocyte Ratio, 28-Day Mortality, Prognosis, Biomarkers.
Prevalence Study of Prehypertension, Hypertension, and Risk Factors in the Adult Population in Medan, Indonesia: A Community Cross-Sectional Study Siregar, Fazidah Aguslina
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 2 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i2.25520

Abstract

Background: Prehypertension and hypertension are serious public health issues that are frequently disregarded. The condition is linked to morbidity and is known to increase the risk of kidney, cardiovascular, and cerebrovascular illness. Objectives: The objective of this study was to determine the prevalence of pre hypertension and hypertension and factors associated among the adult population Settings and Design: This was an observational study with cross sectional design. Methods and Materials: The sample included 200 recruits from 4 subdistricts in Medan city that selected using purposive sampling. Data were collected by interviews and measurements. Statistical analysis: Data were analyzed using multiple logistic regression. Results: Prevalence of hypertension as 24.5% an hypertension as much as 34.5%. The majority of respondents were aged 45 years or younger (66.0%), 185 were female (92.5%), 124 were low income (62.0%), 143 had no family history (71.5%), 95 were overweight (47.5%), 137 were normal blood glucose, 183 had no smoking habit (91.5%), and 134 were physically inactive (67,0%). Of the Multiple Logistic regression showed that Basal metabolic index and daily vegetables and fruit consumption are significant factors contribute to prehypertenion, while age, Basal metabolic index and daily vegetables and fruit consumption are significant factors contribute to hypertension among adult population in Medan City. Conclusions: BMI and daily vegetables and fruit consumption are signifant factors to pre hypertension, while BMI and daily vegetables and fruit consumption are significant factors to hypertension among adult population. Intervention programs should be primarily focused on the risk factors such as losing weight and maintaining an ideal body weight and implementing healthy lifestyle. Keywords:  Pre Hypertension, Hypertension, Prevalence, Determinant.
Association Between Home Physical Environment, Individual Characteristics and Personal Hygiene and the Incidence of Leprosy in Cirebon Regency Irene Silitonga; Nurjazuli Nurjazuli; Sulistiyani Sulistiyani; Budiyono Budiyono; Suhartono Suhartono
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 8, No 1 (2026): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v8i1.27397

Abstract

Leprosy is a contagious disease caused by the bacterium Mycobacterium leprae, which attacks the peripheral nerves and skin. This study aims to analyze whether household ventilation, housing density, window availability, wall and floor conditions, room separation, and personal hygiene behaviors are significantly associated with leprosy incidence in Cirebon regency.  This research is an analytical observational study with a case-control design, involving 77 case respondents and 77 controls randomly selected. Data were collected through observation and interviews regarding home conditions and personal habits, and then analyzed using the chi-square test. The results show that the variables of ventilation size (p-value < 0.001 and OR = 5.361), window condition (p-value < 0.001 and OR = 3.640), room separation (p-value < 0.001 and OR = 6.249), and occupancy density (p-value = 0.014 and OR = 2.387) were significantly associated with the incidence of leprosy, while floor type (p-value = 0.297 and OR = 1.539) and wall type (p-value = 0.250 and OR = 1.543) were not associated with leprosy incidence. Regarding personal hygiene factors, knowledge (p-value < 0.001 and OR = 7.125), attitude (p-value < 0.001 and OR = 6.818), shared towel use (p-value < 0.001 and OR = 5.2), and nail-cutting habits (p-value < 0.001 and OR = 3.433) had a significant effect on leprosy, while bathing frequency (p-value = 0.294 and OR = 1.539) did not show a significant relationship. The findings indicate that the physical housing environment and personal hygiene are associated with leprosy occurrence in Cirebon Regency, suggesting that control efforts should prioritize housing improvements and the promotion of proper hygiene practices Keyword: Leprosy, Physical Home Environment, Knowledge, Attitude, Personal hygiene
The Effect of Curcumin on Reactive Oxygen Species (ROS) Levels in the Hearts of Wistar Rats (Rattus norvegicus) as a Preeclampsia Model Sukaji, Lina Zafirah; Pertiwi, Berliana Noviasih; Rahardjo, Bambang; Khotimah, Husnul
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25816

Abstract

Abstract Background: Reactive Oxygen Species (ROS) are reactive oxygen molecules that play a central role in the pathogenesis of preeclampsia through oxidative stress mechanisms. Elevated ROS levels trigger damage to membrane lipids, proteins, and DNA, as well as activate inflammatory pathways, leading to injury of target organs, including the heart. Curcumin, a polyphenolic compound derived from Curcuma longa, possesses antioxidant and anti-inflammatory properties with the potential to suppress ROS production and improve cellular function. Objective: To examine the relationship between ROS and curcumin by integrating experimental findings in a Wistar rat preeclampsia model with supporting literature. Methods: A literature review was conducted through searches in PubMed, Scopus, and Google Scholar using the keywords “Reactive Oxygen Species,” “Curcumin,” and “Preeclampsia.” Primary data were obtained from thesis research with a post-test only control group design, using L-NAME induction to generate a preeclampsia model and administering curcumin at a specific dose. ROS levels were measured using the spectrophotometry method. Results: The study showed that ROS levels in the preeclampsia group increased significantly compared to the control group (p < 0.05). Curcumin administration reduced ROS levels by 39.21% compared to the preeclampsia group, approaching control values. These findings are consistent with literature reports indicating that curcumin suppresses ROS through NADPH oxidase inhibition, increased antioxidant enzyme activity, and modulation of the NF-κB pathway. Conclusion: Curcumin significantly reduces ROS levels in the preeclampsia model and has the potential to serve as an adjunctive therapy in preventing complications mediated by oxidative stress. Keywords: Curcumin, Reactive Oxygen Species, Preeclampsia, Oxidative Stress, Antioxidant.

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