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Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 72 Documents
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The Relationship between Self-Esteem and Anxiety Levels in Final-year Medical Students Adiwijaya, Janice Nathania; Felita, Fiona; Fitrikasari, Alifiati; Sarjana, Widodo; Hadiati, Titis
Diponegoro International Medical Journal Vol 5, No 1 (2024): July 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i1.22515

Abstract

Background: Self-esteem is an evaluation of oneself that can be positive or negative. Self-esteem affects the way individuals value and views themselves and others. Self-esteem increases gradually during young adulthood. On the other hand, anxiety disorders are also prone to occur during this time. Individuals with low self-esteem arefound to often experience symptoms of anxiety.Objective: The purpose of this study is to examine the relationship between self-esteem and anxiety levels among final year medical students, Faculty of Medicine, Diponegoro University.Methods: This research is a correlational analytic observational study with a cross-sectional design. Total sampling was used in this research involving final year medical students, Faculty of Medicine, Diponegoro University (Class of 2018). Self-esteem was assessed using the Rosenberg Self-esteem Scale (RSES), and anxiety levels were assessed using the Zung Self-rating Anxiety Scale (ZSAS) that had been tested valid and reliable. Data were analyzed using Spearman and Lambda Correlation Tests.Results: There were 226 respondents involved in this study. The majority of respondents had high self-esteem (69.5%) and a mild level of anxiety (84.1%). Gender was known to affect the level of anxiety (p=0.026) but not self-esteem. Academic achievement and residency status was known not to affect self-esteem and anxiety levels. There was a significant relationship (p=0.000) between self-esteem and anxiety levels with a moderate negative correlation (r=-0.289).Conclusion: There was a significant relationship between self-esteem and anxiety levels.
Can a Mood Tracker Improve Young People's Mental Health? Kaneko, Izumi
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.19735

Abstract

Background: Today, mental health is a major concern among all age groups. Japan is the only country among G7 countries where suicide is the largest cause of death among youths 10-19 years old. However, many people find it difficult to confide in others about private mental health issues. Objective: We pilot-tested a “Mood Tracker” tool intended to help users record, reflect upon, and exercise control over their own emotions, in order to assess its acceptability and to explore its impact among Japanese university students.Methods: Participants were 20 medical students recruited at Fukushima Medical University. They were given a calendar and a paper listing 16 different emotions, with instructions to designate a different color for each emotion on the list, and to color each day of a month according to that day’s overall emotion. In addition, participants filled out a questionnaire before, right after, and a month after mood tracking, for self-assessment of mental state and satisfaction with the tool. Results: All participants except for one completed the intervention and provided positive comments. Although not statistically significant, the proportion of students who were highly satisfied with their school life increased from 25% before the intervention to 42% one month after the intervention. Conclusion: This small-scale pilot test suggested that mood tracking was well accepted among Japanese medical students and worth further investigation for its potential to positively impact mental health. 
Effectiveness of Etanol Extract Bajakah Wood (Spatholobus sp.) on the Growth of Staphylococcus aureus ATCC 25923 Banjarnahor, Rifanny Paruma
Diponegoro International Medical Journal Vol 5, No 1 (2024): July 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i1.21598

Abstract

Background: Infectious diseases are still an important issue for Indonesia. One of the opportunistic bacteria that causes various infectious diseases is Staphylococcus aureus. There is a need for new alternative treatments that have the same high potential as antibiotics. Bajakah wood (Spatholobus sp.) is a plant that grows abundantly in the tropical forests of Central Kalimantan. This plant has the potential antibacterial potential because it contains secondary metabolite compounds, namely alkaloids, tannins and glycosides.Objective: This study aims to determine the effectiveness of Bajakah wood (Spatholobus sp.) on the growth of S. aureus ATCC 25923 bacteria through antimicrobe sensitivity test.Methods: In this study, three different methods were used, the disc method, the well method and the Whatman paper method using a concentration of 5%; 15%; 25%; 50% and 100% extract.Results: The results showed that the ethanol extract of Bajakah Wood (Spatholobus sp.) had antibacterial activity against S. aureus ATCC 25923 at the lowest concentration, namely 5%. The disk method obtained an average inhibition zone of 11.1 mm, the well method obtained an average inhibition zone of 16.8 mm and the Whatman paper method obtained an average inhibition zone of 10.8 mm.Conclusion: From this study, the ethanol extract of Bajakah wood (Spatholobus sp.) has antibacterial potential against S. aureus bacteria with its secondary metabolite compounds.
RISK FACTORS FOR SMELL AND TASTE DISORDER IN MILD AND MODERATE COVID-19 IN SEMARANG Dewi, Anna Mailasari Kusuma; Astika, Ismiar; Farokah, Farokah; yunika, kanti; Marliyawati, Dwi
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.17892

Abstract

ABSTRACK Background: COVID-19 can make smell and taste disorder due to Angitensin Converting Enzyme 2 (ACE2) binding to olfactory tractus and taste bud that affected by gender, age, comorbid and COVID-19 severerity.Aim: To analyze age, gender, comorbid and COVID-19 severity as risk factor for smell and or taste disorder in mild and moderate Covid -19 patient in SemarangMethods: Observational research used cross section design. Sample is COVID-19 patients age >10 years old with severity mild and moderate nonhospitalize that record on Health Center of Semarang City June – July 2021. Sampling metode using purposive sampling with secondary data. Association between variable analyze using Chi square or Fisher exact test, multivariate analyze with logistic regression.Results: Research on 4337 people, 2.0% smell disorder and 0.5% taste disorder. Prevalence COVID-19 mostly on women 50.5% and adult (20-60 years old) 82.5%. Risk factor gender, age and COVID-19 severity is not associated with smell and taste disorder on COVID-19 patients (p<0.05). Chronic liver disease as a risk factor only for smell disorder on COVID-19 patients (p 0.04, CI 3.029-786.993, RP 48.828). Conclusion: Chronic liver disease is a comorbid as a risk factor for smell disorder ini COVID-19 patients at Semarang. age, gender and other comorbid not as a risk factor for smell and or taste disorder. 
A review of single-handed coaxial phacoemulsification technique for cataract surgery Setyandriana, Yunani; Zain, Nurul Attikah
Diponegoro International Medical Journal Vol 5, No 1 (2024): July 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i1.21666

Abstract

Background: Currently, cataract surgery is categorized into two main techniques: phacoemulsification and femtosecond-laser-assisted-cataract-surgery (FLACS)..Objective: The objective of this study was to present a comprehensive review of the existing literature on the single-handed coaxial phacoemulsification technique used in cataract surgery.Methods: The study conducted a systematic review of PubMed, EMBASE, and Scopus databases. The participants included in our study were individuals diagnosed with simple cataract. These individuals had treatment using either single-handed or two-handed phacoemulsification or FLACS techniques. Publications predating the year 2000 were omitted from consideration. The abstracts of the publications were analyzed utilizing the PRISMA diagram, and those deemed to be somewhat and highly pertinent were incorporated. In total, a comprehensive analysis was conducted on six research, consisting of two randomized controlled trials (RCTs) and four non-randomized controlled trials (nonRCTs).Results: The visual acuity (VA) shown a statistically significant improvement in the single-handed group compared to the two-handed group at the one-week postoperative assessment (p<0.05). However, this difference was not observed at the one-month and three-month postoperative assessments.  The single-handed group had a smaller angle of error (AE) compared to the two-handed group (p=0.005). Additionally, another study observed an improvement in visual acuity (VA) in individuals who underwent single-handed, two-handed group, and femtosecond laser-assisted cataract surgery (FLACS). However, the study did not identify any statistically significant variations in VA improvement across the three groups. There was no statistically significant difference observed among the three groups in relation to ECL and CCT. The intraoperative phacoparameter exhibited a statistically significant decrease in the single-handed group (P<0.01) compared to the two-handed group, while it did not differ substantially from the femtosecond laser-assisted cataract surgery (FLACS) group.Conclusion: When comparing the two-handed phacoemulsification technique to FLACS, it was observed that a single-handed method exhibited a reduced angle of error, minimized corneal damage, and exhibited early visual outcomes.
RECURRENCE IN NON-EPITHELIAL OVARIAN CANCER PATIENTS AT RSUP DR. KARIADI SEMARANG Badia, Gabriele Emi; Iskandar, Teuku Mirza; Suhartono, Suhartono
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.20963

Abstract

BACKGROUND: Non-epithelial ovarian cancer is a very rare type, accounting for less than 10% of ovarian cancers. This type of cancer originates from germ cells or stromal-sex cord cells. Disease-free survival (DFS) in cancer is the length of time after primary treatment for cancer ends so that patients survive without signs or symptoms of cancer. Recurrence is the return of cancer that has been declared in remission, usually after a certain period in which cancer cannot be detected. Cancer can return to the same place (primary) or other parts of the body. Ovarian cancer is a disease with a high probability of recurrence, after achieving a complete response to chemotherapy, >70%. Assessment of the recurrence rate is one of the ways used to assess the effectiveness of therapyAIM: Knowing the incidence of recurrence in patients with non-epithelial ovarian cancer who have received operative therapy with or without adjuvant chemotherapyMETHOD: Descriptive study with a case series research design and analytical works. The research sample was 50 non-epithelial ovarian cancer patients who were treated at RSUP Dr. Karadi Semarang from 2018-2019 who met the inclusion criteria and did not have exclusion criteria, 22 patients were loss of follow up during observation. The data collection technique used is total sampling. Data analysis was performed using the Chi-Square test with a significance level of p<0.05.RESULT:  The most reported types of non-epithelial ovarian cancer were granulosa (39.3%), dysgerminoma (21.4%), yolk sac (17.9%), and mixed germ cell (17.9%). Most of the cancer cases are progressive (60.7%). There were 3 recurrence incidents happen during observation period, 2 patients with granulosa cell tumor in >50 years age group and 1 patient with Yolk Sac cell tumor in 20-50 years age group. Higher survival rates were found for tumor residues <2cm compared to >2cm at 6 months (54.5% vs 45.5%), 12 months (54.5% vs 36.4%), 18 months (45.5% vs 36.4%), and 24th month (45.5% vs 36.4%).CONCLUSION: Optimization of surgery depends on the type of non-epithelial ovarian cancer cells, age, and the stage when the diagnosis was first established to be a factor in the incidence of recurrence. 
The Relationship Between Social Media Addiction and Self-Esteem in Medical Students of Diponegoro University Subiyakto, Difa Maulana; Saktini, Fanti; Sumekar, Tanjung Ayu
Diponegoro International Medical Journal Vol 5, No 1 (2024): July 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i1.21729

Abstract

Background: In the modern era, social media has become a necessity in carrying out daily activities. Playing social media too often can have negative effects. These negative effects include addiction. Social media addiction can interfere with daily activities and affect the level of self-esteem.Objective: To prove the relationship between social media addiction and selfesteem among medical students at Universitas Diponegoro.Methods: This research was an analytical observational investigation utilizing a cross-sectional methodology. The study was carried out over a span of one month, involving 90 participants from the medical students batch 2022 at Universitas Diponegoro. The  questionnaires used were the Social Media Addiction Scale-Student Form (SMAS-SF) and Rosenberg Self Esteem Scale (RSES). The assessment of the correlation between social media addiction and self-esteem using the Spearman test.Results: 2.2% of respondents had a very low level of social media addiction; 52.2% had a low level; 44.4% had a high level; and 1.1% had a very high level. In terms of self-esteem, the data revealed that 84.4% of respondents had a high level of self-esteem, while 15.6% had a low level. In the correlation test between demographic factors, social media addiction, and self-esteem,  an insignificant relationship was found with a p-value greater than 0.05. Meanwhile, a significant relationship was found in the correlation test between social media addiction and the level of self-esteem (p=0.001, r=-0.335).Conclusion: A significant relationship exists between social media addiction and the level of self-esteem among medical students at Diponegoro University.
Gender Identity and Phenotypic Variation of Sex Chromosome Disorders: A Study at Center for Disorder of Sex Development in Indonesia Azalia, Putri; Juniarto, Achmad Zulfa; Winarni, Tri Indah
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.24332

Abstract

Background: Sex chromosome DSD (Disorder of Sex Development) can be caused by numerical or structural abnormality in sex chromosome, which will lead to the atypical development in phenotype and also psychosexual. Gender assignment often become the primary problem in management of individual with DSD.Objective: To describe gender identity and phenotype variability based on karyotype classification among sex chromosome DSD cases in Indonesia Methods: This study is a descriptive retrospective study. Analyzing gender identity, karyotype classification and phenotype data from medical record of patients with cytogenetic analysis results classified as sex chromosome DSD in CEBIOR over 18 years period from 2004 to 2022.Results: Data showed the sex chromosome DSD classification with karyotype 45,X and variant  (without Y chromosome), constituted 43.7% (42/96) cases, 100 % (42/42) patients have female gender identity; 19.8% (19/96) cases had karyotype 45,X/46,XY or Turner variant mosaicism with Y chromosome, majority of patients have male gender identity 73.7% (14/19); 18.7% (18/96) cases  had 47,XXY (Klinefelter syndrome) and variant, majority of patients have male gender identity in 88.9 % (16/18) cases; 11.4% (11/96) cases had 46,XX/46,XY karyotype, majority have male gender identity in 81.8 %(9/11) cases ; and 6 cases (6.25%) classified as others, 66.67% (4/6) cases all of which contain Y chromosome, have male gender identity.Conclusion: . This study shows  the presence of Y chromosome in the karyotype support a male gender identity.  Sex chromosome DSD constitute high karyotype diversity and wide phenotypic abnormalities that necessitates careful clinical and cytogenetic evaluation
THE EFFECT OF COMBINATION FOSFOMYCIN AND SAMBILOTO (Andrographis paniculata) LEAF EXTRACT ON THE LEUKOCYTES COUNT, NITRITE LEVELS, AND LACTOFERRIN LEVELS IN WISTAR RATS (Rattus norvegicus) URINARY TRACT INFECTION MODEL Sutriono, Sutriono; Lestari, Endang Sri; Agung Nugroho, Eriawan; Nindita, Yora; Addin, Sofyan Rais
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/potensi.%Y.24216

Abstract

Background: Fosfomycin is the first-line of antibiotic for urinary tract infection (UTI). To prevent antibiotic resistance, antibiotics and herbal medicines combination was developed. Studies have shown that Andrographis paniculata has antimicrobial and anti-inflammatory agent.Objective: To investigate the effect of A. paniculata extract for treating UTI in animal modelMethods: Using post test only control group design, thirty females Rattus norvegicus rats were induced by 1 cc transurethral inoculation of E. coli and then randomly grouped into negative control (NC) received no treatment, positive control (PC) that had 54 mg fosfomycin, and treatment groups which were divided into T1 (A. paniculata 100 mg/kgBW), T2 (A. paniculata 200 mg/kgBW), T3 (fosfomycin 54 mg with A. paniculata 100 mg/kgBW), T4 (fosfomycin 54 mg with A. paniculata 200 mg/kgBW). Urinary samples were utilized to count leukocytes under microscope, nitrite levels with a dipstick, and lactoferrin using ELISA.Results: Combination of fosfomycin and A. paniculata led to a reduction in the number of leukocytes and nitrite levels compared to the single therapy group, particularly in T4 group (p<0.001). There were no significant differences in lactoferrin levels among all study groups (p>0.05).Conclusion: Combination of A. paniculata with fosfomycin resulted in a more pronounced reduction in the number of leukocytes and nitrite levels compared to single therapy, while lactoferrin levels were unaffected.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian //  TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Clove Flower Extract (Syzygium aromaticum) enhance Wound Healing Time, Bacterial Count, and IL 10 Levels in Methicillin Resistant Staphylococcus aureus infected Rats Muttaqien, Rizal Arief,; Lestari, Endang Sri; Prajoko, Yan Wisnu; Susilaningsih, Neni
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/potensi.%Y.24213

Abstract

To determine the effect of clove flower extract on the healing time of incision wounds, bacterial count and IL-10 levels in rats infected with MRSA.Method. Experimental study with a post-test-only control group design in rats that were given incisions on their backs. Random allocation was carried out to divide the Sprague Dawley rats into 6 groups (@5 rats). Healing time was assessed based on the length of days, the bacterial count was examined from the blood and then counted by culture using nutrient agar. IL-10 levels were examined from the venous blood of rats and then measured using an ELISA kit assessed by a certified microbiologist. Data were analyzed and processed using the One Way Anova - Post Hoc hypothesis test.Results. The bacterial count in the clove flower extract group was lower than the group without antibiotics and there was no difference compared to the group given antibiotics. IL-10 levels in the group given clove flower extract were lower when compared to the group given antibiotics. The wound healing time in the clove flower extract group was faster when compared to the group with or without antibiotics.Conclusion. Clove flower extract enhancewound healing in MRSA-infected rats.

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