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All Journal Journal of Fundamental and Applied Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Cerdika: Jurnal Ilmiah Indonesia Prosiding Seminar Informasi Kesehatan Nasional Usada Nusantara: Jurnal Kesehatan Tradisional Journal of Educational Innovation and Public Health Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Desy Ayu Irma Permatasari
Universitas Duta Bangsa Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Antioxidant Activity Evaluation from Tomatoes’ N-Hexane, Ethyl Asetate, and Water Fraction with DPPH Ratna Sari Dewi; Desy Ayu Irma Permatasari; Tatiana Siska Wardani; Muladi Putra Mahardika
Journal of Fundamental and Applied Pharmaceutical Science Vol 2, No 2 (2022): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v2i2.13023

Abstract

Antioxidants are compounds that can stabilize free radicals in the body. Free radicals are highly reactive molecules as they have unpaired electrons to interact with body cell molecules. Tomatoes contain flavonoids, saponins, solanine tannins, folic acid, malic acid, citric acid, protein, fat, vitamins, minerals, and histamine, which can be used as antioxidants. This study aims to evaluate the antioxidant activity of n-hexane, ethyl acetate, water fraction, and ethanol extracts of Tomatoes and to determine the greatest antioxidant activity between n-hexane, ethyl acetate, water and vitamin C. Tomatoes (Lycopersicum esculentum Mill.) was extracted using the maceration method with ethanol  followed by fractionation using n-hexane and ethyl acetate solvents. The test of antioxidant activity to DPPH radical was conducted on n-hexane, ethyl acetate, water, and vitamin C. The antioxidant activity results, expressed by IC50 value to the n-hexane, ethyl acetate, water fraction of Tomatoes fruit, were 4.4603 ppm; 4.0868 ppm; and 4.0527 ppm, respectively. Thus, the greatest antioxidant activity was the water fraction.
Qualitative and Quantitative Analysis of Dexamethasone in Rheumatic Pain Herbal Medicine Using Thin-Layer Chromatography (TLC) – Densitometry Desy Ayu Irma Permatasari; Novita Kurniasri; Muladi Putra Mahardika
Journal of Fundamental and Applied Pharmaceutical Science Vol 2, No 1 (2021): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v2i1.12450

Abstract

Chemical medicine is chemical substances that is used as the main ingredient of chemical drugs. This compound is usually added to herbal medicine preparation to strengthen the indication of the traditional medicine.Chemical medicine was prohibited from being added to traditional medicinal preparations. But in reality, a lot of medicinal herbs could have contained medicinal chemicals on the market sale. This purpose of this research was to know the chemical contamination of the dexamethasone also the concentration contained in the rheumatic pain herbal medicine. This research was used three kind of rheumatic pain herbal medicine sample to identify dexamethasone, the sample code is S1, S2, and S3. The analysis of qualitative method are organoleptic test, FTIR characteristic test, TLC evaluation. The analysis of quantitative were purposed to know the dexamethasone concentration contained on the rheumatic pain herbal medicine using TLC-Densitometric method. The result show that the three sample of rheumathic pain herbal medicine were contaminated by dexamethasone chemical medicine. Based on organoleptic test, the results show color, smell, and taste. Characterization of the dexamethasone using FTIR were to know functional groups of dexamethasone contained in the rheumatic pain herbal medicine sample, the functional groups of the sample S1, S2, and S3 were compared to dexamethasone standard. To identify of TLC method, obtained Rf value of dexamethasone standard and the sample, visualizing a stain color purple-fluorescence on the UV 254 nm. The analysis of quantitative dexamethasone concentration using TLC-Densitometric showed the presence of dexamethasone in the sample for S1, S2 and S3. The concetration of dexamethasone obtained of sample S1, S2, S3 were 1014.64 µg/g ; 131.15 µg/g ; 135.54 µg/g respectively.
QUALITATIVE AND QUANTITATIVE ANALYSIS OF PARACETAMOL CONTAMINATION IN RHEUMATIC PAIN TRADITIONAL MEDICINE Desy Ayu Irma Permatasari; Rini Setyowati; Muladi Putra Mahardika
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.5497

Abstract

Analgesic drugs are often added illegally in rheumatic pain traditional medicine. Paracetamol is one of chemical drugs that have a large possibillity to be added in rheumatic pain traditional medicine. The aims this research were to know paracetamol and concentration of paracetamol in rheumatic pain traditional medicine in Borobudur District. This research is experimental research, the analysis data were used microsoft excel and linear regression. Qualitative analysis method using organoleptic test to description the sample, TLC test to evaluation Rf value and FTIR test for characterization. Quantitative analysis method using LC-MS test to know the paracetamol concentration contained on the rheumatic pain traditional medicine. Organoleptic test the results show description the shape, color, smell and taste of sample A, B and C. The results of the TLC evaluation showed sample A and B were positive, indicated by a purple spot and the Rf value of the sample was exactly same compared to Rf value of standard paracetamol, while sample C is negative. The result of the FTIR spectra showed that sample A and B have same functional group as the standard paracetamol, while sample C showed none. LC-MS test results after calculating the concentration in samples A and C the concentration was obtained < 4,4 μg/kg below the Detection Limit (LoD): 4,4 μg/kg, while sample B the concentration was obtained 2,22%. Based on the results of all three samples tested, the sample A and sample B were positively contaminated by chemical medicine paracetamol while sample C were negative.
ANTIOXIDANT ACTIVITY OF PURSLANE PLANT (Portulaca oleracea L.) EXTRACT AS AN ANTIAGING SERUM IN SPRAY GEL USING DPPH METHOD Desy Ayu Irma Permatasari; Tatiana Siska Wardani; Ikrima Rahmasari; Kezia Putri Maha Dewi
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6084

Abstract

Skin aging is a problem for women caused by external factors, namely exposure to free radicals such as sunlight, antiaging cosmetic products containing antioxidants have been widely circulated to maintain skin health from the effects of free radicals. The content of antioxidant chemical compounds in the purslane plant (Portulaca oleracea L.) is believed to be able to prevent free radicals. Purslane plant extract serum preparations were made by formulating preparations with ingredients such as HPMC, chitosan, tween 80. Furthermore, antioxidant testing of extracts and preparations of serum spray formulas was carried out using the DPPH method, after which evaluation of the preparations included homogeneity, pH, adhesion, viscosity, and hedonic. The preparation of purslane plant extract serum in the spray gel preparation produces a brownish green color, has a slightly sour smell and has a soft texture. The resulting viscosity in the serum ranged from 1330 - 1362 cPs with a pH value in the range of 5.67 - 5.72. From the hedonic test carried out, the results obtained were that the color and aroma were less favored by the panelists while for the convenience of using spray gel the panelists liked the texture of all purslane (Portulaca oleracea L.) plant extract formulas. Based on this research, the IC50 value of purslane (Portulaca oleracea L.) plant extract was 132.87 ppm, while the formula had an IC50 value of 83.91 ppm. Therefore, antiaging serum in spray gel formulation has stronger antioxidant activity than purslane (Portulaca oleracea L.) plant extract.
Total Flavonoid Content of Lemongrass Leaf (Cymbogoncitratus (DC.) Stapf) Extract and Antioxidant Activity with Frap Ahda Maulida Ulufan Nurinnafi&#039;a; Kusumaningtyas Siwi Artini; Desy Ayu Irma Permatasari
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15556

Abstract

Lemongrass (Cymbogoncitratus (DC.) Stapf) leaves contain alkaloids, saponins, tannins, anthraquinones, steroids, phenols and flavonoids. Flavonoids act as antioxidants as they can reduce free radicals. This study aims to determine the total flavonoid content, antioxidant activity, and IC50 value of lemongrass leaf extract (Cymbogoncitratus (DC.) Stapf). Extracts were made by maceration using 96% ethanol as solvent. Testing of total flavonoid content with the AlCl3 method using UV-Vis spectrophotometry was carried out three times. The antioxidant activity test used the FRAP (ferric reducing antioxidant power) method on extracts containing 100, 200, 300, 400, and 500 ppm. The test results showed that the leaf extract of citronella (Cymbogoncitratus (DC.) Stapf) had a total flavonoid content of 22,60 mg QE/g extract. Furthermore, there was antioxidant activity in the leaf extract of lemongrass (Cymbogoncitratus (DC.) Stapf indicated by the formation of a blue color purplish when reacted with FRAP solution, and IC50 extract value was 71,59 ppm and included in the category of strong antioxidants.
ANALISIS KANDUNGAN LOGAM BERAT Pb, Cd, DAN Hg PADA AIR MINUM ISI ULANG DEPOT AIR MINUM (DAM) DI KECAMATAN TANGEN MENGGUNAKAN SPEKTROSKOPI SERAPAN ATOM Qonitaatun Nur Hidayah; Muladi Putra Mahardika; Desy Ayu Irma Permatasari
Duta Pharma Journal Vol. 1 No. 1 (2021): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.13 KB) | DOI: 10.47701/djp.v1i1.1193

Abstract

Depot air minum isi ulang merupakan badan usaha yang bergerak dibidang pengelolaan air minum untuk memenuhi kebutuhan masyarakat. Dalam pengelolaan tidak semua depot dikelola dengan baik terutama tentang kualitas air minum yang aman bagi kesehatan. Tujuan dari penelitian ini adalah untuk mengetahui kandungan logam berat dan kadar Pb, Cd, dan Hg beserta mengetahui kualitas air minum isi ulang yang diperoleh dari depot air minum isi ulang yang berada Kecamatan Tangen berdasarkan pada PERMENKES No. 492/MENKES/Per/IV/2010. Metode yang digunakan untuk analisis sampel adalah spektroskopi serapan atom. Parameter dari penelitian ini berupa parameter fisika yang meliputi : bau, rasa, dan suhu. Sedangkan parameter kimia berupa pH, logam Pb, Cd, dan Hg. Air minum isi ulang diperoleh dari tiga tempat yang berada di Kecamatan Tangen (Lokasi I, II, dan III). Hasil penelitian menunjukkan bahwa parameter fisika dan parameter kimia berupa pH memenuhi standar untuk ketiga lokasi. Parameter Pb yang melebihi standar kualitas air minum yang berasal dari lokasi I,II, dan III secara berturut-turut sebesar 0,35 mg/L; 0,17 mg/L; dan 0,05 mg/L. Parameter Cd telah memenuhi standar kualitas air minum. Parameter Hg yang diperoleh dari lokasi I melebihi standar yaitu 0,0024 mg/L dan untuk lokasi II dan III telah memenuhi standar kualitas air minum. Kata Kunci : Air minum isi ulang, logam berat, spektroskopi serapan atom
Formulation and evaluation of antibacterial nanoemulsion mouthwash from active fraction of lemongrass stem (Cymbopogon Nardus) Weri Veranita; Desy Ayu Irma Permatasari
Proceeding of International Conference on Science, Health, And Technology Proceeding of the 3rd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.017 KB) | DOI: 10.47701/icohetech.v3i1.2277

Abstract

Currently, the use of pharmaceutical preparations based on natural ingredients has begun to be in great demand by the public. This is because the use of synthetic drugs has weaknesses such as being able to cause resistance. Dental caries is one of the most common oral diseases in humans. One of the plants that has the potential to be used as an antibacterial in the oral cavity is Lemongrass (Cymbopogon Nardus L.). The use of emulsion mouthwash in the oral cavity is one of the treatments that is still being carried out. Mouthwash with nano size has advantages such as being able to enter the body more easily. This study aims to determine the physical properties of mouthwash nanoemulsion ethyl acetate extract of Serai Wangi (Cymbopogon Nardus L.) by evaluating the preparation. The nanoemulsion mouthwash was made with the composition of Palm Oil as the oil phase, 96% ethanol as the cosurfactant, Tween 80 as the surfactant, and phosphate buffer pH 6 as the water phase. Then the mixture was stirred at a speed of 1000 rpm and sonicated and then tested for evaluation of the preparation including pH test, homogeneity test, organoleptic test, centrifugation test and transmittance test using UV-Vis Spectrophotometer. The results of the analysis of the entire nanoemulsion formula showed that the more the mangosteen rind extract was incorporated into the oil phase, the more concentrated the color of the nanoemulsion formed and the smaller the percentage of transmittance produced.
Penetapan Kadar Flavonoid dan Uji Aktivitas Antioksidan Ekstrak Etanol 70%, Fraksi N-Heksana, Etil Asetat, dan Air dari Kubis Putih dan Kubis Ungu Menggunakan Metode Frap Budi Santoso; Danang Raharjo; Desy Ayu Irma Permatasari
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 9 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (606.585 KB) | DOI: 10.59141/cerdika.v2i9.441

Abstract

Cabbage contains various vitamins such as vitamin A, vitamin C and phytonutrient compounds that are natural antioxidants. Flavonoids are compounds with antioxidant activity that can protect the body from free radicals. This study aims to determine the flavonoid content and antioxidant activity of 70% ethanol extract, n-hexane fraction, ethyl acetate, and water from white cabbage (Brassica oleracea l.) and purple cabbage (Brassica oleracea l. Var. Capitata f. Rubra) FRAP method. This study was conducted experimentally including sample preparation, phytochemical screening, simplisia characterization, determination of total flavonoid content using colorimetric method with AlCl3 reagent and quercetin was used as a comparison. Antioxidant activity testing was carried out using the FRAP method with vitamin C as a comparison measured using a UV-Visible spectrophotometer. The results showed that the total flavonoid levels contained in white cabbage and purple cabbage were 5.664 mg QE/g sample and 10.145 mg QE/sample. Ethanol extracts of white cabbage and purple cabbage n-hexane, ethyl acetate and water fractions have antioxidant capacity of 71.534 mg AAE/ gram extract, 69.651 mg AAE/ gram extract, 93.781 mg AAE/ gram extract, 74.941 mg AAE/ gram extract and 78.08 mg AAE/ gram extract, 77.913 mg AAE/ gram extract, 99.145 mg AAE/ gram extract, 76.319 mg AAE/ gram extract. It can be concluded that the antioxidant activity of purple cabbage is higher than that of white cabbage.
PENGGUNAAN METODE HPLC PADA ANALISIS JAMU DEPOT YANG MENGANDUNG ANTALGIN Rifda Husna Arifah; Desy Ayu Irma Permatasari; Kusumaningtyas Siwi Artini
Jurnal Jamu Kusuma Vol. 3 No. 1 (2023): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jurnaljamukusuma.v3i1.52

Abstract

Penyalahgunaan penambahan BKO ke dalam sediaan herbal sering diidentikkan untuk penanganan penyakit seperti rematik, pereda nyeri, dan afrodisiak. Salah satu herbal yang biasa digunakan untuk meredakan nyeri adalah herbal pegal linu untuk mengurangi nyeri,meredakan nyeri otot, kelelahan, nyeri otot dan tulang, memperlancar peredaran darah, memperkuat daya tahan tubuh, serta meredakan nyeri di seluruh tubuh Identifikasi penambahan BKO dapat dilakukan dengan HPLC (High Performance Liquid Chromatography)dengan teknik identifikasi, pemisahan, dan kuantifikasi komponen dalam suatu campuranyang sangat cocok digunakanuntuk senyawa yang tidak mudah menguap, tidak stabil secara termal danmempunyaiberat molekul yang besar. Pemisahan analit tersebut dilakukan berdasarkan kepolarannya, alatnya terdiri dari kolom sebagai fasediamdan larutan tertentu sebagai fasegeraknya.Analisis kadar antalgin dapat menggunakan metode High Performance Liquid Chromatography (HPLC), yaitu dengan menggunakan fase gerak berupa metanol p.a dan aquabides dengan perbandingan 75 : 25, fase diam dengan kolom C18 sertadengan volume injeksi sebanyak 20 μL pada konsentrasi 20 ppm, 40 ppm, 60 ppm, 80 ppm, dan 100 ppm. Tujuan dari penelitian ini adalah untuk mengetahui keunggulan penggunaan metode HPLCdalam menganalisis kadar antalgin dalam suatu sediaan jamu. Hasil yang diperoleh yaitu adanya kandungan antalgin pada sediaan jamu dengan persentase 14,87 %. Kadar tersebut sangat tidak diperbolehkan terkandung dalam sediaan jamu dan telah melanggar pasal 196 Undang-undang Nomor 36 Tahun 2009.
NANOEMULSION-BASED MOUTHWASH OF ETHYL ACETATE FRACTION OF SERAI WANGI STALK: FORMULATION, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY TEST Desy Ayu Irma Permatasari; Weri Veranita; Novalisa Nindhi Soraya; Eva Kholifah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.908

Abstract

Serai wangi or citronella (Cymbopogon nardus L.) has long been used in Indonesia as a component of traditional medicine. A recent study aimed to determine the antibacterial activity of the most active fraction of Citronella stalk extract and to formulate it  into a nanoemulsion mouthwash. Fractionation of the ethanolic extract was carried out using liquid-liquid extraction, and it was found that the ethyl acetate fraction (EAF) was the most active. This fraction was then varied at concentrations of 25%, 12.5%, 6.25%, 3.125%, 1.5625%, and 0.78125% for the antibacterial activity test using the disc diffusion test method. To determine the potency of microbial activity, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated. Subsequently, the ethyl acetate fraction was formulated into a nanoemulsion and characterized by measuring the transmittance percentage, droplet size, and polydispersity index (pdI) using a particle size analyzer. The results showed that the ethyl acetate fraction at a concentration of 25% obtained an inhibition zone diameter of 10.67 mm. MIC and MBC values ??were obtained at a fraction concentration of 6.25%. In addition, characterization of formulae exhibited particle size and pdI as follow 101.6 nm and 0.681 (Formula I); 84.1 nm and 0.609 (Formula II); 108.3 nm and 0.527 (Formula III).  Keywords:  Citronella stalk; fractionation; Streptococcus mutans; nano-emulsion; mouth wash
Co-Authors Ahda Maulida Ulufan Nurinnafi&#039;a Anita Dwi Septiarini Anita Dwi Septiarini Annisa Nurlaila Sari Bangkit Riska Permata Bangkit Riska Permata Budi Santoso Danang Raharjo elva wahyu kurnia cici Eva Kholifah Febriyanto Eko Syahputra Fevi Indri Oktaviani Gezha Icsvanditra Hasanah Nurul Hijjah Ikrima Rahmasari Isna Nur Khasanah Kezia Putri Maha Dewi Kharisma Jayak Pratama Kusumaningtyas Siwi Artini Listyani, Tiara Ajeng Lutfi Indah Irmayanti Marshela Duta Larasati Muladi Putra Mahardhika Muladi Putra Mahardika Muladi Putra Mahardika Muladi Putra Mahardika Ning Rusmiyati Novalisa Nindhi Soraya Novita Kurniasri Putri Solihah Kartika Sari Qonitaatun Nur Hidayah Ratna Sari Dewi Regita Fortunata Rifda Husna Arifah Rini Setyowati Setianto, Rony Silvia Devi Siti Nur Indriyah Tatiana Siska Wardani Veranita, Weri Wardani, Tatiana Siska Weri veranita