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Anna Safitri
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jsmartech@ub.ac.id
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jsmartech@ub.ac.id
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Research Center for Smart Molecule of Natural Genetics Resources (SMONAGENES) office: 2nd floor MIPA Building, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Jl. Veteran Malang, East Java, Indonesia – 65145
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JSMARTech : Journal of Smart Bioprospecting and Technology
Published by Universitas Brawijaya
ISSN : 26860805     EISSN : 27147894     DOI : https://doi.org/10.21776/ub.jsmartech.2020.001.02.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
JSMARTech : Journal of Smart Bioprospecting and Technology (p-ISSN: 2686-0805, e-ISSN : 2714-7894) is an Open Access Scientific Journal published by Research Center of Smart Molecule and Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Malang, East Java, Indonesia, since 2019. It is a journal covering of bioprospecting, biochemical, biotechnology, bioinformatics, natural product, pharmaceuticals, biomedical, genetics engineering, nutrigenomic, and nanotechnology. The journal publishes a manuscript written in English for original research papers, short communications, and review articles. The paper published in this journal implies that the work described has not been, and will not be published elsewhere, except in abstract, as part of a lecture, review or academic thesis.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 9 Documents
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Search results for , issue "Vol 2, No 1 (2020)" : 9 Documents clear
Front Matter JSMARTech, October 2020, Vol. 2 No.1 Safitri, Anna; Sari, Dewi Ratih Tirto
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.0

Abstract

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Molecular Docking Study of Active Compounds in Amaranthus tricolor Leaves as High Mobility Group Box 1 (HMGB1) Inhibitor in Breast Cancer Ardiana, Rachmawati; Khasanah, Dewi Uswatun; Permatasari, Diah; Adianingsih, Oktavia Rahayu
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.28

Abstract

Breast cancer shows the proliferation of malignant epithelial cells that limit the ducts and lobes of the breast. If this process is not controlled, it will cause lumps that can then spread to other parts of the body and cause death. High-mobility group box protein 1 (HMGB1) has been reported to play roles in promoting cell survival of breast cancer cells. The inhibition of HMGB1 could be a reasonable target for the treatment of breast cancer. Amaranthus tricolor has been found could reduce the viability of breast cancer cells. In this study, we aim to predict the ability of the active compounds in Amaranthus tricolor leaves to inhibit the HMGB1 through molecular docking study. The molecular docking was conducted by using the PyRx software. This study shows that the four active compounds in Amaranthus tricolor leaves, namely isorhamnetin, routine, myricetin, and quercetin, have the smallest bond energy, indicating that the four compounds are the most stable and have the highest potency as HMGB1 inhibitor.
Community Empowerment Through 2nd Generation Tempeh Innovation Towards a Food Organized Village Raharjo, Sentot Joko; Fidyasari, Ambar
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.43

Abstract

Tempeh is one of Indonesia's traditional foods. Currently proposed to be a world cultural heritage in UNESCO. Tempeh cannot last long, so it takes innovation that can increase the economic value of tempeh itself. The main objective of this empowerment program is to optimize the potential of “UKM” (Small and Medium Industries) in the food sector for tempeh craftsmen and reduce the losses of tempeh craftsmen for those whose tempeh is not sold. The target partner of this community assistance program is the “UKM” group Tempeh Village in Beji Village, Junrejo, Batu City who has been economically productive as Tempeh craftsmen. The method used is Asset Based Communities Development (ABCD), where the community service focuses on assets owned by the community as the main basis for program development. The efforts carried out are assistance to SMEs to deliver material on the nutritional value of 2nd generation tempeh, workshops and 2nd generation tempe making practices, entrepreneur assistance and evaluation. This innovation is expected to be a solution to the unsold tempeh problem. This assistance was carried out for 3 months. The output of this empowerment activity is in the form of material modules, 2nd generation tempeh products, understanding of the nutritional value concept of second generation tempeh and digital marketing media plans.
Screening of COVID-19 Using Rapid Test Before Gastrointestinal Procedures; Experience in a Limited Resource Hospital Yusuf, Fauzi; Maghfirah, Desi; Muhsin, Muhsin
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.35

Abstract

Corona Virus Disease 2019 (COVID-19) is an emerging disease announced by World Health Organization (WHO) as a pandemic disease since March 2020. Several international guidelines suggested use of reverse transcriptase polymerase chain reaction (RT-PCR) test as screening tool before starting gastrointestinal (GI) procedures. Although RT-PCR is a gold standard, it has limitation as it is expensive and requires special expertise therefore difficult to implement in limited resource hospitals. Due to lack of RT-PCR tests available and in accordance with Indonesian government regulation, thirty patients in a tertiary referred hospital in Banda Aceh were screened with rapid test antigen and antibody for COVID-19 before underwent emergency and urgency GI procedures such as endoscopy, colonoscopy and abdominal ultrasonography. Several laboratory parameters and chest X-ray in all patients were assessed. All health care workers in procedure room were also tested with rapid antigen 1 week after the procedures. The study showed that laboratory parameters and chest X-ray were relatively normal for all patients. All procedures were conducted safely and leave no new COVID-19 case amongst health care workers. In conclusion, rapid test can be used in hospitals with limited resources, although RT-PCR test is still needed to confirm COVID-19 cases. Safe GI procedures can still be performed in limited resource hospital, although the possibility for disease transmission is still high. A modified guideline is needed in these hospitals in order to conduct safe GI procedures.
Molecular Docking Analysis of α-Tomatine and Tomatidine to Inhibit Epidermal Growth Factor Receptor (EGFR) Activation in Non-Small-Cell Lung Cancer (NSCLC) Amalia, Intan Fitri; Sayyidah, Assyifa; Larasati, Kirana Aisyah; Budiarti, Sarah Fadilah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.1

Abstract

The use of chemical drugs is the most common option for NSCLC therapy but mostly it has side effects,suchasdiarrhea,skinproblems,excessivebodyfeeling,andmouthsores.Therefore,NSCLC therapy using herbal medicine from plant bioactive compound began to be developed to minimize the side effect of chemical drugs consumption. Tomato (Lycopersiconesculentum Mill.) is one of the herbal source which contains bioactive compounds such as α-tomatine and tomatidine. The aims of this study is to analyze the effectiveness of α-tomatine, tomatidine, and combination of both of them to inhibit EGFR activity by molecular docking. The ligand and protein preparations were done using Discovery Studio 2016 then Hex 8.0.0 is used for docking. Visualization were done using Discovery Studio 2016 as well. Alpha tomatine, tomatidine, and combination of both of them have potential as inhibitors of the interaction between EGFR and EGF as native ligands. Combination alpha tomatine and timitidine have the best results among other complex that has been tested with thread of alpha tomatine applied before tomatidine. Alpha tomatine and tomatidine can be considered as drugs that can control overexpression of EGFR and decrease activation of one of the lung cancer signaling pathways. 
Developing Herbal Medicine, The Role of β-1,3/1,6-D-Glucan Forms of Polysaccharide Peptide (PsP) from Mycelia Ganoderma lucidum Extracts for Lowering Elevated Total Cholesterol Level in Patients with Heart Failure in Ischaemic Heart Disease Sargowo, Djanggan; Wihastuti, Titin Andri; Dewi, Elvira Sari; Saputri, Diana Nanda
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.40

Abstract

High levels of total cholesterol can worsen the condition of ischemic heart failure. Polysaccharide peptide (PsP) is a capsule of Ganoderma lucidum extract. This study aims to measure changes in total cholesterol levels in patients with ischemic heart failure before and after the administration of PSP and Placebo and to analyze differences in decreases in total cholesterol levels between PSP and Placebo group. This research is a true experiment with a prospective double-blind randomized control method through pre-post test design. The sample consisted of 26 patients, divided into 2 groups and given PSP or placebo capsules per oral interventions carried out every day for 90 days. Venipuncture blood was taken before and after the intervention to measure total cholesterol levels by spectrophotometry methods. Paired T Test was used to determine the average reduction in total cholesterol levels for each group. Independent T Test was used to determine the difference of reduction in total cholesterol average between the two groups. The decrease of total cholesterol average level in PsP group was 24.3 mg/dl (p value 0.001) and an increase of Placebo group was 8.3 mg/dl (p value 0.099). Comparison of the average reduction in total cholesterol levels in PsP : Placebo group was 24.31: -8.31 mg/dl (p value 0.000). There was significant decrease total cholesterol levels in PsP group and neither was of the Placebo group. In addition, there was significant difference in the reduction of total cholesterol levels between PSP and Placebo group.
Virtual Prediction of Lycopene and Quercetin Effects on Angiogenesis Through VEGFR-2 Pathway Samoedra, Rizky Senna; Sari, Fikriya Novita; Pratama, Setyaki Kevin
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.7

Abstract

Angiogenesis is a complex process that is required for cancer cells to perform metastasis. The binding of a growth factor such as VEGF to its receptor is one of the factors to trigger angiogenesis through VEGFR-2 pathway. This study is conducted to analyze the effect of lycopene and quercetin, which are compounds found in watermelon (Citrullus lanatus) on angiogenesis through VEGFR-2 pathway. The study was carried out in silico. Ligands were obtained from PubChem and prepared using PyRx while the protein was obtained from PDB and prepared using BIOVIA Discovery Studio 2019. The docking was done by using HEX 8.0.0 and the results were visualized using BIOVIA Discovery Studio 2019. Lycopene and quercetin were able to bind with VEGFR-2 to interrupt the binding of VEGFA. The presence of lycopene and quercetin also lowers the binding strength of VEGFA with VEGFR-2 as they can affect interactions between VEGFA and VEGFR-2 at 4 and 5 amino acid residues by changing the type of interactions to make the binding strength weaker. The binding of lycopene and quercetin have the potential to interrupt the downstream pathway of angiogenesis through VEGFR-2 pathway.
In Silico Screening of Schleichera oleosa Phytocompounds as Estrogen Receptors Alpha Inhibitors for Breast Cancer Pratiwi, Radita Intan Aisyah; Rahayu, Tintrim; Mubarakati, Nurul Jadid
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.14

Abstract

Abstrak: This study aimed to predict the potential activity, toxicity, and interaction of fifteen bioactive compounds from Schleichera oleosa as estrogen receptors alpha inhibitors via in silico analysis. Active compound was downloaded from the PubChem database, and the 3D structure of the human estrogen receptor alpha (ERα) was obtained from the Protein Data Bank database with 4-Hydroxytamoxyfen as a positive control. The interaction of bioactive compounds with macromolecule was examined via a molecular specific docking using AutoDock Vina with PyRx 9.5 software. The protein was visualized using Discovery Studio 4.1. The drug-likeness property and human intestinal absorption of those fifteen bioactive compounds were evaluated through absorption, distribution, metabolism, and excretion (ADME) analysis using the pkCSM online tool program. The interactions between proteins and ligands are largely through the formation of hydrogen and van der Waals bonds. The binding energy of lupeol acetate, lupeol, schleicheol 1, betulinic acid, betulin, beta-sitosterol, schleicherastatin 7, schleicherastatin 2, schleicherastatin 4, scopoletin, schleicherastatin 3, schleicherastatin 1, schleicherastatin 6, schleicherastatin 5 alpha and schleicherastatin receptors including -8.3, -8.3, -7.1, -7.1, -6.7, -6.6, -6.6, -6.5, -6.5, -6.3, -6.2, -6.2 -6.1, -5.9 and -5.5 kcal / mol, respectively . The in silico ADME analysis also revealed that lupeol and lupeol acetate were the best active compound that passes the test based on the Lipinski rule, ADME, and toxicity. Therefore, it can be stated that Schleichera oleosa has potential as an inhibitor of alpha estrogen receptors. The inhibitory activity of alpha estrogen receptors has led to new breakthroughs in plant-based medicinal products, particularly for breast cancer. Keyword: Schleichera oleosa, alpha estrogen receptors, phytocompound, breast cancer and in silico
Molecular Docking Chlorogenic Acid and Isomer Compound as Cyclooxygenase-2 (COX-2) Inhibitor in Atherosclerosis Nurarifa, Ratna; Rachmawati, Devi Era; Utari, Dwi
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.22

Abstract

Atherosclerosis is an inflammatory disease caused by oxidized LDL. Chloroghenic acid (CGA) is a polyphenol compound and its isomers such as Caffeoylquinic acid (CQA) and Feruloylquinic acid (FQA) can increase the activity of antioxidant activity and can significantly reduce total cholesterol in the blood. Cyclooxygenase (COX) is an enzyme that correlates with the inflammatory process. COX is divided into two isoforms, COX-1 and COX-2. Prostanoid synthesis via the action of cyclooxygenase-2 (COX-2) is a component of the inflammatory response. All prepared compound of Chlorogenic acid (CGA) and its isomer, Caffeolycquinic acid (CQA) and Feruloylquinic acid (FQA) is used for molecular docking by using HEX 8.0.0. Visualization process is done by using Discovery Studio Client 4.1 software. The results showed docking between COX-2 with CGA compounds and its isomers also drug Ibuprofen shows energy binding COX-2 - CGA of -320 kcal / mol, COX-2 - CQA of -298 kcal / mol, COX-2 - FQA of -282 kcal / mol, and COX-2 - Ibuprofen of -230 kcal / mol. The docking results show the CGA compound and its isomers have smaller energy bindings than the drug Ibuprofen. This shows that the CGA compound and its isomers are better than the Ibuprofen drug so that it has the potential as an anti-inflammatory which can be used to prevent the formation of atherosclerosis.

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