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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 20, No 1 (2013)" : 14 Documents clear
ASAM HIDROKSIINDOLASETIK 5 (5-HIAA) AIR KEMIH DI KANKER KOLOREKTAL Mansyur Arif; Yosep F. Tallulembang; Burhanuddin Bahar; Ibrahim Abd. Samad; Ibrahim Labeda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.438

Abstract

Colorectal cancer, in fact is one of the three most malignant tumour types found in the world. Early detection is recommended to find out the problem and will affect better life expectancy. Various study have been conducted looking for a test that can be easily, non invasive, inexpensive, no special equipment and skills required such as by detecting 5-hidroxyindolacetic acid that can be found in the urine. The aim of this study was to analyze 5-HIAA in the urine of colorectal cancer patients. The study was conducted at the Clinic and Surgical Ward, and Clinical Pathology Laboratory, at Dr. Wahidin Sudirohusodo Hospital in Makassar during the period May–August 2011. The study was conducted on 42 patients and 45 controls ranging from 35−74 years old and 20−52 years old, respectively. The diagnosis is based on the histopathological and most were in stage III of adenocarcinoma profile. Rated of 5-HIAA colorectal cancer the highest is in the value of 4–6 and all normal control had value of 1–3. There is a significant association between 5-HIAA and colorectal cancer, that shown the highest stadium of colorectal cancer, and the highest value of urine 5-HIAA. The ideal cut-off point for screening is two (2) with its sensitivity and specificity values are 100% and 88. 9%, respectively. 5-HIAA urine test can be used as a tumor marker for colorectal cancer in conjunction with other supporting tests. Further study is needed to determine the cut-off point with a various clinical stage.
ACQUIRED β−THALASSEMIA IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) Maria Christina Shanty Larasati; Mangihut Rumiris; Mia Ratwita Andarsini; I Dewa Gede Ugrasena; Bambang Permono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.444

Abstract

Thalassemias are heterogeneous group of genetic disorders. β-thalassemia is existed due to impaired production of beta globins chains, which leads to a relative excess of alpha globin chains. The abnormalities of haemoglobin synthesis are usually inherited but may also arise as a secondary manifestation of another disease, most commonly haematological neoplasia. This article presenting two cases of acquired β-thalassemia in children with ALL focusing on the diagnosis and the possible relationship between the two haematological diseases. The first case is a four (4) year old boy with ALL-L1 type at maintenance phase of chemotherapy, he suffered from anaemia with Hb 8.0 g/dL, WBC 22,600/mm3 and platelets count of 200,000/mm3, peripheral blood smear revealed anisocytosis, polychromes, hypochromia, basophilic stippling, and normoblastocytes. The result of Hb electrophoresis of Hb A of 54.9%, Hb F of 29.4%, Hb E of 13.4% and Hb A2 of 2.3%. The patient was diagnosed as ALL-L1 type and β-thalassemia. The second case, is a 13 year old girl with remission ALL-L1 type after chemotherapy, she suffered from anaemia with Hb 6.7 g/dL, WBC 12,400/mm3, platelet count was 200,000/mm3, and peripheral blood smear obtained anisocytosis, hypochromia, normoblastocytes, myelocytes and basophilic stippling. The result of Hb electrophoresis are: Hb F 0.41%, Hb A1c 0.78%, Hb A2 2.95% with the conclusion of a β-thalassemia trait, this patient was diagnosed with ALL-L1 type remission + β-thalassemia trait. The case reviewers assume that acquired β-thalassemia which happened in those patients were the altered expression of globin chain which mechanism for this syndrome might be the acquisition of a mutation that affects RNA or proteins involved in β-globin gene regulation and resulting the reduction of the (α/β)-globin biosynthetic ratios, or/and associated with chemotherapy-inducement.
KUMAN DAN UJI KEPEKAAN ANTIBIOTIK DI KAKI DIABETIK Ari Sutjahjo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.443

Abstract

The purpose of this study was to know the bacterial pattern causing foot infections in diabetes mellitus (DM) patients and the sensitivity test results of the bacteria against various antibiotics that have been set. This research was conducted as a retrospective study using medical records. The study was carried out on diabetic foot patients of all In-patient Wards, Department of Internal Medicine, Dr. Soetomo Hospital, who met the inclusion criteria between January 1, 2003 up to December 31, 2007. The stages were classified according to the Wagner - Merrit criteria. Laboratory and clinical data were taken from the medical records of the patients who were admitted. Infected diabetic foot was found in 30.9% of patients. The causative bacteria consisted of: Pseudomonas (20.3%), Streptococcus (15.25), Klebsiella (13.9%), E.coli (12.6%), Proteus (12.6%), and Staphylococcus (11.3%). The Imipenem antibiotic showed the highest sensitivity (99.2%), followed by Norfloxacin (98.8%), Meropenem (98.2%), Ofloxacin (97.7%) and Cefuroxime (95.3). In this study, it was found that the most resistancy was to Erythromycin (46.3%) followed by Chloramphenicol (44.2%), Ceftazidime (41.1%), Cefotaxime (36.6%) and Ciprofloxacin (33.5%). It can be concluded that most of the bacteria causing the diabetic foot infections were Gram-negative aerobic bacterias and the highest sensitivity was to Imipenem, Norfloxacin, Meropenem as well as Cefuroxime.
AKTIVITAS CKMB DAN MASA CKMB TERKAIT KARDIAK TROPONIN-I DALAM GEJALA KORONER AKUT Tonang Dwi Ardyanto; Tahono Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.434

Abstract

Coronary Heart Disease (CHD) is the leading cause of death recently, including in Indonesia which is raised to 25%. Acute Coronary Syndrome (ACS) is its common clinical manifestation. Therefore, the necessity for a sensitive as well as specific diagnostic biomarker for ACS should be addressed in discriminating the ACS patient and its related risks. The diagnostic sensitivity of characteristic electrocardiography pattern in ACS cases were reported to be variatively between 55–75%. In laboratory diagnostic, ACS markers among others are CKMB activity, CKMB mass as well as Cardiac Troponin-T and Troponin-I (cTnT and cTnI). Currently, cTnI is the gold standard. The present study is to know the analysing of the CKMB activity as well as the mass diagnostic performance in the detectionof ACS in the patient presenting with chest-pain at RSDM, by using cTnI as the standard of reference. As many 30 samples, 18−65 years old, were selected trough incidental sampling method from the subjects presenting with chest-pain no longer than 6 hrs before admission. The blood samples were drawn at admission and 6 hrs afterward. The CKMB activity (immunoinhibition assay), CKMB mass (ELFA) and cTnI (ELFA) measurement were performed on each sample. The analysis showed that cTnI cut-off on 0.1 μg/L (ESC/ACC 2000) was most optimal in the laboratory diagnostic of ACS compared to that of 0.01 μg/L (ESC/ACC 2007 update) and 1.0 μg/L (WHO). Using the cTnI cut-off on 0.1 μg/L, on admission (0 hr) the diagnostic efficiency of CKMB mass was 56.7% while that of CKMB activity was 60.0%. While on the serial measurement (6 hrs), the diagnostic efficiency of CKMB mass was 76.6% while that of CKMB activity was 56.7%. The results showed that by serial measurements, CKMB mass is superior than CKMB activity in the diagnosis of ACS in patient presenting with chest-pain. Further researches are necessary to elaborate the comparison elucidatively. The results of the study considered that in designing the protocol for laboratory examination should carried out in patient presenting with chest pain.

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