cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muhamad Thohar Arifin
Contact Email
Thohar@gmail.com
Phone
+6281325861628
Journal Mail Official
dimjoffice@gmail.com
Editorial Address
Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
Location
Kota semarang,
Jawa tengah
INDONESIA
Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 72 Documents
 4   5   6   7   8 
Sleeve Gastrectomy Improved TGF-β and IL-10 Expression in Obesity and Diabetes Mellitus Rats Mukti, Sindhu Nugroho; Prasetyo, Sigit Adi; Shobirin, Muhammad Ali; Rozy, Abdul Mughni; Prajoko, Yan Wisnu; Sagap, Ismail Bin
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.24232

Abstract

Introduction: Atherosclerosis is a cardiovascular disease which is the leading cause of 16% of the world's total deaths. The main comorbidities of atherosclerosis are obesity and diabetes mellitus. One of obesity surgery treatment that is currently very often used is the Sleeve Gastrectomy. Sleeve Gastrectomy is the most effective and significant long-term therapy for weight loss and preventing various comorbidities such as heart disease. This study analyze the effect of sleeve gastrectomy on the expression of atherosclerosis anti-inflammatory cytokines (TGF-β and IL-10) in the abdominal aorta on the process of atherosclerosis in obesity and diabetes mellitus subjects.Methods: An in vivo laboratory experimental study with post-test control group design on 15 male rats (Sprague Dawley) that was randomly divided into 3 groups: K1 (negative control), K2 (positive control with obesity and diabetes mellitus) and P1 (obese and DM rats treated with sleeve gastrectomy). After 10th day of the procedure, we analyze the body weight, fasting blood glucose, and gene expression of TGF-β and IL-10 using the PCR method. Statistical analysis was done using Anova, Kruskal Wallis and Post Hoc LSD.Results: There was significant decrease in body weight (p=0,000) and fasting blood sugar levels (p=0,000) in the P1 compared to the K2. There was significant increase of TGF-β (p = 0,005) and IL-10 (p = 0,002) gene expression in P1 compared to K1 and K2.Conclusion: SG decreased body weight and fasting blood sugar levels of obese and DM subjects. Also improved the expression of atherosclerosis anti-inflammatory cytokines (TGF-β and IL-10) in abdominal aorta.
Disorders of Sex Development: A Review of Medical and Psychosocial Aspects Saktini, Fanti; Asikin, Hang Gunawan; Sarjana A.S, Widodo; Utari, Agustini
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.25084

Abstract

Background: Disorders of Sex Development (DSD) refer to a spectrum of congenital conditions involving atypical chromosomal, gonadal, or phenotypic development. Although recent studies have improved our understanding of the medical management of DSD, the psychosocial impact and the role of multidisciplinary care in addressing these challenges remain less well known.Objective: This review aims to examine the classification, diagnostic approaches, and medical and psychosocial challenges associated with DSD, while also highlighting the importance of multidisciplinary support.Methods: A narrative review was conducted to explore the current research and clinical guidelines on DSD, including studies on medical management and psychosocial interventions.Results: The review found that early diagnosis and management are essential to reducing life-threatening risks and psychosocial distress in individuals with DSD. The impact of societal stigma, gender identity complexities, and increased rates of anxiety and depression were observed to contribute to body image concerns. A multidisciplinary care team, involving psychiatrists, endocrinologists, and other specialists, was highlighted as critical for holistic patient care.Conclusion: The findings underscore the importance of a multidisciplinary approach in addressing both the medical and psychosocial aspects of DSD. While collaborative decision-making and individualized care strategies showed positive outcomes, further research is needed to optimize long-term health and quality of life for individuals with DSD.
THE EFFECT OF HIIT (HIGH INTENSITY INTERVAL TRAINING) TRAINING ON THE MUSCLE STRENGTH OF THE UPPER BODY OF FK UNDIP STUDENTS Stanley, Marvin; Kumaidah, Endang; Adji, Raden Mas Soerjo; Sumardi, Widodo
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.22210

Abstract

Background: High-Intensity Interval Training (HIIT) is a form of physical training characterized by its high intensity, faster speed than regular physical training, and faster recovery speed. High-Intensity Interval training is often used by athletes because of its potent effect in increasing muscle growth and promoting health. The upper limb muscles are often used on a day to day basis. This research was conducted to find out the effectiveness of HIIT training in developing the upper body muscles.Objective: To determine the effectiveness of HIIT in developing the upper body muscles.Methods: The research is quasi experimental, with pre-test and post-test control group, with 2 participating groups, which are the sample group and the control group. The independent variable of the research is High-Intensity Interval Training, while the dependent variable is upper body muscle strength.Result: Based on the study, High Intensity Interval Training that focuses on the upper body muscles has a significant correlation with the upper body strength of Diponegoro University Medical College students. The treatment group showed an increase in throw distance during the SMBT, while the control group showed stagnating and decreasing throw distance.Conclusion: High-Intensity Interval Training is proven to be an effective exercise to increase upper-body strength on Diponegoro University Students.Keywords: High-Intensity Interval Training, Upper body muscle strength.
The Effect of Binahong Leaf Extract Emulsion (Anredera cordifolia) on Histopathological Description of Common Carotid Artery Study on Male Wistar (Rattus novergicus) Rats Induced by Diabetes Mellitus Using Streptozotocin Fauzi, Muhammad Iqbal; Pudjonarko, Dwi; Indraswari, Darmawati Ayu; Istiadi, Hermawan; Wati, Arinta Puspita
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.23268

Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disease that can cause microvascular and macrovascular complications. The formation of superoxide (O2-) by dysfunctional mitochondria in diabetes has been recognised as a major driver of diabetic complications. Consequently, the utilisation of antioxidants may prove advantageous. The plant Andredera cordifolia contains flavonoids, which act as antioxidants.Objective : to investigate the effect of binahong leaf extract on the development of atherosclerosis in the carotid artery.Methods: The research employed a laboratory experimental method with a randomised post-test control group design. The research subjects were 15 Wistar rats (Rattus norvegicus). In this research, the extraction of the active compounds was achieved through a maceration process using 96% ethanol (1:3) and emulsification by the addition of sunflower oil, CMC, Span80 and Tween 20. The analysis of Anredera cordifolia extract content included the determination of flavonoid content and IC50. The intervention will be conducted for a period of 14 days. The rats were administered 1 ml of aquades per day, 45 mg/kg BW of metformin (K+), 200 mg/kg BW of EAC (P1), and 400 mg/kg BW of EAC (P2). The diabetic model was induced using a single dose of 50 mg/kgBW streptozotocin intraperitoneally. On the fourteenth day following the induction of treatment, blood glucose measurements were taken using the GOD-PAP method, and a histopathological examination of the common carotid artery was conducted using eosin haematoxylin staining at a magnification of 100-400x.Results: The total flavonoid content of binahong leaves is 1525 mg/100 g extract, while the IC50 value is 1.9 ppm. The results of the ANOVA indicate a statistically significant difference between the fasting blood glucose levels of the two groups (p < 0.05). The post hoc test demonstrated that a 400 mg/kgBW dose can result in a reduction in glucose levels to 305.75 mg/dl, with a p-value of 0.001 (p < 0.05). The Mann-Whitney test revealed a statistically significant difference among the groups (p < 0.05) for the inhibition of atherosclerosis in the common carotid artery. Conclusion: A significant difference was observed in the administration of 400 mg/kgBB binahong leaf emulsion extract in comparison to a negative control group, with regard to the histopathological picture of atherosclerosis of the common carotid artery
Screening of Refractive Disorders and Eye Health Awareness: Knowledge, Attitudes, and Behaviors of Elementary School Children in Semarang Saubig, Arnila Novitasari; Nugroho, Trilaksana; Rahmi, Fifin Luthfia; Dharma, Andhika Guna
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.23477

Abstract

Introduction: Refractive disorders are the leading cause of visual impairment. Uncorrected refractive errors in children can significantly impact their development, especially regarding education and psychosocial growth.Objective: This study aims to determine the prevalence of refractive disorders and to assess the knowledge, attitudes, and behaviors related to eye health among elementary school children at SemarangMethodology: This is a descriptive study involving 200 students from SDN Wonotingal Semarang as the sample. The study included eye examinations to identify refractive disorders in students and a questionnaire to collect data on their knowledge, attitudes, and behaviors regarding eye health. Data were collected through school-based eye screening and were analyzed using Microsoft Excel and SPSS version 26.Results: The prevalence of refractive disorders among children at SDN Wonotingal Semarang was 14%, with Astigmatism Myopia Compositus being the most common type of refractive disorder at 67.9%. Among the 28 children with refractive disorders, the majority were 11 years old (75%). Refractive disorders were more prevalent in females (64.29%) than males (35.71%). The questionnaire data revealed that a large number of children had poor knowledge about eye health (97.9%). However, most children exhibited good attitudes (79.5%) and behaviors (66.0%) regarding eye health.Conclusion: The prevalence of refractive disorders among children at SDN Wonotingal Semarang is 14%, with Astigmatism Myopia Compositus being the most common type. A significant number of children still have poor knowledge about eye health.
A Systematic Review of High-Intensity Interval Training Protocols and Their Effects in BMI And Metabolic Biomarkers in Obese Adolescents: A Focus on Randomized Controlled Trials Ajoekesoema, Tanti; Crisdayani, Carissa Putri; Syaravina, Elita; Rachmawati, Banundari; Susanto, Hardhono; Tulaar, Angela B. M.
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.26720

Abstract

Background: Adolescent obesity is a growing public health concern, associated with chronic diseases such as cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. High-Intensity Interval Training (HIIT) has been identified as a potential intervention to improve weight management and metabolic health in this population.Objective: To evaluate the impact of HIIT, alone or in combination with dietary advice, on weight management and metabolic health indicators, including Body Mass Index (BMI), fasting serum glucose levels, and metabolic biomarkers in adolescents with overweight or obesity.Methods: This systematic review included randomized controlled trials (RCTs) focusing on adolescents aged 16 to 19 with a BMI of 23 kg/m² or above. Studies were selected based on predefined criteria, excluding cross-over trials and quasi-randomized studies. Primary outcomes were changes in BMI, fasting serum glucose, and metabolic biomarkers. Secondary outcomes included measures of insulin resistance. The GRADE methodology was used to appraise the certainty of evidence.Results: Five RCTs were included, demonstrating that HIIT, especially when combined with dietary advice, significantly improves insulin sensitivity, reduces waist circumference, and enhances cardiometabolic health. The interventions varied in duration and intensity but consistently showed positive outcomes in physical fitness, metabolic biomarkers, and body composition.Conclusion: HIIT, particularly when integrated with dietary advice, offers a promising strategy for managing obesity and improving metabolic health among adolescents. This review supports the adoption of multidisciplinary approaches in clinical practice, aiming to enhance the overall health outcomes of adolescents with overweight or obesity.
The Effect of Nasal Irrigation on The Severity of Nasal Obstruction among Toll Gate Officers : A Randomized Controlled Trial Karmilah MH, Faradis; Kusuma Dewi, Anna Mailasari
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.26920

Abstract

Background: Traffic-related air pollution can trigger inflammation of the nasal tissues, potentially leading to nasal obstruction. Toll gate officers are at risk of exposure to this pollution. Nasal irrigation with isotonic saline solution can lessen the symptoms of nasal obstruction.Objective: To evaluate the effect of nasal irrigation on the severity of nasal obstruction on toll gate officers.Methods: This true experimental study employed a randomized controlled trial (RCT) with a pre-and posttest design. A total of 42 toll gate officers from Jasamarga Company, Semarang, participated in the study. Two groups were formed from the participants: one received the treatment, the other served as a control. Participants in the treatment group received nasal irrigation with isotonic saline solution once daily for 14 days. Nasal obstruction was evaluated using the NOSE Scale and PNIF. Statistical analyses were accomplished using the T-test, Wilcoxon test, and Mann-Whitney U test.Results: A clear difference was detected in the degree of nasal obstruction, both as measured by NOSE Scale (p=0,018) or PNIF (p=0,014 ; 95% CI, 4.19 to 34.86). The degree of nasal obstruction using NOSE Scale within the treatment group decreased significantly (p = 0.035) in comparison to control group (p = 0.341). The degree of nasal obstruction using PNIF measurement in the treatment group decreased significantly (p = 0.002 ; 95% CI, -34.16 to -9.17) compared with the control group (p = 0.651 ; 95% CI, -5.89 to 9.23).Conclusion: Nasal irrigation with isotonic saline solution significantly reduces the severity of nasal obstruction.
Physical Exercise In Schizophrenia Sumekar, Tanjung Ayu; Asikin, Hang Gunawan
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/baf.%v.%i.%Y.%p

Abstract

Background: Schizophrenia is a mental disorder characterized by positive and negative symptoms, with antipsychotics effectively addressing the former but less so the latter. Recent studies suggest that physical exercise may help alleviate negative and cognitive symptoms, though its role is not well established.Objective: This review examines the role of physical exercise as a complementary intervention in the psychosocial rehabilitation of individuals with schizophrenia.Methods: A narrative literature review was conducted, focusing on research exploring the effects of various exercise types on psychiatric symptoms, cognitive function, and physical health in individuals with schizophrenia.Results: Physical exercise was found to improve cognitive function, reduce negative symptoms, and mitigate the metabolic side effects of antipsychotic medications. Neurobiological changes, such as increased neurogenesis and synaptic plasticity, were also observed, contributing to better mental health and quality of life. Aerobic and anaerobic exercises were particularly effective in reducing psychiatric symptoms and enhancing social integration.Conclusion: Physical exercise offers significant benefits in schizophrenia care and should be integrated into multidisciplinary treatment strategies. Future research should focus on optimizing exercise protocols and assessing their long-term clinical impact.
Risk Factors of Ectopic Pregnancy at Dr. Kariadi Hospital Zahwa, Kamila Zettira; Trisetiyono, Yuli; Pramono, M Besari Adi; Dewantiningrum, Julian
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.25368

Abstract

Background: Ectopic pregnancy lead to maternal death. There were several risk factors for ectopic pregnancy, including age, IUD, parity, history of ectopic pregnancy, history of pelvic and abdominal surgery, infertility, history of PID, history of abortion, and infertility treatment. This study aimed to prove the correlation between these factors with ectopic pregnancy at RSUP Dr. Kariadi.Objective: This study examines to prove the correlation between these factors with ectopic pregnancy at RSUP Dr. KariadiMethods: This study was an analytical observational study with case control design consisted of 134 samples, divided into ectopic pregnancy (n=67) and threatened abortion as controls (n=67), collected from patient medical records from 2019 – 2024 using purposive sampling. Data analysis was carried out using bivariate analysis with Chi Square & Fisher Exact Test and multivariate analysis with Logistic Regression Test.Results: There were correlation between history of ectopic pregnancy (p = 0,034), history of abortion (p = 0,002), and infertility (p = 0,009) with ectopic pregnancy. Other variables didn’t have significant relationship with ectopic pregnancy (p>0,05). Two risk factors were identified for ectopic pregnancy: history of abortion (p = 0,001; aOR = 3,516; 95% CI 1,632 – 7,577) and infertility (p = 0,005; aOR = 2,913; 95% CI 1,387 – 6,119).Conclusion: There were correlation between history of ectopic pregnancy, history of abortion, and infertility with ectopic pregnancy, while other variables were not related to ectopic pregnancy. History of threatened abortion and infertility were risk factors for ectopic pregnancy.
Relationship Between the Degree of Premenstrual Syndrome (PMS) among Female Students’s Haemoglobin levels Parmasari, Wahyuni Dyah; Ananda, Dimas Ghani; Margaretha, Yunitati Maria
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Red blood cells include a protein called haemoglobin, which is responsible for transporting carbon dioxide gas (CO2) from the tissues back to the lungs and oxygen (O2) from the lungs to every part of the body. Low hemoglobin levels may impact numerous bodily functions related to hemoglobin. One of the symptoms of Premenstrual Syndrome (PMS) is menstrual pain, which low haemoglobin levels can bring on because they can reduce the amount of oxygen in the blood and stimulate the myometrium’s decreased blood flow. This leads to an increase in uterine muscle contraction. For one or two weeks before menstruation, women experience a collection of physical, emotional, and behavioural symptoms known as PMS, which arises during the luteal phase of the menstrual cycle. Students are generally in a transition phase where learning activities and imbalanced hormones trigger stress, thus worsening PMS levels.Objective: Determining the correlation between haemoglobin levels and the intensity of PMS in students. An observational analytical research design was used in this study.  The group consisted of all students who met the inclusion and exclusion criteria and comprised the sample. To choose the sample, basic random sampling was employedMethods: An observational analytical research design was used to investigate. The analysis’s findings demonstrated a correlation between haemoglobin levels and the intensity of PMS among female students aged 20 to 23 years old enrolled in the Faculty of Medicine at Wijaya Kusuma University in Surabaya.Results: Haemoglobin levels and the severity of Premenstrual syndrome (PMS) among students were shown to be related, according to the analysis’s findings. The Spearman Correlation test sig result of 0,002 (<0,05) demonstrates this.Conclusion: This indicates a correlation between haemoglobin levels and the severity of PMS among female medical students in Wijaya Kusuma University of Surabaya. 

Page 7 of 8 | Total Record : 72

 4   5   6   7   8 

Filter by Year

2020 2025


Reset
Filter By Issues
All Issue Vol 6, No 1 (2025): July 2025 Vol 5, No 2 (2024): December 2024 Vol 5, No 1 (2024): July 2024 Vol 4, No 2 (2023): December 2023 Vol 4, No 1 (2023): July 2023 Vol 3, No 2 (2022): December 2022 Vol 3, No 1 (2022): July 2022 Vol 2, No 2 (2021): December Vol 2, No 1 (2021): July Vol 1, No 2 (2020): December Vol 1, No 1 (2020): July More Issue