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INDONESIA
Journal La Lifesci
Published by Newinera Publisher
ISSN : 27211304     EISSN : 27211207     DOI : https://doi.org/10.37899/journallalifesci
Core Subject : Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Chemistry Earth & Planetary Sciences Environmental Science Immunology & microbiology
International Journal La Lifesci is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles and Review Article editorial comments etc in all fields of life sciences including Agricultural, Fisheries, Earth, Environmental Science, Botany, Zoology, Microbiology, Ecology, Ethnobiology, Biodiversity And Conservation Biology, Genetics, Biochemistry , Bioinformatics, Biophysics, Biostatistics, Cytobiology Developmental Biology, Entomology, Immunology , Molecular Biology, Virology, agronomy, plant and animal breeding, agricultural economics and rural sociology, Veterinary science, Ornithology, Primatology, Biogeography, Histology, Marine biology, Biochemical Sciences Aquaculture, Fishery Hydrography, Fishery Engineering, Aquatic ecosystem, Fish farming, Fisheries management, Fishery Biology, Wild fisheries, Ocean fisheries, and all fields related to life sciences.
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 192 Documents
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Biochemical Disturbances and Profile of Lipid in Chronic Renal Failure Patients on Maintenance Hemodialysis Raghda M. Ameer
Journal La Lifesci Vol. 7 No. 3 (2026): Journal La Lifesci
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallalifesci.v7i3.3300

Abstract

This study was conducted in AL-Hakeem Hospital in Al Najaf Al Ashraf City between January and March of 2026. 77 people, 53 men and 24 women, aged 21 to 65, were enrolled in order to assess the serum lipid profile, albumin, and hemoglobin in patients with renal failure receiving hemodialysis. The patient was diagnosed with renal failure for both sexes based on the patient's medical history, clinical examination, and renal function test findings. Medical professionals and family members who showed no signs of diabetes mellitus, hypertension, lipid issues, or renal sickness comprised the 50 control groups. There were twenty women and thirty men, ages ranging from 22 to 66. The samples of blood were obtained from the patients (8-12) hr. after night fasting. The study's discoveries include a significant alteration in the majority of variables (Lipid profile, Liver enzymes, Albumin, Urea, Uric acid, Hb, and PCV), with the exception of HDL, which was not significant. Additionally, the following changes (urea and uric acid) seem to be significantly correlated with the length of CRF disease, although the other parameters remain unchanged (TC, LDLc, HDLc, VLDLc, TG, Hb, PCV, GOT, GPT, and Albumin). On the other hand, the anova analysis of statistical analysis reveals the following: PCV vs Uric acid, PCV vs Albumin, PCV vs Hb%, GOT vs Uric acid, VLDL vs TG, Hb% vs TG, Hb% vs VLDL, LDL vs HDL), According to the current study, patients with chronic renal failure often have high TG and aberrant haematological markers.
Diagnostic Value of Serum Semaphorin-3A and Cartilage Oligomeric Matrix Protein in Rheumatoid Arthritis Sarah Abbas Obaid
Journal La Lifesci Vol. 7 No. 3 (2026): Journal La Lifesci
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallalifesci.v7i3.3301

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder characterized by persistent synovial inflammation and progressive joint damage. The identification of reliable circulating markers could potentially improve early detection of the disease. To evaluate the diagnostic potential of circulating levels of Semaphorin-3A (SEMA3A) and Cartilage Oligomeric Matrix Protein (COMP) and their combined diagnostic potential in patients with Rheumatoid Arthritis. Comparative case-control study design was conducted in Division of Rheumatology, in Al-Najaf Teaching Hospital in Al-Najaf city of Iraq, for the period between July 2025 and January 2026, included 90 participants 45 of them patients with Rheumatoid Arthritis according to ACR/EULAR criteria and 45 apparently healthy controls. Blood samples were collected from all participants, and levels of circulating SEMA3A and COMP were estimated by Enzyme-Linked Immunosorbent Assay (ELISA). The serum concentration of both COMP and SEMA3A was significantly reduced (P < 0.001) in RA patients compared with controls (7.82 ± 2.31 pg/mL and 5.41 ± 1.62 ng/mL) vs. (11.96 ± 3.04 pg/mL and 8.73 ± 2.07 ng/mL). ROC analysis showed a good degree of discrimination for SEMA3A (84%, 80%, AUC = 0.88) and COMP (80%, 76%, AUC = 0.85) in RA patients. Combination of both biomarkers resulted in a better discrimination power (88.9%, 84.4%, AUC = 0.92). Serum SEMA3A and COMP show a good degree of discrimination for RA, and the combination of both biomarkers shows a better discrimination power for the diagnosis of RA.

Page 20 of 20 | Total Record : 192

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