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INDONESIA
Jurnal Farmanesia
Published by Universitas Sari Mutiara Indonesia
ISSN : """"     EISSN : 25282484     DOI : https://doi.org/10.51544/jf.v8i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 248 Documents
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SKRINING FITOKIMIA DAN UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL JAHE MERAH (Zingiber officinale Rosc. Var Rubrum) DAN EKSTRAK ETANOL JAHE PUTIH (Zingiber officinale Rosc. Var Officinarum) PADA MENCIT PUTIH JANTAN Siti Nurbaya; Yosy Cinthya Eriwaty Silalahi; Trionaldo Putra
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

One of the medicinal plants is ginger. The ginger plant has properties in overcoming pain, but it is not yet known how big the percentage of the strength of the analgesic activity of the ginger plant is. The components consisting of oleoresin are a complete picture of the content of ginger, namely essential oils and fixed oils consisting of gingerol, shagaol, and resin. Mice were divided into eight treatment groups (CMC 0.5%, Acetosal, EEJM (Red Ginger Ethanol Extract) 100, EEJM 200, EEJP (White Ginger Ethanol Extract) 100, EEJP 200, Combination 100, Combination 200). orally. Animals were induced with 3% acetic acid. Pain is characterized by the emergence of stretching which is indicated by the abdomen touching the base of the footing and both pairs of legs being pulled back. Observe stretching at intervals of every 10 minutes for 90 minutes. The characterization of red ginger rhizome simplicia and white ginger rhizome has met the requirements set by the Indonesian Herbal Pharmacopoeia. The results of phytochemical screening showed that simplicia and extracts from red and white ginger rhizome contained alkaloids and triterpenoids/steroids. The results showed that all treatment groups had an analgesic effect, which was not significantly different from the acetosal treatment (P>0.01). The highest analgesic power and effectiveness was seen in the EEJM 200mg/kg BW treatment group.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN INSULIN (Smallanthussonchifolius) TERHADAP BAKTERI Bacillus cereus Kesaktian Manurung; Ahmad Ghazali; Ulfayani Mayasari
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Insulin leaves are known as one of the ingredients of traditional medicine. Insulin leaves contain potential substances such as tannins, alkaloids, flavonoids, saponins, and terpenoids which have antibacterial abilities. This study aims to determine the effectiveness of insulin leaf ethanol extract as an antibacterial. This research is an experimental study that includes the collection and processing of insulin leaf samples, examination of the characteristics of Simplisia, phytochemical screening, testing of the antibacterial diffusion method using a disk paper brace, and using the One Way ANOVA analysis method. The test results showed that the ethanol extract could inhibit bacterial growth at a concentration of 50 - 60% with an average resistor potential of 14.8 - 17.83 mm while Ampicillin as a comparison control averaged 33.62 mm. So that the ethanol extract of insulin leaves was effective in inhibiting the growth of Bacillus cereus bacteria with a minimum resistance concentration of 60 mg/ml. Keywords: Antibacterial, Bacillus cereus, insulin leaf extract
UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN BANGUN-BANGUN (Plectranthus amboinicus Lour.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Zuhairiah Zuhairiah; Yosy Cinthya Eriwaty Silalahi; Ariyanti Ariska
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Bangun-Bangun leaves contain phytochemical compounds such as phenolic compounds and flavonoids which have potential as antioxidant activity. This study aims to determine the antidiabetic activity of the ethanolic extract of Bangun-Bangun leaves on reducing blood glucose levels (KGD) of male white rats by using the glucose tolerance test method and the alloxan induction test. The study was conducted by grouping rats where each group consisted of 5 rats, the fasting KGD was measured. Then, a group I was given Na-CMC 1% BW, group II was given glibenclamide 0.45 mg/kg BW, group III was given EEDBB at a dose of 200 mg/kg BW, group IV was given EEDBB at a dose of 250 mg/kg BW and group V was given EEDBB dose of 300 mg/kg BW. In the glucose tolerance test, each group was given a 50% concentration of glucose solution. Furthermore, measurements of KGD were carried out at 30, 60, 90, and 120 minutes. In alloxan induction, 25 test animals weighing ±150-200 g that had been fasted were divided into 5 groups and then KGD was measured. The rats were then induced with a dose of 150 mg/kg BW of alloxan intraperitoneally. Diabetic rats were then given the test preparation orally for 15 consecutive days. Furthermore, glucose levels were measured on the 3rd, 5th, 7th, 9th, 11th, 13th, and 15th days. The results concluded that EEDBB can reduce blood glucose levels of male white rats induced by alloxan.
PENETAPAN KADAR FLAVONOID TOTAL DARI EKSTRAK ETANOL DAUN ANDALIMAN (Zanthoxylum acanthopodium DC.) Cut Masyithah Thaib; Siti Nurbaya; Martha Uli Oktavrina Rajagukguk
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Flavonoids are a class of polyphenolic compounds that have an antioxidant effect by donating hydrogen atoms and linking them with metal ions. Most flavonoids are found in plants. One of the plants that contain lots of flavonoids is andaliman (Zanthoxylum acanthopodium DC). The purpose of this study was to determine the compounds contained in the Andaliman leaf and to determine the total flavonoid content of the Andaliman leaf extract. The type of research conducted was descriptive, including identification of plant material, collection of plant material, phytochemical screening, and examination of total flavonoids with visible ultraviolet spectrophotometry. Samples were taken from LobuSiregar village, Siborong-Borong, North Tapanuli. Andaliman leaf extract (Zanthoxylum acanthopodium DC) was obtained by the maceration method using 96% ethanol. Determination of total flavonoid content was carried out by the colorimetric method. The results of phytochemical screening showed the presence of alkaloids, flavonoids, tannins, and steroids. Determination of total flavonoid content calculated as quercetin with the regression equation y= 0.03278 X + 0.04086, and r = 0.99825. The measurement results of the total flavonoid content of the ethanol extract of Andaliman leaves were 39.65 ± 0.08 mg QE/g.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli, Shigella dysentriae, DAN Salmonella typhi Yosy Cinthya Eriwaty Silalahi; Realisni Telaumbanua
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.167 KB) | DOI: 10.51544/jf.v4i2.2705

Abstract

One of the medicinal plants is the areca nut (Areca catechu L.) from the Arecae family which has the potential as an anticancer having antioxidant and antimutagenic, astringent, and anthelmintic effects. Areca nut seeds contain alkaloids, such as arekoline, arekolidine, arekain, guvakolin, guvasine and isoguvasine. This study aims to determine the characteristics of the betel nut (Areca catechu L.) simplicia, class of compounds, and the antibacterial activity of the ethanol extract of areca nut (Areca catechu L.) against the growth of Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria. The method used is the ethanol extract of areca nut (Areca catechu L.) obtained from the maceration process with 96% ethanol. The results of phytochemical screening showed that the ethanolic extract of areca nut (Areca catechu L.) contains a group of alkaloid compounds, tannins, flavonoids, saponins, and triterpenoids. The effect of giving young betel nut ethanol extract to Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria was indicated by the formation of an inhibition zone of optimum concentration. The ethanol extract of old betel nut against Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria was characterized by the formation of an optimum concentration inhibition zone. Based on the results, it can be concluded that the ethanol extract of areca nut (Areca catechu L.) has antibacterial activity against Escherichia coli, Shigella dysentriae, and Salmonella typhi.
PENGARUH INFUSA KULIT BUAH MANGGIS (Garcinia mangostana) TERHADAP PROFIL FARMAKOKINETIKA PARASETAMOL PADA TIKUS PUTIH JANTAN (Rattus norvegicus L.) Kesaktian Manurung; Siti Nurbaya; Rezkita Raysyah
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.94 KB) | DOI: 10.51544/jf.v4i2.2706

Abstract

Mangosteen rind is traditionally used by residents of Southeast Asia, especially Indonesia, to treat various diseases. Drug interactions can reduce or eliminate efficacy and cause serious health problems or problems. This study aims to determine the effect of mangosteen rind infusion on the pharmacokinetic profile of paracetamol administered orally to male white rats. Infusion of mangosteen rind was made in doses of 10% and 20%. The study was conducted by giving the solution successively for 7 days and on the 7th day after 4 hours, paracetamol solution was given orally. Furthermore, the blood of each male rat was taken with a time of 0 minutes, 10 minutes, 20 minutes, 30 minutes, 40 minutes, 60 minutes, 90 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes, and 360 minutes and measured by UV spectrophotometry. a wavelength of 257 nm. The results showed that there was an effect of mangosteen rind infusion on paracetamol in test animals.
FORMULASI DAN EVALUASI SEDIAAN LIP BALM DENGAN PEWARNA EKSTRAK UBI JALAR UNGU (Ipomoea batatas (L.) Lamk.) Supartiningsih Supartiningsih; Elly Nurita Sitorus; Yosy Cinthya Eriwaty Silalahi; Khairunnisa Khairunnisa
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.496 KB) | DOI: 10.51544/jf.v4i2.2707

Abstract

Lip balm is a cosmetic preparation with the main components such as wax, fat, and oil from natural or synthesized extracts with the aim of preventing dryness of the lips by increasing lip moisture and protecting the adverse effects of the environment on the lips. The use of purple sweet potato as a dye is because purple sweet potato (Ipomoea batatas (L.) Lamk.) has an attractive color, the color of purple sweet potato is due to the presence of anthocyanin pigments which are derivatives of flavonoid compounds which are generally soluble in polar solvents. This study aims to formulate and evaluate lip balm preparations using purple sweet potato extract at concentrations of 3%, 6%, 9%, and without using purple sweet potato extract. This research is experimental research. Lip balm preparations were made by adding purple sweet potato extract with various concentrations (F1) 3%, (F2) 6%, (F3) 9%, and blank formula (F0) as the basis for lip balm preparations without purple sweet potato extract. Evaluation of the preparation includes homogeneity test, stability test, smear test, adhesion test, spreadability test, and pH test. The test results showed that purple sweet potato extract can be formulated in lip balm preparations that have a homogeneous composition, have good smearing power, good adhesion F0 (1 minute), F1 (1 minute 3 seconds), F2 (1 minute 8 seconds). seconds), F3 (1 minute 11 seconds), spreadability (5-5.7cm), pH test on all preparations showed a pH that was in accordance with the pH of the skin. And obtained formula 3 is the best formula.
PENETAPAN KADAR KALSIUM PADA BEDAK TABUR DARI BAHAN BAKU CANGKANG KERANG BULU (Anadaraantiquata) SECARA KOMPLEKSOMETRI Siti Nurbaya; Artha Yuliana Sianipar; Elly Nurita Sitorus; Winton F. Situmorang
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.652 KB) | DOI: 10.51544/jf.v4i2.2708

Abstract

Until now, the utilization of clamshell waste has been limited to handicraft materials, whereas shellfish waste has a high calcium carbonate composition of about 98% which can be used as a source of calcium in the synthesis of compounds containing calcium metal. The purpose of this study was to determine the level of calcium contained in the shells of mussels and to determine the levels of calcium in the preparation of talcum powder which was added with powdered shells of feathers as an abrasive. Complexometric titration is also used to determine calcium levels in powder preparations formulated with feather shells powder. The results showed that the shells of feather shells contained calcium levels of 19.49% while the loose powder preparations contained calcium levels of 1.475%. The test results of the research on the formulation of loose powder preparations met the physical evaluation requirements. The pH test on loose powder, namely pH 7, meets the requirements of SNI 16-4399-1996, the pH value of cream cosmetic products is required to range from 4.5 to 8.0. The fine degree test is qualified because the loose powder can pass the sieving using a 100 mesh.
PENETAPAN KADAR VITAMIN C PADA DAUN JELATANG (Urtica dioica L.) DENGAN MENGGUNAKAN SPEKTROFOTOMETRI ULTRAVIOLET Zuhairiah Nasution; Siti Nurbaya; Supartiningsih Supartiningsih; Tiurma Sitompul
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.499 KB) | DOI: 10.51544/jf.v4i2.2709

Abstract

Nettle leaf (Urtica dioica L) is the most widely known species in the genus Urtica and has many benefits for the community, one of which is to treat venereal diseases, kidney disorders, allergies, diabetes, anemia, and digestive tract diseases. Vitamins contained in nettle leaves that are useful for the body is vitamin C. Vitamin C has properties that are easily damaged by heat, and easily soluble in water. This study aims to determine the levels of vitamin C in young and old nettle leaves by an ultraviolet spectrophotometric method using Aquadest solvent and read a wavelength of 265 nm with a linear regression equation y= ax + b with a value of y= 0.0525 + 0.0618 with r = 0.9878 each treatment was replicated 6 times. Based on the results of the qualitative test experiment, it was stated that in nettle leaves there was vitamin C with iodine solution reagent, FeCl3, Fehling A&B, and obtained vitamin C levels in old nettle leaves 0.2526 mg/g and in young nettle leaves 0.2026 mg/g. So that the levels of vitamin C in old nettle leaves are higher than in young nettle leaves.
PENGARUH MINYAK SAWIT MERAH (RPO) DAN MINYAK ZAITUN MURNI (EVOO) TERHADAP PERTUMBUHAN RAMBUT PADA KELINCI Ahmad Gazali Sofwan; Adiansyah Adiansyah; Rika Rosalinda Tampubolon
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.15 KB) | DOI: 10.51544/jf.v4i2.2710

Abstract

Haircare products are very important to prevent one of the problems of hair damage, both from synthetic and natural ingredients. One of the natural ingredients of hair care products is Red Palm Oil (RPO) and Extra Virgin Olive Oil (EVOO). This research is an experimental study that aims to see whether Red Palm Oil and Extra Virgin Olive Oil have effectiveness in growing hair. This research method used 4 groups of test animals, namely the red palm oil group, extra virgin olive oil, negative control (aqua dest), and positive control (minoxidil). The hair growth activity test was carried out by applying each formula to the marked rabbit's back and measuring the length of the hair using a caliper on the 5th, 10th, 15th, 20th, 25th, and 30th days. On the 31st day, the hair weight was tested by weighing the hair using an analytical balance. The results showed that each formula had hair growth activity, but the most effective oil preparation in accelerating hair growth was Red Palm Oil (RPO).

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