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All Journal Folia Medica Indonesiana Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Ari Sutjahjo, Ari
Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia - Dr. Soetomo General Hospital Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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ADIPONEKTIN HIGH MOLECULAR WEIGHT DAN KEKAKUAN VASKULAR DI PENYAKIT DIABETES MELITUS TIPE 2 TERKAIT GABUNGAN GLIMEPIRIDE METFORMIN DOSIS TETAP Sutjahjo, Ari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1089

Abstract

Diabetic patients have the tendency to develop micro vascular and macro vascular complications due to the hyperglycaemic state. Thereare various types of oral hypoglycaemic agents available in Indonesia, nevertheless, these agents fail to decrease mortality and morbiditydue to the endothelial dysfunction in diabetic patients. It is not yet known whether glimepiride metformin fixed dose combination isable to improve the serum High Molecular Weight (HMW) adiponectin and vascular stiffness which are important parameters of thecardiovascular risk factors. This study was to know the effect of glimepiride metformin fixed dose combination by investigation after 12weeks of treatment towards HMW adiponectin level and vascular stiffness using ba-PWV in type 2 diabetes. This research was carried outby a Quasi experimental study with pre and post test design. The subjects were type 2 diabetes patients who came to the EndocrinologyOutpatient Clinic at the Dr. Soetomo Hospital and 6 health centres in Surabaya during December 2010 to December 2011. In this study,measuring the HMW adiponectin level in plasma was by using ELISA method and the ba-PWV by using the V Serra-1000 before and aftertreatment with glimepiride metformin fixed dose for 12 weeks. Based on the thirty five type 2 diabetic patients who met the inclusion andexclusion criteria and who were enrolled in this study, after 12 weeks of treatment, the median HMW Adiponectin level was increasedfrom 1736 ng/mL to 1770 ng/mL, which was statistically not significant (p=0.317). After 12 weeks treatment, the median of ba-PWVwas decreased from 1580 cm/sec to 1450 cm/sec, which was statistically significant (p=0.028). The level of HMW adiponectin was notsignifantly different between before and after treatment. The level of brachial ankle Pulse Wave Velocety (ba-PWV) was significantlydifferent between before and after treatment. Glimepiride metformin fixed dose combination decreases the vascular stiffness, which isone of the parameters of the endothelial dysfunction.
KUMAN DAN UJI KEPEKAAN ANTIBIOTIK DI KAKI DIABETIK Ari Sutjahjo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.443

Abstract

The purpose of this study was to know the bacterial pattern causing foot infections in diabetes mellitus (DM) patients and the sensitivity test results of the bacteria against various antibiotics that have been set. This research was conducted as a retrospective study using medical records. The study was carried out on diabetic foot patients of all In-patient Wards, Department of Internal Medicine, Dr. Soetomo Hospital, who met the inclusion criteria between January 1, 2003 up to December 31, 2007. The stages were classified according to the Wagner - Merrit criteria. Laboratory and clinical data were taken from the medical records of the patients who were admitted. Infected diabetic foot was found in 30.9% of patients. The causative bacteria consisted of: Pseudomonas (20.3%), Streptococcus (15.25), Klebsiella (13.9%), E.coli (12.6%), Proteus (12.6%), and Staphylococcus (11.3%). The Imipenem antibiotic showed the highest sensitivity (99.2%), followed by Norfloxacin (98.8%), Meropenem (98.2%), Ofloxacin (97.7%) and Cefuroxime (95.3). In this study, it was found that the most resistancy was to Erythromycin (46.3%) followed by Chloramphenicol (44.2%), Ceftazidime (41.1%), Cefotaxime (36.6%) and Ciprofloxacin (33.5%). It can be concluded that most of the bacteria causing the diabetic foot infections were Gram-negative aerobic bacterias and the highest sensitivity was to Imipenem, Norfloxacin, Meropenem as well as Cefuroxime.
Association of Metabolic Syndrome with Albuminuria in Diabetes Mellitus Type 2 Thamrin, Husin; Sutjahjo, Ari; Pranoto, Agung; Soelistijo, Soebagijo Adi
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.341 KB) | DOI: 10.20473/bhsj.v2i2.14964

Abstract

Background : Metabolic syndrome is a risk factor for cardiovascular disease as well as the occurrence of chronic kidney disease. According to the IDF, the metabolic syndrome is diagnosed when central obesity obtained with 2 or more metabolic abnormalities that include impaired glucose metabolism, increased blood pressure, hypertriglyceridemia, and low HDL-C. Several previous studies reported an  significant association found between the metabolic syndrome with albuminuria. In Indonesia, the association of metabolic syndrome with albuminuria in type 2 diabetes have not been.reported.Objectives : To investigate the association of metabolic syndrome with albuminuria in type 2 diabetes patients.Methods : This is an analytic observational study, cross-sectional design in type 2 diabetes mellitus patients and we studied 131 subjects. Criteria metabolic syndrome according to IDF consensus and albuminuria assessed using the ACR method and the classification of albuminuria was based on consensus of Perkeni 2006. As for Statistical analysis using spearman correlation and Mann-whitney test. Significance level used was 0.05.Results : Of the 131 type 2 diabetes patients with metabolic syndrome were found  normoalbuminuria proportion 65.4%, microalbuminuria 27.1% and macroalbuminuria 7.5%. Obtained a significant association between systolic blood pressure with albuminuria, p = 0.000, r = 0.325. Fasting blood sugar with albuminuria, p = 0.01, r = 0.223. But not found significant association between diastolic blood pressure with albuminuria, p = 0.153, r = 0.125, waist circumference with albuminuria, p = 0.311, r = 0.089, low HDL with albuminuria p = 0.771, r = -0.025. Hypertriglyceridemia with albuminuria, p = 0.727 and r=0,031  Conclusion : The results of this study indicate a strong association between the components of metabolic syndrome, systolic blood pressure with albuminuria, and fasting blood sugar with albuminuria. Whereas diastolic blood pressure, waist circumference, low HDL, and hypertriglyceridemia were not found significant associations.
PROFILE OF TYPE II DIABETES MELLITUS WITH CENTRAL OBESITY IN DR. SOETOMO HOSPITAL Munir, Misbakhul; Sutjahjo, Ari; Sustini, Florentina
Folia Medica Indonesiana Vol. 51 No. 3 (2015): July - September 2015
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (38.87 KB) | DOI: 10.20473/fmi.v51i3.2831

Abstract

Obesity, especially central obesity is often associated with insulin resistance and type 2 diabetes mellitus. Diabetes mellitus is a disease of the number six cause of death in Indonesia with the proportion of deaths by 5.8%. The purpose of this study was to identify central obesity in patients with type 2 diabetes mellitus in Poly Endocrine Dr. Soetomo Hospital, Surabaya. The study design was descriptive study. The sample was 100 type 2 diabetes mellitus patients taken with purposive sampling technique. The variable was central obesity and type 2 diabetes mellitus. The data obtained by interviewing patients and performing measurements on body weight, height and waist circumference. Data were analyzed by interpreting how the description of the variables studied and compared with other studies and theories. The results was the characteristics of patients most were female (66%), level of education was medium, unemployment, most of patient's age was more than 50 years old, 43% for interval 51-60 years old, 43% were 1,50-1,59 meters in height and 28% were 50-59 kilograms and 28% were 60-69 kilograms in weight. According to Body Mass Index (BMI) measure that 54% the patients are normal in average 25,56 8,12 kg/m2. Measurement of waist circumference showed that 73.5% male and 81.8% female patients had central obesity. The conclusions, precentage of patients with type II diabetes mellitus who have central obesity were 81,82% female and 73, 53% male.
PROFIL DATA PASIEN DIABETES MELITUS TIPE 2 DENGAN KOMPLIKASI ULKUS DIABETIKUM DI RSU DR.SOETOMO SURABAYA TAHUN 2012 Drestha Pratita Windriya; Ari Sutjahjo; Hermina Novida
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 2 No 1 (2013): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

WHO mencatat terdapat 120 juta penderita DM pada tahun 1996 dan jumlahnya akanmeningkat dua kali lipatnya pada tahun 2025. Pasien dengan DM memiliki peluang lima kalilebih besar terkena gangren. Penelitian ini bertujuan untuk mengetahui profil dan distribusi datapasien DM tipe 2 (DMT 2) dengan komplikasi ulkus maupun gangren diabetikum. Penelitian inimerupakan penelitian deskriptif dengan desain potong lintangberdasarkan data dari DokumenMedik Kesehatan (DMK) pasien. Dari 101 pasien yang diteliti, 61% pasien berjenis kelaminwanita dan rentang usia pasien terbanyak adalah 51-60 tahun. Lima puluh persen pasien telahmenderita DMT2 selama 1-5 tahun. Pada pemeriksaan radiologis,gambaran terbanyak yangdidapat adalah ulkus saja tanpa kelainan (32%) dan gangren (27%).Sebanyak 28% pasiendatang dengan kadar gula darah acak (GDA) 201-300 mg/dL. Dari 30% pasien yang melakukanpemeriksaan kultur nanah, Staphylococcus sp. merupakan kuman terbanyak yang ditemukan(25%). Perawatan 25% pasien DMT 2 dengan ulkus diketahui membutuhkan waktu selama 6-10 hari dengan 70% pasien dipulangkan karena kondisinya yang membaik, meski beberapadiantaranya harus dilakukan tindakan amputasi.
Co-Authors Agung Pranoto Drestha Pratita Windriya Florentina Sustini Hermina Novida, Hermina Misbakhul Munir Soelistijo, Soebagijo Adi Thamrin, Husin