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Proceeding of Mulawarman Pharmaceuticals Conferences
Published by Universitas Mulawarman
ISSN : -     EISSN : 26144778     DOI : https://doi.org/10.25026/mpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 45 Documents
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Search results for , issue "Vol. 13 (2021): Proc. Mul. Pharm. Conf." : 45 Documents clear
Potensi Ekstrak n-Heksana dan Ekstrak Etanol dari Daun Sirih (Piper betle Linn) Sebagai Penghilang Bau Mulut yang Disebabkan Bakteri Staphylococcus aureus: Potential of n-Hexane and Ethanol Extract from Betel Leaves (Piper betle Linn) as a Mouth Remover Caused by Bacteria Staphylococcus aureus Nunung Kurniasih; Assyifa Junitasari; Lilis Nurjanah; Anggita Rahmi Hafsari
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.563 KB) | DOI: 10.25026/mpc.v13i1.475

Abstract

The mouth is an ideal place for the growth and development of microorganisms because the mouth has moisture and a regular intake of food. Microbes found in the mouth, namely Staphylococcus aureus which can cause bad breath, one type of plant that is used as a bad breath remover is betel leaf. Betel leaf (Piper betle Linn) contains chavikol and betlephenol which can inhibit bacterial growth. This study aims to identify the class of compounds in betel leaf that have potential as antibacterial properties against S. aureus bacteria. The betel leaf was dried, then crushed to expand the surface of the sample (simplicia). Simplicia as much as 300 grams of macerated stratified with n-hexane, ethyl acetate and ethanol. The result was evaporated and the weight of each extract was 6.4371 g (n-hexane), 8.8007 g (etylacetate) and 9.2173 g (ethanol). Phytochemical tests and thin layer chromatography (TLC) using eluent n-hexane and ethyl acetate (8: 2) showed that n-hexane extract was thought to contain flavonoids, ethyl acetate extract containing saponins and ethanol extract containing polyphenols. Antibacterial activity test was carried out by using the paper disc diffusion method. Both the n-hexane extract and the ethanol extract of betel leaf showed very strong antibacterial activity, characterized by a diameter of inhibition above 20 mm.
Penambatan Molekul Senyawa Turunan Beta Asaron Sebagai Antimalaria: Molecular Docking of Derivated Compounds of Asaron Beta as an Antimalaria Salahuddin Salahuddin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.56 KB) | DOI: 10.25026/mpc.v13i1.476

Abstract

Beta Asarone derivatives are known for their potential as antimalarial. In the current study, the quantitave structure-activity relationship (QSAR) and molecular docking on 31 asarone derivatives was performed to search for novel more potent asarone derivatives as antimalaria. The obtained QSAR model was log IC 50 = 2.57917 + 0.019377 (AM1_HF) + 5.82755 (glob) + 0.61384 (log s) + (-1.63312 (mr)) + 0.05564 (vol). Designing new compound of asarone derivatives was performed using the validated QSAR model and the result showed that two compounds, A5 and A18, had better activities than the parent compound (ASN27). Molecular docking study showed that the two compounds were able to interact with crucial amino acid residues in the allosteric site of protein receptor (PDB code: 1CET) through hydrogen bonds and van der Waals interactions. The current study indicated that the two compounds had affinity significantly different to native ligand and might be useful to be advanced in the drug discovery process.
Traditional Medicine Pattern for Self-Medication in Temajuk Village, a 3T (Frontier, Outermost, and Underdeveloped) Region in West Kalimantan Muhammad Akib Yuswar; Eka Kartika Untari; Robiyanto Robiyanto
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.671 KB) | DOI: 10.25026/mpc.v13i1.477

Abstract

Living in a 3T region (frontier, outermost, and underdeveloped) of West Kalimantan, people who live in Temajuk village, have long been practicing self-medication using traditional medicines. Despite the existence of a primary care service in Temajuk, the people’s habit in utilising natural herbal medicine to cure their illness still exists until now. The aim of this study was to identify patterns of traditional medicine as self-medication treatment among Temajuk villagers. This study was a cross sectional descriptive study using 138 participants who met the criteria including aged 20-50 years and have been practising self-medication. The participants were asked to fill a set of questionnaire. The results of this study showed that the average age of participants was 33.86 y.o. They used Piper betle folium mostly (39.86%) in self-medication practice. 44.2% of participants believed in traditional medicine. Fever (22.47%) was the most chosen indications to use traditional medicine for self-medication. 60.87% respondents used traditional plant from their back and 59.42% of them made it into decocta or infusum. Most of participants did not experience any adverse effect (86.96%) during self-medication practice. In brief, this study proved that the practice of self-medication using traditional medicine is often to occur and still important for people in Temajuk village.
Review: Flavonoid pada Tanaman Kumis Kucing (Orthosiphon stamineus Benth.): Review: Flavonoid Compounds in Orthosiphon stamineus Fahrauk Faramayuda; Silvy Julian; Ari Sr Windyaswari; Totik Sri Mariani; Elfahmi Elfahmi; Sukrasno Sukrasno
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.862 KB) | DOI: 10.25026/mpc.v13i1.478

Abstract

Orthosiphon stamineus has long been used in traditional medicine in East India, Indo China, Southeast Asia, and tropical Australia, where this plant is usually found. Based on the color of the flowers and petals, Orthosiphon stamineus is classified into two varieties: white flowers (white varieties) and purple flowers (purple varieties). Orthosiphon stamineus has traditionally been used to treat hypertension, diabetes, bladder and kidney disorders, gallstones, gout, and rheumatism. The leaves of Orthosiphon stamineus were introduced to Europe and Japan as tea for health. The main compounds possessed by Orthosiphon stamineus are rosmarinic acid, eupatorium, and sinensetin. In addition, several studies have isolated the plant of Orthosiphon stamineus. This journal review aims to review studies related to the content of secondary metabolites, traditional uses, pharmacological activities, and levels of flavonoids contained in plants.
Formulasi dan Uji Mutu Fisik Sabun Padat Ekstrak Kulit Nanas (Ananas comosus L.): Formulation and Physical Quality Test of Pineapple Peel Extract (Ananas comosus L.) Solid Soap Milani Agustina Putri; Elly Purwati; Cikra Ikhda Nur Hamidah Safitri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.941 KB) | DOI: 10.25026/mpc.v13i1.479

Abstract

Nanas (Ananas comosus L.) merupakan salah satu tanaman di indonesia yang sangat berpotensi untuk dikembangkan karena mempunyai banyak manfaat. Nanas mengandung banyak vitamin B12, vitamin C, vitamin E dan enzim bromelin. Sedangkan kulit nanas yang hanya dianggap sampah yang tidak memiliki manfaat, padahal kulit nanas mengandung enzim bromelin, karotenoid, vitamin C dan flavonoid yang baik bagi kesehatan. Kandungan flavonoid dalam kulit nanas dapat dimanfaatkan sebagai antioksidan, anti alergi, anti inflamasi, dan anti bakteri. Antioksidan kulit nanas dapat dimanfaatkan sebagai pelindung kulit karena dapat mencegah terjadinya radikal bebas dan dapat diaplikasikan dalam bentuk sediaan sabun padat. Penelitian ini bertujuan untuk menghasilkan sabun padat ekstak kulit nanas dan menguji mutu fisik sesuai Standar Nasional Indonesia (SNI). Metode penelitian ini bersifat eksperimental yang terdiri dari pembuatan simplisia dan ekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Formulasi menggunakan ekstrak kulit nanas dengan konsentrasi 0% (basis), 1% (F1), 3% (F2). Evaluasi karakteristik fisik sabun padat meliputi pengamatan organoleptis, pengujian homogenitas, uji pH, uji daya busa. Sediaan di evaluasi selama 4 minggu, data dianalisis secara deksriptif. Hasil penelitian ini menunjukkan ke tiga formula menghasilkan sabun padat yang homogen, bertekstur padat dan halus, beraroma wangi, Basis (berwarna putih pekat kekuningan), F1 (berwarna putih pekat kekuningan), F2 (berwarna putih pekat kekuningan). Nilai pH pada basis, F1, F2 adalah 9,52 ,9,35, 9,45. Hasil organoleptis pada sediaan sabun padat basis, F1, F2 tidak mengalami perubahan. Nilai homogenitas pada sabun padat basis, F1, F2 tidak mengalami perubahan. Nilai uji daya busa sabun padat basis, F1, F2 tetap stabil. Kesimpulan pada penelitian ini yaitu mutu fisik sediaan sabun padat ekstrak kulit nanas memenuhi syarat SNI dan stabil selama penyimpanan 4 minggu.

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