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Rachmat Hidayat
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Eureka Herba Indonesia
Published by HM Publisher
ISSN : -     EISSN : 27465152     DOI : https://doi.org/10.37275/ehi.v1i1.1
Core Subject : Health,
Medicine & Pharmacology
Eureka Herba Indonesia (EHI) is peer review scientific journal that focused on reserach in exploration potential Herba of Indonesia for enhancing healthy. EHI focused on : 1. Medicinal Plants. 2. Efficacy of Herba Study. 3. Safety of Herba Study. 4. Animals that potential for developing as healthy products. 5. Minerals that potential for developing as healthy products.
Arjuna Subject : Kedokteran - Kedokteran Komplemen dan Alternatif
Articles 103 Documents
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How to Increasing Prolactine Levels of Breastfeeding Mother with Consumption Katuk (Sauropus androgynous(L)Merr) Leaf Ulfa Primadhani
Eureka Herba Indonesia Vol. 2 No. 2 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i2.30

Abstract

Inadequate breast milk production is the most common inhibiting factor causing the cessation of exclusive breastfeeding practices an effort to increase the rate of secretion and production of breast milk is through the use of traditional herbal medicines such as decoction and extraction of katuk leaf (Sauropus androgynous). Katuk leaf extract (Sauropus androgynous) has been known to have a variety of pharmacological activities. This paper aims to review the botany, phytochemistry, ethnopharmacology, and pharmacological activities of S. androgynous, and discuss the known chemical constituents at work in S. androgynous-induced prolactin levels to increase breast milk in humans. The data presented in this review were collected from published literature as well as the electronic databases of PubMed, CNKI, Web of Science, SCI finder, ACS, Science Direct, Wiley, Springer, Taylor, Google Scholar, and a number of unpublished resources, (ex: books, and Ph.D. and M.Sc. dissertations). Searching for research articles in several databases using certain keywords breast milk human and katuk (Sauropus Androgynus) leaf literature. All abstracts retrieved were screened for inclusion. All types of articles, including case series and case reports, were included due to the lack of herbal katuk leaf clinical trials. Exclusion criteria consisted of non - English and nonhuman articles. In conclusion, there was a significant effect of katuk leaf consumption towards increasing breastmilk production volume.
Potential Combination of Xanthone Compounds from Mangosteen Fruit (Garcinia mangostana) with Eugenol Compounds in Basic Leaf (Ocimum sanctum) as Alternative Therapy in Preeclampsia Muhammad Al Farisi Sutrisno
Eureka Herba Indonesia Vol. 2 No. 2 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i2.32

Abstract

Preeclampsia is a hyperdynamic condition that is syndromed by hypertension and proteinuria after 20 weeks of pregnancy. Preeclampsia incident is the first cause of 6- 8 % number morbidity/mortality maternity and fetus in the world. Preeclampsia is related to the disability of physiology adaptation that can decrease perfusion of uteroplacental. Xanthone derivatives in mangosteen have been reported to possess a wide range of biological properties, including antioxidant and antihypertensive activities. Eugenol is a primary component of basil oil. It is known for its antioxidant, antiinflammatory, and vasorelaxant actions. These beneficial effects of eugenol make it an excellent therapeutic candidate for the treatment of hypertensive disorders of pregnancy. This study wants to analyze the best available research evidence on the potential combination of xanthone compounds from mangosteen fruit (Garcinia mangostana) with eugenol compounds in basil leaf (Ocimum sanctum) as an alternative therapy in preeclampsia. A literature review was conducted in the electronic databases PubMed and Google Scholar using the index terms "xanthone" and "eugenol" and "hypertension" and "preeclampsia." All types of studies were included for this study, such as randomized controlled trials, systematic reviews, literature reviews, and pilot studies published between 2010 and 2021. Articles which not written in English were excluded from the study. This search resulted in 10 papers. Antioxidant properties of mangosteen peel extract compounds derived from xanthone, the most significant component is α-mangosteen and γ-mangosteen. Eugenol is vasorelaxant action by increasing the expression of its target genes, Sarco/endoplasmic reticulum Ca²⁺-ATPase and adequate potassium-calcium- activated potassium channels channel, thereby relaxing vascular smooth muscle cells and decreasing blood pressure. With this review, we suggest that eugenol, which is a vasorelaxant combined with xanthone which is an antioxidant by obstructing free radical and oxidative stress, can be a potent therapeutic for preeclampsia and intend to motivate researchers (e.g., chemistry, biology, pharmaceutical, and therapeutic areas) to provide evidence of these compounds for the management of preeclampsia.
The Anticancer Activity of Curcumin: A Literature Review Pratia Mega Sari
Eureka Herba Indonesia Vol. 3 No. 1 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i1.35

Abstract

Cancer is the world's second largest cause of mortality and one of the most serious public health issues. Despite significant advancements in cancer treatment, cancer incidence and mortality rates remain high. Current research is still focused on developing more effective and less hazardous cancer treatment options. Curcumin has gotten a lot of press in the last two decades as an anti-oxidant, anti-inflammatory and cancer-fighting agent Curcumin modulated intracellular signaling pathways that affect tumor growth, angiogenesis, metastasis, inflammation, invasion, and apoptosis, among other things. Curcumin suppresses tumor cell growth and enhances apoptosis via upregulating the expression and activity of p53. Curcumin also has a strong inhibitory impact on the NFB and COX2 activity, which are involved in the upregulation of antiapoptotic genes like Bcl2. It can also reduce the control of antiapoptosis PI3K signaling and enhance MAPK expression, resulting in endogenous reactive oxygen species generation. The goal of this research is to review curcumin's anticancer properties.
Effectiveness of Insulin plant in Management of Diabetes Mellitus Yonis Ismed
Eureka Herba Indonesia Vol. 3 No. 1 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i1.45

Abstract

Diabetes mellitus, to this day, is still one of significant health problems and created significant morbidity and mortalityamong world populations. Current diabetic drugs still have unpleasant side effects and costly price. Seeking new diabetic drugs from natural resources is one of the practical action for alternative management of the disease. Insulin plant, originated from Andes, has been cultivated in Indonesia. Insulin plant is rich in caffeic acid, clorgenic acid, flavonoid, fenolic compound and sesquiterpenic lactone has antihyperglycemic and antioxidant effect that possibly have a role in diabetes management. Several studies have reported potential of insulin plant as antidiabetic agent. This review aims to summarize and organize current literature on effectiveness and role of insulin plant on diabetes mellitus patient
Effectiveness of Ginger in Treating Nausea and Vomiting of Pregnancy Ahmad Ramadhanu
Eureka Herba Indonesia Vol. 3 No. 1 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i1.46

Abstract

Nausea and vomiting in pregnancy (NVP) is one of the common main complaint in pregnancy. NVP can be a significant burden to the patient, make a decrease in quality of life, pregnancy threatening or even worse can lead to nutritional loss and death. NVP diagnosed when in first trimester of pregnancy and the other possible cause of NVP is excluded. Management of NVP is included maintaining hydration, nutrition, and lifestyle modification. Also avoiding the smells, food, or activity that can cause nause are necessary. There are some methods to treat NVP including pharmalogical or non-pharmalogical. The non-pharmalogical approach is change nutritional habits, lifestyle and medications. Several pharmalogical agents that can be used to relief the symptoms of NVP are pyridoxine, anti- histamines, metoclopramide, pyridoxine/doxylamine, promethazine and metoclopramide. Some patients also want to try more “natural” medications for NVP like ginger. The pharmacological activity is thought to stand in the pungent principles (gingerols and shogaols) and volatile oils (sesquiterpenes and monoterpenes). The true mechanism of action of ginger is probable to be a gastric effect, to increase tone and peristaltic due to anticholinergic and antiserotonin act. Ginger acts straight to the digestive tract and avoids the CNS side effects common to centrally acting antiemetics. Ginger is available in capsule or syrup form or in candy, cookies, beer, tinctures, teas, sodas, and jam. Nowadays, true dosing is available only if one uses standardized extracts; however, women may choose to use another form of ginger.
Effect of Andrographis paniculata on Blood Sugar Levels Through Regulation of Alpha-Glucosidase Enzyme Expression: An In Vivo Study Rachmat Hidayat; Patricia Wulandari
Eureka Herba Indonesia Vol. 3 No. 1 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i1.56

Abstract

Diabetes mellitus (DM) is a disease characterized by an increase in blood glucose levels caused by insulin deficiency, either absolute or relative. The α-glucosidase enzyme functions to accelerate the absorption of glucose by the small intestine by catalyzing the hydrolytic cleavage of oligosaccharides into monosaccharides. This study aims to explore the potential of AP extract in regulating blood sugar levels through inhibition of α-glucosidase activity in the intestine. This study is an in vivo experimental study. A total of 30 \ rats were divided into a control group and treated with Andrographis paniculata. Examination of blood sugar levels was carried out by spectrophotometry and examination of alpha-glucosidase enzymes by ELISA. Data analysis was performed using SPSS software with univariate and bivariate analysis. Andrographis paniculata extract was able to reduce blood sugar levels and was able to decrease the activity of the alpha-glucosidase enzyme as the dose increased. Andrographis paniculata extract is able to reduce blood sugar levels by inhibiting the activity of the alpha-glucosidase enzyme in the intestine.
Topical Application of Coconut Oil as Neonatal Management: A Review Ivani Ridwan
Eureka Herba Indonesia Vol. 4 No. 1 (2023): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v4i1.28

Abstract

Neonates or children under 28 days of age, are at the highest risk of dying. There were 4 million neonates who reported deaths each year in 2000 and 2.4 million in 2019 at the first 4-week of their life. It arises especially in low-income and middle-income countries. The cause of neonatal deaths was related to a preventable and treatable condition indeed postnatal management. Coconut oil proved as one of the herbals which safe and efficient for neonatal management. It’s had a low-cost, reachable, and widely produced in developing countries. This review collects and analyzes randomized controlled trial published studies. The database used from PubMed. The result demonstrates that coconut oil as a topical treatment is safe for neonatal management. It’s also feasible for use and has various benefits in reducing the risk of infant weight problems, apnea, hypothermia, trans-epidermal water loss (TEWL), and increasing the quality of skin conditions, vitamin D3 serum level, and increasing motor-mental development. Coconut oil could be considered a proven therapeutic option.
Use of Herbal Medicinal Products among Children Marda Sakinah
Eureka Herba Indonesia Vol. 4 No. 1 (2023): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v4i1.29

Abstract

The use of herbal medicinal products for the treatment and prevention of diseases has a long tradition over the world. The herbal medicinal products are defined as exclusively herbal active substances-contained medicinal products which used for prevention or treatment of disease. Because of its process, it chemically different defined substances in several aspects; mostly because they consist of complex multi-component mixtures which from the extraction of plant parts such as roots and leaves. Many substances could be used for relieving clinical symptoms among children. The perception that “natural” products are harmless is still dominant in many consumers. Therefore, adverse effects of herb medicines are rarely reported by patients who have taken them.4 This review will discuss about use of herbal medicinal products and what is the impact for using this in children.
The Potency of Ginkgo Biloba in Treating Tinnitus: A Review Daniel Yakin Eliamar Aritonang
Eureka Herba Indonesia Vol. 3 No. 2 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i2.34

Abstract

Extracts of Ginkgo biloba leaves are used for medicinal purposes for at least 5000 years in China. More recently Ginkgo biloba extracts have been used in Western countries. In the USA, Canada and the UK extracts are widely available as nonprescription food supplements. In France and Germany, a standardized dry leaf extract is registered as a drug and is commonly prescribed for. Several studies have been conducted to measure the usefulness and properties of Ginkgo Biloba in connection with the treatment of Tinnitus. This literature review aims to identify the components and the mechanism of action of Ginkgo Biloba in the treatment of tinnitus. The articles selected were all published within the past five years from PubMed. 11 articles were obtained and were included in the review. Based on the articles, The most important active chemical compounds in Ginkgo Biloba are flavonoids (ginkgo-flavone glycosides) and terpenoids (ginkgolides A, B, C, J, and bilobalide). Gingko Biloba has vasoregulatory effect, antagonism of platelet activator factor, antioxidant activity, enhance neuroplasticity and inflammatory. In conclusion, Ginkgo Biloba demonstrated effectiveness in the treatment of tinnitus, through the significant improvement in self-perception of tinnitus loudness and severity.
The Use of Herbal Medicines for Allergic Rhinitis Prisya Dhiba Ramadhani
Eureka Herba Indonesia Vol. 3 No. 2 (2022): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v3i2.48

Abstract

Allergic rhinitis (AR) is an immunoglobulin E–mediated illness that causes inflammation of the nasal mucosa. In recent years, the global incidence and prevalence of AR has been increased. AR has been treated with antihistamines, intranasal corticosteroids, decongestants, intranasal anticholinergics, intranasal cromolyn, leukotriene receptor antagonists, and immunotherapy. However, because many of the present medicines have documented negative side effects, there is a need to look for more effective and safer alternatives. Herbal therapy has long been used to treat the symptoms of AR, but its usefulness and safety have not been validated scientifically. In this review, recent research on the use of herbal medicine as a treatment for allergic rhinitis is collated and critically analyzed. From 2016 to 2021, the data was gathered mostly from English language publications published in journals or research from Pubmed databases. "Herbal medication" and "Allergic Rhinitis" were the terms or keywords used to discover relevant studies. This literature study may be useful in determining the potential utility of herbal medicine as a treatment for allergic rhinitis, determining the underlying mechanisms of action, and identifying natural product candidates for the development of innovative anti-allergic rhinitis drugs in the future.

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