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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 84 Documents
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The Correlation between Perceived Social Support with Suicide Ideation Prima Kusumastuti; Innawati Jusup; Alifiati Fitrikasari; Titis Hadiati
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.10540

Abstract

Background: Based on data from WHO in 2015, it shows that the death rate due to suicide in the world was recorded to have increased by 23.2% compared to 2009. Research in 2016 shows that the largest age range who experienced suicide was from 15-29 years. Many things are predicted to be a protective factor against suicide, including social support. Research on suicide protection factors is useful in preventing the increasing number of suicides.Objective: To analyze the correlation between perceived social support with suicidal ideationMethods: This research is a quantitative study with cross sectional design. Samples were taken from vocational school and academy in Semarang, who met the inclusion and exclusion criterias. The sample selection was carried out by the simple random sampling method. This research used the Indonesian version of the SSI (Scale of Suicide Ideation) and the MSPSS (Multidimentional Scale of Perceived Social Support) questionnaires.Results: It was found that the prevalence of high suicidal ideation score was 50.8% while the low suicidal ideation score was 49.2%. There was a significant correlation between suicidal ideation with perceived of family support (p = 0.002) and peer support (p = 0.050). Meanwhile, there was no significant correlation between the suicidal ideation and the support from significant others (p = 0.154). Conclusion: There was a correlation between perceived of family and peer support with suicidal ideation
Case Report: Pregnancy with Fetal Hydrathorax Putra, Aditya Arya; Wicaksono, Rahmad Rizal Budi; Pramono, M. Besari Adi; Rini, Arsita Eka
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.11060

Abstract

Background: Cases of fetal hydrothorax (FHT) are rare, with an occurrence probability of 1 in every 10,000-15,000 pregnancies. The condition may remain undiagnosed, and the fetus may be aborted, or death may occur soon after birth in outlying hospitals before transfer to a tertiary care center. The incidence rate of FHT is higher in males than females (2:1). One of the most effective methods of diagnosing fetal hydrothorax is sonography. Three forms of currently available treatments are: thoracentesis, thoracoamniotic shunting (TAS), and thoracomaternal cutaneous drainage. Fetal outcomes could be improved by performing the Extrauterine Intrapartum Treatment (EXIT) procedure.Case Presentation: We present two cases of first pregnancy primary FHT. In the first case, a 24-year-old woman was diagnosed with asymptomatic FHT in the 28th week of gestation without any prior history. In the second case, a 22-year-old woman with poor medical history was diagnosed in the 35th week of pregnancy and was experienced difficulty of breathing. Both pregnancies were delivered by cesarean section based on obstetric indications. Thoracentesis was performed on both neonates, and pathological examination of the pleural fluid was conducted. However, they died shortly after birth.Conclusion: The EXIT procedure is still a challenging method. A fetus with FHT is at significant risk of pulmonary hypoplasia and respiratory distress following delivery. Early diagnosis and intervention of FHT are vital to ensure a good prognosis. Approaching multidisciplinary groups, providing supportive diagnostic facilities and financial support is essential in improving fetal outcomes and preventing FHT in subsequent pregnancies.
Case Report: Early Recognition and Repair of Distal Iatrogenic Ureteral Injury During Laparoscopic Rectal Surgery Mughni, Abdul; Fuadi, Ahmad Fathi; Daniswara, Nanda
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.12259

Abstract

Background: Ureteral injury is an uncommon complication of the colorectal procedure. The colorectal procedure is the second most common cause of ureteral injury. The laparoscopic approach for colorectal surgery has contributed to the increase of ureteral injury. Delayed diagnosis of the iatrogenic ureteral injury is associated with higher morbidity. However, the early diagnosis of ureteral injury during the operation is difficult. We presented an early recognition and laparoscopic repair of iatrogenic ureteral injury during laparoscopic rectal cancer surgery cases and the strategy for recognizing and managing that injury for the surgeon.Case Presentation: A Male, 34 years old, had an iatrogenic ureteral injury during laparoscopic low anterior resection for rectal cancer. The left distal ureter was transected by an energy device. The diagnosis of ureteral injury was prompt. The repair of the ureter was done endo-laparoscopically. The patient had an uneventful recovery and was discharged on day 6 after surgery.Conclusion: The iatrogenic ureteral injury, although uncommon, is a serious complication of laparoscopic colorectal surgery. Direct visual identification of the distal ureter is mandatory in every rectal surgery. The iatrogenic ureteral injury is not an indication for open conversion when there is an adequate resource to do the endo-laparoscopic ureteral repair.
The Relationship Between Severity of Periodontitis With the Degree of Atherosclerosis in Ischemic Stroke Patients Tikalaka, Elisabeth Romana; Husni, Amin; -, Retnaningsih; Tugasworo, Dodik; Hartono, Jimmy Eko Budi; Rahmawati, Maria Belladonna; Puspitasari, Iva
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.9605

Abstract

AbstractBackground : Periodontal diseases affect up to 80% of the global population. Periodontitis is a long-term inflammatory disease that affects the soft and hard tissues around the teeth. It may also play a role in the pathogenesis of atheroma formation and is associated with cerebrovascular disease. The Carotid Intima Media Thickness (CIMT) is a good marker for detecting early and progressive atherosclerosis. Several hypotheses link chronic infectious diseases, including periodontal tissue disease, to the atherosclerosis process and are risk factors for stroke.Objective : To determine the relationship between the severity of periodontitis and the degree of atherosclerosis in ischemic stroke.Methods : This is an analytic observational study with a case-control approach. Subjects were ischemic stroke patients with inclusion criteria. Analyzed the severity of periodontitis with Miller’s Mobility Index (MMI), the degree of progression of atherosclerosis assessed by measuring the CIMT using an ultrasound device or B mode to detect the presence and progression of atherosclerosis.Results : 54 subjects with a mean age were 63,43 ± 7,19 years, and the dominant sex was male. There was a significant relationship between severity of periodontitis  ( P : 0,011, OR : 3,425, CI 95% 1,332-8,807) and type of profile lipid triglyceride ( P : 0,027, OR : 6,840, CI 95% 1,242-37,676)  to Carotid intima media thickness.Conclusion :  There is an association between the severity of periodontitis and the degree of atherosclerosis. Severe periodontitis is related to the increases of CIMT, which is a marker of atherosclerosis, a risk factor for stroke.
Differences of The Number of Maternal References In Semarang Public Health Center Based on MEOWS Scoring System Patriajati, Aji
Diponegoro International Medical Journal Vol 2, No 2 (2021): December
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v2i2.11120

Abstract

Background: The maternal mortality rate in Semarang is 121.5 per 100,000 live births, the second-highest in Central Java. The early warning system with the Early Warning Score and the maternal emergency early warning system (PDKM) still has various shortcomings to reduce MMR.Objective: This study aims to prove the effectiveness of the application of the PDKM Modified Early Obstetric Warning System (MEOWS) as an assessment of the risk of pregnancy in primary health facilities to reduce MMR in Semarang.Methods: The study was conducted on all pregnant women who came to Tlogosari Wetan, Tlogosari Kulon, Bandarharjo, and Bangetayu public health center in Semarang and were willing to participate in the study and were referred to government hospitals using national health assurance BPJS. Sampling was done by cluster random sampling by dividing the intervention and control groups. The study used a pretest-posttest control group design method by comparing the use of the MEOWS and the Poedji Rochjati Scorecard (KSPR) to the number of public health center referrals in Semarang. The data obtained will be analyzed statistically with the bivariate test, Mann-Whitney difference test, relative risk reduction, and absolute risk reduction.Results: The results showed that 21 of 43 (48.8%) patients were referred to the control group and 26 of 36 (72.2%) patients were referred to the intervention group. Mann-Whitney test of the number of referrals after the intervention within 3 months showed significant results (p = 0.033; p <0.05). There was an increase in the number of maternal referrals at the public health center in Semarang after the implementation of the MEOWS score by 1.48 times compared to using the KSPR (RR : 1.48 ; 95% CI : 1.02 – 2.13).Conclusion:The use of the MEOWS score can increase awareness of potential referrals and is associated with complications in patients.Background: The maternal mortality rate in Semarang is 121.5 per 100,000 live births, the second-highest in Central Java. The early warning system with the Early Warning Score and the maternal emergency early warning system (PDKM) still has various shortcomings to reduce MMR.Objective: This study aims to prove the effectiveness of the application of the PDKM Modified Early Obstetric Warning System (MEOWS) as an assessment of the risk of pregnancy in primary health facilities to reduce MMR in Semarang.Methods: The study was conducted on all pregnant women who came to Tlogosari Wetan, Tlogosari Kulon, Bandarharjo, and Bangetayu public health center in Semarang and were willing to participate in the study and were referred to government hospitals using national health assurance BPJS. Sampling was done by cluster random sampling by dividing the intervention and control groups. The study used a pretest-posttest control group design method by comparing the use of the MEOWS and the Poedji Rochjati Scorecard (KSPR) to the number of public health center referrals in Semarang. The data obtained will be analyzed statistically with the bivariate test, Mann-Whitney difference test, relative risk reduction, and absolute risk reduction.Results: The results showed that 21 of 43 (48.8%) patients were referred to the control group and 26 of 36 (72.2%) patients were referred to the intervention group. Mann-Whitney test of the number of referrals after the intervention within 3 months showed significant results (p = 0.033; p <0.05). There was an increase in the number of maternal referrals at the public health center in Semarang after the implementation of the MEOWS score by 1.48 times compared to using the KSPR (RR : 1.48 ; 95% CI : 1.02 – 2.13).Conclusion: The use of the MEOWS score can increase awareness of potential referrals and is associated with complications in patients.
CORELLATION OF STRESS LEVEL DURING COVID-19 PANDEMIC AND THE INSIDENCE OF ACNE ON STUDENTS: STUDY ON UNDERGRADUATE STUDENTS OF THE FACULTY OF MEDICINE OF DIPONEGORO UNIVERSITY Fanti Saktini
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14960

Abstract

Background: Acne vulgaris (Acne) is the most common inflammatory disease of skin among adolescents and young adults (85%). Corona Virus Disease (COVID-19) pandemic had enforced lockdowns and thus inevitably converted the conventional schooling system to online learning. These changes raised psychological burden among students, including medical students. Psychological distress might influence the emergence of acne or added its severity.Aim: To know the correlation between stress level during pandemic and the incidence of acne vulgaris among students in Faculty of Medicine Diponegoro University.Method: This study used cross-sectional design, incorporating 97 undergraduate students (batch of 2018-2020) of Faculty of Medicine Diponegoro University, whom suffered from acne, had consented to participate consecutively. Data consisted of subjects’ characteristic and Depression and Anxiety Stress Scale 21 questionnaire. These data were analysed using Chi-square test.Results: Most of the subjects suffered from acne (60.8%), whereas the level of stress varied from normal (61.9%), mild (25.8%), moderate (9,3%), to severe (3.1%). There was no significant relationship between stress level during COVID-19 pandemic and the incidence of acne vulgaris among subjects. (p=0,805).Conclusion: There was no significant relationship between stress level during COVID-19 pandemic and the incidence of acne vulgaris among medical students.
Association of Type of Antiepileptic Drugs and Serum Vitamin D Levels among People with Epilepsy Adelia Putri Maharani; Hasna Syariva; Dwi Ngestiningsih; Arinta Puspita Wati; Santoso Jaeri
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14540

Abstract

Background: Epilepsy is a brain disease characterized by repeated unprovoked seizures at least two times with an interval of more than 24 hours between the first seizure and subsequent seizures. Valproic acid is an anti-seizure drug. Long-term use of valproic acid may be associated with metabolic disorders such as weight gain, and lipid profile changes, including vitamin D levels. Objectives: To determine the association of type of antiepileptic drugs and serum vitamin D levels among people with epilepsy.Methods: A cross-sectional study among 24 people with epilepsy was obtained from the outpatient clinic Diponegoro National Hospital Semarang. The subjects were then classified based on the type of antiepileptic drugs into two groups. The first group was subjects who used valproic acid (n=15) and the second group was subjects who used phenytoin (n=9). The demographic and clinical data were collected, then the measurement of vitamin D levels was performed using ELISA. The two independent samples T-test were performed to determine the differences of serum vitamin D levels among people with epilepsy.Results: The mean of serum vitamin D levels among 24 subjects were 17,32 + 6,37 ng/mL, and the mean of serum vitamin D levels based on the type of antiepileptic drugs were 16,92 + 4.27 ng/mL for the first group and 18 + 9.16 ng/mL for the second group. Furthermore that there was no significant difference in the serum vitamin D levels in both groups (p=0,697).Conclusion: There is no different effect of valproic acid and phenytoin on the serum vitamin D levels among people with epilepsy.
Wound Healing Response to Full-Thickness Skin Defect Sprague Dawley Rats Given Ozonated Black Cumin Oil Viewing from The Profile of Neutrophil and Macrophage Count Igor Rizkia Syahputra
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14955

Abstract

The incidence of wounds keeps increasing and inadequate treatment can cause the wound to become infected. Ozone has antibacterial properties and can help activate pro-inflammatory agents in the wound healing process; one of the methods is oil ozonation, for example with black cumin oil. Topical administration of black cumin plays a role in wound healing because of its antibacterial and antifungal properties, and plays a role in increasing the epitalization process. To determine the effectiveness of applying ozonated black cumin oil (Nigella sativa) on the healing process of full-thickness skin defects in Sprague Dawley rats, in terms of the number of macrophage and neutrophil cells. This research was an experimental study with a post-test only control group design method. Total sample of 48 Sprague Dawley rats was divided into 6 groups. The first group was given gentamicin ointment, the second group was given 0.9% normal saline, the third to the fifth group was given ozone black with doses of ozone respectively, namely 1400 mg/ml, 1800 mg/ml and 2200 mg/ml. Incision for taking the tissue samples was held on the 3rd and 7th day according to the treatment group. The tissue samples were subjected to histopathological examination with HE staining. A significant decrease in neutrophil levels occurred at the dose of 1,400mg/ml ozonated black cumin oil on day 7 (p=<0.001), dose of 1,800 mg/ml on day 3 (p=0.021) and day 7 (p=<0.001), doses of 2,200mg/ml at day 3 (p=0.020) and day 7 (p=<0.001) compared with a positive control group (given gentamicin). A significant decrease in macrophage levels occurred at a dose of 1,400mg/ml on day 3 (p=0.037) and 7 (p=0.019), a dose of 1,800 mg/ml on day 3 (p <0.001) and 7 (p=0.020), dose 2,200mg/ml on day 3 (p=<0.001) and day 7 (p=0.020).
The Relationship Between Obstructive Sleep Apnea And Levels Of Depression And Anxiety In Young Adults Kanti Yunika
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.14961

Abstract

ABSTRACTBackground: Obstructive sleep apnea (OSA) is one of the most common and serious sleep disorders that can cause various neurocognitive disorders such as depression and anxiety. OSA can occur in young adults, whom are in an important developmental age in human life. The relationship between OSA and levels of depression and anxiety has never been studied in young adults, especially college students. Early identification and treatment is expected to have an impact on better quality of life and productivity..Aim: To determine the relationship of OSA with levels of depression and anxiety in young adultsMethods: An observational study with a cross sectional design. Data were obtained from Berlin questionnaire, Zung Self-Rating Depression Scale and Zung Self-Rating Anxiety Scale which were filled out in September-November 2021. Bivariate analysis of OSA's relationship with depression and OSA with anxiety was tested using chi-square test. Multivariate logistic regression analysis was performed to test for confounding variables.Results:  There was a significant relationship between OSA and depression (p=0,000, OR 4.07) and OSA and anxiety (p=0,000, OR 4.5) in young adults. Logistic regression analysis showed that gender was a confounding variable of anxiety (p=0.044) in young adults.Conclusion: There is a significant relationship between OSA and levels of depression and anxiety in young adults. Young adults who have OSA are 4.07 times more likely to be depressed than young adults who don’t have OSA. Young adults who have OSA are 4.5 times more likely to experience anxiety than young adults who don’t have OSA. There is a significant relationship between OSA and the level of anxiety controlled by the confounding variable, namely gender.
Histological and Clinical Stage Profiles of Young-aged Breast Carcinoma Alda Vania Sugiarto Hadiyanto; Ika Pawitra Miranti; Yan Wisnu Prajoko; Hermawan Istiadi
Diponegoro International Medical Journal Vol 3, No 1 (2022): July 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i1.13944

Abstract

Background: Breast cancer is the most common type of malignancy in women. Many studies report that the characteristics and prognosis of young-aged breast carcinoma are worse than in old age. Data on young-aged breast carcinoma in Indonesia is relatively lacking and always needs updates.Objective: To determine the incidence and distribution based on histological profiles and clinical stage, as well as the association between molecular subtype with grade and clinical stage of young-aged breast carcinoma (<40 years old) at Dr. Kariadi General Hospital Center in 2018-2020.Methods: This research was an observational descriptive study using medical records of young-aged breast carcinoma patients which were recorded at Dr. Kariadi General Hospital Center from 1st January 2018 until 31st December 2020. The data were processed with Microsoft Excel and SPSS.Results: The results showed that there were 110 patients consisting of 25 people in 2018, 37 people in 2019, and 48 people in 2020. The most common histological and clinical stage was IBC-NST with 75 people (68,18%), Luminal B with 53 people (48,18%). grade II with 71 people (64,65%), and stage IV with 45 people (40,09%). There is a significant association between molecular subtype and grade (p=0.003). There is no significant association between molecular subtype and clinical stage (p=0.704).Conclusion: The incidence of young-aged breast carcinoma at Dr. Kariadi General Hospital Center in 2018-2020 was increasing every year. The most common histological profiles and clinical stage during that period were IBC-NST, Luminal B, grade II, and stage IV. There is a significant association between molecular subtype and grade.Keywords: Breast carcinoma, clinical stage, grade, histological type, molecular subtype, young age

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