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Eureka Herba Indonesia
Published by HM Publisher
ISSN : -     EISSN : 27465152     DOI : https://doi.org/10.37275/ehi.v1i1.1
Core Subject : Health,
Medicine & Pharmacology
Eureka Herba Indonesia (EHI) is peer review scientific journal that focused on reserach in exploration potential Herba of Indonesia for enhancing healthy. EHI focused on : 1. Medicinal Plants. 2. Efficacy of Herba Study. 3. Safety of Herba Study. 4. Animals that potential for developing as healthy products. 5. Minerals that potential for developing as healthy products.
Arjuna Subject : Kedokteran - Kedokteran Komplemen dan Alternatif
Articles 121 Documents
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Multi-Target Modulation of the Gut-Liver Axis by Beras Kencur and Kunyit Asam Phytomolecules: Shotgun Metagenomic Re-Analysis, AGORA2 Metabolic Flux Modeling, and Biosynthetic Enzyme Docking in Metabolic Steatohepatitis Louisa Istarini; Arsan Saliha
Eureka Herba Indonesia Vol. 6 No. 2 (2025): Eureka Herba Indonesia
Publisher : HM Publisher in collaboration with CMHC Research Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v6i2.151

Abstract

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is driven by breakdown of the gut-liver axis. Loss of short-chain fatty acid (SCFA)-producing commensals weakens mucosal tight junctions and allows portal translocation of lipopolysaccharide (LPS), which activates hepatic Kupffer cells and promotes fibrosis. The Indonesian Jamu formulations Beras Kencur (Kaempferia galanga and Oryza sativa) and Kunyit Asam (Curcuma longa and Tamarindus indica) act at this mucosal interface. Objective: To delineate the multi-target systems pharmacology of Jamu phytomolecules across the gut-liver axis. Methods: Fecal shotgun metagenomes (BioProject PRJNA737472; N = 180: 60 healthy controls, 60 non-alcoholic fatty liver and 60 MASH) were profiled with MetaPhlAn 4 and HUMAnN 3. Community flux balance analysis of a four-species commensal consortium was performed in AGORA2 using COBRApy, and molecular docking was run in AutoDock Vina 1.2.0 against tight junction, innate immune and nuclear receptor targets. Results: Faecalibacterium prausnitzii (−77.4%) and Akkermansia muciniphila (−83.5%) were depleted in MASH (both p < 0.001), together with the SCFA biosynthetic genes but (−58.4%), pct (−46.2%) and ackA (−38.7%). Jamu supplementation restored acetate cross-feeding and raised community butyrate secretion by 84.6% (0.422 to 0.779 mmol/gDW/h). Ethyl p-methoxycinnamate bound the Toll-like receptor 4/myeloid differentiation factor 2 complex (ΔG = −8.84 kcal/mol; inhibition constant, Ki = 0.33 µM), curcumin bound Occludin (ΔG = −8.92 kcal/mol) and demethoxycurcumin bound zonula occludens-1 (ΔG = −8.45 kcal/mol). Barrier reinforcement reduced modeled portal LPS influx by 68%. Conclusion: Beras Kencur and Kunyit Asam restore commensal SCFA cross-feeding, reinforce the mucosal barrier and attenuate endotoxin-driven hepatic inflammation in MASH.

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