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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 72 Documents
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Liquid Smoke and Hydrogel Membrane as Burn Wound Healing Properties Rayhan, Amar
Diponegoro International Medical Journal Vol 4, No 1 (2023): July 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i1.16382

Abstract

Background : Anyone has the potential to get injured, especially burns. Hydrogel membrane and liquid smoke are a combination of antibacterial, anti-inflammatory and antioxidant properties. These properties play an important role in wound healing. In wound healing, the re-epithelialization process is a critical parameter for the success of wound closure.Aim : Analyzed the effect of re-epithelialization length on burns of rats given a liquid smoke combination hydrogel membrane.Methods : Experimental research used post test only with control group design. The number of samples was 15 white wistar rats with burns which were divided into two treatment groups, namely P1 (liquid smoke combination hydrogel membrane), P2 (liquid smoke) and one control group K (hydrogel membrane). Assessment of reepithelialization length has been calculated using a microscope. Statistical test using One Way ANOVA – Post Hoc Bonferroni test.Results : The average length of re-epithelialization (µm) for each group was (P1) 2004.91, (P2) 1534.15 and (K) 1248.16. Based on the results of the One Way ANOVA analysis, we found p value  = 0.028 (p <0.05). This shows that there were significant differences in the data between groups.Conclusions : There was a significant difference on the length of re-epithelialization in rats burn wound between hydrogel membrane group with liquid smoke, liquid smoke group and control group.
Electrocardiographic Pattern of Pregnant Women with Advanced Maternal Age Mangkoesoebroto, Arjatya Pramadita; Pramono, Besari Adi; Mochtar, Aruman Yudanto Ariwibowo Binarso
Diponegoro International Medical Journal Vol 4, No 1 (2023): July 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i1.15837

Abstract

Background: Advanced maternal age (AMA) is becoming increasingly common and is associated with increased maternal and fetal morbidity and mortality. Around 22,2% of maternal deaths were found to be from cardiovascular disease, and women with higher cardiovascular mortality were likely older. Electrocardiography (ECG) is a simple tool for detecting cardiovascular problems. Though there are many studies of the ECG in normal pregnant women, there is still limited data on the ECG pattern in pregnant women with AMA.Objective: Describe the characteristics of the ECG pattern in woman with AMA.Methods: This study used data retrospectively from medical records of patient in Kariadi General Hospital Semarang from 1st to 30th October 2018. The inclusion criteria were advanced age ³ 35 years,  in the last trimester. Demography, clinical, laboratory , and 12-lead ECG data were collected and reported.Results: Thirteen patients were obtained, with mean age of 38,3 years. Majority of patients had preeclampsia (61,5%) and superimposed preeclampsia (15,4%). Mean systolic blood pressure was 168 mmHg. All of the patients was sinus rhythm, with a mean heart rate 92,5 bpm. Mean QTc was 430,7ms, with 3 patients (23,1%) having borderline prolongation grade. Another abnormality was a left atrial abnormality in 3 patients (23,1%), poor R wave progression in 2 patients (15,4%), and a pathological Q wave in 1 patients (7,7%).Conclusion: ECG abnormalities are seen in 38,4% of pregnant women over 35 years old. The performance of an ECG in AMA may be a first step toward improved pregnancy outcomes since it is widely available and easily interpreted by general practitioners.
The Characteristics of Eye Diseases at Merpati Eye Clinic Dr Kariadi Hospital Semarang in 2020-2022 Rahmi, Fifin Luthfia; Wildan, Arief; Maharani, Maharani; Prihatningtias, Riski; Nugroho, Trilaksana; Rikiandraswida, Zahira; Ryamizard, Rizal
Diponegoro International Medical Journal Vol 4, No 1 (2023): July 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i1.17677

Abstract

Background: The COVID -19 pandemic that has occurred since 2020 has changed and affected all aspects of life. In health services, the pandemic has limited patients from coming to health facilities. Recording of ophthalmology cases in health facilities has an important role in providing information about eye health problems that often occur in the community to identify what are the main challenges faced in the field of eye care.Objective: This study aims to identify the characteristics of eye diseases at the Merpati Eye Polyclinic Dr Kariadi Hospital Semarang in 2020-2022.Methods: This study was a retrospective descriptive study. The clinical characteristic data (gender, age, diagnosis, and Clinic) are retrieved from the medical records of patients suffering from eye diseases who underwent treatment at the Merpati Eye Clinic, Dr. Kariadi Hospital Semarang and was diagnosed in 2020-2022. The data obtained were processed and analyzed using the google sheets program.Results: There were 2961 newly diagnosed patients with the 10 most diagnosed diseases are Refractive disorders (12,87%), Cataracts (11,21%), Glaucoma (10,40%), Diabetic Retinopathy (6,75%), Pseudophakia (5,30%), Papile Atrophy (5,10%), Retinal Vein Occlusion (4,22%), Corneal Ulcer (3,92%), Retinal Detachment (3,71%) and Uveitis (3,51%). Based on age category, the most patients were 51-60 years old (22,29%). Based on gender category, female gender (50,35%) is more than male (49,65%).Conclusion: Of all patients, the 10 most diagnosed diseases were Refractive Disorders, Cataracts, Glaucoma, Diabetic Retinopathy, Pseudophakia, Papillary Atrophy, Retinal Vein Occlusion, Corneal Ulcers, Retinal detachment and Uveitis.
Intraoperative Endoscopy as Guidance for Adequate Myotomy in Laparoscopic Heller Procedure: A Rare Case Report Fuadi, Ahmad Fathi; Mahfuddin, Ahmad Za'im Muhtar
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.17840

Abstract

Background: Esophageal achalasia is a rare disorder characterized by the absence of lower esophageal sphincter (LES) relaxation. The cardinal symptom is progressive dysphagia. Laparoscopic Heller myotomy (LHM) for achalasia offers long-term symptom improvement. However, there is no precise length or landmark for adequate myotomy. The intraoperative endoscopy has been proposed as a tool to measure the adequacy of the myotomy. To the best of our knowledge, there is no previous report of intraoperative endoscopy during LHM in Indonesia.Case Presentation: A 30-year-old female patient complained of progressive dysphagia and major weight loss due to esophageal achalasia for the last two months. She underwent LHM after a week of preoperative nutritional support. The endoscopic was conducted after the myotomy to ensure the adequacy of the myotomy and prevent excessive myotomy.Conclusion: The use of intraoperative endoscopy offers many advantages for LHM. It ensures adequate myotomy, thereby minimizing the risk of repeat or additional procedures. Moreover, endoscopy can help identify mucosal perforation. We propose using an intraoperative endoscopy as a routine procedure for LHM.
THE EFFECT OF CALISTHENIC EXERCISE ON LEG EXPLOSIVE POWER Ricardo, William; Kumaidah, Endang; Adji, Raden Mas Soerjo; Adyaksa, Gana
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.20956

Abstract

Background: Physical fitness is a condition where the human body is able to perform daily activities without experiencing excessive fatigue. Physical exercise is one way to achieve physical fitness. Calisthenics is one of the strength exercises that utilize body weight as resistance to increase muscle strength. Previous research has shown that strength training can increase the explosive power of leg muscles measured through vertical jumps.Objective: Knowing the effect of calisthenic exercises on the explosive power of the leg muscles.Methods: Experimental research with quasi experimental design and methods of pre-test and post-test nonequivalent control group. The subjects were 37 active students of Diponegoro University, Semarang who were selected by purposive sampling and grouped into two groups. The control group without treatment (n=19), and the treatment group (n=18) were given calisthenic exercises for 6 weeks. The explosive power of the limb muscles was measured before and after the intervention with the vertical jump instrument and expressed as the vertical jump score (VJ score).Results: The results showed a significant increase in VJ score (p=0.030) in the treatment group compared to the control group. There was also a significant increase in VJ score (p<0.001) before and after the intervention in the treatment group.Conclusion: Calisthenic exercises for 6 weeks can increase muscle explosive power in the young adult age group.
Does Self-Esteem Affect Stress Levels in Final Year Medical Students? (A Study In Final Year Medical Students, Faculty Of Medicine, Diponegoro University) Felita, Fiona; Adiwijaya, Janice Nathania; Hadiati, Titis; Fitrikasari, Alifiati; Savitri, Soesmeyka
Diponegoro International Medical Journal Vol 5, No 1 (2024): July 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i1.22494

Abstract

Background: During young adulthood, individuals are forced to encounter countless and overwhelming challenges and responsibilities. Individuals are very prone during this period due to the fluctuation in self-esteem. Low self-esteem might significantly impact individuals as they could perceive challenges as distress, putting them at an increased risk of harming physical or mental health.Objective: To examine the relationship between self-esteem and stress levels among final year medical students, Faculty of Medicine, Diponegoro University.  Methods: This research is an observational analytic correlational study with a cross-sectional design. Samples were obtained by total sampling method involving final year medical students, Faculty of Medicine, Diponegoro University (Class of 2018). Self-esteem was measured using the Rosenberg Self-esteem Scale (RSES), and stress levels were measured using the Perceived Stress Scale (PSS-10) that had been tested valid and reliable. Data were analyzed using Spearman and Lambda Correlation Tests.Results: There were 226 subjects involved in this research. Most subjects had high self-esteem (69,5%) and moderate level of stress (67,3%). Demographic factors (gender, residency status, academic achievement and economic status) were not significantly associated with self-esteem and stress levels. However, there was a significant relationship (p=0.000) between self-esteem and stress levels with moderate negative correlation (r=-0.385).Conclusion: There was a significant relationship between self-esteem and stress levels.
Effect of DLBS3233, Metformin, and Their Combination on the Expressions of VEGF and Endometriosis Implants in Endometriosis Mice (A Mouse Model in Endometriosis Study) Wardana, Setya Girindra; Trisetiyono, Yuli; Hadijono, Raden Soerjo; Mulyantoro, Inu; Cahyanti, Ratnasari Dwi; Dewantiningrum, Julian
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.18393

Abstract

Abstract Background: Endometriosis is a gynaecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The process of angiogenesis is regulated by VEGF which plays an important role in the development of endometriosis implants. Metformin is an insulin sensitizer that is known to have a beneficial effect in the treatment of endometriosis and DLBS3233 is a PPARγ agonist, it is hoped that it can reduce VEGF and reduce endometrial implants..Objective: To explore the effect of DLBS3233, metformin, and combination on VEGF expression and endometrial implant area of endometriosis-induced mice.Methods: This experimental study used 3-months old 28 BALB/c mice of endometriosis that were randomly and equally divided into four groups (K, P1, P2, and P3). On the 15th day, the K group was given a placebo, the P1 group was given DLBS3233 0.25 mg/day for 14 days, the P2 group was given metformin 4 mg/day for 14 days and the P3 group was given a combination. The immunohistochemistry of VEGF expression was performed from the abdominal cavity and pelvic peritoneal tissues of the mice and measured by the Remmele Scale Index, while the extracted mice's endometrial implants were analyzed with a computer tracing method. All data normality tests were calculated with the Shapiro-Wilk test. The mean difference test of all groups was analyzed using the one-way ANOVA test and the Kruskal-Wallis test.Results: There were significant differences in the expressions of VEGF (p=0.005) and endometrial implants (p=0.001). Expression of VEGF in the P3 group was significantly lower compared to others and endometrial implant area in the P2 group was significantly lower compared to others.Conclusion: DLBS3233 and Metformin may be a potentially effective drug treatments for endometriosis by decreasing VEGF expression and endometrial implants. Keywords: DLBS3233, Endometriosis, Metformin, VEGF
Correlation Between VO2 Max, Speed, and Limb Muscle Explosive Power with Agility in Soccer Players Himmatul Aulia, annisa; Widodo, Sumardi; Indraswari, Darmawati Ayu; Adyaksa, Gana
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.21201

Abstract

Background: Agility is one of football's most critical anaerobic capacities. One component is the ability to change direction. Players change direction (Change of direction speed / CODS) every 2-4 seconds. Agility is influenced by several things, including speed and limb muscle explosive power, and is related to aerobic capacity, namely VO2 Max (maximum oxygen consumption) in the Running economy aspect. It is necessary to research the relationship between VO2 Max, speed, and explosive power of limb muscles with agility in soccer playersObjective: Knowing correlation between VO2 Max, speed, and limb muscle explosive power with agility in soccer players.Methods: Twenty-seven male players (Diponegoro Muda PS Undip) were involved in this study (mean±SD; age 13.22 ± 0.18 years, weight 46.78 ±1.67 kg, height 158± 1.88 cm). This research is a correlational study using a cross-sectional design. Each player will be measured VO2 Max with the Multistage Fitness Test, speed with the 20-meter sprint test, the explosive power of the limb muscles with the surgent jump test, and agility (CODS) using the Illinois agility test. The hypothesis test used is Spearman's hypothesis test and linear regression test.Results: Spearman correlation test found a strong relationship between VO2 Max and agility (r=-0.743; p= <0.001), there was a moderate relationship between speed and agility (r=0.556; p== 0.003), there was a strong relationship between muscle explosive power limbs with agility (r=-0.766; p= <0.001), and the results of linear regression of variables VO2 Max, speed, limb muscle explosive power on agility showed a strong relationship (r=0.806; r2= 0.650; p=<0.001).Conclusion: Conclusions: VO2 Max correlates with agility; speed correlates with agility; limb muscle explosive power correlates with agility; and the variables of VO2 Max, speed, and limb muscle explosive power have a relationship with agility.
EFFECTS OF GARCINIA MANGOSTANA LINN PERICARP EXTRACT AND PHYSICAL EXERCISE ON ATHEROEMBOLIC HISTOPATHOLOGIC FEATURES KIDNEY IN WISTAR RATS WITH METABOLIC SYNDROME Perdana, Evangga Yudha; Miranti, Ika Pawitra
Diponegoro International Medical Journal Vol 5, No 1 (2024): July 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i1.21750

Abstract

Background: Renal atheroembolism is an under-recognized cause of renal failure . Atheroembolism is caused by cholesterol crystals from ulcerated atherosclerotic plaques and is influenced by inflammation and endothelial dysfunction. The formation of complicated atherosclerotic lesions is a prerequisite for the development of cholesterol crystal emboli. Non-pharmacological therapeutic management (such as diet and physical exercise) is an important factor in preventing and reducing the risk of atherogenesis. Garcinia Mangostana Linn pericarp can inhibit the process of atherosclerosis through the reduction of free radicals and improvement of endothelial function Objective: To investigate the effect of Garcinia Mangostana Linn Pericarp administration along with Physical Exercise on the histopathologic features of renal atheroembolism in Wistar rats with metabolic syndrome. Methods: This study is a true experimental study with research subjects in the form of male Rattus norvegicus Wistar rats which were randomly divided into 3 groups. K (not given therapy), P1 (garcinia pericarp extract 800 mg / kg / day with physical exercise), and P2 (nanoemulsion 50 mg / kg / time of administration with physical exercise). Results: In the group treated with garcinia pericarp extract 800 mg/kg bw/day with physical exercise and the group with nanoemulsion 50 mg/kg bw/day with physical exercise, there were no fatty streaks, inflammation, and impaired myocyte coherence. There was 0-5% fibrous connective tissue, one layer of foam cell layer and myocyte-lipid, no cholesterol crystal embolism was found. Conclusion: The administration of Garcinia Mangostana Linn pericarp extract and/or nanoemulsion with physical exercise can have an effect on the histopathological picture of the kidneys of Wistar rats with metabolic syndrome. There was no difference in effect between the two treatments. However, it could not be compared with the group that was not given any treatment because it had died completely before the end of the study period.
Incident Rate of Vesicovaginal Fistula at Dr. Kariadi General Hospital Semarang in 2022 Zunaidhi Bahar, Rully; Arya Putra, Aditya; Agung Nugroho, Eriawan; Wiryawan Cahyono, Chemmy; Erwinanto, Erwinanto; Santosa, Ardy; Sindhu Wibisono, Dimas; Daniswara, Nanda; Rais Addin, Sofyan
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.17873

Abstract

Background: Vesicovaginal fistula (VVF) is an abnormal connection between the vesicourinaria and the vagina which causes urine to continuously leak through the vagina. The etiology of VVF fistulas has changed from being obstetric to being more hysterectomy related. While management is as early as possible appropriately and prevents further complications that can occur. Aim: Analyzing the comparison of the characteristics of patients with VVF at Dr. Kariadi General Hospital Semarang in 2022.Methods: The study design in this study was a retrospective descriptive observational study. Results: During the period from 3 January to 30 December 2022, 20 patients were found with VVF. Based on the data obtained, the average age of the patients was 39.4 years. Parity in the study subjects consisted of 2 nulliparas (10%), 5 primiparas (25%) and 13 multiparas (65%). Types of fistulas in patients included 14 fistulas after gynecological surgery (70%), 4 fistulas after caesarean section (20%), 1 fistula after radiotherapy (5%) and 1 fistula after trauma (5%). Conclusion: VVF incident in Dr. Kariadi General Hospital Semarang in 2022 were 20 cases with the majority of fistula types after gynecological surgery as many as 14 cases.  

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