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Alexander Patera Nugraha
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Fakultas Kedokteran Gigi, Universitas Airlangga Kampus A, jl. Prof. Dr. Moestopo No. 47 - 60132, East Java, Indonesia
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Kota surabaya,
Jawa timur
INDONESIA
Indonesian Journal of Dental Medicine
Published by Universitas Airlangga
ISSN : -     EISSN : 27221253     DOI : 10.20473/ijdm.v3i1.2020.1-3
Core Subject : Health,
Dentistry
Indonesian Journal of Dental Medicine accepts original manuscripts in the many fields of dentistry, including research reports and literature reviews. The spread of fields include: Oral epidemiology, Oral health services research, Preventive dentistry, Oral health education and promotion, Clinical research, Behavioural sciences related to dentistry, Ethics and oral health economics, Healthcare management, Pediatric dentistry, Periodontic dentistry, Oral & maxillofacial surgery, Oral biology, Forensic dentistry, Prosthodontic dentistry, Dental radiology and many more
Arjuna Subject : Kedokteran Gigi - Kedokteran Gigi (Lain-Lain)
Articles 152 Documents
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Immunomodulatory and regenerative potential of mesenchymal stem cells in recurrent aphthous stomatitis: A narrative review Vemilia Pasha Hawini; Iswerya Bala Subramaniam; Andari Sarasati; Fatma Yasmin Mahdani; Reiska Kumala Bakti; Diah Savitri Ernawati; Faezah Binti Rokhan
Indonesian Journal of Dental Medicine Vol. 9 No. 2 (2026): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v9i2.2026.105-111

Abstract

Background: Recurrent Aphthous Stomatitis (RAS) is a chronic inflammatory disorder of the oral mucosa characterized by recurrent, painful ulcerations with an etiology that is not yet fully understood. Immunological, genetic, and environmental factors play significant roles in its pathogenesis. Conventional therapies, such as topical corticosteroids, antiseptics, and anti-inflammatory agents, are primarily symptomatic, providing temporary relief from pain and inflammation without addressing the underlying immune dysregulation or promoting mucosal regeneration. These limitations have led to increasing interest in novel therapeutic approaches, including Mesenchymal Stem Cell (MSC)–based therapy, which offers potential immunomodulatory and regenerative effects. Purpose: This narrative review aims to integrate and discuss the existing evidence regarding the immunomodulatory and tissue-repair roles of mesenchymal stem cells (MSCs) in recurrent aphthous stomatitis (RAS), with a focus on underlying biological mechanisms and current research gaps. Review: The current literature indicates that MSC-mediated immunomodulation in RAS is primarily inferred from preclinical models, in which reductions in pro-inflammatory cytokines and increased secretion of growth factors have been observed. Although these findings support a mechanistic rationale for MSC involvement in epithelial repair, direct and consistent evidence of ulcer healing and inflammation resolution remains limited. Translational application of these findings is constrained by heterogeneity in experimental designs and a lack of well-controlled clinical studies. Conclusion: RAS remains a chronic inflammatory condition without a definitive curative treatment. MSC-based therapies demonstrate promising dual immunomodulatory and regenerative potential; however, further clinical studies are required to establish safety, optimal delivery methods, and long-term efficacy.
Dento-alveolar injury associated with severe extrusive-buco luxation of primary tooth Dimas Prasetianto Wicaksono; Gifa Alfi Syahrin; Frida Chusna Achirularofa; Udijanto Tedjosasongko; Kittipong Laosuwan; Soegeng Wahluyo
Indonesian Journal of Dental Medicine Vol. 9 No. 2 (2026): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v9i2.2026.95-99

Abstract

Background: Traumatic dental injury in primary tooth is one of damaging of primary tooth and surrounded tissues due to physical impact. This damage often occurs in children and adolescent due to fall, sport activity or accident. The impact of this injury in several cases not only involving just the tooth, but also surrounded tissue such as periodontal tissue, gingiva. One of the traumatic dental injuries in primary tooth aim is preventing the damaging of permanent tooth bud, then the treatment of this injury should be done in quick and appropriate. Purpose: to present the management of dento-aveolar injury with severe extrusive-buco lateral luxation in primary tooth. Case: A female toddler 2 years old came to the outpatient, Department of Pediatric Dentistry, Universitas Airlangga to treat his complaint. She was complained mobility of her incisive together with difficulties to eat. Based on the history, she went to dental emergency room 2 days earlier, Academic Dental Hospital, Universitas Airlangga due to falling down the stairs at her home. After getting treatment in emergency room, she was referred to pediatric dentistry department. Case Management: The diagnose of her complain was dento-aveolar injury with severe extrusive-buco lateral luxation on primary mandibular left central incisor (71) and traumatic ulcer on left lower labial. Extraction of tooth 71 was the option to treat her complain, together with administration some medicines. Conclusion: Extraction is the option for severe extrusive buco-lateral luxation in a primary tooth to restore function, prevent aspiration and permanent tooth bud damage.

Page 16 of 16 | Total Record : 152

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