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Dr. dr. Puspa Wardhani, SpPK
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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 9 Documents
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Search results for , issue "Vol 14, No 2 (2008)" : 9 Documents clear
PARAS INTERLEUKIN-18 PENDERITA TUBERKULOSIS PARU DAN PERAWAT SEHAT BERISIKOTUBERKULOSIS Sianny Herawati; J Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.900

Abstract

Tuberculosis is an infectious disease which is the second cause of death in the world. Indonesia belongs to the third ranks as themost prevalent tuberculosis country. However the eradication is programmed only to focus on finding the case and treatment of theactive tuberculosis patients. Health care workers are at risk to tuberculosis infection, but there is no examination yet for early detectionactivity of tuberculosis. In order to know the activity of tuberculosis, other examinations are needed such as IL-18 examination. Today, no research about IL-18 is performed yet in Indonesia; therefore this study is performed in order to know the difference of IL-18level in active tuberculosis patients and nurses at risk. This study is to know the difference between IL-18 plasma of active tuberculosispatients and nurses at risk by analysis. A cross sectional, observational analytical study of 8 nurses at risk of tuberculosis and 8 activetuberculosis patients, has been conducted from February up to April 2007, at the Dr. Soetomo General Hospital and Karang TembokHospital in Surabaya. The diagnosis of active tuberculosis patients was based on positive sputum bacteriological examination, positiveradiology examination and who never had received anti-tuberculosis drugs. Nurses at risk of tuberculosis consisted of those who had beenworking more than 2 years, and was examined by negative bacteriological and radiology examination, TB-dot and positive tuberculinskin test with a diameter – 10 mm. IL-18 examination was done by double antibody sandwich ELISA method (MBL/Medical & BiologicalLaboratories Co.Ltd). IL-18 level in active tuberculosis patients was 491.4–1215.3 pg/ml (mean 794.6 pg/ml, SD 222.6), in nursesat risk of tuberculosis was 88.9–429.0 pg/ml (mean 256.2 pg/ml, SD 137.6). There was a significant difference of IL-18 level amongactive tuberculosis patients and nurses at risk of tuberculosis (p < 0.001); the IL-18 level in active tuberculosis patients was significantlyhigher than in nurses at risk of tuberculosis.
ALBUMIN KREATININ PENDERITA HIPERTENSI HAKIKI (ESENSIAL) T. Wongso; Dewi LS; Z. Lubis
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.904

Abstract

Increasing of urine albumin excretion in hypertension patient is early sign of renal excretion disorder. Increasing of urine albuminexcretion could not detect with conventional methods, but with more sensitive methods, one of them is examined ratio of urine albuminand urine creatinine (ACR). Knowing ACR rate in essential hypertension. This research was done by cross sectional with consecutivesampling of hypertension patient with JNC VII 2003 criteria. Research used quantitative urine albumin with Albumin Tina QuantMethods draught Immunoturbidinetry. The urine creatinine was analyzed with Jaffe Methods using Roche Hitachi 902. From 25 peopleof hypertension group found ACR < 30 mg/g amount 16 people and ACR rate 30–300 mg/g amount 9 people. Mean while from 22people of non hypertension, all had ACR < 30 mg/g. In this research also found strong correlation between ACR with hypertension,diastolic and systolic blood pressure. It was found that ACR rate of hypertension group was higher than the non hypertension group. Itwas also found a strong relation between ACR with hypertension, systolic and blood diastolic pressure.
LEUKEMIA MEGAKARIOBLASTIK AKUT PADA SEORANG ANAK Nyoman Suci Widyastiti; Ima Arum Lestarini; Yetty Movieta Nancy; Umi S Intansari; R. Lindeman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.906

Abstract

Acute Megakaryoblastic Leukemia (FAB AML M7) occurs in all age groups with two peaks in distribution. The one is in adults and theother in children 1 to 3 years of age especially in those with Down’s syndrome. The diagnosis of AML M7 requires more than 30% of thenucleated bone marrow cells being megakaryoblasts. The AML M7 was under diagnosed before the availability of monoclonal antibodies.The more common types of AML MO-M6 have to be excluded by morphological and cytochemical analysis whereas immunology is neededto exclude ALL. The megakaryocytic nature of the leukemia has to be proven by ultrastructural demonstration of platelet peroxidase or byimmunological demonstration of CD61, CD42, CD41 on the surface of the leukemic blasts. Megakaryocytic/megakaryoblastic leukemiasshow a wide morphologic spectrum. Cytoplasmic blebs and protrusions are the most prominent feature of many cases. The nuclei ofthese cells are round with more finely reticulated chromatin and with prominent nucleoli. The megakaryoblastic nature of these cells canbe suggested by morphology. Cytochemistry is of limited diagnostic value in megakaryoblastic leukemias. Usually it is used to excludethe more common types of leukemia. An eighteen months girl was admitted to hospital with anemia and hepatosplenomegaly. There isdismorphic - hypertelorism face and enlargement of neck lymph nodes. The laboratory examination found anemia, hyperleukocytosis with75 % blast cells. Morphologically the blast cells show prominent blebs and cytoplasmic budding resemble features of budding platelets.The cytochemistry staining for granulocyte and erythrocyte lineages were negative. The expressions of lymphoid and myeloid lineagesmarkers by immunoflowcytometry method were also negative. Cytogenetic examination was followed. The physical and laboratoryexamination result conclude a child with Acute Megakaryoblastic Leukemia. Cytogenetic examination was followed
PEMETAAN PERUBAHAN (MUTASI) VIRUS HEPATITIS B Tonang DA; Rina AS; JB Suparyatmo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.901

Abstract

Recently, the issue of Hepatitis B Virus (HVB) mutation is becoming a significant point to consider. The mutation might rendersignificant problems as the virus might escape from the detection method, vaccination induced-protection and treatment modalities. Thestudy was to analyze the profile of serological parameters in the HVB infected serum in Surakarta. As many as 36 HBsAg-positive serawere randomly retrieved from the patients in Moewardi Hospital and donors in Blood Bank of Indonesian Red Cross (PMI) in Surakartaduring August-September 2007. Having analyzed by immunoanalyzer, 13 (36.1%) of 36 sera were HBeAg-positive suggesting an activeinfection and potent of transmission. Interestingly, 3 (8.3%) of 36 sera were Anti-HBs-positive, while the other 5 (13.8%) showeddetected level of Anti-HBs even lower than the cut-off (12 mIU/ml). Accordingly, 22 (61.1%) of 36 serum were Anti-HBe-positive, whileone (2.8%) sera was HBe-Ag-positive as well as Anti-HBe-positive. The data suggested some possibilities: double infection with two ormore subtypes of HBV, mutation resulting in quasi-species phenomenon, or the so-called healthy carrier. More extensive and specificstudies are necessary to confirm and elucidate the profile.
DETEKSI ANTI GLUTAMIC ACID DECARBOXILASE/TYROSINE PHOSPHATASE (ANTI GAD/IA2) PADA PENDERITA DM TIPE 1 ANAK Puspa Wardhani; S Darmadi; M Faizi; Netty Harjantien
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.907

Abstract

Our study evaluated anti GAD/IA2 levels in Type 1 DM patients in Dr. Soetomo Hospital Surabaya. We conducted cross sectionalstudy, involving Type 1 DM patients that already been established (C-Peptide bellow normal). Patient’s age range was from 2.8 yearsold to 17 years old, so they were regarded as children. We used anti GAD/IA2 reagents from Euroimmun wich had basic principal EIA.Twelve patients was involved in this study. The average level of anti GAD/IA2 was 210.37 IU/mL. The Average level of anti GAD/IA2was higher in female than male patients (227.38 IU/mL dan 162 IU/mL). All patients had anti GAD/IA2. This examination can beusefull for screenimg one who has high risk in developing type 1A DM, especially first degree relatives.
MENGENAL SISTEM PENERANGAN LABORATORIUM/LIS Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.909

Abstract

Clinical laboratory as a supporting tool to establish diagnostic as well as the efficiency of laboratory results will need on time report,accurate result, and satisfaction of the customer should necessary supported by suitability equipments. Most laboratories using automaticmachine need the assistance of LIS (Laboratory Information System) to enhance good results. To prepare its ready use of these laboratoryinstruments, request orders of the physicians’ should be explicit and content satisfaction of the clinically symptoms as well. The laboratorypersonnel and the supervisor of LIS software should know well how to operate it to match with the other laboratory equipment used.The result of laboratory’s orders should be recorded by LIS and send back to the physicians. In this computerisation world, automationof clinical laboratory is necessary if efficient results are the main need.
PREDIKSI JUMLAH SEL LIMFOSIT T CD4+ MENGGUNAKAN NILAI TLC (TOTAL LYMPHOCYTE COUNT) PADA PENDERITA HIV/AIDS Rostina Rostina; Suci Aprianti; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.902

Abstract

AIDS is a severe disease caused by Human Immunodeficiency Virus (HIV) that affects patient’s immune system, especially CD4+ Tcells (CD4). Hence, CD4 count is used as parameter to starting ARV treatment or monitoring the progress of the disease. However, themeasurement of CD4 is expensive and available in big hospitals. In small or remote hospitals there are no means to measure the CD4.Some studies suggest that in an area where CD4 count is unavailable, the total lymphocyte count (TLC) of HIV/AIDS patients can roughlybe used to predict CD4 values. This study is aimed to see whether the TLC values can be used to roughly predict the CD4 count of HIV/AIDS patients and to formulate the correlation form between them. A cross sectional study design was applied to 79 blood samples ofHIV/AIDS patients from Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital from January to September 2007. The bloodsamples were tested for TLC as well as CD4 values. The correlation of TLC and CD4 values was tested with Pearson Correlation Test andthe correlation formula was derived from curve estimation of Regression Analysis. Sensitivity, specificity, PPV and NPV of various cutpoint of TLC (1000, 1200, 1500, 2000) to predict CD4 < 200/ul were determined using cross tabulation Fisher Exact Test. A positivecorrelation was found between TLC and CD4 count (R = 0.528, p < 0.001) with the regression formula is CD4 = 0.09TLC – 1.42.The WHO standard cut point TLC1200/ul give best result for sensitivity, specificity, PPV and NPV: 80.6%, 91.7%, 98.2% and 45.8%,respectively. The cut point of TLC1200 can be used to roughly predict CD4 < 200/ul of HIV/AIDS patients, so, can be use as a mark forstarting ARV therapy in the place were measurement of CD4 is unavailable
PENINGKATAN AMINOTRANSFERASE SEBAGAI PENANDA CEDERA HATI PADA PENDERITA DEMAM DENGUE Madina Sahnaz; Corriejati Rita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.899

Abstract

Dengue infection can give unusual manifestation such as acute liver failure. The increased frequency of this complication in dengueinfection have been reported and have a high mortality. Elevated serum transaminase levels of dengue patients indicate the possibleimpact of dengue virus infection on liver function. The aim of this study was to know the frequency of the increased of aminotransferasein patient with dengue fever. An analysis was made of 67 serologically confirmed dengue cases at Hasan Sadikin Hospital. Thegrade of hepatic aggression was establish according to the alteration in the aminotransferase levels: grade A, have a normal levelsof aminotransferase, grade B have elevated aminotransferase, with increased levels of at least one of the enzymes, grade C elevatedaminotransferase, with the level of at least one of the enzymes increased more than three times the reference value. Among the 67serologically confirmed dengue cases, 7% (n = 5) have a primary dengue infection, 49% (n = 33) have secondary dengue infection,43.3% (n = 29) have a mix infection (secondary and primary infection). 88% (n = 59) have elevated levels of serum aspartataminotransferase (AST) and 68% (n = 46) have elevated level of serum ALT. 67.2% (n = 45) have elevated both AST and ALT. 1.7%(n = 1) presented a normal level of amiotransferase (grade A), 31.3% (n = 21) presented alterations in the aminotransferase (gradeB), 56% (n = 38 ) have elevated aminotransferase more than three times the reference value (grade C). As a conclusion, liver damagewith elevation of aminotransferase was common complication of dengue virus infection.
IMUNOSUPRESI UNTUK PENCANGKOKAN GINJAL (Bagian I) Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.905

Abstract

Renal transplantation is the treatment of choice for most patients with end stage renal disease. Most of the time, transplantationrejection is immunological mediated. Both T cells and circulating antibodies are induced against allograft. Successful organtransplantation requires the use of immunosuppressive drugs to prevent the host’s immune system from rejecting the transplanted organ.The development of immunosuppressive drugs is the key to successful allograft function Immunosuppressive agents are used for induction(intense immunosuppressant in the initial days after transplantation), maintenance and reversal of established rejection. This reviewfocuses on agents that are either approved or in phase 2 or phase 3 trials in kidney transplantation.

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