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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 16, No 1 (2009)" : 14 Documents clear
NILAI DIAGNOSTIK MALARIA ANTIGEN CASSETTE PENYAKIT MALARIA Binawati .; Prihatini .; M.Y Probohoesodo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1031

Abstract

Malaria is an endemic disease in many countries. In 103 endemic countries with around 2.5 billion population, 1−3 million death cases were reported every year. Clinical criteria and blood smear established the diagnosis of malaria. ICT (imuno chromatographytest) is needed in peripheral areas where there are no experienced laboratory technicians. The procedure is simple, practical, easy, aswell as quicker than the conventional method, and no experienced technicians are needed this ICT advantages. The aim of this study isto know the diagnostic value of Malaria Antigen Cassette with microscopic examination as the gold standard examination of malaria.This research used observational cross-sectional method This study was done in Nusa Tenggara Barat during May−June 2008. Bloodsamples were taken by finger prick in patients with Malaria symptoms: fever, chill and sweating, followed by examining the blood smearby Malaria Antigen Cassette from Focus Diagnostic. The diagnostic value was then evaluated by calculating the sensitivity, specificity,positive predictive value as well as the negative predictive value. The diagnostic value of Malaria Antigen Cassette in patients withmalaria falciparum was found as follows: sensitivity 95.2%, specificity 100%, positive predictive value 100%, and negative predictivevalue 97.6%. The diagnostic value of Malaria Antigen Cassette in patients other types than malaria falciparum was as follows: sensitivity94.8%, specificity 100%, positive predictive value 100%, and negative predictive value 95.3%. The diagnostic value of Malaria AntigenCassette was very high in diagnosing malaria falciparum compared to other types than malaria falciparum.
, DALAM KEADAAN (STATUS) IMUNOLOGIS DAN KLINIS PENGOBATAN ANTIRETROVIRAL PENDERITA HIV/AIDS CD38 LIMFOSIT CD8 + , TAMPANG (PROFIL) CD4 + Ira Puspitawati; Umi S. Intansari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.994

Abstract

ABSTRACTThe relationship between immune activation and pathogenesis of Human Immunodeficiency Virus (HIV) infection is unproven. It has been hypothesized that state that HIV-induced activation enhances the magnitude of HIV replication other study shown that viralreplication impaired immune activation. One of the best immune activation marker is CD38 expression on CD8because it has thestrongest significant prognostic markers. It was previously shown that increased CD8+ T-cell activation has predictive value for diseaseprogression but the relation is still controversial. One hypothesis state that HIV-induced activation enhances the magnitude of HIVreplication, other said that viral replication impaired immune activation. To know the profile of immunology and clinical state of HIV/AIDS patients by determining the CD38 molecule expression on CD8+ profiles and clinical state.Crosssectonal, observasional study was done. Twenty nine HIV/AIDS patients who routinely had medical check up and having routine +cells as an activation marker, CD4+antiretroviral therapy at Sardjito hospital and 8 healthy people as normal controls were involved in this study. The count of CD4 +cells counts had significantnegative correlation with WHO stage (p = 0.012). Expression of CD38 molecule on CD8absolute counts and expression of CD38 molecule on CD8 cells were measured using flowcytometry. The CD4+cells of HIV/AIDS patients were highercompared to normal controls, 209.29 ± 76.56, 109.61 + 32.29 respectively (p < 0.05). That expression was not correlated with CD4 + +counts and CD4incrementafter therapy was statistically significant (p = 0.003). The CD4+increment. It might be caused by the time of measurement was not at the begining of diseases. The CD4 + count was negatively correlated with the WHO stage. Expression ofCD38 molecule on CD8+ cells of HIV/AIDS patients were significantly higher compared to normal controls but it wasn’t correlated withthe CD4++ number and CD4+increment after therapy.
HASIL HITUNG NORMOBLAS ANTARA SEDIAAN HAPUSAN DARAH TEPI PENDERITA AML DENGAN ALL Hidayat .; Nina Susana Dewi; Nadjwa Zamalek Dalimoenthe
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.997

Abstract

Normoblast is an immature form of erythrocyte in erythropoietin system. Normally, normoblast can be found in peripheral blood healthy neonates. The existence of normoblast in peripheral blood might be the sign of pathologic conditions such as hemolytic anemia,acute blood loss, and ischemia and bone marrows abnormalities like malignancy or leukemia. In acute leukemia (Acute MyeloblasticLeukemia and Acute Lymphoblastic Leukemia), normoblast existence in peripheral blood may due to erythropoietin system suppression.The aim of this study is to compare normoblast count between AML and ALL, and also to find out the correlation between leukocyte andnormoblast count in AML and ALL. The subject of this study were patient diagnosed as AML (30) and ALL (30) in Hematology Divisionof Clinical Pathology Department at Dr.Hasan Sadikin Hospital Bandung in July 2006–August 2008. In this study we examined 30peripheral blood smears from AML and 30 peripheral blood smears from ALL. Leukocyte count result was derived from CBC performedwith Sysmex KX-21. The mean value of normoblast count from AML blood smear patients is 1930.60 (3.60/100 WBC) while ALL bloodsmear patients is 309.60 (0.43/100 WBC). Statistically this difference is significant (p < 0.001). There are strong correlation betweenleukocyte count and normoblast count within both group (r = 0.851, r = 0.948; p < 0.001).
EVALUASI AKTIVITAS TRANSAMINASE, DAN KADAR BILIRUBIN PADA PENDERITA VIRUS HEPATITIS B DAN C Yosepin .; Benny Rusli; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.996

Abstract

Hepatitis virus replicates only in hepatocyte. In hepatocyte injury, transaminase enzymes which normally intracellularly will transform to the blood circulation. And there are variation of increasing transaminase activities in HBV and HCV. To evaluatetransaminase activities, and bilirubin level in patients with HBV and HCV. Study design was cross sectional of 76 patients with HBVand HCV, data from medical record at Wahidin Sudirohusodo Hospital, Makassar, from January 2006 until July 2008 period. Datawas analyzed with Mann Whitney test using SPSS. windows versi on 12. of 76 patients with HBV and HCV were found 59 Men and 17women, age 15–72 years old. In there were no statistical significance between transaminase activites, bilirubin direct,indirect (p > 0.05),but there was significance difference of total bilirubin between HBV and HCV (p < 0.05). There were no statistical difference of AST,ALT, bilirubin direct and bilirubin indirect between HBV and HCV. Injury hepatocelluler because of HBV and HCV can not be identifiedjust by transaminase activities and bilirubin level, but there are other factor that influence.
TROMBOSIT ABNORMAL PASCAPERSALINAN Prihatini .; S. Hadi; Wijanda H T Sylvaranto; Maksum .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1029

Abstract

Pregnant women with cardio vascular failure caused by hypertension may show pre-eclampsia or eclampsia syndrome. The syndromewas confirmed by the hypertension family history when she was pregnant or during labour formerly. The influence was shown in thehaematological examination, besides inducing hypertension during pregnancy. The examination must be an accurate laboratory procedureto avoid complication. The routine obstetric examination should be a physical, laboratory as well as USG one. Exspecially laboratoryexamination for pre-eclampsic and eclampsic patients like clinical chemistry, blood examination, urinalysis and special examinationas ANA, ACA and TAT The result of laboratoric examination showed anemic,trombosits was normal and TAT abnormal. The baby wasborn normal. After 3 months post labour the result of TAT still hyper-reactive especially for ADP agonist and hypo-reactive for collagenagonist. This patient have a trombosit function failure based on TAT and must be care to cardiovascular disease. Pregnant women withpre-eclamptic or eclamptic risk must be monitored the trombosit function beside clinical laboratoric and obstetric examinations
ANALISIS KADAR ASAM URAT PADA PASIEN KARSINOMA MAMMA Susi Sevianty; Uleng Bahrun; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.992

Abstract

In malignancy cases, an increase of uric acid level is often observed after therapy (Tumor Lysis Syndrome), but some studies also indicated an increase before therapy which is related to a refusal reaction against tumor, and specific only for certain malignancy cases.Carsinoma mammae is the second most common malignancy among women in Indonesia, so that studying the phenomenon occurredin carcinoma mammae including uric acid level are expected to provide insight in management of carcinoma mammae. A longitudinalstudy was conducted by collecting secondary data from medical record of carcinoma mammae patients in Wahidin SudirohusodoHospital for period of July 2007–June 2008. Data were analyzed by using Wilcoxon Signed Rank Test with alpha 0.05. 12 of subjectsare considered eligible for study criteria, with the age ranging from 28–60 years old. In generally, uric acid level determined beforeand after chemotherapy showed a level in normal range, except for 3 samples before therapy and 3 different samples after therapyshowed a level more than 5.7 mg/dL. Statistic result showed mean uric acid level before chemotherapy was 4.508 ± 1.2566 mg/dL andafter chemotherapy was 5.025 ± 1.3240 mg/dL (p = 0.16). Increased of uric acid level is not significant level was found in serum ofcarcinoma mammae before and after chemotherapy.
PENETAPAN TARIF PEMERIKSAAN LABORATORIUM PATOLOGI KLINIK BERDASARKAN METODA JAROS ML Maria I; Diah P; Tahono .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1030

Abstract

A hospital as an institution of public health assistance expected to extend comprehensive service and complex appropriate around public demand, capable of sophisticated laboratory examination with achievable cost. To be successful in the financial management of thelaboratory, we must be able to identify and categorize costs, understand the relationship between revenue and reimbursement, becomefamiliar with the budget process and use financial ratios and information to make sound decisions. Cost per test laboratory examinationsare needed to determine the real costs, cost information, and to appraise examination efficiency and budget. Laboratory costing per testbased on Jaros ML method demonstrates various ways to determine the cost of a test and how to establish its charge. The greater thedemand laboratory tests per month, the lower the cost per reportable result (CPRR) and the greater the efficiency of laboratory test.
ANTI HCV DAN JUMLAH PENDERITA JANGKITAN (PREVALENSI INFEKSI) VIRUS HEPATITIS C Isti Setijorini Wulandari; Kismardhani .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.993

Abstract

ABSTRACTIn various prevalence Hepatitis C Virus (HCV) infections was found all over the world. There is no accurate data about the spreading of HCV infection in Indonesia. Indonesian Department of Health makes a program to make a database from all provinces in Indonesiaabout prevalence of HCV. This is supported by request from the district Health Department of Daerah Istimewa Yogyakarta (DIY)Province to conduct HCV infection surveillance in 2007. Data of HCV infection from blood transfusion service show approximately 2%.To complete the basic data by knowing the prevalence of HCV in Dr. Sardjito General Hospital Yogyakarta at DIY province. This is an Hospital Yogyakarta at DIY province. This is anHospital Yogyakarta at DIY province. This is an observational descriptive study about HCV infection prevalence in Dr. Sardjito General Hospital Yogyakarta. Data was collected fromSeptember 2007−August 2008 conducted on Microbiology, Immunology & Infection Sub Laboratory of Clinical Pathology Departmentin Dr Sardjito General Hospital Yogyakarta. There was 753 request of anti HCV test from September 2007−August 2008. Initial reactiveresult was found in 131 patients. In the first quarter in 2007 (January−April 2007) there were 27 initial reactive from 175 samples ofanti HCV test (15.42%). In the second quarter were found 36 initial reactive out of 176 samples of anti HCV test (20.45%) and in thelast trimester in 2007 were found 19 initial reactive out of 134 samples (14.17%). In 2008, first quarter were found 21 positive resultout of 123 samples (17.03%) and in the second quarter (May−August 2008) were found 32 positive result out of 145 samples (22.06%).There are gradually increased percentage rates of initial reactive anti HCV test based on the result from each trimester HCV test based on the result from each trimesterHCV test based on the result from each trimester (15.42−20%, 45−14 %, 17−17%, 03−22.06%)
PENGUKURAN DAN APLIKASI KLINIK THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1032

Abstract

Cross regulation of coagulation and fibrinolysis plays an important role in preserving a balanced hemostatic process. These process are exquisitely regulated and protect the organism from excessive blood loss or excessive fibrin deposition. Identification of ThrombinActivatable Fibrinolysis Inhibitor (TAFI) as an inhibitor of fibrinolysis and one of the main intermediates between coagulation andfibrinolysis, greatly improved our understanding of cross regulation of coagulation and fibrinolysis. As TAFI is an enzyme that is activatedby thrombin generated by the coagulation system, its activation is sensitive to the dynamics of the coagulation system. This review willdiscuss the role of TAFI and characterize it with respect to its activation, regulation, and clinical application.
KESEPANCARAN (HOMOLOGI) LEGIONELLA PNEUMOPHILA JARINGAN DISTRIBUSI AIR DAN PNEUMONIA NOSOKOMIAL Noormartany .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1028

Abstract

L. pneumophila is one of the nosocomial pneumonia causes that contaminated hospital water distribution system. The aim of this study was to determine the homology between L. pneumophila 16S rRNA base sequence found in the water distribution systemand the sequence derived from the sputum of nosocomial pneumonia patients identified at RSHS Bandung as well as the homology of L. pneumophila 16S rRNA found in the same system network. The study also include the nosocomial pneumonia patients at RSHSBandung with L. pneumophila from GenBank. The research using descriptive bioinformatics BLAST method by comparative analyticapproach, which performed from April 2006 to February 2008. The material consists of 60 biofilm samples from water distributionsystem and pneumonia nosocomial patient’s sputum is positive L.pneumophila from water distribution system in her/his room. Inthe result was found: out of the 60 biofilm samples from the water distribution system, there are seven (7) L. pneumophila positivePCR and culture. During the 12 months of observation, there is only one (1) out of 31 pneumonia nosocomial patients with positively L. pneumophila PCR and culture. The conclusion so far can be mentioned that: The water distribution system in RSHS for patient roomsmay become the source for nosocomial pneumonia transmission of L. pneumophila and also was detected a new species of L. pneumophilathat is genetically different from that has been found in GenBank.

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