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INDONESIA
Jurnal Farmanesia
Published by Universitas Sari Mutiara Indonesia
ISSN : """"     EISSN : 25282484     DOI : https://doi.org/10.51544/jf.v8i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 248 Documents
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PENGGUNAAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereuscostaricensis (F.A.C. Weber) Britton & Rose.) DALAM FORMULASI PEWARNA RAMBUT Cut Masyithah; Siti Maimunah; Zuhairiah Zuhairiah; Cahaya Amalia Sitorus
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.282 KB) | DOI: 10.51544/jf.v4i2.2711

Abstract

Hair is a symbol of beauty in humans which is one of the adnexa (parts) of the skin that grows from the skin. Hair grows from the root, hair that is in the dermis layer, and through the hair follicle channel out of the skin. There are some differences in each hair such as type, shape, amount, and color. Dragon fruit peel is an agricultural waste that contains high anthocyanin natural dyes. Anthocyanin is a dye that plays a role in giving red color which has the potential to be a natural colorant for food and can be used as an alternative to synthetic dyes that are safer for health. Anthocyanin was taken by the extraction method. The results showed that the higher the concentration of the adjuvant used, the darker the gray hair. The use of auxiliary materials in a concentration of 0.5% produces a brownish-black color, and a concentration of 1% produces a dark black color. The preparation of gray hair dye made with the formula of 2.5% dragon fruit peel extract and 1% adjuvant produces a deep black color, so pyrogallol, copper (II) sulfate, xanthan gum with a concentration of 0.5% are used in order to distinguish changes on white hair (grey), due to the EKBN formula or from added additives.
UJI AKTIVITAS EKSTRAK ETANOL BAWANG PUTIH (Alliumsativum L.)YANG DIHITAMKAN SEBAGAI ANTI INFLAMASI YANG DIINDUKSI OLEH KARAGENAN TERHADAP Mus musculus Dicky Yuswardi Wiratma; Kesaktian Manurung; Supartiningsih Supartiningsih; May Fransisca Telaumbanua
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.897 KB) | DOI: 10.51544/jf.v4i2.2712

Abstract

One of the plants used as an alternative to traditional medicine is Garlic (Allium sativum L.). Garlic which is rich in organic organo sulfur compounds (amino acids and essential oils) in the form of allin has many benefits in treating various types of diseases. One of the processed forms of garlic is black garlic. Black garlic is a heating product from garlic that is heated at a temperature of 70oC with a relative humidity of 70-80%. This study aims to determine the use of black garlic as an anti-inflammatory, how to make black garlic and at what concentration black garlic has an anti-inflammatory effect. The method used in this research is a pure experimental method. The results of the %R measurement, the negative control group had the highest level of inflammation and the lowest was the black garlic extract group with a concentration of 60%. Meanwhile, in the %IR measurement, the black garlic extract group with a concentration of 60% had the greatest ability to block inflammation. From the tests that have been carried out, black garlic is obtained from heating results and the results of measuring the effectiveness of its anti-inflammatory activity, namely black garlic extract with a concentration of 60% have a better anti-inflammatory effect compared to other concentrations and diclofenac sodium.
UJI AKTIVITAS GETAH GAMBIR(Uncariagambir Roxb.) TERHADAP BAKTERI Escherichia coli DAN Salmonella typhi Adiansyah Adiansyah; Ahmad Gazali Sofwan; Siti Nurbaya; Lestari Simanjuntak
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (462.752 KB) | DOI: 10.51544/jf.v4i2.2713

Abstract

Gambir is an extract of the leaf sap and twigs of the Gambir plant (Uncariagambir Roxb.) which has been dried. According to information, Gambir sap can be used as a mixture of drugs for burns, headache medicine, diarrhea medicine, mouthwash, thrush medicine. Because there is the main content of catechins and tannins. The purpose of this study was to determine the antibacterial activity of secondary metabolites and the concentration of Gambir sap (Uncariagambir Roxb.) against Escherichia coli and Salmonella typhi bacteria. The method used is agar diffusion using disc paper. The results showed that the diameter of the inhibition of Gambir sap on Escherichia coli bacteria at a concentration of 300 mg/ml in the bacterial test was 16.03 mm, at a concentration of 200 mg/ml there was a bacterial test of 15.00 mm and Salmonella typhi at a concentration of 300 mg/ml contained bacterial test 16.06 mm, at a concentration of 200 mg/ml bacterial test 16.03 mm.
ANALISA KADAR CEMARAN LOGAM MERKURI PADA IKAN SARDEN (Sardinella lemuru) KEMASAN KALENG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Yosy Cinthya Eriwaty Silalahi; Cut Masyithah Thaib; Siti Nurbaya
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.177 KB) | DOI: 10.51544/jf.v4i2.2714

Abstract

Food packaging in cans is a food preservation technology using high-temperature sterilization. Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. This study aims to determine the levels of mercury contamination in canned sardines. The samples used in this study were 6 different brands of canned sardines. The method used to determine mercury (Hg) levels is qualitatively using color reagents and quantitatively using AAS (Atomic Absorption Spectrophotometry). The results obtained from 6 samples of canned sardines that were positive for heavy metal mercury (Hg) were indicated by the formation of orange color with KI reagent, yellow precipitate with NaOH, white precipitate with HCl. The wavelength used is 253.7 nm. The results showed that Brand A mercury 4.9814 ± 0.0301 mg/kg, Brand B 0.8757 ± 0.0308 mg/kg, Brand C 1.4899 ± 0 mg/kg, Brand D 1.4175 ± 0 mg/kg , Brand E 0.7527 ± 0 mg/kg, and Brand F 0.5270 ± 0 mg/kg. This study concludes that the mercury content in canned fish circulating in the Medan Brastagi Supermarket is above the maximum limit allowed by the National Standardization Agency (2016) in SNI 8222-2016, which is 0.5 mg/kg.
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK ETANOL DAGING BUAH ALPUKAT (Persea americana Mill.) Yettrie Simarmata; Kesaktian Manurung; Karnerius Harefa; Mei Sri Rezeki Hasibuan
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (451.698 KB)

Abstract

Diabetes mellitus is a set of symptoms that arise in a person characterized by blood glucose levels exceeding normal (hyperglycemia) due to a lack of insulin in the body. One of the medicinal plants that can be used is avocado flesh. This study aims to determine the antidiabetic activity of avocado pulp extract (Persea americana Mill) against male white rats. This study used 25 male white rats divided into 5 groups, namely the negative control group CMC-Na 1%, the positive control group glibenclamide 0.45 mg/kg BW, the EEBA test group at doses of 50, 100, 200 mg/kg BW. The results of the one-way ANOVA analysis of the Tukey HSD test showed that the administration of EEBA at a dose of 100 mg/kg BW and EEBA at a dose of 200 mg/kg BW had a significant difference with a significance value of 0.024 and 0.026 and EEBA at a dose of 50 mg/kg BW had no significant difference with the significance 0.275. Based on the results of the study, it can be concluded that EEBA doses of 50, 100, 200 mg/kg BW have antidiabetic activity.
PENENTUAN KADAR VITAMIN C PADA JERUK MANIS (Citrussinensis) MENGGUNAKAN METODE TITRASI TITRASI NA-2,6 DICHLOROPHENOL INDOPHENOL DAN SPEKTROFOTOMETRI Siti Nurbaya; Muhammad Taufik; Artha Yuliana Sianipar; Zulfan Zulfan
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.609 KB)

Abstract

Vitamin C is one of the vitamins that is needed by humans and also one of the water-soluble vitamins, Vitamin C plays a role in the formation of intercellular collagen. For the solubility of vitamins B1, B2, B3, B5, B6, B7, B9, B12, and C are included in the types of water-soluble vitamins, and for the solubility vitamins A, D, E, and K are included in the types of soluble vitamins in fat. Vitamin C functions as an antioxidant and counteracts free radicals that can damage cells. Sources of vitamins are fresh fruits and vegetables. Sweet orange fruit contains vitamin C which is quite high. This study aims to determine and compare the results of vitamin C levels in sweet oranges using the Na 2,6 Dichlorophenol Indophenol titration method and spectrophotometry. The content of vitamin C using Na 2.6 Dichlorophenol Indophenol titration is 0.042%, while the content of vitamin C in sweet oranges using the UV-Vis spectrophotometry method produces levels of 0.351%. These results, shows that the levels of vitamin C obtained by using the UV-Vis spectrophotometry method are higher than those obtained by the iodometric method.
FORMULASI EKSTRAK TONGKOL JAGUNG (Zea mays L.) SEBAGAI TABIR SURYA DALAM SEDIAAN LOTION UNTUK WAJAH Maringan Silitonga; Pandapotan Nasution; Cut Masyithah Thaib; Mei Revolinda Haloho
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.89 KB)

Abstract

Corn cobs (Zea mays L.) can be used as sunscreen because it contains phenolic compounds. The purpose of this study was to determine the characteristics of the physical and chemical properties of sunscreen lotion preparations of corncob ethanol extract and the formula and concentration that had the highest effectiveness in the value of Sun Protection Factor (SPF). The lotion was chosen because it is a topical preparation that is often used by the community. Corn cob powder was extracted by the maceration method. The results were formulated with extract concentrations, formulation I (5%), formulation II (10%), and formulation III (15%). The three formulas were tested for organoleptic, pH test, homogeneity, and lotion type. The resulting data were analyzed descriptively. The results showed that all formulas with varying concentrations of extracts had good physicochemical characteristics during storage based on the results of pH, homogeneity, organoleptic, and emulsion-type tests. Corncob ethanol extract sunscreen lotion in Formula 1 (5%) has an SPF value of 2 (UV-A rays) and an SPF value of 7 (UV-B rays). Formula 2 (10%) has an SPF value of 2,3 (UV-A rays) and has an SPF value of 9 (UV-B rays) and Formula 3 (15%) has an SPF value of 3 (UV-A rays) and has a value of SPF 12 (UV-B Rays).
PERBANDINGAN UJI AKTIVITAS ANTI DIABETES EKSTRAK ETANOL BUAH PARE (Momordicacharantia L.) DANDAUN LIDAH BUAYA (Aloe vera L.) PADA MENCIT JANTAN Erly Sitompul; Supartiningsih Supartiningsih; Samsia Yolanda Sari
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (498.224 KB)

Abstract

Diabetes is a non-communicable degenerative disease that will increase in number in the future. This is evidenced by the increasing incidence of diabetes every decade. Bitter gourd and aloe vera are an alternative in treating Diabetes Mellitus because these plants contain saponins, flavonoids, and polyphenols (strong antioxidants), as well as glycosides cucurbitacin, momordicin, and charantin that can lower blood sugar, saponins, flavonoids, and alkaloids. This study aims to determine secondary metabolite compounds, anti-diabetic activity, and the combination of aloe vera extract and bitter melon extract that has antidiabetic activity. The method used in this study is an experimental method, namely testing the antidiabetic effect of extracts obtained from ethanol of bitter melon and aloe vera leaves on alloxan-induced mice. The results obtained from the research are that the administration of aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group with the ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW showed a very good effect on reducing BGD. This means that aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group given ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW had good antidiabetic activity.
ANALISIS KADAR KALSIUM DAN BESI PADA DAUN TANAMAN BAYAM MERAH (Alternantheraamoena Voss) DAN DAUN TANAMAN BAYAM KAKAP (Amaranthus hybridus L) SECARA SPEKTROFOTOMETRI SERAPAN ATOM Ahmad Gazali Sofwan; Siti Nurbaya; Adiansyah Adiansyah; Pontisari Sitanggang
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Spinach (Amaranthus spp) is a leaf vegetable plant that is highly nutritious and favored by all levels of society. According to information, spinach plants can be used as an additional intake in the prevention of osteoporosis (bone loss) and anemia (lack of blood) because of the high calcium and iron content in them. Two types of spinach are known in the community, namely red spinach (Alternanthera amoena Voss) and spinach snapper (Amaranthus hybridus L). The purpose of this study was to determine the levels of calcium and iron in red spinach and snapper spinach leaves. The assay was carried out using an atomic absorption spectrophotometer with an air-acetylene flame. Quantitative analyzes were carried out at wavelengths of 422.7 nm for calcium and 248.3 nm for iron. The results showed that the levels of calcium and iron obtained with the levels of calcium and iron listed in the literature were different. The results also showed that there were differences in calcium and iron levels between red spinach and snapper spinach. Calcium levels in red spinach and snapper spinach leaves were 26.8016 mg/100g and 24.2759 mg/100g, respectively. The levels of iron in red spinach and snapper spinach leaves were 714.2621 mg/100g and 236.5369 mg/100g, respectively.
PENGGUNAAN JERUK NIPIS (Citrus aurantifolia) DAN LIDAH BUAYA (Aloe vera L.) SEBAGAI SEDIAAN HAIR TONIC Elly Nurita; Cut Masyithah Thaib; Adiansyah Adiansyah; Irmayanti Hutasoit
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.814 KB)

Abstract

Lignin compounds and polysaccharides, the nutritious substances in aloe vera, are useful as a carrier for the nutrients needed by the skin to repair hair roots, strengthen and stimulate hair growth. The purpose of this study was to determine the efficacy of the combination of lime extract and aloe vera extract as a hair tonic preparation for hair growth. Lime and aloe vera extracts were obtained by maceration method using 96% ethanol as solvent. The combination of lime extract and aloe vera extract is formulated to be a hair tonic, with a combination of 1 (1%:1%), combination 2 (2%:1%), and combination 3 (1%:2%). Then evaluate the stability of the hair tonic preparation, homogeneity, pH, hair growth activity, and hair weight of rabbits. The results of the stability test of the hair tonic preparation of a combination of lime extract and aloe vera extract did not change color, shape, and odor. The results of the homogeneity examination of the formulations of formulas 1, 2, and 3 were homogeneous. The result of pH observation was that the higher the concentration of the combination of lime extract and aloe vera extract, the higher the pH of the preparation. The results of the measurement of rabbit fur length showed that the highest hair growth rate was formula 3 combinations (1%:2%). The results of the three formulations of the combination of lime extract and aloe vera extract showed that the longer the hair growth of the rabbit, the heavier the weight of the rabbit's hair.

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