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Aji Winanta
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Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 3, No 1 (2022): August" : 5 Documents clear
Formulation and Evaluation of Body Scrub Using Flour-Based from Fruits of Indramayu Variety of Cengkir Mango (Mangifera indica L) Ismanurrahman Hadi; Dadan Hidayattullah; Ade Irawan
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15569

Abstract

Cengkir Mango (Mangifera indica L) is a variety of mango known in the northern part of West Java and widely used as food, beverage, and natural-based pharmaceutical product. This fruit is potentially used as body scrub ingredients due to its richness in polyphenols contain. This study aims to formulate natural-based body scrub using the Cengkir Mango as an active ingredient. The formulation was divided into 3 groups with different concentrations of mango fruit flour, respectively 35, 46, and 50 grams (F1, F2, and F3). The product evaluation included homogeneity, stability, pH, and hedonic test. The organoleptic of body scrub indicated mango scent and light brownish-darker colors, responding to an increase of concentration for each formulation. The homogeneity test showed that the body scrub had no granulation of mango flour. The evaluation of pH showed the product had pH respectively at 7.5, 7.5, and 7.0 (F1, F2, and F3). These results indicated that the body scrub had good physical properties. Investigation of body scrub stability was used to evaluate the fragrance, color, and consistency of the formulation in storage for 3 weeks at room temperature. The results showed no change in color and consistency but a loss of mango fragrance after 3 weeks. The hedonic test indicated that most participants favored F1 (35 grams of mango flour). Based on these results, the flour of Cengkir mango had good performance as an active ingredient in a natural-based body scrub.
Antimicrobic Activity of IPPU Padang (Ammannia octandra L.f.) Leaves Ethanol Extract against Skin Pathogenic Microbials Muharni Saputri; Vriezka Mierza; Nirwana Putri
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v2i2.13505

Abstract

Ippu Padang plant (Ammannia octandra L.f.) belongs to the family of Lythraceae, a hardy plant that can grow to a height of 50 cm. According to previous research, Ippu Padang leaves contain glycosides, alkaloids, flavonoids and tannins. The presence of alkaloid compounds, flavonoids and tannins is predicted to have potential as an antifungal agent against fungi and antibacterial agent. This research used an experimental method. The steps included collecting plant material, plant identification, processing plants into Simplicia powder, phytochemical screening of Simplicia powder, extracting Simplicia by maceration method using ethanol solvent, antifungal and antibacterial activity test using agar diffusion method and determination of inhibition diameter of leaf ethanol extract. The results of phytochemical screening showed that ippu Padang leaves contained secondary metabolites, namely alkaloids, flavonoids, glycosides, anthraquinone glycosides, tannins, saponins and steroids. The results also revealed that the concentration with the largest inhibitory diameter was 400 mg/ml, namely 12.4 mm against the Candida albicans, 17.46 mm against the Dermacoccus nishinomiyaensis bacteria, 18.53 mm against the Micrococcus luteus bacteria, 19.38 mm against the Pseudomonas aeruginosa bacteria, and 17.71 mm against Staphylococcus epidermidis bacteria. It was concluded that the ethanol extract of ippu Padang leaves could inhibit the growth of the Candida albicans, the bacteria Dermacoccus nishinomiyaensis, Micrococcus luteus, Pseudomonas aeruginosa and Staphylococcus epidermidis.
Antioxidant effect of Abelmoschus Esculentus against acetaminophen-induced nephrotoxicity: an experimental study Mervan Bekdas; Arzu Meyri Yoldas; Aysegul Danıs; Selma Erdogan Duzcu; Murat Alisik; Ayhan Cetinkaya; Huseyin Kocabey; Idris Turel; Mustafa Dilek; Gokce Kaya Dincel
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15284

Abstract

Acetaminophen(APAP) intoxication is an important cause of nephrotoxicity and hepatotoxicity. N-acetylcysteine(NAC) is used in the treatment, but it has some serious side effects. Abelmoschus esculentus(AE) has various benefits as well as antioxidant effects. This study aims to investigate the effect of AE in APAP-induced acute nephrotoxicity. Forty male Wistar rats were divided into five equal groups: Control, AE, APAP, APAP+AE, and APAP+AE+NAC. Significant changes were observed in serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), Neutrophil Gelatinase-Associated Lipocalin(NGAL) and Kidney Injury Molecule-1(KIM-1) after induction with APAP. NGAL and KIM-1 in the AE group remained low compared to those receiving APAP (p=0.022 and p0.001, respectively). When the APAP group was compared with the AE and AE+NAC groups, it was found that even the administration of AE alone significantly decreased NGAL and KIM-1(p=0.036 vs.p=0.029 and p0.001 vs. p0.001, respectively), these results were attributed to the effects of AE on reducing MDA and increasing SOD. Histopathological studies also confirmed these results. These results demonstrated that AE had protective and therapeutic effects on APAP-induced nephrotoxicity. This benefit of AE is due to its antioxidant effect. In addition, AE may also increase the regenerative capacity of the kidney, which APAP reduces.
Aqueous Leaf Extract of Chromolaena odorata Attenuates Methotrexate-Induced Hepatotoxicity in Wistar Rats Bridget Osamuyimen Ikponmwosa; Usunomena Usunobun
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15652

Abstract

Methotrexate (MTX) usage, despite its toxicity in body organs, has increased steadily over the years due to its broad applicability for treating different ailments, including various forms of cancer. Certain plant species have been shown to possess therapeutic properties by offering a protective effect against drug side effects. Thus, the current study was carried out to evaluate the potential of aqueous Chromolaena odorata leaf extract (AEOC) to attenuate the effect of MTX-induced hepatotoxicity in Wistar rats. The study divided thirty (30) male Wistar rats into five groups consisting of six each: Group I (control), Group II (AEOC at 250 mg/kg BW), Group III (MTX at 7 mg/kg BW), Group IV (AEOC at 250 mg/kg BW + MTX at 7 mg/kg BW), and Group V (Vitamin C (100 mg/kg BW) + MTX at 7 mg/kg BW). Chromolaena odorata and Vitamin C was administered for ten consecutive days, while MTX was administered on day 8 for three consecutive days. Rats were sacrificed 24hrs after the last administration. Serum collected was used for the determination of Aspartate Aminotransferase (AST), Alanine transaminase (ALT), Albumin (ALB), Total Bilirubin (TB), and Total protein (TP), while liver tissue was used for assessment of Superoxide Dismutase (SOD), Malondialdehyde (MDA) and Catalase (CAT) as well as histopathological analysis. The result showed a significant increase in the level of SOD, CAT and a significant reduction in MDA in Chromolaena odorata or Vitamin C treated groups compared with MTX. Furthermore, Chromolaena odorata or Vitamin C significantly reduced liver function enzymes and Total Bilirubin levels while increasing synthetic molecules compared to the MTX group. Chromolaena odorata attenuated the toxic effect of MTX, which was corroborated by histopathological analysis. In conclusion, Chromolaena odorata attenuated MTX-induced hepatotoxicity by enhancing antioxidant status; thus, scavenging free radicals and reducing oxidative stress.
Total Flavonoid Content of Lemongrass Leaf (Cymbogoncitratus (DC.) Stapf) Extract and Antioxidant Activity with Frap Ahda Maulida Ulufan Nurinnafi'a; Kusumaningtyas Siwi Artini; Desy Ayu Irma Permatasari
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15556

Abstract

Lemongrass (Cymbogoncitratus (DC.) Stapf) leaves contain alkaloids, saponins, tannins, anthraquinones, steroids, phenols and flavonoids. Flavonoids act as antioxidants as they can reduce free radicals. This study aims to determine the total flavonoid content, antioxidant activity, and IC50 value of lemongrass leaf extract (Cymbogoncitratus (DC.) Stapf). Extracts were made by maceration using 96% ethanol as solvent. Testing of total flavonoid content with the AlCl3 method using UV-Vis spectrophotometry was carried out three times. The antioxidant activity test used the FRAP (ferric reducing antioxidant power) method on extracts containing 100, 200, 300, 400, and 500 ppm. The test results showed that the leaf extract of citronella (Cymbogoncitratus (DC.) Stapf) had a total flavonoid content of 22,60 mg QE/g extract. Furthermore, there was antioxidant activity in the leaf extract of lemongrass (Cymbogoncitratus (DC.) Stapf indicated by the formation of a blue color purplish when reacted with FRAP solution, and IC50 extract value was 71,59 ppm and included in the category of strong antioxidants.

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