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Asian Australasian Neuro and Health Science Journal (AANHS-J)
Published by TALENTA PUBLISHER
ISSN : 26860848     EISSN : 26860848     DOI : https://doi.org/10.32734
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Asian Australasian Neuro and Health Science Journal (AANHSJ) provides a forum for publishing the full research articles in the area of Neurosurgery and Health related to topics from the following subject areas: Neuro-Anatomy Neuro-Physiology Neuro-oncology Neuro-Spine Neuro-Pediatric Neuro-Trauma Neuro-Vascular Neuro-Fungsional Basic Science Biomoleculer in Neurology Radiology in Neurosurgery
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 103 Documents
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Comprehensive review of the optimal period for surgical treatment in parkinson’s disease progression : a meta analysis Hutagalung, Tommy Rizky; Rasyid, Fahmi; Sembiring, Arya Sadewa
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 8 No. 01 (2026): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhs-j.v8i01.24964

Abstract

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established surgical intervention for advanced Parkinson’s disease (PD). However, the optimal timing for surgical intervention remains debated. This meta-analysis aims to evaluate the clinical efficacy of early versus late DBS based on disease progression. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar for studies published between January 2015 and July 2025. Eligible studies included randomized controlled trials comparing early (within ~5 years of diagnosis) and late STN-DBS in idiopathic PD patients. Primary outcomes included motor improvement (UPDRS-III), levodopa equivalent daily dose (LEDD) reduction, and quality of life (PDQ-39). Risk of bias was assessed using the Cochrane RoB tool, and data were pooled using RevMan 5.4. Results: Six RCTs comprising 708 patients were included. Meta-analysis showed significantly greater motor improvement in the early DBS group (mean difference [MD] −7.45; 95% CI: −9.12 to −5.79; p < 0.001), greater LEDD reduction (MD −250.7 mg/day; 95% CI: −325.3 to −176.1; p < 0.001), and better quality of life scores (PDQ-39 MD −6.32; 95% CI: −8.79 to −3.84; p < 0.001). Heterogeneity was low to moderate across outcomes. Conclusion: Early STN-DBS is associated with superior motor and quality-of-life outcomes and reduced medication burden compared to late intervention. These findings support reconsidering DBS timing in clinical practice, advocating for earlier surgical referral in appropriately selected patients with idiopathic PD.
Circulating MicroRNA as a Non-Invasive Prognostic Biomarker in Traumatic Brain Injury: A Narrative Review of Current Evidence and Translational Considerations for Resource-Limited Settings Yefri, Rezka Fadillah; Ilyas, Muhana Fawwazy; Wardhana, Aji Wahyu; Kurniawan, Azhar Farisyabdi; Prasetya, Mustaqim; Arham, Abrar
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 8 No. 01 (2026): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhs-j.v8i01.25356

Abstract

Background: Traumatic brain injury (TBI) is a leading cause of neurological morbidity and mortality worldwide, with a disproportionate burden in low- and middle-income countries, including Indonesia. Prognostic assessment continues to rely on clinical scales such as the Glasgow Coma Scale (GCS) and on computed tomography, both of which have limited availability or variable performance in resource-constrained settings. Circulating microRNAs (miRNAs) are small non-coding RNAs notable for their stability in blood and quantifiability using widely available reverse transcription quantitative polymerase chain reaction (RT-qPCR) techniques, and they have emerged as candidate prognostic biomarkers after TBI. Objectives: This narrative review synthesizes current evidence on circulating miRNAs as non-invasive prognostic biomarkers in TBI and examines translational and implementation considerations within the Indonesian and broader low-resource neurosurgical context. Methods: A structured literature search was conducted in PubMed, Scopus, Google Scholar, and Cochrane for English-language human studies published between 2015 and 2024, using the keywords “microRNA”, “traumatic brain injury”, “prognosis”, and “biomarker”. After PRISMA-based screening, 32 studies were retained for narrative synthesis and complemented by foundational methodological references and high-quality reviews. Results: miR-21, miR-146a, miR-155, and miR-124, together with additional candidates such as miR-16, miR-92a, miR-93, miR-191, miR-499, miR-206 and miR-549a-3p, recurrently appeared across studies as associated with injury severity and neurological outcome measured by GCS, Glasgow Outcome Scale (GOS), or its Extended version (GOSE). Multi-miRNA panels generally outperformed individual miRNAs, and models integrating miRNAs with clinical variables reported higher discriminative performance than conventional single protein biomarkers alone. Across studies, the early post-injury window of approximately 24 to 72 hours appeared most informative for prognostication. Major barriers to translation include pre-analytical variability, the absence of consensus normalization strategies, and heterogeneity in analytical platforms and reporting. Conclusions: Circulating miRNAs represent a mechanistically grounded and logistically feasible candidate biomarker class for non-invasive TBI prognostication. Clinical translation will require multicenter validation, consensus pre-analytical and analytical standards, and phased implementation pathways adapted to local infrastructure. In Indonesia, leveraging the molecular diagnostic capacity expanded during the COVID-19 response could accelerate feasibility testing and early-phase clinical validation.
Predictor of Percutaneous Radio-Frequency Rhizotomy Outcomes for Trigeminal Neuralgia: A Single Center Prospective Cohort Study Prasetya, Mustaqim; Wardhana, Aji Wahyu; Adidharma, Peter; Yefri, Rezka Fadillah; Sulistyanto, Adi; Fadhil, Fadhil; Oswari, Selfy; Keswani, Ryan Rhiveldi; Kusdiansah, Muhammad; Aji, Yunus K.; Arham, Abrar
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 8 No. 01 (2026): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhs-j.v8i01.25357

Abstract

Background: Percutaneous radiofrequency rhizotomy (PRFR) offers a minimally invasive alternative for trigeminal neuralgia (TN) patients who are ineligible for microvascular decompression (MVD) or who suffer from refractory TN following MVD. However, clinical outcome predictors for PRFR, particularly in low-to-middle-income countries, remain insufficiently documented. Objectives: This study aims to (1) present the clinical characteristics of patients undergoing PRFR at a national tertiary brain center, and (2) identify clinical variables that predict optimal surgical outcomes. Methods: This prospective cohort study included 37 surgery-naïve and post-MVD recurrent TN patients who underwent PRFR between 2014 and 2020. Patient characteristics and offending pathologies were documented. Postoperative outcomes were assessed using the Barrow Neurological Institute (BNI) scales and the Numerical Rating Scale (NRS). Univariate and bivariate analyses were utilized to construct prediction models. Results: The cohort had a mean age of 59 ± 15 years. Among the patients, 51.4% were surgery-naïve, while 48.6% had a history of previous MVD. The PRFR procedure yielded significant NRS improvements in both the surgery-naïve (p < 0.001) and post-MVD (p = 0.001) groups, with no statistically significant difference in pain reduction between the two (p = 0.151). Preoperative identification of the offending pathology was a significant predictor of surgical success (p = 0.019), with small artery compression showing the highest rate of satisfactory outcomes. Conclusion: PRFR provides profound and immediate pain relief for both surgery-naïve patients and those with post-MVD recurrences. The nature of the offending pathology serves as a crucial clinical predictor for achieving optimal outcomes, making PRFR a highly reliable and cost-effective therapeutic pillar in the management of refractory TN.

Page 11 of 11 | Total Record : 103

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