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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Effect of Sweet Potato Anthocyanin (Ipomoea Batatas L.) on Levels of Follicle Stimulating Hormone and Folliculogenesis in Rattus Norvegicus Exposed to Cigarette Smoke Astika Gita Ningrum1 , Retty Ratnawati2 , Sri Andarini3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13674

Abstract

Cigarette smoke is one of the exogenous free radicals that can enter the blood circulation so that it candisrupt all body cells and tissues, including the reproductive organs. The anthocyanin in purple sweetpotato is one of the bioactive that can counter free radicals. This study was conducted to prove the effectof anthocyanin in purple sweet potato from Gunung Kawi cultivar on follicle-stimulating hormone (FSH),and folliculogenesis levels on Wistar rats (Rattus norvegicus) exposed to cigarette smoke. This study wasan experimental study with Randomized Post Test Only Control Group Design, using 30 female Wistar ratsaged 1-2 months weighing 150-200g. The rats were divided into three groups of where they were exposedto cigarette smoke and administered with anthocyanin (each group with the doses of 20, 40 and 80 mg/kgbw/day). One positive control group was exposed to cigarette smoke without being administered withanthocyanin for 56 days, and one more group served as a negative control. The FSH levels in the serum weremeasured by employing the ELISA method, and the folliculogenesis (follicle amount and number of ovaryfollicular granulosa cells) was measured from histopathological slides with Haematoxylin-Eosin staining.The results indicated that anthocyanin in purple sweet potato significantly increased the FSH levels, thefollicle amount and the number of primary follicular granulosa cell, secondary, and Graafian on femaleWistar rat ovaries exposed to cigarette smoke with a p-value of less than 0.05. To ensure the anthocyanindose that had maximum effect, more research is required with more dose variations and chronic toxicity testsfor the safety of the anthocyanin in purple sweet potato of Gunung Kawi cultivar.
Correlation between the Expression of E6 HPV with p53 and p16INK4A at Cervical Adenocarcinoma and Cervical Normal Gondo Mastutik1 , Alphania Rahniayu2,3, Nila Kurniasari2,3, Anny Setijo Rahaju2,3, Rahmi Alia4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13675

Abstract

Introduction: Cervical adenocarcinoma is the second most common type of cervical cancer. The markerto predict the risk of this cancer is still need to be improved. This study aimed to evaluate the correlationbetween expression of E6 HPV with p53 and p16INK4A in cervical adenocarcinoma and cervical normal.Methods: This study was a cross sectional study conducted at the Department of Anatomic Pathology, Dr.Soetomo General Academic Hospital Surabaya Indonesia using 49 paraffin blocks during period JanuaryDecember 2017. The E6 HPV, p53, and p16INK4A expression were detected by immunohistochemistrystaining. Results: There were significant differences between the expression of E6 HPV and p16INK4Ain cervical adenocarcinoma and cervical normal, but the expression of p53 was no significant differencewith p=0.060 (P>0.05). There was a positive correlation between the expression of E6 HPV with p53 andp16INK4A (p<0.05) in cervical adenocarcinoma and cervical normal, and in cervical adenocarcinoma group,there was a significant correlation between the expression of E6 HPV with p53 (p=0.004) and p16INK4A(p=0.028), but no correlation was found between p53 with p16INK4A expression (p=0,092). Conclusion:It suggests that p16INK4A might serve as marker for predicting the risk of developing cervical cancer fromthe epithelium of cervical normal.
Correlation of Physical Activity with Fear of Fall in Patients with Total Knee Replacement - A Research Protocol Nupur Thombare1 Shalaka Dhankar2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13676

Abstract

Background: An elderly patient who has undergone total knee replacement may have fear of fall. Fear offall after TKR and its impact on physical activity is sparsely researched. This study was aimed to find acorrelation of physical activity with fear of fall in patients with Total Knee Replacement. Physical activity isassessed using the Physical activity scale for the elderly (PASE) Scale. The PASE Scale is understandable,reliable, and is a valid tool to assess physical activity in the elderly. Fall efficacy scale (FES) is a valid toolto assess fear of fall. Objectives: The objective of the current study is to assess physical activity and fearof fall and to find Correlation of physical activity with fear of fall in patients with TKR. Methods: Thisstudy will be carried out in Physiotherapy OPD, Ravi Nair Physiotherapy College and AVBRH HospitalSawangi Meghe, Wardha .100 Patients undergone TKR will be examined. Physical activity and fear of fallwill be assessed using the PASE scale and Fall Efficacy Scale respectively. Results: Upon completion ofthe Study result will be estimated by statistical analysis. Conclusion: After going through various studies,maximum studies indicated that there is a decrease in physical activity in patients with TKR but very fewstudies indicated fear of fall in the patients. Therefore, the current study is being carried out which couldhelp to reach the conclusion to find whether there is any correlation between physical activity and fear offall in patients undergone TKR. Because rehabilitation after TKR is mainly concentrated on improving thephysical function however if the patient has fear of fall this may interfere with the patient returning to his orher physical activity
The Risks of Femoral Nailing in the Positioning of Hemilithotomy on Traction Table Getting A Contralateral Well-Legdrop-Foot Jasraj Kaur Bhamra1 , Manpreet Kaur Bhamra1 , Waqar M. Naqvi2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13677

Abstract

Introduction: Postoperative contra lateral morbidity following fracture fixation surgery is rare due tohemilithotomy placement on traction table. Following a typical orthopedic femoral nailing, we should notea case of unexplained typical peroneal nerve palsy formed on the contra lateral side, manifesting with dropfoot.Case report: After prolonged femoral nailing, a 32-year-old male suffered an uncommon common peronealnerve palsy that manifested itself toward lateral drop foot. This iatrogenic and intermittent disorder wasdelineated to be position-related neuropraxia after neurophysiological analysis and review of applicableliterature.Conclusion: Place modification at intervals or complete avoidance of excessive hyperflexion of the knee isadvised to prevent typical peroneal nerve morbidity against the lateral.
Correlation between Workload and Work Environment with Work Stress Shabrina Firsta Aulia1 , Putri Ayuni Alayyannur2 , Endang Dwiyanti3 , Tri Martiana4 , Shintia Yunita
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13678

Abstract

Competition in the business world nowadays caused many pressures on workers and resulting in work stress.During 2001, the problem of stress had cost the organization up to $ 300 billion in terms of reimbursingmaintenance costs, workers’ compensation, absenteeism and labor turnover. In Indonesia, especially Jakarta,around 1.33 million residents experience stress. This figure reaches 14% of the total population with severestress levels of 7-10% and acute stress of 1-3%. It was also reported that Health care costs were almost 50%higher for treating workers who experienced high levels of stress in their work. Previous studies had foundout that work stress was caused by several factors including work environment and workload. The purposeof this study was to analyze the correlation between workload and work environment with work stress on theMaintenance and Repair Division workers of PT. PAL Indonesia (Persero). This research design was a crosssectional study. The population in this study were all technician workers on the Maintenance and RepairDivision of PT. PAL Indonesia (Persero) as many as 51 workers. The sample was calculated using a simplerandom sampling technique so that a sample of 49 workers was obtained in the Production Department,Maintenance and Repair Division of PT. PAL Indonesia (Persero). The study was conducted in June 2019.Variables in this study were work climate, noise, lighting, physical workload, mental workload, and workstress. The data were analyzed by using the chi-square test and spearman test because there are differencesin the scale of the data on the variables. The results are: work climate is not related to work stress (sig 0.715> ?), noise is not related to work stress (sig 0.380 > ?), lighting is not related to work stress (0.322 > ?),physical workload is related to work stress (sig 0.004 < ?), mental workload has no relationship with workstress (sig 0.377 > ?). The conclusion of this study is that only physical workload has a correlation withwork stress.
The Role of Ultrasonography in The Diagnosis of Oral and Maxillofacial Disease Ni Putu Mira Sumarta1 , David Buntoro Kamdjaja2 , Roberto Manahan Yantie Simandjuntak3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13680

Abstract

Objective: Ultrasonography, as a diagnostic tool, constitutes a non-invasive, cost-effective, readily-availableand repeatable imaging technique. Ultrasonography has been used as a means of diagnosing various medicalconditions for many years. However, in the field of maxillofacial surgery it represents a relatively new aidin the diagnosis of various diseases affecting the oral and maxillofacial regions. These include: infection,soft-tissue related diseases and vascular anomalies which can be detected using Doppler ultrasonography.This article presents four cases, in which ultrasonography was employed to confirm diagnoses and act as aguide to treatment. Methods: Four cases of soft tissue swelling and enlargement were diagnosed with theaid of ultrasonography, namely: a submasseteric abscess, a nasolabial cyst, a dermoid cyst and a left buccalspace abscess caused by a foreign body (i.e. a fish bone). Result: In the case of a submasseteric abscess,ultrasonography was used in confirming the diagnosis and therapy, while determining the maximal point ofthe abscess. In the cases of both cysts, ultrasonography highlighted well-defined cystic lesions with internalecho showing fluid accumulation, while in the buccal space abscess, an ultrasonogram confirmed the exactlocation of the fish bone. Conclusion: Ultrasonography is a quick, widely-available, relatively inexpensive,painless procedure which can be repeated as often as necessary without risk to the patient. Thus, ultrasonographyis a valuable diagnostic aid to the oral and maxillofacial surgeon in achieving early and accurate diagnosis.
Association of Gamma-GT Serum and Nerve Conduction Velocity of Nervus Peroneus Motor Vehicles on Diabetic Polyneuropathy Patients Januar1 , Mudjiani Basuki2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13681

Abstract

Background and Objectives: Diabetic Polyneuropathy is one of the common complications of diabetesmellitus (DM) and can lead to foot ulcers or amputation. The pathophysiology of Diabetic Polyneuropathyincludes several factors such as metabolic, vascular, autoimmune, oxidative stress and neurohormonalgrowth-factor deficiency. The recent studies have suggested the use of serum gammaglutamyl transferase(GGT) as an early marker of oxidative stress. Therefore, we investigated whether serum GGT may be usefulin predicting Diabetic Polyneuropathy.Methods: The study was conducted in patients with diabetic polyneuropathy who meet the criteria forinclusion and exclusion in neurological outpatient clinic and EMG room departments of NeurologyDr.Soetomo General Hospital Surabaya consecutively started in June 2014 to April 2015.Result: We obtained 20 study subjects (8 subjects with increased serum levels of gamma GT and 12 subjectswith normal serum levels of gamma GT). There was statistically no significant between serum levels ofgamma GT with motoric nerve conduction velocity (NCV) of peroneal nerve (p = 0.582 ; Odds ratio 0.600).Conclusion: There was no relationship between elevated levels of serum gamma GT with decreased motornerve conductivity velocity peroneal nerve in patients with diabetic polyneuropathy.
In situ Molecular Hybridization of Kaposi, s Sarcoma Associated Virus (Human Herpes Virus 8) in Nasopharyngeal Carcinoma Tissues Zainab A. Hamid1 , Zahraa Ali Abdullah2 , Isra’a Mahdi Al-Sudani3 , Saad Hasan Mohammed Ali4 , Shaki
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13682

Abstract

Background: Viral, dietary and genetic factors are implicated in the etiology ofnasopharyngeal cancer, a raretype of head and neck cancers. Unlike other viruses, HHV-8 encodes several human cytokines homologuesand regulatory genes that play important roles in the viral pathogenesis.Objective: To analyze the rates of HHV-8 infection in tissues obtained from a group of patients withnasopharyngeal carcinoma and inflammatory nasal polyps (INP) .Patients and Method: One hundred- thirty formalin-fixed, paraffin- embedded nasopharyngeal carcinomaand nasal inflammatory polyps tissues enrolled in this study; 65 nasopharyngeal tissue biopsies fromnasopharyngeal carcinoma; 35 tissue biopsies from nasal inflammatory polyps and 30 nasopharyngealtissues with unremarkable pathological changes, as apparently healthy tissuecontrol. Detection of HHV-8was done by chromogenic in situ hybridization (CISH) technique detection system.Results: In nasopharyngeal carcinoma tissues, the HHV-8- DNA positive CISH reactions were detected in23.1% while in nasal inflammatory polyps tissues HHV-8-positive CISH reactions were found in 8.6% ofthe examined tissues. The correlation between HHV-8 and NPC & INP was highly significant (P= 0.001).Conclusion: Significant HHV-8 detection in nasopharyngeal carcinoma & inflammatory nasal polypstissuescould point for their possible role in either pathogenesis or carcinogenesis of both these lesions.
Smoke Exposure at Home to the Incidence of Pneumonia in Children Under 5 Years Old Eny Dwimawati1, Galuh Pradian Yanuaringsih2 , Resmi Pangaribuan3 , Nina Olivia3 , Fitriani Pramita G
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13683

Abstract

Increased levels of pollutants in the room, apart from the penetration of outdoor pollutants, can also comefrom indoor pollutant sources such as cigarette smoke, smoke from using firewood, and the use of mosquitocoils. Pneumonia is the ultimate overlooked child killer (major “forgotten killer of children”). In KlatenDistrict, pneumonia cases in the last 3 years have increased, 1,068, 1,244, and 1,705. This study was todetermine the relationship between the incidence of pneumonia and exposure to smoke at home in childrenunder 5 years of age in Klaten Regency, Central Java Province. This type of research is observational analyticwith case-control studies. The total sample of 278 (139 cases and 139 controls) children under 5 years ofage resided in Klaten Regency and were recorded as pneumonia cases in the public health care registerin 2012 that met the inclusion and exclusion criteria. The research instrument consisted of a structuredquestionnaire. The results of data analysis showed that the relationship with the incidence of pneumonia inchildren under five was the variable exposure to cigarette smoke (OR=2,053; p=0,017 and 95% CI=1,137-3,705) and exposure to kitchen smoke (OR=2,664; p=0,003 and 95% CI=1,4002-5,0680). Factors associatedwith the incidence of pneumonia in children under 5 years of age in Klaten Regency, Central Java Provinceare exposure to cigarette smoke and exposure to kitchen smoke.
Factors Affecting Romantic Relationship Satisfaction of University Students Kyu Eun Lee1 , Hae Kyung Chang2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13684

Abstract

Background/Objectives: The purpose of this study was to identify the factors affecting romantic relationshipsatisfaction of university studentsMethods/Statistical analysis: This study was conducted with 187 students from four universities in citiesand provinces nationwide. Data were collected from September to October 2019 using a self-administeredquestionnaire. Collected data were analyzed through the stepwise regression analysis using the SPSSstatistics program.Findings: The final regression model showed that self-esteem, anxiety attachment, and avoidance attachmentwere significant predictors related to romantic relationship satisfaction in university students and explained34.7% of the variance in romantic relationship satisfaction.Improvements/Applications: The university student period is a time to form an adult attachment, therebypreparing for a happy marriage in the future by increasing the romantic relationship satisfaction. Therefore,it is necessary to develop and apply the educational programs that can increase self-esteem and positiveheterosexual relationship for university students.

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