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PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)
Published by Transpublika Publisher
ISSN : -     EISSN : 28099745     DOI : https://doi.org/10.55047/comorbid
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience Nursing
About the Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) is an international, modern, general medical publication that publishes research on all aspects of medicine, from fundamental research to significant clinical trials and cost-effectiveness analyses. We generally publish human research that contribute to our understanding of medical epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; clinical trials that evaluate the efficacy of particular therapies and comparative trials; and systematic reviews. We want to encourage the conversion of fundamental research into clinical trials and clinical evidence into therapeutic practice. When studies in animal models produce remarkable research findings that are extremely clinically relevant, we publish them on occasion. The international medical community, as well as educators, policymakers, patient advocacy groups, and other interested parties, are among our target audiences. The online edition of COMORBID is updated on a regular basis. Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Articles from all branches of medicine and associated subjects are published in PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol. 3 No. 4 (2024): OCTOBER" : 5 Documents clear
HOMOSEXUALITY: A SCIENTIFIC VIEW Ahmed, Jaafar Omer; Qasab, Zana Ahmad; Saeed, Sarhang Ibrahim
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1474

Abstract

Homosexuality has a long history. The public is exposed to scientific findings through media reports; there are many misunderstandings about homosexuality; and as a result, a person who has homosexual feelings suffers minor stress. Two different directions have emerged. One believes that homosexuals are responsible for the spread of diseases. The second one believes that homosexuality is a normal behavior. The main goal of this narrative review is to revisit this issue, emphasizing the need for consistent interpretation and ongoing research. This review is framed using insights from recent scientific resources. Four main terms related to homosexuality (sex, gender, gender identity, and sexual orientation) and their dimensions are discussed. Some data about homosexual orientations and behaviors are explained. Homosexuality in the past and present, its history as a mental disorder until its removal from textbooks, and its relationship with mental health are mentioned. The reasons why a person is homosexual are multifaceted, etiologically complex, and unclear. Both views—biological and environmental factors—are clarified. Changes in the understanding of homosexuality continue due to the influence of politics, society, and religion. We need more research to better understand the phenomenon, all aspects of the causes, and how to deal with them. These efforts must be free from political and religious directions.
PSYCHIATRIC COMORBIDY IN PATIENTS SUFFERING FROM CHRONIC MEDICAL DISEASES Faraj, Siba Sameer; Mohammad Amin, Nazar Mohammad; Abdulkareem, Makwan Mohammed
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1511

Abstract

Psychiatric symptoms are commonly distributed among general population and commonly comorbid with chronic medical diseases such as diabetes and thyroid diseases. This study aimed at discussing common mental health problems that are comorbid with chronic medical diseases in a single short paper by using different recent sources and references. This review article was conducted by using different recently published articles considering common mental health issues that are comorbid with chronic medical diseases such as diabetes mellitus, ischemic heart diseases, and thyroid diseases. Anxiety symptoms, depression, insomnia and somatization are commonly present among patients who have diabetes mellitus, thyroid disorders, hypertension, ischemic heart diseases, peptic ulcer and rheumatic illnesses.
MOLECULAR DOCKING OF CYMBOPOGON CITRATUS EXTRACTS AS POTENCY FOR DRUG FORMULATION TARGETING FUNGAL SPECIES CAUSING ONYCHOMYCOSIS IN BENUE STATE, NIGERIA Magdalene, Tyona Ngodoo
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1551

Abstract

Onychomycosis is a fungal infection of the nails, characterized by thickening, discoloration, and brittleness. It is caused by dermatophytes, non-dermatophyte molds, and yeasts and poses a significant public health challenge, particularly in tropical regions like Nigeria. Current antifungal treatments often show inconsistent efficacy, prompting the search for alternative therapies. This study explores the potential of Cymbopogon citratus (lemongrass) extracts as antifungal agents targeting key enzymes involved in fungal pathogenesis in onychomycosis in Benue State, Nigeria. Using ethical approval and rigorous laboratory protocols, fungal samples were cultured, and the Squalene Epoxidase (SQLE) gene was identified. Phytoconstituents in C. citratus extracts were analyzed via Gas Chromatography-Mass Spectrometry. Molecular docking using the Schrodinger Glide protocol predicted interactions with SQLE, a critical enzyme for fungal ergosterol biosynthesis. Dodecanoic acid-1,2,3-propane showed the highest docking score (-65.13 kcal/mol) and a molecular weight of 638 g/mol, outperforming terbinafine (-64.39 kcal/mol, 327.9 g/mol). The compounds exhibited strong binding to SQLE, suggesting a mechanism for disrupting fungal membrane synthesis. These findings emphasize the integration of computational predictions with in vitro studies in developing effective treatments for onychomycosis, addressing a significant medical need locally and globally.
THE POTENTIAL ACTIVITY OF ASIATICOSIDE FROM AKAR MANIS (Glycyrrhiza glabra) AS HYPOLIPEMIC Prasetyawan, Fendy; Saristiana, Yuneka; Salmasfattah, Novyananda; Mildawati, Ratna; Mayasari, Shinta
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1608

Abstract

Asiaticoside, a bioactive compound derived from Glycyrrhiza glabra (licorice root), has garnered attention for its potential as a hypolipemic agent. This study explores the lipid-lowering effects of asiaticoside, focusing on its mechanism of action and pharmacological properties. In silico analysis showed a high activation probability (pa=0.934) for asiaticoside, indicating its strong potential to interact with targets involved in lipid metabolism, such as PPAR-α, and reduce blood lipid levels. Additionally, its low inhibition probability (pi=0.003) suggests minimal risk for non-specific biological interference, making it a promising candidate for therapeutic use with a favorable safety profile. Asiaticoside’s antioxidant and anti-inflammatory properties further enhance its potential for cardiovascular protection by reducing oxidative stress, a key factor in atherosclerosis. While preliminary in silico results are promising, further in vitro and in vivo studies are required to confirm its efficacy, safety, and pharmacokinetics. Overall, asiaticoside represents a promising natural agent for managing hyperlipidemia and related metabolic disorders, offering an alternative to conventional synthetic therapies.
SHAPING A CULTURE OF CLEAN AND HEALTHY LIVING BEHAVIOR AT SMP NEGRI 4 LHOK SUKON THROUGH EDUCATION AND PROMOTION PROGRAMS Lensoni, Lensoni; Sakinah, Juliana
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1680

Abstract

Clean and Healthy Living Behavior (CHLB) is a critical component in enhancing public health, particularly within school environments. This study investigates the development of a CHLB culture at SMP Negeri 4 Lhok Sukon through structured education and promotion initiatives. Employing a quantitative descriptive survey approach, data were collected via questionnaires, observations, and document analysis. The findings reveal significant improvements in students' knowledge, attitudes, and practices regarding CHLB following the implementation of educational and promotional programs. Key factors contributing to the program's success included the active participation of teachers, parents, and school administrators, fostering a supportive environment for behavioral change. The study underscores the effectiveness of direct counseling and interactive education over traditional promotional media in cultivating sustainable healthy living habits. Recommendations include enhancing sanitation facilities, integrating CHLB into the curriculum, and organizing regular health workshops to further reinforce these behaviors.

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