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All Journal Journal of Islamic Pharmacy Jurnal Riset Kesehatan Poltekkes Depkes Bandung Sainstech Farma: Jurnal Ilmu Kefarmasian Medfarm: Jurnal Farmasi dan Kesehatan PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Indonesian Journal of Cancer Journal of Engineering Science and Technology Management Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Ilmu Kesehatan Joong-Ki
Salmasfattah, Novyananda
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Penilaian Tingkat Kecemasan Pasien Program Rujuk Balik di Fasilitas Kesehatan Tingkat Pertama Kota Malang Permata, Agung; Fitri, Aldesra; Abdullah, Muhammad Rizal; Salmasfattah, Novyananda
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1591

Abstract

Referral Program Services (PRB) are health services provided to patients in health facilities based on referrals from specialist doctors or sub-specialists who treat these patients. This study aims to look at the characteristics and assess the level of anxiety of the Referral Patient Program at the First Level Health Facility in Malang City. Anxiety level assessment used the Generalized anxiety disorder-7 (GAD-7) questionnaire. This type of research is analytic observational with cross sectional design. The sampling technique was carried out using the convenience sample method. The sample of this study were Patients of the Referral Program (PRB) at First Level Health Facilities in Malang City, to be precise in the outpatient unit during May 2023 who met the inclusive and exclusion criteria. The data collected was analyzed descriptively according to the number of categories for each variable and determined the level of anxiety using the GAD-7 questionnaire to obtain an overview of the data in the form of frequency and proportion (%). The results of the study showed that there were 37 (37%) males and 63 (63%) females, the highest age was >60, namely 36 patients (36%), the highest diagnosis of hypertension was 58 patients (58%), last education the highest was at the senior high school level, namely 42 patients (42%), in the employment status of the highest DRR patients, namely not working, 51 patients (51%), in marital status, 100 patients were married (100%), and the highest monthly income was <Rp. 2,500,000 ie 66 patients (66%). The anxiety level of PRB patients at FKTP Malang City obtained the highest level of anxiety at the mild anxiety level (48%) and the lowest at the severe anxiety level (2%).
PENGARUH KEPATUHAN MINUM OBAT TERHADAP OUTCOME PASIEN EMFISEMA DI RUMAH SAKIT WAVA HUSADA MALANG Salsabila, Dia; Salmasfattah, Novyananda; Mardianto, Rudy
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 2 (2023): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i2.235

Abstract

Emfisema merupakan bagian dari penyakit paru obstruktif kronik, dimana prevalensinya cenderung meningkat di Indonesia. Salah satu faktor pencetus utama emfisema adalah merokok. Laki-laki yang usianya diatas 60 tahun merupakan populasi yang paling rentan terkena emfisema. Untuk menjaga kualitas hidup pasien, maka diperlukannya kepatuhan minum obat untuk memberikan outcome yang baik bagi pasien. Penelitian ini bertujuan untuk mengetahui adakah pengaruh kepatuhan minum obat dengan outcome pasien emfisema yang menjalani pengobatan secara rawat jalan di Rumah Sakit Wava Husada Malang. Metode yang digunakan berupa deskriptif kuantitatif dengan pendekatan secara cross-sectional, menggunakan kuesioner MMAS-8 dan data rekam medis guna untuk menggumpulkan data. Hasil dari penelitian ini terdapat 80 responden yang dijadikan sebagai ukuran sampel penelitian. Berdasarkan pengelompokan gender, penelitian menemukan 47 responden (58,75%) adalah laki-laki. Terdapat 34 reponden (42,50%) berusia diatas 70 tahun. Pada obat-obatan yang digunakan diperoleh 79 resep (23,80%) mendapatkan obat salbutamol, paling banyak obat diberikan secara peroral (81,80%), serta diberikan secara kombinasi (98,75%) dari 80 responden ada 63 responden (78,75%) yang patuh terhadap pengobatan dan terdapat 57 responden yang tidak mengalami sesak (71,25%). Hasil uji binomial test menunjukkan nilai sebesar 0,000. Penelitian ini pengaruh antara kepatuhan minum obat terhadap outcome pasien emfisema di Rumah Sakit Wava Husada Malang. Kata kunci: emfisema, outcome, kepatuhan
EFEKTIVITAS DAUN KITOLOD (Isotoma longiflora) TERHADAP PENYEMBUHAN LUKA BAKAR PADA MENCIT (Mus musculus) Anggyadinata, Frisma; Salmasfattah, Novyananda; Ardianto, Nanang; Ibrahim, Kevvy Buana
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 1 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i1.2472

Abstract

Luka bakar merupakan rusaknya jaringan, biasanya disebabkan beberapa faktor. Cara mengurangi resiko infeksi serta mencegah luka menjadi kronis yaitu mengobati luka secara tepat. Salah satu tumbuhan yang biasa digunakan dalam pengobatan tradisional adalah tanaman kitolod (Isotoma longiflora). ). Penelitian ini bertujuan untuk mengetahui efektivitas sediaan ekstrak etanol 96% daun kitolod (Isotoma longiflora) pada pemulihan luka bakar pada mencit jantan (Mus musculus). Penelitian dilakukan pada Agustus sampai September 2023 bertempat di Laboratorium Kimia, Farmakognosi dan Hewan ITSK RS DR. Soepraoen. Metode yang digunakan adalah ultrasonik dengan menggunakan sampel daun kitolod. Hasil menunjukkan percepatan penyembuhan luka bakar dalam uji One Way ANOVA dengan nilai signifikansi p=0,003 yang berarti terdapat perbedaan yang signifikan pada data diameter luka bakar, dengan hasil terbaik diameter terkecil pada kontrol positif sebesar 9,678 mm, diikuti kontrol negatif 12,477 mm, konsentrasi 10% 13,683 mm, kontrol 40% 16,237 mm, dan diameter terbesar pada kontrol 20% 16,280 mm.  Diketahui bahwa efektivitas salep ekstrak daun kitolod yang terbaik dalam proses penyembuhan luka bakar pada mencit adalah pada konsentrasi 10% dengan diameter luka bakar pada hari ke-14 sebesar 13,683 mm. Disarankan peneliti selanjutnya menguji efektivitas ekstrak daun kitolod menggunakan metode dan kosentrasi sediaan salep yang sama namun menempatkan hewan uji pada ruangan yang sesuai dengan ukuran mencit yang terkontrol suhu dan kelembaban lingkungannya.
Studi In Silico Glibenclamid Sebagai Kandidat Obat Antikanker Pada Inhibitor MAP2K1 dengan Metode Revers Docking Afiansyah, Ahmad Gasya; Mardianto, Rudy; Salmasfattah, Novyananda
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 16 No 1 (2024): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v16i1.2484

Abstract

Tingkat keparahan efek samping yang terkait dengan obat antikanker yang saat ini beredar di pasaran termasuk efek samping yang berpotensi fatal seperti kardiotoksisitas pada kasus dokxorubisin. Penelitian ini bertujuan untuk menemukan kandidat obat baru yang memiliki efek samping rendah. Pendekatan in silico adalah metode komputasi untuk menemukan kandidat obat baru. Ligan glibenclamide dan doxorubicin diperoleh dari database PubChem, dan protein target MAP2K1, yang diperoleh dari database SwissModel, berfungsi sebagai reseptor. Pada penelitian ini ligan dan protein dipreparasi menggunakan alat PyMOL, dan hasil docking yang diperoleh dari alat PyRx berupa nilai afinitas pengikatan. Afinitas pengikatan antara protein dengan glibenclamide dan doxorubicin masing-masing adalah -9,9 kkal/mol dan -8,8 kkal/mol, hasil docking divisualisasikan menggunakan PyMOL. Senyawa tersebut mengikat glibenklamode kurang erat dibandingkan senyawa yang mengikat doxorubicin, tetapi masih berinteraksi kuat dengan protein MAP2K1. PLIP dapat digunakan untuk memvisualisasikan efek interaksi ini. Menurut temuan penelitian, senyawa glibenklamid memiliki interaksi yang baik dengan protein MAP2K1, sehingga menjadikannya target yang menjanjikan untuk obat kanker di masa depan. Untuk memvalidasi temuan ini, diperlukan lebih banyak penelitian biokimia, in vivo, dan in vitro.
THE POTENTIAL ACTIVITY OF ASIATICOSIDE FROM AKAR MANIS (Glycyrrhiza glabra) AS HYPOLIPEMIC Prasetyawan, Fendy; Saristiana, Yuneka; Salmasfattah, Novyananda; Mildawati, Ratna; Mayasari, Shinta
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1608

Abstract

Asiaticoside, a bioactive compound derived from Glycyrrhiza glabra (licorice root), has garnered attention for its potential as a hypolipemic agent. This study explores the lipid-lowering effects of asiaticoside, focusing on its mechanism of action and pharmacological properties. In silico analysis showed a high activation probability (pa=0.934) for asiaticoside, indicating its strong potential to interact with targets involved in lipid metabolism, such as PPAR-α, and reduce blood lipid levels. Additionally, its low inhibition probability (pi=0.003) suggests minimal risk for non-specific biological interference, making it a promising candidate for therapeutic use with a favorable safety profile. Asiaticoside’s antioxidant and anti-inflammatory properties further enhance its potential for cardiovascular protection by reducing oxidative stress, a key factor in atherosclerosis. While preliminary in silico results are promising, further in vitro and in vivo studies are required to confirm its efficacy, safety, and pharmacokinetics. Overall, asiaticoside represents a promising natural agent for managing hyperlipidemia and related metabolic disorders, offering an alternative to conventional synthetic therapies.
Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
Effect of Most Favored Regions of Estrogen Receptor β (ERβ) Molecules on MolDock Score Using Tamoxifen Ligand Salmasfattah, Novyananda; Permata, Agung; Prasetyawan, Fendy
JIKES : Jurnal Ilmu Kesehatan Vol. 3 No. 1 (2024): Juli-Desember 2024
Publisher : Yayasan Pendidikan Tanggui Baimbaian Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The estrogen receptor β (ERβ) molecule is one of the target proteins in cancer treatment. The type of ERβ molecule in the protein data bank (PDB) determines the value of most favored regions and MolDock score. The purpose of this study was to determine the effect of most favored regions of ERβ molecules on MolDock score using Tamoxifen ligand. There are 37 molecules that have ERβ protein, 7 molecules were selected to be analyzed for the value of most favored regions and MolDock score, based on the r table value, pearson correlation value 0.548 < 0.754 (r table). This is also the same when viewed from the significance value of 0.203 > 0.05. It can be concluded that there is no correlation between the value of most favored regions and MolDock score.
Virtual Screening and Comparison of the Binding Effectiveness of Doxorubicin, Paclitaxel, and Ergoloid to ERβ-MDM2 Complex Protein as New Breast Cancer Drug Candidates Salmasfattah, Novyananda; Dhiani, Binar Asrining; Muslikh, Faisal Akhmal; Putra, Galih Satrio
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1325

Abstract

Background: The prevalence of breast cancer continues to increase, it is the second leading cause of death after lung cancer. Estrogen receptor beta (ERβ) has an important role in breast cancer pathology, activation of Akt pathway will trigger E3 ubiquitin ligase murine double minute 2 (MDM2) to ERβ, which will increase the risk of breast cancer. Thus, both proteins have potential as therapeutic agents in breast cancer drug development. This study aims to find breast cancer drug candidates from natural products and compare the effectiveness of these compounds with Doxorubicin and Paclitaxel.Method: ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) proteins were combined using ClusPro 2.0. Doxorubicin and Paclitaxel ligands were obtained from PubChem, there are 842 natural products obtained from the ZINC database, when the energy minimization is reduced to 839 natural products. Virtual screening between proteins and ligands was performed using PyRx 8.0, followed by analysis of amino acid residues resulting from interactions between proteins and ligands using protein interaction calculator (PIC) and protein ligand interaction profiler (PLIP). Results: Ergoloid compounds have the lowest binding affinity compared to doxorubicin and paclitaxel compounds, and are able to interact strongly with the ERβ-MDM2 Protein as determined from the results of interactions between proteins and ligands using PIC and PLIP.Conclusion: Ergoloid compounds can interact well with ERβ-MDM2 Protein. Thus, it can be used as a breast cancer drug candidate in the future. In vitro, in vivo, and biochemical testing needs to be done to confirm this discovery
Molecular Docking of Hygrophila auriculata (Schum.) Heine Compounds Targeting PBP2 Protein in Neisseria gonorrhoeae Salmasfattah, Novyananda; Prayogi, Syaiful; Prasetyawan, Fendy
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.31740

Abstract

Antibiotic resistance in gonorrhoea cases and patients is detrimental. Amidst the rising cases of gonorrhoea caused by Neisseria gonorrhoeae, Hygrophila auriculata (Schum.) Heine has activity as an antibiotic for the disease. The penicillin-binding protein 2 (PBP2) is a transpeptidase that catalyses the formation of cross-bridges on bacterial cell wall peptidoglycan, which will be the target of this plant. The purpose of molecular docking study is to see the binding affinity, compounds in Hygrophila auriculata (Schum.) Heine and ceftriaxone which is used as a comparison drug, will be targeted at PBP protein. Discovery studio visualizer v21.1.0.20298 was used for PBP2 protein preparation and visualisation. DoG Site Scorer was used to predict ligand binding sites on PBP2 proteins. PyRx 0.8 was used for virtual screening, validating of the docking method, and ligand preparation. Compounds in Hygrophila auriculata (Schum.) Heine as ligands were derived from MPDB 2.0 and the following PubChem codes; apigenin CID 5280443, luteolin CID 5280445, allagic acid CID 5281855, gallic acid CID 370, quercetin CID 5280343, lupeol CID 259846, lupenone CID 92158, betulin CID 72326, stigmasterol CID 5280794, and comparator drug ceftriaxone CID 447043. The binding affinity of ellagic acid -9,8 from Hygrophila auriculata (Schum.) Heine was lower than ceftriaxone -9,4 on the target PBP2 protein. Some of the amino acid residues that appear in protein-ligand docking include: ALA A:310, THR A:500 and 347, LYS A:313, and SER A:362. These amino acid residues owned by the PBP2 protein serve as the bonding bridge. Ellagic acid, the compound has potential as an antibiotic in gonorrhoea. Further testing and studies are needed to strengthen the evidence of the findings in this study
Education on the Use of Vitamin A (Retinol) for the Prevention of Myopia in Adolescents in Gembleb Trenggalek: Edukasi Penggunaan Obat Vitamin A (Retinol) Untuk Pencegahan Penyakit Miopi Pada Remaja di Dusun Gembleb Trenggalek Prasetyawan, Fendy; Saristiana, Yuneka; Salmasfattah, Novyananda; Savitri, Lisa; Herman; Kadir, Mujtahid Bin Abd
KOMUNITA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 4 No 2 (2025): Mei
Publisher : PELITA NUSA TENGGARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60004/komunita.v4i2.177

Abstract

This community service program aimed to increase adolescents' awareness and knowledge regarding the role of Vitamin A (Retinol) in preventing myopia, particularly in rural areas such as Gembleb Village, Trenggalek. The activity was conducted on Saturday, May 3, 2025, in collaboration with the Government of Gembleb Village and supported by the Institute for Research, Community Service, and Publication (LP3M) of Universitas Kadiri. A total of 15 adolescents participated in the educational intervention, which included a pre-test, a lecture session, and a post-test evaluation. The results showed a significant improvement in participants’ knowledge about myopia and the importance of Vitamin A for eye health. Pre-test scores averaged lower compared to post-test results, with an average increase of 20–25 points. This finding suggests that structured education can effectively enhance health literacy among youth, particularly regarding nutritional prevention of visual disorders. These outcomes underscore the importance of continued community-based health education programs, especially in underserved areas, as a strategic effort to reduce the prevalence of preventable eye diseases
Co-Authors Abdullah, Muhammad Rizal Afiansyah, Ahmad Gasya Aldesra Fitri Anggyadinata, Frisma Ardianto, Nanang Besan, Emma Jayanti Binar Asrining Dhiani Faisal Akhmal Muslikh Fendy Prasetyawan Galih Satrio Putra Herman Ibrahim, Kevvy Buana Indrayanti, Dian Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Laili, Nur Fahma Mardianto, Rudy Megasari, Elly Mildawati, Ratna Muhammad Nurul Fadel Neni Probosiwi Permata, Agung Prayogi, Syaiful Salsabila, Dia savitri, Lisa Shinta Mayasari Sugeng, Santoso Tsamrotul Ilmi Yuneka Saristiana