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Antibacterial Activity Test of N-Hexan, Ethyl Acetate and Water from Ethanol Extract of Kitolod Leaf (Isotoma Longiflora (L.) C. Presl.) AGAINST Staphylococcus Aureus ATCC 25923 Tatiana Siska Wardani; Triya Choirin Nisa; Kusumaningtyas Siwi Artini
Proceedings of the International Conference on Nursing and Health Sciences Vol 3 No 1 (2022): May 2022
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v3i1.984

Kitolod plant (isotoma longiflora (L) C.Presl) contains alkaloids, flavonoids, and saponins. The content of this compound has antibacterial activity. This study aims to determine the antibacterial activity of the n-hexane, ethyl acetate and water fractions from the ethanolic extract of kitolod leaves against Staphylococcus aureus, and to determine the most active fraction in inhibiting bacteria. This research is an experimental descriptive study. The ethanolic extract of kitolod leaves was obtained by maceration method using 96% ethanol solvent, the viscous extract obtained was fractionated with three solvents, and dissolved in 1% DMSO then tested for its antibacterial power by diffusion and dilution method against Staphylococcus aureus at concentrations of 15%, 20%, 25%, and 30% using ofloxacin positive control. The test results obtained were analyzed using the One Way Anova test followed by the Post Hoc Test using the Tukey method using SPSS16. The results of the test using the diffusion method showed that the ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction had antibacterial activity against Staphylococcus aureus. The most active fraction was the water fraction at a concentration of 30%, with an average inhibition zone diameter of 19.0 mm. The inhibitory power was lower than the positive control ofloxacin (28.3 mm). The dilution method of the water fraction showed a minimum inhibitory concentration and a minimum kill concentration at a concentration of 15%.

Total Flavonoid Content of Lemongrass Leaf (Cymbogoncitratus (DC.) Stapf) Extract and Antioxidant Activity with Frap Ahda Maulida Ulufan Nurinnafi'a; Kusumaningtyas Siwi Artini; Desy Ayu Irma Permatasari
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15556

Lemongrass (Cymbogoncitratus (DC.) Stapf) leaves contain alkaloids, saponins, tannins, anthraquinones, steroids, phenols and flavonoids. Flavonoids act as antioxidants as they can reduce free radicals. This study aims to determine the total flavonoid content, antioxidant activity, and IC50 value of lemongrass leaf extract (Cymbogoncitratus (DC.) Stapf). Extracts were made by maceration using 96% ethanol as solvent. Testing of total flavonoid content with the AlCl3 method using UV-Vis spectrophotometry was carried out three times. The antioxidant activity test used the FRAP (ferric reducing antioxidant power) method on extracts containing 100, 200, 300, 400, and 500 ppm. The test results showed that the leaf extract of citronella (Cymbogoncitratus (DC.) Stapf) had a total flavonoid content of 22,60 mg QE/g extract. Furthermore, there was antioxidant activity in the leaf extract of lemongrass (Cymbogoncitratus (DC.) Stapf indicated by the formation of a blue color purplish when reacted with FRAP solution, and IC50 extract value was 71,59 ppm and included in the category of strong antioxidants.

Antibacterial Activity Test of N-Hexan, Ethyl Acetate and Water from Ethanol Extract of Kitolod Leaf (Isotoma Longiflora (L.) C. Presl.) AGAINST Staphylococcus Aureus ATCC 25923 Tatiana Siska Wardani; Triya Choirin Nisa; Kusumaningtyas Siwi Artini
Proceedings of the International Conference on Nursing and Health Sciences Vol 3 No 1 (2022): January-June 2022
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v3i1.984

Kitolod plant (isotoma longiflora (L) C.Presl) contains alkaloids, flavonoids, and saponins. The content of this compound has antibacterial activity. This study aims to determine the antibacterial activity of the n-hexane, ethyl acetate and water fractions from the ethanolic extract of kitolod leaves against Staphylococcus aureus, and to determine the most active fraction in inhibiting bacteria. This research is an experimental descriptive study. The ethanolic extract of kitolod leaves was obtained by maceration method using 96% ethanol solvent, the viscous extract obtained was fractionated with three solvents, and dissolved in 1% DMSO then tested for its antibacterial power by diffusion and dilution method against Staphylococcus aureus at concentrations of 15%, 20%, 25%, and 30% using ofloxacin positive control. The test results obtained were analyzed using the One Way Anova test followed by the Post Hoc Test using the Tukey method using SPSS16. The results of the test using the diffusion method showed that the ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction had antibacterial activity against Staphylococcus aureus. The most active fraction was the water fraction at a concentration of 30%, with an average inhibition zone diameter of 19.0 mm. The inhibitory power was lower than the positive control ofloxacin (28.3 mm). The dilution method of the water fraction showed a minimum inhibitory concentration and a minimum kill concentration at a concentration of 15%.

Literature Review: Antioxidant Test of Basil Leaves (Ocimum Sanctum) Noka Riyani; Kusumaningtyas Siwi Artini; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Basil leaves is family of lamiaceace, which is known as daun kemangi (Indonesia). This plant is widely use as a herb. Indonesian also used basil leaves as a seasoning in their food. It has chemical compound such as flavonoid so it has an antioxidant effect. The aim of this reseach is to find out the antioxidant effect of the basil leaves, the chemical compound of basil leaves. The method by reviewing online articles at Pubmed, sciencedirect and Google Scholar. Cemichal compound wes identified in some reseach. It show different potential base on the extraction proses. The antioxidant effect was tested using the DPPH method for determination of IC50. By reviewing articles, we can conclude that basil leaves have an antioxidant effect.

Literature Review: Hand sanitizer formulation from extract and essential oil of betel leaf (Piper betle Linn.) As well as antibacterial activity test Weri veranita; Kusumaningtyas Siwi Artini; Danang Raharjo; Ferry Effendi
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

The pandemic encourages us to look for various ways to overcome it, from various sides, including physical mobility management, vaccine development, to drug discovery. Indonesia has long recognized and used medicinal plants as an effort to overcome health efforts. Piper betle Linn or betel is a plant known to have antiseptic properties. Traditional use is usually by boiling the betel leaf. Utilization of stew and betel leaf extract as natural antibacterial agents has advantages. This is because these plants have natural compounds that are safer than the use of drugs that contain synthetic ingredients. Research reveals that betel leaf with an extract content of more than 15% is equivalent to alcohol and ethanol content. Research and utilization of betel leaf as an antiseptic and hand sanitizer products have been done a lot, one of which is by using extracts and essential oils from betel leaves. The aim of this study was to compare the antibacterial activity of the betel leaf hand sanitizer formulation using extracts and essential oils against the tested bacteria. This research is a literature review. Information on the hand sanitizer formulation of Piper betle Linn betel leaf was collected from online databases such as Pub Med, Direct Scient, and Google Scholar.

Literature Review: The Potencial Effect of Dandang Gendis Leave (Clinacanthus nutans Lindau) Kusumaningtyas Siwi Artini; Weri Veranita; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Indonesian are used to use herb to medicate a disease. One of the medicinal plants used is Clinacnathus nutans (Burm.f.) Lindau. Clinacnathus nutans Lindau is a traditional plant, commonly known as dandang gendhis (Java – Indonesia), ki tajam (Sunda – Indonesia), belalai gajah (Malaysia), Sabah Snake Grass (Singapore), and phaya yo (Thailand). It belonging to the Acanthaceae family. This study aimed to find out the the effect of giving the extract of Clinacnathus nutans Lindau to subject. This research method was using literature review. The information about Clinacanthus nutans Lindau collected from an online database such as Pub Med, Scient direct and Google Scholar. The number of chemical compound were identified from leaves. It contain of alkaloid, flavonoid, polifenol, saponin and tanin Some of the potential effect shown such as antihypoglycemic, antioxidant and anticancer, and analgetic. In this study,we can conclude that in the future Clinacnathus nutans Lindau is valuable to use as herbal medicine with more investigation.

Literature Study of Three Plant Formulations with Anti-Candida Albicans Activity in Feminine Liquid Soap Preparations Tatiana Siska Wardani; Kusumaningtyas Siwi Artini; Ilham Latansa
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Candida albicans is a fungus that causes vaginal discharge in women. Leucorrhoea is a discharge from the vagina with a relatively small frequency, odorless, and clear. In Indonesia, there are many plants that have medicinal properties that are used in traditional medicine and are believed to have antifungal activities.Feminine hygiene soap is a liquid cleansing preparation for femininity which is made from basic ingredients and is used to clean the feminine area without causing irritation to the skin.This study aims to provide information about plants that have anti-fungal activity and their formulation as a good female liquid soap preparation with their activity as an anti-candida albicans. The method in this research is by searching literature studies from various journals. The results showed that each female liquid soap preparation with plants as the active substance gave different inhibition diameters. The difference between the active substance and the additive in the formulation affects the resulting inhibition diameter. Based on the results of a literature review, basil,cabbage (Brassica oleracea var. capitata alba) and waru (Hibiscus tiliaceus), has activity as an antifungal against Candida albicans.

ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACTS AND FRACTIONS KETEPENG CINA LEAVES(Cassia alata) WITH ABTS Assay Danang Raharjo; Nur Hidayah; Kusumaningtyas Siwi Artini
Proceeding of International Conference on Science, Health, And Technology Proceeding of the 3rd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Antioxidants are compounds that have a molecular structure that can donate electrons to free radical molecules and can break the chain reaction of free radicals. This research was conducted to analyze the flavonoid content in the ethanol extract of ketepeng cina leaves and to determine the antioxidant activity of the ethanol extract and the fraction of the ketepeng cina leaves. This research is an experimental descriptive study. Ketepeng cina leaves were extracted using 96% ethanol, then partitioned using the liquid-liquid partition method. Flavonoid levels were determined using UV-VIS spectrophotometry at a wavelength of 435 nm. Antioxidant activity test using the ABTS method at a wavelength of 740 nm. The results showed that the flavonoid content of the ethanol extract of the ketepeng cina leaves was 11,054 ± 0.228 QE. The results of the antioxidant activity test of the ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction with IC50 values were 23,709 ppm, 106,598 ppm, 14,534 ppm, and 49,844 ppm, respectively. The highest antioxidant activity was indicated by the ethyl acetate fraction with an IC50 value of 14,534 ppm with very strong activity

Antibacterial Activity of Abrus precatorius L. Leaves Against Streptococcus mutans ATCC 25175 Bacteria Nadia Aisy Andika; Kusumaningtyas Siwi Artini; Tatiana Siska Wardani
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.16206

One of the herbal plants that have medicinal properties is Abrus precatorius L or commonly known as Saga in Indonesia. Empirically, the boiled water of saga leaves is widely used as an ingredient in cough medicine, cancer sores and swollen tonsils. The chemical constituents of antibacterial activity in the saga leaves are glycosides (abrusoside AD and abrusgenin), flavonoids and saponins (glycerin). This study aims to determine the antibacterial activity of extracts and fractions from saga leaves and the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the most active fraction of saga leaves on the growth of Streptococcus mutans ATCC 25175. Saga leaf powder was macerated using 96% ethanol, then fractionated using n-hexane, ethyl acetate, water as solvent, 96% ethanol extract, and n-hexane fraction. The antibacterial activity test using the diffusion method showed that the extract, n-hexane fraction, ethyl acetate fraction, and water fraction of saga leaves had antibacterial activity against Streptococcus mutans. The most active fraction was the ethyl acetate fraction, with a concentration of 50% with an average inhibition zone diameter of 12.2 mm. The ethyl acetate fraction from saga leaves had the most active antibacterial activity compared to ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction, as seen from the average diameter of the inhibition zone obtained. The test results of the dilution method of the ethyl acetate fraction of saga leaves showed a Minimum Inhibitory Concentration of 12.5% and a Minimum Killing Concentration of 25%.

RASIONALITAS PENGGUNAAN OBAT ANTIDIABETES PADA PASIEN DM TIPE 2 PASIEN RAWAT JALAN DI RSUD Dr. MOEWARDI SURAKARTA Kusumaningtyas Siwi Artini; Tiara Ajeng Listyani; Galuh Puspitasari
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i1.160

Diabetes mellitus adalah penyakit degeneratif yang terjadi karena adanya gangguan produksi insulin sehingga terjadi peningkatan kadar insulin. Prevalensi kejadian Diabetes mellitus terus meningkat karena gaya hidup yang kurang baik. Pasien dengan penyakit diabetes mellitus harus menjalani pengobatan seumur hidup dan membutuhkan obat yang tepat dan rasional agar tujuan terapi tercapai. Tujuan dari penelitian ini adalah untuk mengetahui profil penggunaan antidiabetes dan rasionalitas penggunaan obat antidiabetes melitus pada pasien diabetes melitus tipe 2 yang menjalani rawat jalan di RSUD Dr. Moewardi Surakarta. Penelitian ini dilaksanakan dengan menggunakan metode cross sectional dan pengambilan data dilaksanakan dengan cara retrospektif. Hasil dari penelitian ini adalah obat antidiabetes diberikan secara kombinasi dengan antiabetes oral atapun dengan insulin. Rasionalitas tepat penggunaan obat didapatkan hasil tepat diagnosis sebesar 100%, tepat indikasi 100%, tepat obat 100%, tepat dosis 100%, dan tepat interval waktu pemberian 100%. Kata kunci: antidiabetes, diabetes mellitus tipe 2, rasional, rsud dr. moewardi ABSTRACT Diabetes mellitus is a degenerative disease that occurs due to impaired insulin production resulting in increased insulin levels. The prevalence of diabetes mellitus continues to increase due to unfavorable lifestyles. Patients with diabetes mellitus must undergo lifelong treatment and need appropriate and rational drugs so that therapeutic goals are achieved. The purpose of this study was to determine the profile of antidiabetic use and the rationality of antidiabetic drug use in type 2 diabetes mellitus patients undergoing outpatient care at RSUD Dr. Moewardi Surakarta. This research was conducted using the method cross sectional and data collection was carried out retrospectively. The results of this study are anti-diabetic drugs given in combination with oral anti-diabetics or with insulin. Rationality for the right drug use results in the right diagnosis of 100%, the right indication 100%, the right drug 100%, the right dose 100%, and the right time interval for giving 100%. Keywords: antidiabetic, diabetes mellitus type 2, rational, rsud dr. moewardi

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