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Krisni Subandyah
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Departemen Ilmu Kesehatan Anak FKUB (Department of Pediatrics, Faculty of Medicine, Universitas Brawijaya). Jl. Jaksa Agung Suprapto No. 2 Malang, Provinsi Jawa Timur, Indonesia
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Pediatric Sciences Journal
Published by Universitas Brawijaya
ISSN : 27220427     EISSN : 27221474     DOI : https://doi.org/10.51559/pedscij
Core Subject : Health,
Health Professions Public Health
Pediatric Sciences Journal (PedSciJ) is published by the Medical Faculty of Brawijaya University, Indonesia, as an Open Access & Peer Reviewed Multidisciplinary Journal. The aims and scope of the Journal include pediatric, neonatal healthcare, and perinatology/ The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions that promote the exchange of ideas and rational discourse between practicing educators and medical researchers worldwide. Pediatric Sciences Journal (PedSciJ) publishes peer-reviewed clinical research articles, case reports, serial case reports, systematic reviews, meta-analyses, and letters to the editor twice a year in June and December. Articles published in the Pediatric Sciences Journal (PedSciJ) embrace the full scope of the manuscript related to the health and diseases of infancy, neonates, children, adolescents, and those related to pediatric topics. The Journal also explores legal and ethical issues, neonatal technology, and product development based on COPE. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians, pediatric subspecialists, obstetrics, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists
Arjuna Subject : Kedokteran - Pediatrics, Perinatology, and Child Health
Articles 73 Documents
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Advanced infant HIV infection with Cytomegalovirus coinfection following interruption of maternal antiretroviral therapy: a case report Prisillia Brigitta; Adinda Paramitha Sukma Damayanti; Delicia Rudy; I Putu Oka Kresna Jayadi
Pediatric Sciences Journal Vol. 7 No. 1 (2026): Available Online : 1 June 2026
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v7i1.153

Abstract

Background: Despite major global progress in the prevention of mother-to-child transmission (PMTCT), vertical HIV transmission continues to occur, particularly in settings where continuity of maternal care and viral suppression are not maintained. Infants infected perinatally remain at high risk for rapid disease progression, severe immunosuppression, and early mortality, especially in the absence of timely diagnosis and antiretroviral therapy (ART). Coinfections such as cytomegalovirus (CMV) may further complicate the clinical course and influence management decisions. Case Presentation: We report a case of a 7-week-old female infant presenting with chronic diarrhea, fever, severe malnutrition, jaundice, and pancytopenia. The infant was born at term via elective cesarean section to a mother with known HIV infection who had discontinued ART prior to and during pregnancy. Neonatal prophylaxis consisted of zidovudine monotherapy based on reported maternal adherence. Early Infant Diagnosis confirmed HIV-1 infection with profound immunosuppression (CD4 37 cells/µL, 2.6%) and a high viral load (2.99 ×10⁶ copies/mL). Further evaluation revealed active CMV infection with significant hepatobiliary involvement. Management included supportive stabilization, treatment of CMV infection, opportunistic infection prophylaxis, and carefully timed ART initiation in the context of severe hepatic dysfunction and risk of immune reconstitution inflammatory syndrome. Conclusion: This case highlights how disruption along the PMTCT cascade, including interruption of maternal ART and misclassification of neonatal transmission risk, can lead to advanced HIV disease in early infancy despite obstetric preventive measures. Sustained maternal viral suppression, accurate perinatal risk assessment, and timely initiation of ART remain critical to preventing severe pediatrics HIV.
Impact of radiocontrast media on microscopic urine morphology and output in children following cardiac catheterization Ketut Indah Karina Mahardika; Putu Andrie Setiawan; Ni Putu Veny Kartika Yantie; Eka Gunawijaya
Pediatric Sciences Journal Vol. 7 No. 1 (2026): Available Online : 1 June 2026
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v7i1.155

Abstract

Background: The incidence of contrast-induced acute kidney injury (CI-AKI) was relatively high, especially in lower-income countries following cardiac catheterization. Urine morphology outperforms serum creatinine as an early, more specific, and cost-effective marker for detecting and differentiating CI-AKI. Urine output (UO) is also a cost-effective marker capable of detecting early CI-AKI. This study aims to determine differences in urine morphology and UO in pediatric patients pre- and post-cardiac catheterization, including subgroup analysis based on contrast type. Methods: A one-group pre-post experimental study from pediatric congenital heart disease (CHD) diagnosed by echocardiography patients aged 0-18 years, who underwent cardiac catheterization at a tertiary referral hospital in Bali (June-December 2025). Urine samples for urinalysis were obtained 2-12 hours before and 12-48 hours after the intervention. Fluid balance and urine output were collected using a urine bag or pediatric urine collector and totaled over 24 hours, 2-12 hours before and 24 hours after contrast administration. Urinalysis was analyzed using standard urine microscopy for morphology at a standardized private clinical laboratory. Data were analyzed using SPSS version 29.0. Results: A total of 43 pediatric patients who underwent cardiac catheterization; 3 declined participation; 40 eligible subjects. Urine morphology findings were not significantly different pre- and post-catheterization (McNemar exact test, p = 0.25, CI 95%). Urine output (mL/kg/hour) was significantly different and higher post-catheterization (Wilcoxon signed-ranks test, Z = −3.105, p = 0.002). There were significant differences in urine output between pre-and-post catheterization in Iohexol (p=0.004) but slightly not significant in Iopromide group (p=0.051). The increase in UO levels in the Iohexol group is significantly (p=0.042) higher than in the Iopromide group. Conclusion: No significant changes in urine morphology were observed pre-and-post catheterization. There is a significant change in urine output, which increased significantly after cardiac catheterization.
Gut microbiota-targeted nutritional interventions for growth recovery in children with acute malnutrition: A systematic review Risma Nopara Sigmahadewi; I Gusti Lanang Sidiartha
Pediatric Sciences Journal Vol. 7 No. 1 (2026): Available Online : 1 June 2026
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v7i1.165

Abstract

Background: Acute malnutrition in children is a clinical condition characterized by rapid weight loss, wasting muscle mass, and impaired nutrient absorption. This systematic review aims to evaluate the effectiveness of gut microbiota on growth recovery in children with acute malnutrition. Methods: This systematic review was developed following the PRISMA 2020 guidelines. A literature search was conducted in three electronic databases, namely PubMed, ScienceDirect, and Cochrane. Included studies were randomized clinical trials and controlled trials evaluating gut microbiota-based nutritional interventions in children with acute malnutrition. Data was analyzed qualitatively. Results: Fourteen studies met the inclusion criteria, encompassing a total of 3,833 subjects (please verify against Table 1) from various low- and middle-income countries. The interventions evaluated included microbiota-directed complementary foods (MDCF), probiotics, prebiotics, synbiotics, and locally sourced therapeutic formulas. MDCF was associated with the most consistent improvements in Weight-for-Length Z-score (WLZ), Weight-for-Age Z-score (WAZ), and Mid-Upper Arm Circumference (MUAC), and growth-related biological profiles across included studies. Certain probiotic strains, particularly Bifidobacterium infantis EVC001, provided significant ponderal improvements in some populations, although consistency across studies was limited. Prebiotics and locally sourced formulas demonstrated potential benefits on certain outcomes, but results varied. Conclusion: Nutritional interventions targeting the gut microbiota, particularly MDCF, have the potential to support growth recovery in children with acute malnutrition. Their effectiveness depends heavily on the type of intervention, its composition, the child's age, the malnutrition category, and the duration of administration.

Page 8 of 8 | Total Record : 73

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