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INDONESIA
Indonesia Natural Research Pharmaceutical Journal (INRPJ)
Published by Universitas 17 Agustus 1945 Jakarta
ISSN : -     EISSN : 25028421     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Indonesia Natural Research Pharmaceutical Journal (INRPJ) merupakan jurnal ilmiah yang diterbitkan oleh Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta yang terbit dua kali dalam setahun.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 3 Documents
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Search results for , issue "Vol 10, No 2 (2025)" : 3 Documents clear
REVIEW ARTICLE: VALIDATION OF GAS CHROMATOGRAPHY-MASS SPECTROMETRY (GC-MS) METHODS IN THE ANALYSIS OF VOLATILE COMPOUNDS IN NATURAL MATERIALS Fauzan, Ki Agus Rifki; Wea Bii, Maria Febriani; Salsabila, Atikah; Rahma, Siti; Wulandari, Destiana; Yanto, Ari
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 10, No 2 (2025)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v10i2.9195

Abstract

Natural ingredients from plants are a major source of volatile compounds with biological activities such as antimicrobial, antioxidant, anti-inflammatory, and antifungal, particularly in essential oils. Testing of these compounds relies on reliable techniques such as gas chromatography-mass spectrometry (GC-MS), which separates and identifies components through retention time and mass spectra, with validation ensuring linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). This review article assesses the use and validation of GC-MS methods for the analysis of volatile compounds from natural ingredients, based on national and international literature over the past five years. The review approach included a structured search of databases such as PubMed, ScienceDirect, Google Scholar, and SINTA journals, with a focus on validation parameters and GC-MS instrument settings. The findings show that GC-MS stably detects key compounds such as monoterpenes and sesquiterpenes with 97-99% accuracy, and validates them according to AOAC standards (R² > 0.99; RSD < 8%; recovery 80-100%), where different extraction techniques affect their biological content and effectiveness. GC-MS validation is important to encourage innovation of environmentally friendly natural products in the pharmaceutical, food, and cosmetic sectors as a substitute for synthetic preservatives.
In Silico Study of Kaempferol Targeting MMPs and COX-2 for Anti-Aging and Wound Healing Handoyo, Theodorus Rexa
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 10, No 2 (2025)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v10i2.9214

Abstract

Skin aging and impaired wound healing are complex biological processes involving chronic inflammation and excessive degradation of the extracellular matrix. Matrix metalloproteinases (MMP-1, MMP-3, and MMP-9) and cyclooxygenase-2 (COX-2) play crucial roles in these processes and are considered important molecular targets for anti-aging and wound healing therapies. Kaempferol is a natural flavonoid compound known for its antioxidant and anti-inflammatory activities; however, its molecular interaction mechanisms with these targets remain incompletely understood. This study aimed to evaluate the potential of kaempferol as an anti-aging and wound healing agent through a molecular docking approach targeting MMP-1, MMP-3, MMP-9, and COX-2. Molecular docking simulations were performed using Molegro Virtual Docker 6.0, while ligand-protein interactions were visualized and analyzed using BIOVIA Discovery Studio Visualizer v.21.1.0.20298. The docking results indicated that kaempferol exhibited favorable binding affinities toward all target proteins, with the strongest interactions observed for MMP-9 and COX-2. Kaempferol formed conventional hydrogen bonds as well as hydrophobic and aromatic interactions within the active sites of the proteins. In conclusion, kaempferol demonstrates potential as a multitarget natural compound for anti-aging and wound healing applications, although further in vitro and in vivo studies are required to validate its biological activity.
REVIEW ARTIKEL: TINJAUAN VALIDASI METODE ANALISIS MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS PADA SENYAWA FENOLIK DALAM BERBAGAI SAMPEL Larasati, Chikita Intan; Safitri, Madinah; Ikramullah, Nazwa; Syah, Bintang Shaifana; Pujawati, Pujawati; Riyanti, Putri
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 10, No 2 (2025)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v10i2.9194

Abstract

Spektrofotometri UV-Vis ialah metode analisis yang banyak dipakai karena prosedurnya sederhana, biaya yang relatif rendah, serta sensitivitas yang memadai. Review artikel ini bertujuan untuk meninjau penerapan spektrofotometri UV-Vis dalam validasi metode analisis pada senyawa fenolik dalam berbagai sampel. Kajian dilakukan secara sistematis terhadap jurnal ilmiah nasional dan internasional yang dipublikasikan dalam sepuluh tahun terakhir (2015-2025) melalui penelusuran beberapa basis data elektronik dengan kriteria inklusi dan eksklusi. Artikel terpilih dianalisis secara kualitatif dengan fokus pada parameter-parameter validasi metode, yang meliputi linearitas; akurasi;presisi; batas deteksi (LOD) ; batas kuantitasi (LOQ). Hasil review bahwa spektrofotometri UV-Vis telah diaplikasikan secara luas dalam analisis senyawa fenolik serta menunjukkan pemenuhan terhadap kriteria validasi metode yang berlaku. Review ini diharapkan dapat memberikan gambaran mengenai keandalan spektrofotometri UV-Vis dalam validasi metode analisis senyawa fenolik.

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