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Krisni Subandyah
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Departemen Ilmu Kesehatan Anak FKUB (Department of Pediatrics, Faculty of Medicine, Universitas Brawijaya). Jl. Jaksa Agung Suprapto No. 2 Malang, Provinsi Jawa Timur, Indonesia
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INDONESIA
Pediatric Sciences Journal
Published by Universitas Brawijaya
ISSN : 27220427     EISSN : 27221474     DOI : https://doi.org/10.51559/pedscij
Core Subject : Health,
Health Professions Public Health
Pediatric Sciences Journal (PedSciJ) is published by the Medical Faculty of Brawijaya University, Indonesia, as an Open Access & Peer Reviewed Multidisciplinary Journal. The aims and scope of the Journal include pediatric, neonatal healthcare, and perinatology/ The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions that promote the exchange of ideas and rational discourse between practicing educators and medical researchers worldwide. Pediatric Sciences Journal (PedSciJ) publishes peer-reviewed clinical research articles, case reports, serial case reports, systematic reviews, meta-analyses, and letters to the editor twice a year in June and December. Articles published in the Pediatric Sciences Journal (PedSciJ) embrace the full scope of the manuscript related to the health and diseases of infancy, neonates, children, adolescents, and those related to pediatric topics. The Journal also explores legal and ethical issues, neonatal technology, and product development based on COPE. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians, pediatric subspecialists, obstetrics, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists
Arjuna Subject : Kedokteran - Pediatrics, Perinatology, and Child Health
Articles 67 Documents
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A comparison of test duration for the clinical diagnosis of pediatric tuberculosis using Tuberculin Skin Test (TST) and Interferon Gamma Release Assays (IGRA) Olivianto, Ery; Iskandar, Agustin; Akmaly, Triyana Dian Dhuha; Mirza, Sarah Zoraya; Jahono, Maxie Felix
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.118

Abstract

Background: Tuberculosis (TB) remains a major global health challenge, particularly among children. Diagnosing pediatric TB is complicated due to nonspecific symptoms and the difficulty of obtaining sputum samples for microbiological confirmation. Immunological tests, such as the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs), are commonly used to support diagnosis. However, TST has several limitations, including the need for multiple patient visits and potential cross-reactivity with Bacillus Calmette-Guérin (BCG) vaccination. This study aimed to compare the efficiency of IGRA and TST in terms of turnaround time and patient compliance. Methods: A diagnostic time comparison study was conducted in pediatric patients with suspected pulmonary or extrapulmonary TB at Saiful Anwar Hospital, Malang. Patients underwent both TST and IGRA testing. The time required to obtain results and patient compliance was recorded and analyzed. o Results: A total of 94 pediatric patients were included, with 17 diagnosed with extrapulmonary TB and 77 with pulmonary TB. IGRA demonstrated a significantly shorter turnaround time (25.43 ± 6.31 hours for pulmonary TB, and 25.58 ± 6.37 hours for extrapulmonary TB) compared to TST (50.16 ± 6,93 hours for extrapulmonary TB and 50.34 ± 7.16 hours for pulmonary TB). Additionally, IGRA provided higher positivity rates in both pulmonary and extrapulmonary TB cases. Conclusion: IGRA offers a faster and more convenient alternative to TST for diagnosing pediatric TB. Despite its higher cost, the efficiency and single-visit requirement of IGRA makes it a preferable diagnostic tool in clinical settings, especially for children suspected of having TB.
Unveiling associated factors related to congenital heart disease in children: A case-control study Wijaya, Lisa Amelia; Yantie , Ni Putu Veny Kartika; Gunawijaya, Eka
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.125

Abstract

Background: Congenital heart diseases (CHDs) remain a significant global health burden and a leading cause of child mortality. However, limited evidence exists regarding the factors associated with CHDs, particularly in Indonesia. This study aims to identify factors associated with congenital heart defects (CHDs) in children. Methods: A case-control study was conducted using secondary data from pediatric cardiology patients at Ngoerah Hospital between 2021 and 2023, extracted from pedcardiobali.com. Patients aged 0–18 years who were diagnosed with CHD via echocardiography were included in the case group. Those with normal echocardiographic findings comprised the control group. Patients with incomplete medical records were excluded from the study. A total of 300 eligible subjects were selected, with 150 assigned to each group using a combination of purposive and random sampling methods. Multivariate logistic regression analysis was performed using SPSS version 29.0. Results: Among the 300 subjects, low birth weight (<2,500 grams) was significantly associated with CHDs (OR 3.365; 95% CI: 1.48–7.65; P = 0.004). Prematurity, maternal alcohol consumption, and congenital anomalies were identified as potential confounding factors (OR 1.19; 95% CI: 0.61–2.35; P = 0.61; OR 1.65; 95% CI: 0.45–6.06; P = 0.45; OR 1.98; 95% CI: 0.56–6.94; P = 0.29, respectively). No significant associations were found with maternal or paternal age, multiparity, multiple gestation, smoking, family history of CHDs, or maternal infection. Conclusion: Low birth weight is a dominant factor associated with CHDs. Early prenatal care and targeted interventions are crucial in reducing this risk. Further research is warranted to investigate the underlying mechanisms and genetic contributions to coronary heart disease (CHD).
Patent ductus arteriosus and pulmonary hypertension in a fifteen-year-old boy with congenital rubella syndrome and cerebral palsy: a case report Putri, Jeanaya Hedya Alfara; Haris, Ivana Angelica; Nahdah, Jaudah; Putri, Jenniefer Clarissa; Hamdy, Irza Hasanal; Pikir, Rizqi Rokhmadhoni; Adam, Olivia Mahardani; Adiwinoto, Ronald Pratama
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.96

Abstract

Introduction: Congenital Rubella Syndrome (CRS) is characterized by congenital cataracts, congenital heart disease (CHD), hearing loss, and developmental delay. It is caused by maternal rubella infection during pregnancy, transmitted transplacentally or via respiratory droplets. CRS carries a high risk of morbidity and mortality, with approximately 10–20% of affected infants dying within the first year of life. This case report describes a 15-year-old boy with CRS who developed pulmonary hypertension (PH) due to a persistent patent ductus arteriosus (PDA). Case Description: A 15-year-old boy presented with progressive abdominal distension over one week. Initially suspected of having nephritic syndrome, further evaluation revealed bilateral congenital cataracts, non-cyanotic CHD in the form of PDA, sensorineural hearing loss, and developmental delay, fulfilling criteria for CRS. The patient also exhibited delayed motor milestones (walking at age seven) and limb rigidity suggestive of cerebral palsy (CP). Echocardiography confirmed PDA (0.4 cm) with severe tricuspid and aortic regurgitation, and chest X-ray demonstrated cardiomegaly with PH. The PDA was successfully closed using an Amplatzer Duct Occluder (ADO) via catheterization. Conclusion: This case underscores the importance of early diagnosis and intervention in CRS patients with PDA to prevent irreversible pulmonary vascular disease. Despite a very late PDA closure at age 15, the patient achieved hemodynamic improvement and maintained functional capacity, highlighting that catheter-based closure remains feasible and beneficial even in adolescence. Multidisciplinary care, including timely cardiac intervention and neurodevelopmental support, can improve quality of life in CRS survivors.
The effect of breastfeeding compared with formula milk on the growth of infants with congenital heart disease: Evidence-based case report Melinda; Permadi, Prasetya Ismail; Yuliarto, Saptadi; Kadafi, Kurniawan Taufiq; Koentartiwi, Dyahris; Rahmadany, Aulya Farra; Fauzi, Muhammad Rizki; Muharrom, Muhammad Aji
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.123

Abstract

Introduction: Children with Congenital Heart Disease are at high risk of feeding and growth problems. Nutrition practices for children with CHD still vary widely across institutions, including breastfeeding. This study aims to conduct a critical review to compare the effects of breastfeeding versus formula on the growth of infants with congenital heart disease. Methods: The article search was conducted online using the PubMed, EBSCO, and ProQuest databases with the keywords “Congenital Heart Disease,” “Human Milk,” “Formula,” and “Growth.” Result: Two articles were obtained in the form of systematic review studies. Results of the study stated that in infants with CHD with breastfeeding compared to formula milk Weight for age score is better with breastfeeding because breast milk is easier to digest Conclusion. Breast milk has been shown to have significant benefits on the growth of infants with CHD compared to formula, especially in terms of weight-for-age z-score.
Management of refeeding syndrome in a severely wasted complex case pediatric patient in a limited facilities hospital: a case report Rahman, Arief; Sari, Riona; Saputra, Epriyan
Pediatric Sciences Journal Vol. 6 No. 2 (2025): In Press Online : December 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i2.134

Abstract

Backgrounds: Refeeding syndrome is a life-threatening metabolic complication that may occur during nutritional rehabilitation in patients with severe malnutrition. Diagnosing this condition is particularly challenging in resource-limited settings due to the lack of comprehensive laboratory facilities, although prompt recognition and treatment are essential to prevent serious outcomes. Case Presentation: We report an 11-month-old boy presenting with pallor, generalized weakness, severe wasting, a senile facial appearance, prominent ribs, abdominal distention, phimosis, pedal edema, and global developmental delay. Pulmonary auscultation revealed fine crackles bilaterally. Laboratory investigations demonstrated very severe anemia (hemoglobin 2.7 g/dL), leukocytosis, hypoalbuminemia, and the presence of Ascaris lumbricoides ova. Chest radiography suggested pulmonary tuberculosis. The patient was treated with packed red cell transfusions, broad-spectrum intravenous antibiotics, multivitamins, folic acid, and first-line anti-tuberculosis drugs. Nutritional support was initiated cautiously following stabilization, but on day five, the patient developed recurrent pedal edema, hypokalemia, hypernatremia, and a further decline in serum albumin. Based on the consensus criteria of the American Society for Parenteral and Enteral Nutrition (ASPEN), a diagnosis of refeeding syndrome was established. Electrolyte abnormalities were corrected, and nutritional support was restarted from the stabilization phase with close monitoring. Anthelmintic and iron therapy were administered during the rehabilitation phase. The patient showed gradual clinical improvement and was discharged on day 26. Conclusion: Early diagnosis of refeeding syndrome is feasible in resource-limited hospitals using the updated diagnostic criteria provided by ASPEN. Careful nutritional repletion, timely administration of thiamine and multivitamins, correction and monitoring of electrolytes, and vigilant clinical observation are essential for the effective management of pediatric refeeding syndrome.
Dengue Shock Syndrome (DSS) complicated by severe hyponatremia and seizure in a pediatric patient: a rare case report Fitria, Triola; Viorika, Erli Meichory
Pediatric Sciences Journal Vol. 6 No. 2 (2025): In Press Online : December 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i2.138

Abstract

Background: Dengue Shock Syndrome (DSS) represents the most severe form of dengue virus infection, driven by massive plasma leakage and profound hemodynamic instability. Severe hyponatremia in this context is uncommon and may precipitate neurological manifestations, including seizure, compounding disease complexity and mortality risk. This study aims to describe the clinical course, management, and outcome of a pediatric DSS case complicated by severe symptomatic hyponatremia and seizure. Case Presentation: We report the case of an 8-year-11-month-old boy presenting with fever, abdominal pain, diarrhea, and a generalized tonic–clonic seizure at home. Laboratory findings confirmed secondary dengue infection, hemoconcentration, thrombocytopenia, and severe hyponatremia (Na⁺ 100–122 mEq/L). The patient developed DSS with large-volume ascites and bilateral pleural effusions during the critical phase. Management included fluid resuscitation per WHO protocol, hypertonic saline correction of sodium, albumin infusion, and close hemodynamic and neurological monitoring. Seizure activity resolved with gradual sodium normalization. Conservative management of effusions avoided invasive intervention. The patient was discharged in stable condition on day six with no recurrent neurological events. This case illustrates the diagnostic and therapeutic challenges of managing DSS complicated by severe hyponatremia and seizure. Management requires balancing volume restoration with prevention of sodium dilution and fluid overload, alongside multidisciplinary coordination. Conclusion: Severe hyponatremia with seizure in DSS is rare but life-threatening. Early electrolyte evaluation in dengue patients with neurological symptoms is essential, and individualized management can optimize survival.
Packed red cell transfusions in preterm neonates: a retrospective study Sulistio, Ivena Clairine; Delicia Rudy; Putu Siska Suryaningsih; I Wayan Bikin Suryawan
Pediatric Sciences Journal Vol. 6 No. 2 (2025): In Press Online : December 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i2.142

Abstract

Introduction: Preterm neonates are highly vulnerable to anemia. Packed red cell (PRC) transfusions are often necessary but must be carefully considered due to associated risks. This study aims to assess the characteristics of preterm infants who received PRC transfusions to guide safer and effective transfusion practices. Methods: This study was conducted using a retrospective descriptive approach. It included preterm neonates who received PRC transfusions, as documented in the medical records from July 2022 to March 2025. Patient characteristics, hemoglobin level, transfusion profile, and comorbidities in preterm neonates receiving PRC transfusions were evaluated. Results: The sample consisted of 52 neonates, 37 boys, and 15 girls. The gestational age of infants was mainly between 28 and <32 weeks (64,5%). Most neonates were very low birth weight, which is 53,8%. The mode of delivery was relatively similar between spontaneously and cesarean section. The average length of hospital stay was 35.27 ± 16.62 days. The initial hemoglobin level of preterm infants receiving PRC transfusions averaged 10.88 ± 1.33 g/dL. The first transfusion was typically administered at 18.10 ± 9.69 days of life. Notably, most infants (59.6%) required three or fewer transfusions. The most common comorbidity among preterm infants receiving PRC transfusions was respiratory distress syndrome (RDS) at 78.8%, followed by neonatal jaundice (53.8%) and asphyxia (40.4%). Most RDS cases (69.2%) were caused by hyaline membrane disease (HMD). Conclusion: Preterm neonates receiving PRC transfusions had a high-risk profile, underscoring the importance of individualized transfusion thresholds and close post-transfusion monitoring to improve clinical outcomes.

Page 7 of 7 | Total Record : 67

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