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Contagion: Scientific Periodical Journal of Public Health and Coastal Health
Published by Universitas Islam Negeri Sumatera Utara
ISSN : -     EISSN : 26850389     DOI : 10.30829/contagion
Core Subject : Health,
Health Professions Public Health
Contagion: Scientific Periodical Journal of Public Health and Coastal Health, A Scientific Periodic Journal of Public Health published by the Public health Study Program of The Faculty of Public Health UINSU Medan. This Journal prioritiez the collaboration of lecturers and students with scope of the discussion is about Public Health, Health and Islam, and Coastal Health. This Journal is published twice, published on June and December.
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Articles 518 Documents
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Relationship between Clinicopathological Features and Expression of COX-2 among Colorectal Cancer Patients: A Prospective Observational Study Romdhoni, Mohamad; Lukman, Kiki; Rudiman, Reno; Purnama, Andriana; Sulthana Degrees, Bambang Am'am Setya; Ruchimat, Tommy; Wijaya, Alma; Degrees, Yunia Sribudiani; Nugraha, Prapanca
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.24233

Abstract

Colorectal cancer (CRC) is the third most common cancer globally and a leading cause of cancer-related mortality. Cyclooxygenase-2 (COX-2) plays a critical role in CRC pathogenesis by promoting inflammation, tumor proliferation, and metastasis. COX-2 inhibitors, such as NSAIDs, have shown potential in reducing CRC progression. However, the relationship between COX-2 expression and clinicopathological features remains controversial. This study aims to assess the correlation between COX-2 expression and clinicopathological characteristics in CRC patients in Indonesia. A prospective observational study was conducted on 81 CRC patients at a tertiary hospital in West Java, Indonesia, from January to June 2024. COX-2 expression was quantified using qPCR from tumor tissue samples. Clinicopathological data, including age, sex, tumor grade, stage, and complications, were collected and analyzed. Among the 81 participants, 81.5% were over 50 years old. Low-grade adenocarcinoma was the most prevalent histopathological type (73%), followed by high-grade adenocarcinoma (11%) and mucinous adenocarcinoma (11%). The majority of cases were in regional or early stages (74%), while 26% were in late stages. Higher COX-2 expression was more frequent in males, rectal tumors, high- grade adenocarcinomas, advanced stages, and metastatic cases. Although no statistically significant association was found, a trend toward increased COX-2 expression in advanced CRC was observed. No significant association was found between COX-2 expression and clinicopathologic characteristics of CRC. However, higher COX-2 expression may be associated with advanced disease. Keyword: Clinicopathological features, Colorectal cancer, Cyclooxygenase-2, Inflammation, Metastasis
Peer Educators in Religious Moderation and Mental Resilience through Strengthening Religious: Moderation Writing Classes Budiman, Budiman; Putra, San; Siregar, Prima Yanti; Siregar, Putra Apriadi; Ramadi, Bagus; Nabila, Zahrani; Adinda, Faiza; Safira, Putri; Saragi, Dhea Rizky Fitri; Widadi, Ryanda Iqbaal Pradipta
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.26462

Abstract

This community service program addressed the need to strengthen religious moderation and mental resilience among students (santri) in Indonesia's diverse socio-religious context. Implemented at Pesantren Ulumul Qur'an, the initiative designed and evaluated an empowerment model that integrated two core components: the training of peer educators and the facilitation of a religious moderation writing class. The primary objective was to enhance the santri's knowledge, attitudes, and practical skills related to religious moderation and emotional management through a participatory, peer-based learning approach. The methods involved a series of structured activities, including training workshops, mentoring sessions, and facilitated writing and peer-review discussions, engaging a total of 31 santri. Data collected through pre- and post-program questionnaires revealed significant positive outcomes. The results showed marked improvements in several key areas: santri participation in writing activities increased, the consistent use of credible references in their writing rose from 25.8% to 38.7%, the practice of outlining arguments before writing grew from 38.7% to 67.7%, and the application of polite and inclusive language became more prevalent. Furthermore, the santri exhibited a strong consensus in supporting democratic values, interfaith cooperation (96.8%), and the protection of minority rights (96.8%). In conclusion, this service program effectively demonstrates that a model combining peer education and critical literacy through writing is a powerful tool for fostering a generation of santri who are not only knowledgeable and resilient but also active promoters of moderation and harmony in society. Keywords: Religious Moderation, Peer Educator, Writing Class, Santri, Community Empowerment.
Therapeutic Potential of Phaleria Macrocarpa Flavonoid Extract Regulating Rantes in Endometriosis Amalia, Fany Hardiati; Diarsy, Amina; Sutrisno, Sutrisno; Ratnaningrum, Safrina Dewi
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25587

Abstract

Endometriosis is a long-term inflammatory disease that affects women of childbearing age. It is caused by endometrial tissue growing in places other than the uterus. RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) and other important inflammatory mediators are very important in making the inflammatory responses related to this disorder worse. The aim of this study was to evaluate the impact of the ethanolic extract of flavonoids derived from the fruit of Phaleria macrocarpa (Mahkota Dewa) on RANTES levels in a rat model of endometriosis. Thirty female rats were divided into six groups: one healthy control group, one endometriosis control group, and four treatment groups that received doses of 3.75, 7.5, 15, and 30 mg/rat/day of the extract, respectively. The endometriosis model was established by transplanting myometrial and endometrial tissues from a patient with adenomyosis into the peritoneal cavity of immunosuppressed rats. Once the model was set up, the rats got the extract every day for 15 days in a row. We used the ELISA method to measure RANTES levels and histological and immunohistochemical analyses to look at ERβ expression. The results showed that the endometriosis control group (K+) had the highest levels of RANTES (64.05 ? 1.86 pg/mL). Surprisingly, the group that got 30 mg/rat/day (P4) had the biggest drop in RANTES levels (45.95 ? 1.07 pg/mL). Moreover, an upregulation of ERβ expression was observed in rats with induced endometriosis, evidenced by intensified brown staining, succeeded by a dose-dependent reduction, signifying modulation of estrogenic activity. In summary, the administration of the ethanolic flavonoid extract from Phaleria macrocarpa significantly reduced RANTES levels in rats with endometriosis, underscoring its potential as an alternative treatment for managing inflammation related to endometriosis.?Keyword: Keywords: Phaleria macrocarpa, flavonoid, endometriosis, RANTES
Dengue Fever Control and Determinants of Dengue Incidence at Huta Rakyat Public Health Center 2024 Kaloko, Aldi Munawar; Pane, Masdalina; Sitorus, Mido Ester Juniati; Nababan, Donal; Harianja, Ester Saripati
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 2 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i2.26528

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern in Indonesia, where it is endemic and frequently leads to outbreaks. Dairi Regency, particularly the Huta Rakyat Public Health Center area, has experienced a marked increase in DHF cases over the past two years. This study aims to analyze the implementation of the dengue control program and identify factors associated with DHF incidence.This research used a sequential explanatory mixed-methods design, beginning with a quantitative phase followed by a qualitative phase to explain and enrich the quantitative findings. The quantitative component employed a cross-sectional survey of 100 respondents, analyzed using logistic regression. The qualitative phase involved 10 in-depth interviews, field observations, and document reviews, with data analyzed through thematic analysis.Quantitative findings indicated that DHF incidence was significantly associated with the waste disposal system (OR = 5.67; 95% CI: 1.773 17.479), attitude (OR = 3.316; 95% CI: 1.032 10.656), and knowledge (OR = 3.057; 95% CI: 1.016 9.198). Poor waste management emerged as the dominant factor, increasing the risk of DHF by 5.67 times. Qualitative findings supported these results, revealing persistent challenges in dengue control, including limited human resources, weak cross-sectoral coordination, irregular community engagement in 3M Plus activities, and a reactive approach that prioritizes fogging only after cases appear. The study recommends strengthening community-based prevention activities, improving waste management through stronger cross-sectoral collaboration, and implementing routine environmental surveillance to inform sustainable intervention planning. These efforts are expected to enhance the effectiveness and long-term sustainability of dengue control in the Huta Rakyat Public Health Center area. Keywords: Dengue Hemorrhagic Fever, Risk Factors, Control, Public Health Center.
The Effectiveness of Sialang Honey in Burn Healing Through the Expression of Vascular Endothelial Growth Factor (VEGF) in Rattus norvegicus Rubenzani, Firdath; Rizal, Syamsul; Amirsyah, Mirnasari; Budiman, Budiman; Khairan, Khairan
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.24978

Abstract

Full-thickness burns require rapid revascularization to prevent tissue necrosis and support the healing process. Sialang honey, a wild multifloral honey from Indonesia, has traditionally been used for wound care, but its specific mechanism in modulating angiogenesis remains poorly understood. This study aimed to evaluate the effectiveness of Sialang honey on the expression of Vascular Endothelial Growth Factor (VEGF) in a mouse model with full-thickness burns. A true experimental study with a post-test only control group design was conducted using 27 male Wistar rats (Rattus norvegicus). Full-thickness burns were induced and treated daily for 14 days. Rats were randomly divided into three groups: Negative Control (0.9% NaCl), Treatment (Topical Sialang Honey), and Positive Control (1% Silver Sulfadiazine). Skin tissue was collected on days 5, 7, and 14. VEGF expression was detected using immunohistochemical (IHC) staining and measured via H-Score. Data were analyzed using One-Way ANOVA and Post-Hoc LSD Test (p<0.05). Treatment with Sialang Honey significantly increased VEGF expression compared to the negative control group. Peak expression occurred on day 7 (mean difference vs. control: p=0.000), indicating strong angiogenesis during the proliferation phase. Notably, VEGF levels in the honey group decreased significantly on day 14 (p<0.05), mimicking the physiological transition to the remodeling phase. The honey group showed a superior angiogenic response compared to Silver Sulfadiazine on day 7. Sialang honey effectively accelerated burn wound healing by modulating VEGF expression promoting an initial surge in angiogenesis followed by a physiological decline. These findings support the potential of Sialang honey as an effective topical agent for burn management. Keywords: Sialang Honey, Vascular Endothelial Growth Factor (VEGF), Angiogenesis.
Strengthening Self-Efficacy in Personal Hygiene Among Children of Indonesian Migrant Workers in Malaysia Susanti, Nofi; Annisa, Aulia; Siregar, Putra Apriadi; Siregar, Prima Yanti; Apriliani, Apriliani; Suraya, Rani; Rezebri, Muhammad; Hafsah, Hafsah
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.26399

Abstract

Children of migrant workers often face limited access to basic services and health education, which can negatively affect their personal hygiene practices. This community engagement initiative aimed to enhance self-efficacy and improve hygiene knowledge and behaviors among migrant children through simple, enjoyable, and contextually relevant approaches. The program was implemented at Sanggar Belajar Negeri Sembilan, Malaysia, in July 2025, involving a total sample of 30 children aged 7-13 years. The intervention combined interactive lectures, demonstrations of the seven-step of proper handwashing, or what is commonly known as CTPS or Cuci Tangan Pakai Sabun, and toothbrushing techniques, as through a modified educational board game based on Snakes and Ladders. Monitoring was conducted descriptively through baseline and final observations, along with informal oral questioning (without formal questionnaires) to assess changes in knowledge, attitudes, participation, and signs of self-efficacy. The results indicated meaningful practical improvements: over 80% of participants could identify 3-5 correct hygiene practices; children showed increased confidence in demonstrating the seven CTPS steps and expressed commitment to brushing their teeth at least twice daily; and high levels of active participation were observed (≥25 children engaged in discussions, Q&A, and games until the end of the session). The program was well received by both participants and facilitators, suggesting that a combination of brief lectures, simulation, and gamification is practically effective for promoting hygiene in migrant community contexts Keywords: Personal Hygiene, Migrant Children, Indonesia, Self-Efficacy, Malaysia
Therapeutic Effect of Curcumin on Hepatic iNOS Expression in a Rat (Rattus norvegicus) Preeclampsia Model Sururi, Desy Aulina; Rizki, Mutiara Putri Nanda; Rahardjo, Bambang; Ariani, Novida
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25824

Abstract

Preeclampsia is a pregnancy-specific disorder characterized by hypertension after 20 weeks of gestation and multisystem involvement, including hepatic dysfunction. Amplified oxidative stress and systemic inflammation contribute to liver damage, partly through the stimulation of inducible nitric oxide synthase (iNOS). Curcumin, a polyphenol derived from Curcuma longa, possesses strong antioxidant and anti-inflammatory properties and has been reported to inhibit iNOS expression in various disease models. The objective of this study was to evaluate the effect of curcumin on hepatic iNOS protein expression in a rat model of preeclampsia. A true experimental post-test-only control group design was employed. Twenty-five pregnant Wistar rats were randomly assigned to five groups: negative control, positive control (L-NAME-induced preeclampsia), and three treatment groups receiving curcumin at 30, 50, or 100 mg/kg body weight alongside L-NAME. Preeclampsia was induced by intraperitoneal administration of L-NAME (125 mg/kg body weight) from gestational day 13 to 19, during which curcumin was administered orally. Liver tissues were collected and subjected to immunohistochemical analysis to quantify iNOS expression. One-way ANOVA with post hoc testing (p < 0.05) revealed significant differences among groups. Quantitative ImageJ analysis iNOS expression (% positive area) showed: 5.06 (negative control), 77.00 (positive control), 64.34 (P1), 33.67 (P2), and 19.78 (P3), indicating a dose-dependent reduction in iNOS expression. Curcumin at 100 mg/kg body weight produced the most pronounced decrease in hepatic iNOS expression in preeclampsia-induced rats. These findings demonstrate that curcumin exerts hepatoprotective effects through the downregulation of iNOS in preeclamptic liver tissue and suggest its potential as an adjunctive therapeutic or preventive strategy for mitigating hepatic inflammation in preeclampsia. Further investigation in advanced preclinical and clinical studies is warranted. Keywords: Curcumin, iNOS, Oxidative stress, Hepatic Inflammation, Preeclampsia.
The Effect of Ladder Drill and Zig-Zag Run Exercises and Motivation on Crescent Kick Performance in Young Athletes: A Health and Fitness Perspective Kahfi, Iqlal; Putra, Aldo Naza; Bafirman, Bafirman; Chaeroni, Ahmad
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25358

Abstract

This study tackles the issue of enhancing athletic performance in Pencak Silat, particularly in the execution of the crescent kick, a technique that demands agility, strength, and coordination. It is known that physical conditioning and motivation can affect how well an athlete performs. Nevertheless, limited research investigates the impact of training methodologies and motivational levels on martial arts performance. To examine this, a quasi-experimental design was utilized, testing two physical training methods (Ladder Drill and Zig-Zag Run) and two motivation levels (high and low) on 40 athletes (20 male and 20 female) from the IKSPI Kera Sakti club. The study employed a 2x2 factorial design, utilizing crescent kick ability as the dependent variable and motivation as a moderating variable. The results showed that the main effects of training methods and motivation levels on crescent kick ability were not statistically significant (p >0.05). However, the overall model explained 92% of the variance in performance (Adjusted R? = 0.905), which shows that both physical training and motivation had a strong effect on performance. Tests for normality and homogeneity of variance showed that the assumptions for parametric analysis were met, which made sure that the results were reliable. This study emphasizes that the amalgamation of physical conditioning and psychological support not only improves athletic performance but also fosters the physical and mental well-being of adolescents, thereby advancing overarching objectives in health promotion. To get the best results in sports and long-term health, you need to look at all of these factors together. Subsequent research ought to incorporate larger sample sizes and longitudinal methodologies to investigate the enduring effects of such interventions on youth development?Keyword: Pencak Silat, Crescent Kick, Physical Conditioning, Motivation, Ladder Drill, Zig-Zag Run
Distribution Pattern Environmental Sanitation Analysis and Diarrhea with Stunting Incidence in Toddlers in Karo Regency North Sumatra Province Sinaga, Jernita; Tanjung, Risnawati; Auliani, Restu; Syaputri, Deli
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.26117

Abstract

Stunting is a national problem because its increasing prevalence and impact can increase less competitive human resources, affect work productivity, increase the risk of overweight and obesity, and trigger metabolic syndrome. Environmental factors such as sanitation and hygiene, drinking water sources, drinking water quality, and toilet ownership are indirect factors causing stunting. This study aims to analyze the distribution of stunting incidence and environmental sanitation factors causing stunting in Karo Regency, North Sumatra, Indonesia. A case-control design was conducted on 246 toddlers with a 1:1 ratio. The distribution pattern of stunting incidence and the relationship between patient characteristics and environmental risk factors were studied using a Geographic Information System. Data on clean and healthy living behavior were collected using a questionnaire, and microbiological laboratory tests measured water quality. Spatial analysis used an average nearest-neighbor overlay. The relationship between characteristics and risk factors with stunting incidence was analyzed using chi-square and logistic regression. The average nearest neighbor analysis showed a nearest neighbor index of 0.19 (<1) (Z score -16.72, p-value 0.01). Regression analysis was carried out using GeoDa software (p-value 0.76). There was a relationship between clean water quality, clean and healthy lifestyles (PHBS), and diarrhea (p-value <0.05) and stunting. Family latrines, waste disposal facilities, and wastewater drainage (p-value >0.05) were not associated with stunting. Case distribution tended to be clustered, and no association was found between population density and stunting. This study's findings provide new insights that health promotion to prevent stunting should not only focus on nutritional fulfillment but also on clean and healthy living behaviors and water quality Keywords: Stunting, sanitation, diarrhea, Karo regency, clean water, waste
The Effect of Curcumin on 5-Lipoxygenase (5-LO) Levels in the Hearts of Wistar Rats (Rattus norvegicus) as a Preeclampsia Model Pertiwi, Berliana Noviasih; Sukaji, Lina Zafirah; Rahardjo, Bambang; Wati, Linda Ratna
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25815

Abstract

Excessive activation of the 5-lipoxygenase (5-LO) pathway plays a pivotal role in promoting inflammation and endothelial dysfunction, thereby aggravating cardiovascular complications in preeclampsia. Curcumin, a natural polyphenolic compound with well-established anti-inflammatory and antioxidant properties, has been suggested to suppress 5-LO activity. This study aimed to evaluate the effect of curcumin administration on cardiac 5-LO levels in pregnant Wistar rats with an L-NAME?induced preeclampsia model. A true experimental post-test?only control group design was conducted using 25 pregnant Wistar rats divided into five groups, consisting of a negative control, a positive control receiving L-NAME, and three treatment groups administered curcumin at doses of 30, 50, or 100 mg/kg body weight alongside L-NAME. Preeclampsia was induced by L-NAME administration at a dose of 125 mg/kg body weight from gestational day 13 to 19, while curcumin was given orally during the same period. Cardiac 5-LO levels were measured from serum samples using enzyme-linked immunosorbent assay (ELISA) and analyzed using one-way ANOVA followed by Tukey?s post hoc test with a significance level of p < 0.05. The results showed a marked elevation of cardiac 5-LO levels in the positive control group compared to the negative control. Curcumin administration significantly reduced 5-LO levels at all tested doses, with the most pronounced effect observed at 100 mg/kg body weight. Furthermore, a very strong negative correlation was identified between curcumin dose and cardiac 5-LO levels (r = &#8722;0.871), indicating a clear dose-dependent response. These findings demonstrate that curcumin effectively suppresses cardiac 5-LO levels in a dose-dependent manner in a preeclampsia rat model and highlight its potential clinical relevance as a natural adjunct therapy for mitigating cardiovascular inflammation and endothelial dysfunction associated with preeclampsiaKeywords: Curcumin, 5-Lipoxygenase, Inflammation, Heart, Preeclampsia

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