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Medical Scope Journal (MSJ)
Published by Universitas Sam Ratulangi
ISSN : -     EISSN : 27153312     DOI : https://doi.org/10.35790/msj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health
Medical Scope Journal (MSJ) diterbitkan oleh Perhimpunan Ahli Anatomi Indonesia (PAAI) Komisariat Manado bekerjasama dengan Fakultas Kedokteran Universitas Sam Ratulangi dua kali setahun pada bulan Juni dan Desember. Tulisan yang dimuat dapat berupa artikel telaah (review article), hasil penelitian, dan laporan kasus dalam bidang ilmu kedokteran baik dalam bahasa Indonesia maupun dalam bahasa Inggris.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 231 Documents
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Patofisiologi dan Faktor Predisposisi yang Berhubungan dengan Omphalocele Angel D. Rarung; Harsali F. Lampus; Eko Prasetyo
Medical Scope Journal Vol. 5 No. 1 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i1.45295

Abstract

Abstract: Omphalocele is one of the most common congenital abnormalities of the abdominal wall. In various countries, the incidence of omphalocele ranges from 1-3.8 per 10,000 pregnancies. This study aimed to determine the pathophysiology and predisposing factors associated with omphalocele. This was a literature review study. Literatures were obtained through several databases: Pubmed, ClinicalKey, and Google Scholar. The results showed 22 articles that fulfilled the inclusion criteria. The pathophysiology of omphalocele was when the abdominal organs herniate for an extended period of time, in results failing the intra-abdominal organs from returning to their normal position. Predisposing factors associated with omphalocele were divided into two aspects namely maternal and neonatal. In conclusion, the pathophysiology of omphalocele is still the same from year to year with the existing theory that there has not been a shift or discoveries. In contrast, for predisposing factors, several studies have reported new aspects of maternal and neonates about factors related to omphalocele. Keywords: omphalocele; pathophysiology; predisposing factors   Abstrak: Omphalocele adalah salah satu kelainan kongenital dinding abdomen yang paling umum terjadi, Insiden omphalocele berkisar pada 1-3,8 per 10.000 kehamilan di berbagai negara. Penelitian ini bertujuan untuk mengetahui patofisiologi dan faktor predisposisi yang berhubungan dengan omphalocele. Jenis penelitian ialah suatu literature review. Literatur diperoleh melalui beberapa basis data yaitu Pubmed, ClinicalKey, dan Google Scholar. Hasil penelitian mendapatkan 22 artikel yang sesuai dengan kriteria inklusi. Patofisiologi omphalocele yaitu ketika terjadi herniasi fisiologis berkepanjangan dari organ abdomen sehingga terjadi kegagalan organ intraabdomen untuk kembali ke posisi normalnya. Faktor predisposisi yang berhubungan dengan omphalocele terbagi atas dua aspek yaitu maternal dan neonatus. Simpulan penelitian ini ialah patofisiologi dari omphalocele masih sama dari tahun ke tahun dengan teori yang ada dimana belum terjadi pergeseran atau penemuan baru sedangkan untuk faktor predisposisinya terdapat beberapa penelitian yang melaporkan hal baru terkait aspek maternal dan neonatus yang berhubungan dengan omphalocele. Kata kunci: omphalocele; patofisiologi; faktor predisposisi
Fibrocystic Breast Tumor: A Case Report Ferry Kalitouw; Christian Manginstar; Melfrits Siwabessy
Medical Scope Journal Vol. 5 No. 1 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i1.46215

Abstract

Abstract: Fibrocystic breast tumor is the most common benign type of breast diseases that affects millions of women worldwide. Fibrocystic breast changes are classified as non-proliferative, proliferative without atypia, or proliferative with atypia. We reported a 34-year-old woman presented with a right breast evaluation of breast tumors since one year before admission. On examination, a solid and hard breast tumor measuring 15x10 cm was palpable, well-defined, tender, mobile, and no nipple discharge. The patient underwent two times of core biopsy and the results were fibrocystic changes. Although clinically the breast tumor had a malignant appearance, but the results of core biopsy examinations revealed fibrocystic changes. The patient was managed by wide excision of the evaluated breast tumor with preservation of the breast skin and nipple areolar complex to maintain its function and aesthetic. In conclusion, evaluation of breast tumors must go through a triple diagnostic procedure namely clinical, imaging, and histopathological examinations. Fibrocystic breast tumor can be managed with wide excision of the tumor with preservation of the skin structure and nipple areolar complex of the breast to achieve a natural aesthetic. Keywords: fibrocystic breast tumor; wide excision of tumor; evaluation of breast tumors
Billiary Tract Obstruction due to Gallbladder Carcinoma at Prof. Dr. R. D. Kandou General Hospital: Two Case Reports Michael Tendean; Toar D. B. Mambu; Leonard A. Melatunan
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.46217

Abstract

Abstract: Gallbladder cancer is the fifth most common gastrointestinal malignancy with a high mortality rate. Detection of gallbladder carcinoma in early stages can be difficult, despite improvements in ultrasound and CT-Scan imaging. It is possible to cure gallbladder cancer surgically at an early stage. We reported two cases of gall bladder carcinoma, 65-year-old and 52-year-old females, with the chief complaints of abdominal pain in the right upper quadrant (RUQ) and obstructive jaundice in both cases. The abdominal CT-scans showed circumferentially irregular focal thickening of gallbladder wall, and severe intra and extrahepatic cholestasis. Endoscopic preoperative biliary drainage using biliary stent was performed in one case. Open cholecystectomy with in toto common bile duct resection and portal lymphadenectomy followed by roux en-y hepaticojejunostomy reconstruction were performed for both cases. Both patients are still well with no cancer recurrences over two-year follow-up. The symptoms of gall bladder cancer were non-specific, and commonly included RUQ abdominal pain, weight loss, anorexia, nausea or vomiting, jaundice, and pruritus. Imaging with ultrasound and CT-Scan had improved preoperative diagnosis of gallbladder cancer. Outcomes of patient with incidental finding of gallbladder cancer had better prognosis since it provided the patient to be staged and managed appropriately with resection. In conclusion, early detection of gallbladder cancer results in better surgical outcome and less patient morbidity and mortality which shows its importance. Keywords: gallbladder carcinoma; early-stage detection; common bile duct resection
Role of Endoscopic Procedure in Foreign Body (Button Battery) Ingestion in Children: A Case Report Harsali Lampus; Candy Candy; Leo Rendy; Andy A. Rangan
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.46219

Abstract

Abstract: Foreign body (FB) ingestion is a common problem especially in children below the age of 5 years. Due to the extensive use of batteries as power supply in electronic gadgets, cases of button battery ingestion have become more common. If a button battery was found in the stomach of a child under the age of five, it should be assessed for esophageal injury and removed endoscopically, if at all possible, within 24 to 48 hours. We reported a 3-year-old boy who swallowed a foreign body three hours before being admitted to the hospital. Initially the patient was playing with robot toys that used batteries, then a battery of the robots was accidently swallowed. The patient had no symptoms and physical examinations showed no abnormalities. Abdominal X-ray examination revealed a foreign body located in the stomach. The patient underwent endoscopic foreign body removal but no foreign body was found until the second part of duodenum. Therefore, an exploratory laparotomy was performed, and the foreign body, a button battery, was removed from the ileum. In conclusion, since endoscopic foreign body removal failed to remove the foreign body in this patient, an exploratory laparotomy was performed and through antimesenterial ileotomy, the foreign body, a button battery, was successfully removed. Keywords: foreign body; endoscopic foreign body removal; exploratory laparotomy
Analisis Pengaruh Faktor-faktor Lingkungan Kerja terhadap Kinerja Pegawai di RSUD Kota Manado Bezaliel R. Narasiang; Erwin G. Kristanto; Herlina I. S. Wungouw
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.49220

Abstract

Abstract: Work environment consists of physical and non-physical factors that affect employees’ performance. The hospital RSUD Kota Manado is still under construction and completion with an average employee performance score that varies each year. This study aimed to analyze the influence of work environment factors on employee performance at RSUD Kota Manado. This was a quantitative study with a cross-sectional design by distributing questionnaires containing statements that had passed the instrument test. The total population was all employees totaling 108 people as study samples. The results showed that the physical factors (X1) and non-physical factors of the work environment (X2) were included in the good category (X1=77.91%; X2=82.53%). Employee performance (Y) was included in the very good category (Y=84.35%). T-test results proved that X1 and X2 had a partial significant effect on Y. The results of multiple linear regression analysis showed that the regression value was positive (Y=19.066; X1=0.215; X2=0.591). The F test obtained an F count of 53.942 > F table of 3.083 and a Sig value of 0.000 (<0.05) proved that X1 and X2 had a simultaneous significant effect on Y. The result of the coefficient of determination (R2) showed that X1 and X2 had a simultaneous effect of 50.7% on Y. In conclusion, work environment factors simultaneously have a linear and significant influence on the employee performance at RSUD Kota Manado. Keywords: physical work environment factors; non-physical work environment factors; employee performance   Abstrak: Lingkungan kerja baik faktor fisik maupun non-fisik memengaruhi cara karyawan bekerja. RSUD Kota Manado masih dalam tahap pembangunan dan perampungan dengan rerata nilai capaian kinerja yang bervariasi tiap tahunnya. Penelitian ini bertujuan untuk menganalisis pengaruh faktor-faktor lingkungan kerja terhadap kinerja pegawai di rumah sakit ini. Jenis penelitian ialah kuantitatif dengan desain potong lintang, dengan menyebarkan kuisioner yang berisi pernyataan-pernyataan yang sudah lolos uji instrumen. Total populasi ialah seluruh pegawai rumah sakit yang berjumlah 108 orang yang menjadi sampel penelitian. Hasil penelitian mendapatkan faktor fisik lingkungan kerja (X1) dan faktor non-fisik lingkungan kerja (X2) masuk dalam kategori baik (X1=77,91%; X2 =82,53%). Kinerja pegawai (Y) masuk dalam kategori sangat baik (Y=84,35%). Hasil uji T membuktikan X1 dan X2 berpengaruh bermakna parsial terhadap Y. Hasil analisis regresi linier berganda menunjukkan bahwa nilai regresi bernilai positif (Y=19,066; X1=0,215; X2=0,591). Hasil uji F diperoleh nilai F hitung 53,942 > F tabel 3,083 dan nilai Sig sebesar 0,000 (<0,05) membuktikan X1 dan X2 berpengaruh bermakna simultan terhadap Y. Hasil koefisien determinasi (R2) menunjukkan bahwa X1 dan X2 memberikan pengaruh simultan sebesar 50,7% terhadap Y. Simpulan penelitian ini ialah faktor-faktor lingkungan kerja secara simultan memiliki pengaruh linier dan bermakna terhadap kinerja pegawai di RSUD Kota Manado. Kata kunci: faktor fisik lingkungan kerja; faktor non-fisik lingkungan kerja; kinerja pegawai
Mycetoma of the Breast: A Case Report Meilany Durry; Lily L. Loho
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.44625

Abstract

Abstract: Mycetoma is a chronic suppurative infection affecting skin, subcutaneous tissue, and bones which is common in tropical and subtropical regions. The manifestations of mycetoma are painless subcutaneous mass, multiple sinuses and purulent or seropurulent discharge that may contain grains. We reported a case of a 39-year-old female with a complaint of skin mass with discharge in her left breast for about a year. The clinical diagnosis was a breast tumour with suspicion of malignancy. A histopathological examination of the breast biopsy was performed which showed foci of granulomas consisting of chronic inflammatory cells, foamy macrophages, and many multinucleated cells. In several granulomas, there were eosinophilic masses with hypha in the peripheral and arranged radially. In conclusion, based on clinical and histopahological examinations the diagnosis of this case was a mycetoma of the breast. Keywords: mycetoma; breast; deep mycosis; mammary infection; pathological diagnosis
Rehabilitasi Medik pada Gangguan Mobilisasi Pasca Stroke Keith J. Legoh; Christopher Lampah; Joudy Gessal
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.45275

Abstract

Abstract: Care and assistance in post-stroke patients require special handling that is often not mastered by caregivers, causing an increase in the number of patients readmitted to the hospital, especially the elderly. This study aimed to find out the available current rehabilitation for patients with post-stroke mobility impairment. This was a literature review study using literatures published and accredited in the last five years based on three databases, namely: PubMed, ClinicalKey, and Google Scholar. The results obtained 10 literatures to be reviewed. Comparisons of conventional and modern therapies, as well as the focus of therapy on impaired mobility of post-stroke patients proved that the design of an appropriate therapy program would provide a better prognosis, but for now, most therapies still focused on gait, balance, and risk of falling. Therapy supported by appropriate and qualified technology would produce a better prognosis compared to therapy with physical activity or with the help of conventional technology. In conclusion, patients with post-stroke mobility impairment need an accurate diagnosis of existing pathologies and manifestations to receive the best medical rehabilitation therapy program. Modernization of technology supported rehabilitation has quite an influence on the prognosis of patients with post-stroke mobility impairment and combination of various types of therapy can be used to solve this problem. Keywords: rehabilitaion; post-stroke; mobility impairment; gait; balance; fall risks   Abstrak: Perawatan dan bantuan pada pasien pasca stroke membutuhkan penanganan khusus yang sering kali belum dikuasai oleh pengasuh sehingga menyebabkan meningkatnya jumlah pasien yang dirawat kembali di rumah sakit, khususnya lanjut usia (lansia). Penelitian ini bertujuan untuk mengetahui modalitas rehabilitasi yang tersedia bagi pasien dengan gangguan mobilisasi pasca stroke berdasarkan perkembangan teknologi yang tersedia saat ini. Metode yang digunakan ialah literature review. Proses pencarian pustaka-pustaka yang diteliti ialah sudah terpublikasi dan terakreditasi selama lima tahun terakhir dan berbasis tiga database, yakni: PubMed, ClinicalKey, dan Google Scholar. Hasil penelitian mendapatkan 10 literatur untuk ditinjau. Perbandingan terapi konvensional dan modern, serta fokus terapi terhadap gangguan mobilisasi pasien pasca stroke membuktikan bahwa rancangan program terapi yang tepat akan memberikan prognosis yang lebih baik, namun untuk saat ini, terapi umumnya lebih berfokus pada gait, balance, dan fall risks. Terapi yang disokong dengan teknologi yang tepat dan mumpuni akan menghasilkan prognosis yang lebih baik dibandingkan dengan terapi aktifitas fisik saja ataupun dengan bantuan teknologi konvensional. Simpulan penelitian ini ialah pasien dengan gangguan mobilisasi pasca stroke memerlukan diagnosis yang tepat terhadap patologi dan manifestasi yang ada untuk menerima program terapi rehabilitasi medik terbaik. Modernisasi dari teknologi penyokong rehabilitasi cukup berpengaruh terhadap prognosis dari pasien dengan gangguan mobilisasi pasca stroke dan dapat dilakukan terapi kombinasi dari beragam jenis terapi untuk menyelesaikan permasalahan ini. Kata kunci: rehabilitasi; pasca stroke; gangguan mobilisasi; gait; balance; fall risks
Tatalaksana Terkini Kejang pada Neonatus Crifer R. J. Rondonuwu; Rocky Wilar; Jeanette I. Ch. Manoppo
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.45371

Abstract

Abstract: Seizures in neonates are caused by a large group of neurons experiencing excessive synchronous depolarization. The therapeutic management of neonates and their prognosis differ, depending on the etiology of the disorder causing the seizures. Management of seizures in neonates use anticonvulsant drugs (phenobarbital, phenytoin, levetiracetam, lidocaine, midazolam, diazepam) so far. This study aimed to determine the current therapy for seizures in neonates. This was a literature review study using the PubMed and Google Scholar databases with the PICOS framework as selection criteria. The results obtained 10 articles to be reviewed. Phenobarbital became the first-line treatment due to its proven efficacy level compared to other anticonvulsant drugs. There were trials of giving levetiracetam as the first-line therapy due to its fewer side effects than phenobarbital. Some other literatures stated that side effects after administration of anti-seizure drugs varied, depending on the underlying etiology. In conclusion, phenobarbital is still the first line treatment for neonatal seizures followed by phenytoin as the second line, midazolam as the third line, and diazepam as the fourth line treatment. However, it is possible that levetiracetam can be used as the first-line anti-seizure drug, or as an alternative treatment. Keywords: neonatal seizures; pharmacologic treatment; current management; anticonvulsant drugs   Abstrak: Kejang pada neonatus disebabkan oleh sekelompok besar neuron mengalami depolarisasi sinkron yang berlebihan. Penatalaksanaan terapeutik neonatus dan prognosisnya berbeda, tergantung dari etiologi gangguan yang menyebabkan kejang. Tatalaksana kejang pada neonatus menggunakan obat antikonvulsan (fenobarbital, fenitoin, levetiracetam, lidokain, midazolam, diazepam). Penelitian ini bertujuan untuk mengetahui terapi terkini untuk kejang pada neonatus. Jenis penelitian ialah suatu literatur review dengan pencarian literatur dari database Pubmed dan Google Scholar menggunakan framework PICOS sebagai kriteria seleksi. Hasil penelitian mendapatkan 10 artikel untuk dikaji. Fenobarbital merupakan pengobatan lini pertama karena tingkat efikasi yang terbukti lebih manjur dari pada pengobatan obat antikonvulsan lainnya. Uji coba pemberian levetiracetam sebagai terapi lini pertama telah dilakukan dengan pertimbangan efek samping yang lebih lurang daripada fenobarbital. Beberapa literatur menyatakan efek samping setelah pemberian obat anti kejang bervariasi, tergantung etiologi yang mendasari. Simpulan penelitian ini fenobarbital masih menjadi pilihan pengobatan lini pertama untuk kejang pada neonates, lini kedua fenitoin, lini ketiga midazolam, dan lini keempat diazepam. Tidak menutup kemungkinan jika levetiracetam dapat digunakan sebagai obat anti kejang lini pertama, ataupun dijadikan sebagai pengobatan alternatif. Kata kunci: kejang neonatus; pengobatan farmakologi; tatalaksana terkini; obat antikonvulsan
C-Reactive Protein dan D-Dimer sebagai Prediktor Mortalitas Pasien COVID-19 Raynaldo E. D. Togas; Mordekhai L. Laihad; Diana C. Lalenoh
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.45408

Abstract

Abstract: High mortality rate of COVID-19 patients is caused by cytokine storms which worsen the condition of COVID-19 patients, so that COVID-19 infection is associated with an inflammatory and prothrombotic state. C-reactive protein (CRP), which is a marker of inflammation, and also D-dimer, which is a marker of coagulation, have increased in relation to the severity of COVID-19 disease. This study aimed to determine whether inflammatory markers (CRP) and coagulation profiles (D-dimer) could be used as predictors of mortality in COVID-19 patients. This was a literature review study by searching three databases, namely Pubmed, Sciencedirect, and Google Scholar. The results obtained 11 literatures with a total sample of 6,440 COVID-19 patients with CRP and/or D-dimer marker test results. Six of seven literatures showed significant results that increased CRP level was a predictor of mortality in COVID-19 patients, and six of the six literatures showed significant results that increased D-dimer level was a predictor of mortality in COVID-19 patients. In conclusion, CRP and D-dimer can be used as predictors of mortality in COVID-19 patients Keywords: COVID-19; C-reactive protein; D-dimer; predictor of mortality; cytokine storms   Abstrak: Tingginya angka mortalitas pasien COVID-19 disebabkan oleh badai sitokin yang meningkatkan perburukan kondisi pasien COVID-19 sehingga infeksi COVID-19 dikaitkan dengan keadaan inflamasi dan protrombotik. C-reactive protein (CRP) yang merupakan penanda inflamasi dan juga D-dimer yang merupakan penanda koagulasi mengalami peningkatan terkait dengan derajat beratnya penyakit COVID-19. Penelitian ini bertujuan untuk mengetahui apakah penanda inflamasi (CRP) dan profil koagulasi (D-dimer) dapat digunakan sebagai prediktor mortalitas pasien COVID-19. Metode penelitian ialah suatu literature review dengan pencarian menggunakan tiga database, yaitu Pubmed, Sciencedirect, dan Google Scholar. Hasil penelitian mendapatkan 11 literatur dengan jumlah sampel penelitian 6440 pasien COVID-19 serta hasil tes penanda CRP dan atau D-dimer. Enam dari tujuh literatur memiliki hasil bermakna bahwa peningkatan kadar CRP sebagai prediktor mortalitas pasien COVID-19, dan enam dari enam literatur memiliki hasil bermakna bahwa peningkatan kadar D-dimer sebagai prediktor mortalitas pasien COVID-19. Simpulan penelitian ini ialah CRP dan D-dimer dapat digunakan sebagai prediktor mortalitas pasein COVID-19. Kata kunci: COVID-19; C-reactive protein; D-dimer; prediktor mortalitas; badai sitokin
Pengaruh Pemberian Probiotik terhadap Neonatus dengan Hiperbilirubinemia Dewi A. R. Hastuti; Johnny L. Rompis; Jeanette I. Ch. Manoppo
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.45410

Abstract

Abstract: Hyperbilirubinemia is a medical condition that is often found in the first week of neonates. The usual treatment for hyperbilirubinemia is phototherapy, however, many studies revealed probiotics as another form of treatment. Probiotics are live microorganisms that have similarities to the normal intestinal flora. They are believed to reduce enterohepatic cycle activity which can reduce serum bilirubin in neonates with hyperbilirubinemia. This study aimed to determine the effect of probiotics on neonates with hyperbilirubinemia. This was a literature review study using three different databases, namely Pubmed, Google Scholar, and ClinicalKey. The results obtained 10 literatures carried out from related inclusion and exclusion selections. After reviewing the ten literatures, it was found that the most widely used probiotic genus was Lactobacillus where the strain that had the greatest influence was Lactobacillus reuteri. Six out of ten literatures stated that probiotics had significant effect as a treatment for neonates with hyperbilirubinemia due to their capability to reduce the total serum bilirubin. In conclusion, probiotics may affect the treatment of neonates with hyperbilirubinemia. Keywords: probiotics; hyperbilirubinemia; neonates    Abstrak: Hiperbilirubinemia merupakan salah satu kondisi medis yang sering dijumpai pada seminggu pertama pada neonatus. Pengobatan yang biasa diberikan pada hiperbilirubinemia ialah fototerapi, namun saat ini telah banyak penelitian mengenai probiotik sebagai bentuk pengobatan lainnya. Probiotik merupakan mikroorganisme hidup yang memiliki kesamaan dengan flora normal usus dan dipercaya dapat menurunkan aktivitas siklus enterohepatik dan selanjutnya bilirubin serum pada neonatus yang mengalami hiperbilirubinemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian probiotik pada neonatus dengan hiperbilirubinemia. Jenis penelitian ialaah suatu literature review berdasarkan pencarian melalui tiga database yaitu Pubmed, Google Scholar, dan ClinicalKey. Hasil penelitian mendapatkan 10 literatur yang telah dilakukan seleksi kriteria inklusi dan eksklusi terkait. Dari 10 jurnal yang telah diulas, didapatkan bahwa genus probiotik yang paling banyak digunakan ialah Lactobacillus, dan strain yang memiliki pengaruh terbesar yaitu Lactobacillus reuteri. Enam dari 10 literatur menyatakan bahwa pemberian probiotik dapat berpengaruh bermakna sebagai pengobatan neonatus dengan hiperbilirubinemia karena probiotik dapat membantu menurunkan nilai total serum bilirirubin. Simpulan penelitian ini ialah probiotik dapat memengaruhi pengobatan neonatus dengan hiperbilirubinemia. Kata kunci: probiotik; hiperbilirubinemia; neonatus

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